赵维民 - 中国科学院上海药物研究所 -

个人简介

教育经历 09/1984 – 07/1989 北京医科大学药学院药物化学专业，获学士学位 09/1989–07/1992 中国科学院上海药物所植物化学研究室，获理学硕士学位 09/1992–07/1995 中国科学院上海药物所植物化学研究室，获理学博士学位工作经历 09/1995–03/1997 中国科学院上海药物所植物化学研究室，助理研究员 10/1995–03/1997 瑞士Lausanne大学药学院生药和植物化学研究所，博士后 04/1997–02/2002 中国科学院上海药物研究所植物化学研究室，副研究员 07/1999–10/1999 美国Illinois大学Chicago分校药学院，高级访问学者 07/2001–10/2001 法国国家科学研究中心天然产物化学研究所，高级访问学者 02/2002至今中国科学院上海药物研究所天然产物化学研究室，研究员 07/2005–10/2005 美国Kentucky大学药学院，高级访问学者

研究领域

1.天然药物活性作用物质基础的发现研究； 2.活性天然产物结构类似物的合成与新药先导化合物的发现研究。

近期论文

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1. Wang LY, Wu J, Yang Z, Wang XJ, Fu Y, Liu SZ, Wang HM, Zhu WL, Zhang HY, Zhao WM. (M)- and (P)-bicelaphanol A, dimeric trinorditerpenes with promising neuroprotective activity from Celastrus orbiculatus. J. Nat. Prod., 2013; 76: 745-749. 2. Liu SZ, Chen ZH, Wu J, Wang LY, Wang HM, Zhao WM. Appetite suppressing pregnane glycosides from the roots of Cynanchum auriculatum. Phytochemistry, 2013; 93: 144-153. 3. Wang XJ, Wang LY, Fu Y, Wu J, Tang XC, Zhao WM, Zhang HY. Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimeric podocarpane type trinorditerpene isolated from Celastrus orbiculatus. Phytomedicine, 2013; 20: 1064-1070. 4. Guo XJ, Chen YT, Liu QF, Wu J, Wang LY, Tang XC, Zhao WM, Zhang HY. Ac-cel, a novel antioxidant, protects against hydrogen peroxide-induced injury in PC12 cells via attenuation of mitochondrial dysfunction. J. Mol. Neurosci., 2013; 50: 453-461. 5. Wu J, Zhou Y, Wang LY, Zuo JP, Zhao WM. Terpenoids from root bark of Celastrus orbiculatus. Phytochemistry, 2012; 75: 159-168. 6. Wang LY, Chen ZH, Zhou Y, Tang W, Zuo JP, Zhao WM. Structural revision of periplocosides and periperoxides, natural immunosuppressive agents from the genus Periploca. Phytochemistry, 2011; 72: 2230-2236. 7. Meng DH, Wu J, Zhao WM. Glycosides from Breynia fruticosa and Breynia rostrata, Phytochemistry, 2010; 71: 325-331. 8. Zhang J, Ni J, Chen ZH, Li X, Zhang RJ, Tang W, Zhao WM, Yang YF, Zuo JP. Periplocoside A prevents experimental autoimmune encephalomyelitis by suppressing IL-17 production and inhibits differentiation of Th17 cells. Acta Pharmacol. Sin., 2009; 30: 1144-1152. 9. Chen C, Qiang SG, Lou LG, Zhao WM. Cucurbitane-type triterpenoids from the stems of Cucumis melo. J. Nat. Prod., 2009; 72: 824-829. 10. Chen ZH, Zhang RJ, Wu J, Zhao WM. New dihydrochalcone glycosides from Lithocarpus litseifolius and the phenomenon of C-H→C-D exchange observed in NMR spectra of phenolic components. J. Asian Nat. Prod. Res., 2009; 11: 508-513.