个人简介
教育经历
1986.09.01 - 1990.06.30 浙江师范大学化学系,本科学习
1990.09.01 - 1993.06.30 天津南开大学化学系,硕士研究生
1993.09.01 - 1996.12.31 厦门大学化学系,博士研究生
工作经历
1997.01.01 - 1999.03.31 厦门大学生物学系,博士后
1999.04.01 - 1999.06.01 上海师范大学化学系,教师
1999.09.01 - 至今 中科院上海药物研究所,副研究员、研究员
研究领域
1.创新药物质量控制与方法学研究与注册申报
2.化合物的理化特性研究(稳定性、溶解性、酸碱解离等)
3.毛细管电泳法开展化合物与蛋白相互作用研究
近期论文
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1.Li-juan Zhao, Dong-Ying Chen∗, Characterization of interactions between methoxatin disodium salt and human serum albumin by pressure-assisted capillary electrophoresis/frontal analysis and circular dichroism spectroscopy, Biomed. Chromatogr. 2014 , Accepted
2.Jian-Ling Wang, Xue-Jiao Xu, Dong-Ying Chen∗, Determination of pKa values of a triptolide derivative and its impurities by pressure-assisted capillary electrophoresis, J. Pharm. Biomed. Anal. 2014, 88, 22-26
3.Shan – Bao Qiao, Min Ji, Li-Li Xiang, Dong-Ying Chen*, RP - HPLC determination of irinotecan hydrochloride( CPT - 11) and its related substances, Chin. J. Pharm. Anal. 2013, 33( 3), 439-442
4.Rui-Li Liu, Ya-Xi Yang, Dong-Ying Chen*, Polymorphism of the 5R-5-hydroxytriptolide, Acta Pharm. Sin. 2011, 46 (11): 1357−1360
5.Jing Lu, Li-Li Xiang, Min Ji, Dong-Ying Chen*, Application of phase optimized liquid chromatography for related substances detection in new drug candidate of tripterygiumforrestii derivative, Chin J. Anal. Chem., 2011, 39(8): 1266-1269
6.Jing Lu, Min Ji, Ronny Ludewig, Gerhard K. E. Scriba , Dong-ying Chen, Application of phase optimized liquid chromatography to oligopeptide separations, J. Pharm. Biomed. Anal. 2009, 51, 764-676
7.Li-li Xiang, Min Ji, Yu-Peng Ren, Dong-Ying Chen, Study on the hydrolysis reaction of a novel camptothecin derivative (l-p) using capillary zone electrophoresis, Chin J. Anal. Chem. 2009, 37(11), 1657-1661
8.Liang Hu, Dong-ying Chen, Application of headspace solid phase microextraction for noncovalent interaction of borneol binding to human serum albumin, Acta Pharmacol. Sin. 2009, 30 (11), 1573-1576