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个人简介

教育经历 1997.09 - 2002.06 沈阳药科大学,药学院,药剂学,博士 1993.09 - 1997.06 沈阳药科大学,药学院,药物分析专业,学士 工作经历 2008.10 - 至今 中国科学院上海药物研究所,药物制剂中心,研究员 2004.10 - 2008.10 中国科学院上海药物研究所,药物制剂中心,副研究员 2002.07 - 2004.07 中国科学院上海药物研究所,博士后

研究领域

1.新型功能性脂质载体的设计及其克服生理屏障机制的研究。 2.具有特殊释药特征(定速和定时释放)创新制剂的设计和产业化研究。

近期论文

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1. Xiuying Li, Miaorong Yu, Weiwei Fn, Yong Gan*, Lars Hovgaard, Mingshi Yang. Orally active targeted drug delivery system for protiens and peptides. Expert Opin Drug Deliv, 2014, 25:1-13. 2. Xinxin Zhang, Feifei Li, Shiyan Guo, Xi Chen, Xiaoli Wang, Juan Li, Yong Gan*. Biofunctionalized polymer-lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells. Biomaterials. 2014, 35(11):3650-3665. 3. Xiuying Li, Shiyan Guo, Chunliu Zhua, Quanlei Zhu, Yong Gan*, Jukka Rantanen, Ulrik Lytt Rahbek, Lars Hovgaard, Mingshi Yang. Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles. Biomaterials 2013, 34: 9678-9687. 4. Li Gan, Jing Wang, Yanan Zhao, Dan Chen, Chunliu Zhua, Jianping Liu, Yong Gan. Hyaluronan-modified core-shell liponanoparticles targeting CD44-positive retinal pigment epithelium cells via intravitreal injection. Biomaterials, 2013, 34: 5978-5987. 5. Hongzhen Yu, Dengning Xia, Quanlei Zhu, Chunliu Zhu, Dan Chen, Yong Gan. Supersaturated polymeric micelles for oral cyclosporine A delivery. Eur J Pharm Biopharm 2013, 85(3) 1325-1336. 6. Li Gan, Yi-ping Gao, Chun-liu Zhu, Xin-xin Zhang, Yong Gan*. Novel pH-sensitive lipid-polymer composite microspheres of 10-Hydroxycamptothecin exhibiting colon-specific biodistribution and reduced systemic absorption, Journal of Pharmaceutical Sciences,2013, 102(6): p. 1752-9. 7. Dan Chen; Dengning Xia; Xiuying Li; Quanlei Zhu; Hongzhen Yu; Chunliu Zhu; Yong Gan*. Comparative study of Pluronic® F127-modified liposomes and chitosan-modified liposomes for mucus penetration and oral absorption of cyclosporine A in rats. Int J Pharm. 2013,5;449(1-2):1-9. 8. Li Gan, Jing Wang, Min Jiang, Hanah Bartlett, Defang Ouyang, Frank Eperjesi, Jianping Liu, Yong Gan*, Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers, Drug Discov. Today, 18(5-6), 290-297, 2013. 9. Jiang Min, Gan Li, Zhu Chunliu, Dong Yang, Liu Jianping, Yong Gan*, Cationic core-shell liponanoparticles for ocular gene delivery, Biomaterials, 33(30), 7261-7230, 2012. 10. Zhang Xinxin, Guo Shiyan, Fan Rong, Yu Miaorong, Li Feifei, Zhu Chunliu, Yong Gan*, Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells, Biomaterials, 33 (29), 7103-7114, 2012. 11. Xiuying Li, Dan Chen, Chaoyi Le, Chunliu Zhu, Yong Gan*, Lars Hovgaard, Mingshi Yang, Novel mucus-penetrating liposomes as potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake, Int. J. Nanomed., 6, 3151–3162, 2011. 12. Hongzhen Yu, Sifei Han, Ping Li, Chunliu Zhu, Xinxin Zhang, Li Gan, Yong Gan*, An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione, J. Pharm. Sci., 100(11), 5048-5058, 2011. 13. Jinqiu Shen, Li Gan, Chunliu Zhu, Xinxin Zhang, Yang Dong, Min Jiang, Jiabi Zhu, Yong Gan*, Novel NSAIDs ophthalmic formulation: flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect, Int. J. Pharm., 412(1-2), 115-122, 2011. 14. Li Gan, Shun Han, Jinqiu Shen, Chunliu Zhu, Xinxin Zhang, Yong Gan*, Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: improving preocular retention and ocular bioavailability, Int. J. Pharm., 396(1-2), 179-187, 2010. 15. Sifei Han, Tingting Yao, Xinxin Zhang, Li Gan, Chunliu Zhu, Hongzhen Yu, Yong Gan*, Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: effects of lipid composition and formulation, Int. J. Pharm., 379, 18-24, 2009. 16. Li Gan, Yong Gan*, Chunliu Zhu, Xinxin Zhang, Jiabi Zhu, Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results, Int. J. Pharm., 365, 143-149, 2009.

学术兼职

中国药学会药剂专业委员会委员 《中国医药工业杂志》、《中国药剂学杂志》、《中国药师》杂志编委 国家新药审评专家 上海市政府采购评审专家

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