个人简介
教育经历
1989.09-1993.06 南京师范大学生物系,获理学学士学位
1993.09-1996.06 南京师范大学生物系,获理学硕士学位
1996.09-1999.06 中国科学院上海药物研究所,获理学博士学位
工作经历
1999.07-2002.03 中国科学院上海药物研究所助理研究员
2001.09-2001.11 芬兰赫尔辛基大学访问学者
2002.04-2005.06 中国科学院上海药物研究所副研究员,研究组长
2002.11-2003.12 瑞典Karolinska Institute博士后
2004.10-2005.01 瑞典Karolinska Institute访问学者
2005.08-2005.11 瑞典Karolinska Institute访问学者
近期论文
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1. Zou Q, Duan H, Ning M, Liu J, Feng Y, Zhang L, Zhu J, Leng Y*, Shen J * 4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists. Eur J Med Chem. 2014 May 13;82C:1-15
2. Deng X, Shen Y, Yang J, He J, Zhao Y, Peng LY, Leng Y*, Zhao QS*. Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: Potential impact in diabetes. Eur J Med Chem. 2013 Jul;65:403-14
3. Zhu J, Ye Y, Ning M, Mandi A, Feng Y, Zou Q, Kurtan T, Leng Y*, Shen J* Design, Synthesis, and Structure-Activity Relationships of 3,4,5-Trisubstituted 4,5-Dihydro-1,2,4-oxadiazoles as TGR5 Agonists. ChemMedChem. 2013 Jul;8(7):1210-23
4. Duan H, Ning M, Chen X, Zou Q, Zhang L, Feng Y, Zhang L, Leng Y*, Shen J*, Design, Synthesis, and Antidiabetic Activity of 4-Phenoxynicotinamide and 4-Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists. J Med Chem. 2012，55(23):10475-89
5. Ye N, Xu XT, Li FY, Ning MM, Liu ZQ, Cao YQ, Leng Y*, Zhang A*. Investigation on the oxidation of aryl oxiranylmethanols and the synthesis of 2-aryl-N-thiazolyl-oxirane-2-carboxamides as glucokinase activators. Tetrahedron Letters 53 (2012) 4738–4742
6. Wang YJ, Huang SL, Feng Y, Ning MM, Leng Y*. Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice. Acta Pharmacol Sin. 2012 Sep;33(9):1195-203
7. Liu X, Zhang LN, Feng Y, Zhang L, Qu H, Cao GQ, Leng Y*.Acute and chronic administration of SHR117887, a novel and specific dipeptidyl peptidase-4 inhibitor, improves metabolic control in diabetic rodent models.Acta Pharmacol Sin. 2012 Aug;33(8):1013-22
8. Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD*, Leng Y*. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia. 2012 May;55(5):1469-81
9. Mao W, Ning M, Liu Z, Zhu Q, Leng Y*, Zhang A*.Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators. Bioorg Med Chem. 20 (2012) 2982–2991
10. Zhang L, Chen J, Ning M, Zou Q, Leng Y*, Shen J*.Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice. Bioorg Med Chem Lett. 2012 15;22(8):2748-52
11. Simo Mpetga JD, Shen Y, Tane P, Li SF, He HP, Wabo HK, Tene M, Leng Y*, Hao XJ*.Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11β-Hydroxysteroid Dehydrogenases. J Nat Prod. 2012 Apr 27;75(4):599-604
12. Liu ZQ, Zhu QZ，Li FY，Zhang LN, Leng Y*，Zhang A* N-(5-substituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators. Med. Chem. Commun., 2011; 2: 531–535
13. Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y* Emodin, a natural product, selectively inhibits 11β-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol. 2010 ;161(1):113-26
14. Li FY, Zhu QZ, Zhang Y, Feng Y, Leng Y*, Zhang A*. Desgin, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)- 2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators. Bioorg Med Chem. 2010;18(11):3875–3884
15. Zhang L, Shen Y, Wang F, Leng Y*, Liu JK*. Rare merosesquiterpenoids from basidiomycete Craterellus odoratus and their inhibition of 11beta-hydroxysteroid dehydrogenases. Phytochemistry 2010 Jan ;71(1):100-3
16. Ye YL, Zhou Z, Zou HJ, Shen Y, Xu TF, Tang J, Yin HZ, Chen ML, Leng Y*, Shen JH*. Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. Bioorg Med Chem. 2009;17(15):5722-32
17. Zhang X, Zhou Z, Yang HY, Chen JH, Feng Y, Du L, Leng Y*, Shen JH*. 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice. Bioorg Med Chem Lett. 2009;19(15):4455-8
18. Zhang L,Li HL, Zhu QZ, Liu J, Chen L, Leng Y*, Jiang HL, Liu H*. Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase. Bioorg Med Chem. 2009:7301-7312
19. Zhang X, Zhou Y, Shen Y, Du LL, Chen JH, Leng Y*, Shen JH*. Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro. Acta Pharmacol Sin. 2009; 30:1344-1350
20. Xu D, Sheng Y, Zhou ZY, Liu R, Leng Y*, Liu JK*. Sesquiterpenes from cultures of the basidiomycete Clitocybe conglobata and their 11 beta-hydroxysteroid dehydrogenase inhibitory activity. Chem Pharm Bull (Tokyo). 2009 Apr;57(4):433-5
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