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个人简介

岳建民研究员,中国科学院院士,现任上海药物研究所学位委员会主任、学术委员会委员。1984年毕业于兰州大学化学系;1987和1990年在该校有机化学专业相继获得硕士和博士学位。其后,分别在中国科学院昆明植物研究所和英国Bristol大学化学院进行博士后研究;1994年至1996年中国科学院昆明植物研究所任副研究员;1996至今上海药物研究所任副研究员、研究员、博士生导师。已在Chem. Rev., J. Am. Chem. Soc., Cell. Res., Org. Lett., J. Nat. Prod.等学术刊物上发表论文280余篇;获得授权专利14项。 2010年获上海市自然科学一等奖;2013年获得国家自然科学二等奖;2016年获得吴阶平-保罗·杨森医学药学奖;2017年获得上海市科技精英。2017年被评选为中国科学院院士。 1990.07–1993.09 博士后,中国科学院昆明植物研究所植物化学研究室,合作导师: 孙汉董院士 1993.09–1994.09 博士后,英国布里斯托尔大学化学学院,合作导师:Geoffrey Eglinton 教授 1994.09–1996.04 副研究员,中国科学院昆明植物研究所植物化学研究室 1996.05–1999.04 高级研究员和项目主管,中国科学院上海有机化学研究所与联合利华联合实验室 1999.05–至今 研究员,中国科学院上海药物研究所天然药物化学研究所 2011.09–2011.11 访问教授,澳大利亚昆士兰大学化学系 2002.01–2002.02 访问教授,瑞士诺华制药有限公司

