个人简介
教育经历
1978.01 - 1982.12 江西医学院医疗系本科,82年获医学学士学位
1983.01 - 1985.12 江西医学院解剖教研室硕士研究生,85年获硕士学位
1989.02 - 1991.12 上海医科大学组织学与胚胎学博士研究生,91年获博士学位
工作经历
1986.01 - 1988.05 江西医学院解剖教研室助教
1988.06 - 1989.01 江西医学院解剖教研室讲师
1992.01 - 1994.08 中科院上海脑研究所博士后
1994.09 - 1997.09 中科院上海脑研究所课题组长、副研究员(1996.06起兼任副所长)
1997.10 - 1999.11 中科院上海脑研究所研究员、课题组长、副所长
1999.12 - 2003.12 中科院神经科学研究所研究员、课题组长(其间1999.12-2002.11兼任副所长;2002.12起兼任上海生科院工会主席;1997-2001每年2-6个月作为访问学者在NIH合作研究)
2004.01 - 至今 中科院上海药物研究所第二药理室课题组长、研究员(2006.03起兼第二药理室主任)
2005.05 - 2014.03 兼任上海药物所工会主席
研究领域
1. 神经退行性疾病的药物筛选和靶点确证及药效学评价
(1) 神经胶质细胞在缺血性脑卒中和帕金森病病理过程中的作用及其作为药物靶点确证和机制研究
(2) 缺血性脑卒中和帕金森病表观遗传学调控及药物作用机制的研究
2. 小分子化合物调控神经干细胞定向分化的研究
(1) 调控间充质干细胞想神经系统细胞跨胚层分化的小分子化合物的筛选和成药性研究
(2) 调控神经干细胞增殖、分化的小分子化合物的筛选和成药性研究
近期论文
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1.Huang L., Wu DD, Feng L.*(2013) Modulation of A2a Receptor antagonist on D2 Receptor internalization and ERK phosphorylation Acta Pharmacologica Sinica, 34: 1292–1300; doi: 10.1038/aps.2013.87; published online 12 Aug 2013
2.Wu DD, Huang L, Zhang L, Wu LY, LI YC, Feng L* (2012) LLDT-67 attenuates MPTP-induced neurotoxicity in mice by up-regulating NGF expression. Acta Pharmacologica Sinica, 33: 1187–1194; published online 3 Sep 2012
3.Zhang P, Hu L, Yin Q, Feng, L*, Li Y* (2012) Transferrin-Modified c[RGDfK]-Paclitaxel Loaded Hybrid Micelle for Sequential Blood-Brain Barrier Penetration and Glioma Targeting Therapy. Molecular Pharmaceutics 39: 04/04 18:04:03
4.Zhang P, Hu L, Yin Q, Zhang ZW, Feng, L*, Li Y * (2012) Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: Synthesis, preparation and in vivo evaluation. Journal of Controlled Release [Epub ahead of print]
5.Jin L, Zhang LM, Xie KQ, Ye Y, Feng L*.(2011) Paeoniflorin suppresses the expression of ICAM-1 in endotoxin-treated human monocytic cells. Br J Pharmacol. 164: 694–703. [Epub ahead of print]
6.Zhan C, Li B, Hu, L Wei X, Feng L, Fu W, Lu W, (2011) Micelle-Based Brain- Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand. Angew Chem Int Ed Engl. 50: 5482 –5485 [Epub ahead of print]
7.Zhang P, Hu L., Wang Y,, Wan J., Feng L*, Li Y. * (2010) Poly (ε-caprolactone)- block -poly(ethyl ethylene phosphate) micelles for brain targeting drug delivery: in vitro and in vivo valuation. Pharmaceutical Research, 27: 2657~2669
8.Ji Y., Lu Y., Yang F., Shen W., Tang T. TT., Feng L., Duan S., & Lu B. (2010) Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nature Neuroscience 302 – 309
9.Huang R, Ke W, Liu Y, Wu D, Feng L, Jiang C, Pei Y. ( 2010) Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model. J Neurol Sci. 290 (1-2):123-30. Epub 2009 Nov 11.
10.Zang Y, Yu LF,, Nan FJ, Feng L, Li J.(2009)AMP-activated Protein Kinase Is Involved in Neural Stem Cell Growth Suppression and Cell Cycle Arrest by – Aminoimidazole -4- carboxamide -1-_-D-ribofuranoside and Glucose Deprivation by Down-regulating Phospho-retinoblastoma Protein and Cyclin D. J Biol Chem. 284(10) 6175–6184
11.Xie KQ., Zhang LM., Cao Y., Zhu J., Feng L.* (2009) Adenosine A1 receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro. Acta Pharmacologica Sinica 30: 889–898
学术兼职
1996.07 - 至今 上海市神经科学会常务理事
2007.05 - 至今 中国药理学会理事
2007.05 - 至今 中国药理学会神经精神专业委员会委员
2008.06 - 至今 《家庭用药》杂志主编