段文虎 - 中国科学院上海药物研究所 -

个人简介

教育经历 09/01/1982-06/30/1986，中国药科大学 09/01/1990-06/30/1993，华西医科大学（现四川大学华西医学中心） 09/01/1993-06/30/1996，中国科学院上海药物研究所工作经历 03/01/2002-至今，中国科学院上海药物研究所，研究员 10/01/2000-2/28/2002，中国科学院上海药物研究所，副研究员 04/01/2000-09/30/2000，亚利桑那大学，博士后 04/01/1999-03/31/2000，德克萨斯州大学奥斯汀分校，博士后 11/01/1997-03/01/1999，伦斯勒理工学院，博士后 02/01/1997-10/31/1997，德克萨斯大学西南医学中心，博士后 07/01/1996-02/01/1997，中国科学院上海药物研究所，助理研究员 07/01/1986-07/01/1990，常州第三制药厂，工程师

研究领域

1.靶点抗肿瘤药物的研究开发，即针对与肿瘤发生、生长、转移密切相关的靶酶/蛋白，综合合理药物设计方法和经典药物设计方法，研究发现新型高效低毒抗肿瘤化合物。蛋白酪氨酸激酶是我们主要研究的靶点，如c-Met、KDR、FGFR等。 2.开展一些具有抗肿瘤活性天然产物的合成及结构修饰工作，旨在以天然产物为先导物，发现具有独特作用机制的抗肿瘤化合物。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Peng T, Wu JR, Li MY, Tong LJ, Xie H, Duan WH, Ding J. Acta Pharmacologica Sinica 2014; 35: 916-928. 2. Zhan ZS, Ai J, Liu QF, Ji YC, Chen TT, Xu YC., Geng MY, Duan WH. Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity. ACS Medicinal Chemistry Letters 2014; 5: 673-678. 3. Lv YC, Li MY, Liu T, Tong LJ, Peng T, Wei LX, Ding J, Xie H, Duan WH. Discovery of a New Series of Naphthamides as Potent VEGFR-2 Kinase Inhibitors. ACS Med Chem Lett 2014; 5: 592-597. 4. Liu JL, Gao GR, Zhang X, Cao SF, Guo CL, Wang X, Tong LJ, Ding J, Duan WH, Meng LH. DW09849, a selective phosphatidylinositol 3-kinase (PI3K) inhibitor, prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110alpha (H1047R). J Pharmacol Exp Ther 2014; 348: 432-441. 5. Liu WJ, Mei DS, Wang W, Duan WH. Highly enantioselective conjugate addition of nitroalkanes to enones catalyzed by cinchona alkaloid derived primary amine. Tetrahedron Letters 2013; 54: 3791-3793. 6. Liu WJ, Mei DS, and Duan WH. Synthesis of 1,7-dimethoxy-2-hydroxyxanthone, a natural product with potential activity on erectile dysfunction. Chinese Chemical Letters 2013; 24: 515-517. 7. Zhang HY, Leng YX, Liu WJ, Duan WH. One-Pot Synthesis of Isoindolinones via Three-Component Mannich/Lactamization Cascade Reaction. Synthetic Communications 2012; 42: 1115-1127. 8. Chen F, Wang Y, Ai J, Zhan ZS, Lv YC, Liang ZJ, Luo C, Mei DS, Geng MY, Duan W H. O-linked triazolotriazines: potent and selective c-Met inhibitors. ChemMedChem 2012; 7: 1276-85. 9. Jiao Y, Liu HC, Geng MY, Duan WH. Synthesis and antitumor activity of 10-arylcamptothecin derivatives. Bioorganic & Medicinal Chemistry Letters 2011; 21: 2071-2074. 10. Zhang HY, Zhang SL, Liu L, Luo GS, Duan WH, Wang W. Synthesis of chiral 3-substituted phthalides by a sequential organocatalytic enantioselective aldol-lactonization reaction. Three-step synthesis of (S)-(-)-3-butylphthalide. J Org Chem 2010; 75: 368-374. 11. Xue F, Liu L, Zhang SL, Duan WH, Wang W. A simple primary amine thiourea catalyzed highly enantioselective conjugate addition of alpha,alpha-disubstituted aldehydes to maleimides. Chemistry A European Journal 2010; 16: 7979-7982. 12. Luo GS, Zhang SL, Duan WH, Wang W. Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction. Tetrahedron Letters 2010; 51: 2667-2667. 13. Leng YX, Chen F, Zuo L, Duan WH. Efficient synthesis of triarylmethanes via bisarylation of aryl aldehydes with arenes catalyzed by silica gel-supported sodium hydrogen sulfate. Tetrahedron Letters 2010; 51: 2370-2373. 14. Zhang XL, Hu YW, Chen SD, Luo RS, Yue J, Zhang Y, Duan WH, Wang HH. Synthesis and evaluation of (S,S)-N,N′-bis-[3-(2,2′,6,6′-tetramethylbenzhydryloxy)-2-hydroxy-propyl]-ethylenediamine (S2824) analogs with anti-tuberculosis activity. Bioorganic & Medicinal Chemistry Letters 2009; 19: 6074-6077. 15. Xiong XS, Fu LL., Wang L, Cai HA, Li L, Jiang HL, Duan WH ,Mei CL. Antitumor activity of a novel EGFR tyrosine kinase inhibitor against human lung carcinoma in vitro and in vivo. Invest New Drugs 2009; 27: 1-11. 16. Xie H, Qin YX, Zhou YL, Tong LJ, Lin LP, Geng MY, Duan WH, Ding J. GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms. Acta Pharmacol Sin 2009; 30: 346-54. 17. Wang WJ, Dai M, Zhu CH, Zhang JG, Lin LP, Ding J, Duan WH. Synthesis and biological activity of novel shikonin analogues. Bioorganic & Medicinal Chemistry Letters 2009; 19: 735-737. 18. Sun QM, Miao ZH, Lin LP, Gui M, Zhu CH, Xie H, Duan WH, and Ding J. BB, a new EGFR inhibitor, exhibits prominent anti-angiogenesis and antitumor activities. Cancer Biol Ther 2009; 8: 1640-1647. 19. Mei K, Jin M, Zhang SL, Li P, Liu WJ, Chen XB, Xue F, Duan WH, Wang W. Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones. Organic Letters 2009; 11: 2864-2867. 20. Ma SC, Zhang SL, Duan WH, Wang W. An enantioselective synthesis of (+)-(S)-[n]-gingerols via the L-proline-catalyzed aldol reaction. Bioorganic & Medicinal Chemistry Letters 2009; 19: 3909-3911.