研究领域

基于药用植物新颖结构天然活性物质的发现、结构和功能研究、药物先导结构的优化和构效关系研究,以及新药研究与开发

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Cui-Ping Liu, Cheng-Ying Xie, Jin-Xin Zhao, Kai-Long Ji, Xin-Xiang Lei, Han Sun, Li-Guang Lou, and Jian-Min Yue*, Dysoxylactam A: A Macrocyclolipopeptide Reverses P?GlycoproteinMediated Multidrug Resistance in Cancer Cells, Journal of the American Chemical Society, 2019, 141(17), 6812-6816. Jin-Xin Zhao, Sha-Sha Wang, Xin-Hua Gao, Li Sheng, Jia Li, and Jian-Min Yue*, Structural Elucidation and Bio-inspired Total Syntheses of Ascorbylated Diterpenoid Hongkonoids A-D, Journal of the American Chemical Society, 2018, 140(7), 2485-2492. Yao-Yue Fan, Hua Zhang, Yu Zhou, Hong-Bing Liu, Wei Tang, Bin Zhou, Jian-Ping Zuo, Jian-Min Yue*,Phainanoids A–F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis, Journal of the American Chemical Society, 2015, 137(1), 138-141. Jin-Biao Xu, Hua Zhang, Li-She Gan, Ying-Shan Han, Mark A Wainberg, and Jian-Min Yue*, Logeracemin A, an Anti-HIV Daphniphyllum Alkaloid Dimer with a New Carbon Skeleton from Daphniphyllum longeracemosum, Journal of the American Chemical Society, 2014, 136(21), 7631-7633. Bo Zhang, Yao Wang, Sheng-Ping Yang, Yu Zhou, Wen-Bin Wu, Tang Wei, Jian-Ping Zuo, Ying Li* and Jian-Min Yue*, Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis, Journal of the American Chemical Society 2012, 134(51), 20605-20608. Fan, Yao-Yue; Shi, Shu-Qin; Deng, Guo-Zhen; Liu, Hong-Chun; Xu, Cheng-Hui; Ding, Jian; Wang, Guan-Wu; Yue, Jian-Min*, Crokonoids A-C, A Highly Rearranged and Dual-Bridged Spiro Diterpenoid and Two Other Diterpenoids from Croton kongensis. Organic Letters, 2020, 22(3), 929-933. Xu-Xin Zhu, Yao-Yue Fan, Li Sheng, Qun-Fang Liu, Jing-Ya Li, Jia Li*, Kun Gao*, and Jian-Min Yue*, Alstonlarsines A–D, Four Rearranged Indole Alkaloids from Alstonia scholaris, Organic Letters, 2019, 21(5), 1471-1474. Yu-Hao Ren, Qun-Fang Liu, Li Chen, Shi-Jun He, Jian-Ping Zuo, Yao-Yue Fan*, and Jian-Min Yue*, Urceoloids A and B, Two C19 Steroids with a Rearranged Spirocyclic Carbon Skeleton from Urceola quintaretii, Organic Letters, 2019, 21(6), 1904–1907. Xin-Hua Gao, Yao-Yue Fan, Qun-Fang Liu, Sang-Hyun Cho, Guido F. Pauli, Shao-Nong Chen, and Jian-Min Yue*, Organic Letters, 2019, 21(17), 7065–7068. Xin-Hua Gao, Yan-Sheng Xu, Yao-Yue Fan, Li-She Gan, Jian-Ping Zuo*, and Jian-Min Yue*, Cascarinoids A?C, A Class of Diterpenoid Alkaloids with Unpredicted Conformations from Croton cascarilloides, Organic Letters, 2018, 20(1), 228-231. Wei-Yi Zhang, Jin-Xin Zhao, Li Sheng, Yao-Yue Fan, Jing-Ya Li, Kun Gao*, and Jian-Min Yue*, Mangelonoids A and B, Two Pairs of Macrocyclic Diterpenoid Enantiomers from Croton mangelong, Organic Letters, 2018, 20(13), 4040-4043. Yao-Yue Fan, Yi-Li Sun, Bin Zhou, Jin-Xin Zhao, Li Sheng, Jing-Ya Li*, and Jian-Min Yue*,Hedyorienoids A and B, Two Sesquiterpenoid Dimers Featuring Different Polycyclic Skeletons from Hedyosmum orientale, Organic Letters, 2018, 20(17), 5435-5438. Bin Zhou, Qun-Fang Liu, Seema Dalal, Maria B. Cassera, and Jian-Min Yue*, Fortunoids A–C, Three Sesquiterpenoid Dimers with Different Carbon Skeletons from Chloranthus fortunei. Organic Letters, 2017, 19(3), 734–737. Guo-Cai Wang, Yao-Yue Fan, Sajan L. Shyaula, and Jian-Min Yue*, Triconoids A-D, Four Limonoids Possess Two Rearranged Carbon Skeletons from Trichilia connaroides. Organic Letters, 2017, 19(8), 2182–2185. Yao-Yue Fan, Li-She Gan, Hong-Chun Liu, Heng Li, Cheng-Hui Xu, Jian-Ping Zuo, Jian