钟大放 - 中国科学院上海药物研究所 -

个人简介

教育经历 03/1978 – 01/1982 沈阳药学院，化学制药专业，本科生，获学士学位 02/1982 – 01/1985 沈阳药学院，药物分析专业，研究生，获硕士学位 09/1986 – 12/1989 德国波恩大学，药物化学专业，研究生，获博士学位工作经历 01/1985 – 09/1986 沈阳药学院，助教 01/1990 – 06/1994 Eschborn德国药师中心实验室，博士后 07/1994 – 05/2005 沈阳药科大学，教授 06/2005至今中科院上海药物研究所，研究员

研究领域

1. 建设符合国际标准的药物代谢研究平台 2. 生物样品定量分析方法研究 3. 药物代谢产物追踪和结构鉴定 4. 创新药物代谢和药动学评价 5. 药物代谢酶和药物转运体相关的体内药物相互作用机制研究 6. 放射性同位素方法用于药物代谢研究

近期论文

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1.Lin LS, Xie C, Gao ZW, Chen XY, Zhong DF*. Metabolism and pharmacokinetics of allitinib in cancer patients: the roles of cytochrom P450s and epoxide hydrolase in its biotransformation. Drug Metab Dispos, 2014, 42: 872-884 2.Ding JF, Chen XY, Gao ZW, Dai XJ, Li L, Xie C, Jiang HY, Zhang LJ, Zhong DF*. Metabolism and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor apatinib in humans. Drug Metab Dispos, 2013, 41: 1195-1210 3.Du JB, You TG, Chen XY, Zhong DF*. Stereoselective glucuronidation of ornidazole in humans: predominant contribution of UDP-glucuronosyltransferases 1A9 and 2B7. Drug Metab Dispos, 2013, 41: 1306-1318 4.Gao CY, Zhang HJ, Guo ZT, You TG, Chen XY, Zhong DF*. Mechanistic studies on the absorption and disposition of scutellarin in humans: Selective OATP2B1-mediated hepatic uptake plays a major role in its unique pharmacokinetic characteristics. Drug Metab Dispos, 2012, 40: 2009-2020 5.Li L, Chen XY, Zhou JL, Zhong DF*. In vitro studies on the oxidative metabolism of 20(S)-ginsenoside Rh2 in human, monkey, dog, rat and mouse liver microsomes, and human liver S9. Drug Metab Dispos, 2012, 40: 2041-2053 6.Liu J, Chen XY, Liu K, Li L, Zhong DF*. Derivatization of (5R)-hydroxytriptolide with benzylamine to enhance mass spectrometric detection: Application to a Phase I pharmacokinetic study. Anal Chim Acta, 2011, 689: 69-76 7.Li L, Chen XY, Li D, Zhong DF*. Identification of 20(S)-protopanaxadiol metabolites in human liver microsomes and human hepatocytes. Drug Metab Dispos, 2011, 39: 472-483 8.Deng P, You TG, Chen XY, Yuan T, Huang HH, Zhong DF*. Identification of amiodarone metabolites in human bile by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry. Drug Metab Dispos, 2011, 39: 1058-1069 9.Gao CY, Chen XY, Zhong DF*. Absorption and disposition of scutellarin in rats: a pharmacokinetic explanation for the high exposure of its isomeric metabolite. Drug Metab Dispos, 2011, 39: 2034-2044 10.Gong AS, Chen XY, Deng P, Zhong DF*. Metabolism of flumatinib, a novel antineoplastic tyrosine kinase inhibitor, in chronic myelogenous leukemia patients. Drug Metab Dispos, 2010, 38: 1328-1340 11.Deng P, Chen XY, Zhang GD, Zhong DF*. Bioanalysis of an oligonucleotide and its metabolites by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal, 2010, 52: 571-579 12.Philip Lee, Hiroyasu Aizawa, Lawrence Gan, Chandra Prakash, Dafang Zhong (Editors). Handbook of Metabolic Pathways of Xenobiotics. ISBN: 978-0-470-74910-4, Wiley, 2840 pages, 2014

学术兼职

1998-2008，国务院学位委员会药学学科评议组成员 2002-2008，中国质谱学会有机质谱专业委员会主任 1996至今，国家药典委员会委员 2003至今，中国药理学会药物代谢专业委员会副主任 2005至今，中国药学会药物分析专业委员会副主任 2012至今，中国生物分析论坛召集人国际期刊Bioanalysis编委药学学报、中国药学杂志、中国药理学与毒理学杂志、中国临床药理学杂志、药物分析杂志、中国医药工业杂志、质谱学报编委