Ding*, and Jian-Min Yue*, Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis. Organic Letters, 2017, 19(17), 4580–4583. Jin-Hai Yu, Qun-Fang Liu, Li Sheng, Guo-Cai Wang, Jia Li and Jian-Min Yue*, Cipacinoids A–D, Four Limonoids with Spirocyclic Skeletons from Cipadessa cinerascens, Organic Letters, 2016, 18(3), 444-447. Cui-Ping Liu, Guo-Cai Wang, Li-She Gan, Cheng-Hui Xu, Qun-Fang Liu, Jian Ding, and Jian-Min Yue*, Ciliatonoids A and B, Two Limonoids from Toona ciliata, Organic Letters, 2016, 18(12), 2894-2897. Gang Ni, Hua Zhang, Yao-Yue Fan, Hong-Chun Liu, Jian Ding, and Jian-Min Yue*, Mannolides A–C with an Intact Diterpenoid Skeleton Providing Insights on the Biosynthesis of Antitumor Cephalotaxus Troponoids, Organic Letters, 2016, 18(8), 1880-1883. Hua Zhang, Sajan L. Shyaula, Jing-Ya Li, Jia Li, and Jian-Min Yue*, Himalensines A and B, Alkaloids with Unprecedented Carbon Skeletons from Daphniphyllum himalense, Organic Letters, 2016, 18(5), 1202-1205. Hua Zhang, Kong-Kai Zhu, Yin-Shan Han, Cheng Luo, Mark A. Wainberg, and Jian-Min Yue*, Flueggether A and Virosinine A, Anti-HIV Alkaloids from Flueggea virosa, Organic Letters, 2015, 17, 6274-6277. Jin-Biao Xu, Yao-Yue Fan, Li-She Gan, Yu-Bo Zhou, Jia Li, and Jian-Min Yue*, Cephalotanins A?D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis, Chemistry - A European Journal, 2016, 22(41), 14648–14654. Kai-Long Ji, Yao-Yue Fan, Zhan-Peng Ge, Li Sheng, You-Kai Xu, Li-She Gan, Jing-Ya Li, and Jian-Min Yue*, Maximumins A-D, Rearranged Labdane-Type Diterpenoids with Four Different Carbon Skeletons from Amomum maximum, Journal of Organic Chemistry, 2019, 84(1), 282–288. Wei-Yan Qi, Jin-Xin Zhao, Yan Wu, Kun Gao*, Jian-Min Yue*, Quorumolides A-C, Three Novel Cembranoids from Euphorbia antiquorum, Journal of Organic Chemistry, 2018, 83(2), 1041-1045. Jin-Xin Zhao, Cui-Ping Liu, Meng-Meng Zhang, Jia Li and Jian-Min Yue*, Dysohonin A, a Meroditerpenoid Incorporating a 6,15,6-Fused Heterotricyclic Ring System from Dysoxylum hongkongense, Organic Chemistry Frontiers, 2018, 5, 2202-2207. Jiao-Jiao Cui, Kai-Long Ji, Hong-Chun Liu, Bin Zhou, Qun-Fang Liu, Cheng-Hui Xu, Jian Ding, Jin-Xin Zhao,* and Jian-Min Yue*, Cytotoxic Tigliane Diterpenoids from Croton damayeshu, Journal of Natural Products, 2019, 82(6), 1550-1557. Zhan-Peng Ge, Hong-Chun Liu, Guo-Cai Wang, Qun-Fang Liu, Cheng-Hui Xu, Jian Ding, Yao-Yue Fan*, and Jian-Min Yue*, Journal of Natural Products, 2019, 82(6), 1565-1575. Yao-Yue Fan, Jin-Biao Xu, Hong-Chun Liu, Li-She Gan, Jian Ding, and Jian-Min Yue*, Cephanolides A–J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis, Journal of Natural Products, 2017, 80(12), 3159-3166. Bin Zhou, Yan Wu, Seema Dalal, Emilio F. Merino, Qun-Fang Liu, Cheng-Hui Xu, Tao Yuan, Jian Ding, David G. I. Kingston, Maria B. Cassera, and Jian-Min Yue*, Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and their Structure-Activity Relationships,Journal of Natural Products, 2017, 80(1), 96-107. Yang Yu, Li-She Gan, Sheng-Ping Yang, Li Sheng, Qun-Fang Liu, Shao-Nong Chen, Jia Li,* Jian-Min Yue*, Eucarobustols A-I, Conjugates of Sesquiterpenoids and Acylphloroglucinols from Eucalyptus robusta, Journal of Natural Products, 2016, 79(5), 1365-1372. Guo-Cai Wang, Jin-Hai Yu, Yu Shen, Ying Leng, Hua Zhang,* and Jian-Min Yue*, Limonoids and Triterpenoids as 11?-HSD1 Inhibitors from Walsura robusta, Journal of Natural Products, 2016, 79(4), 899-906.

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