赵英明 - 中国科学院上海药物研究所 -

个人简介

教育经历 1981.09 - 1984.06 中国，华东化工学院，物理化学，学士(B.Sc.) 1986.09 - 1989.06 中国，中国科学院上海药物研究所，药物化学，硕士学位课程 1989.09 - 1990.12 美国，纽约大学，有机化学，硕士(M.Sc) 1991.01 - 1997.11 美国，洛克菲勒大学，分析生物化学，博士(Ph.D.) 工作经历 1997.11 - 1998.08，美国，美国洛克菲勒大学 (The Rockefeller University)，博士后（Postdoc） 1998.09 - 2000.09，美国，美国西奈山医学院(Department of Human Genetics, Mount Sinai School of Medicine)，助理教授、质谱平台主任 (Assistant professor；Director, Mass spectrometry Core Facility) 2000.09 - 2005.01，美国，德州大学西南医学中心(University of Texas Southwestern Medical Center)，助理教授、蛋白质化学中心共同主任(Assistant professor, Co-Director, Protein Chemistry Core Center) 2005.02 - 2008.09，美国，德州大学西南医学中心，终身职副教授、蛋白质化学中心共同主任(Associate professor with tenure, Co-Director, Protein Chemistry Core Center) 2008.10 - 2011.09，美国，美国芝加哥大学Ben May癌症研究所 ( Ben May Department for Cancer Research, The University of Chicago)，终身职副教授 (Associate professor with tenure) 2011.10 - 至今，美国，美国芝加哥大学Ben May 癌症研究所( Ben May Department for Cancer Research, The University of Chicago)，终身职教授(Professor with tenure) 2012 - 至今，中国，中国科学院上海药物研究所，特聘研究员

研究领域

蛋白翻译后修饰、蛋白质组学和化学生物学。 1.鉴定新的蛋白翻译后修饰通路和新的组蛋白修饰密码, 并研究其生物学功能；　　 2.进行以蛋白翻译后修饰为基础的生物标志物的研究，能够让我们更好地理解候选药物的作用方式；　　 3.发展和应用灵敏的蛋白质组学技术，为药物发展和精准施药去，鉴定以蛋白为基础的生物标志物。

近期论文

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1. Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Mühlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y. Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5. Cell Metab 2014; 19(4):605-17 2. Dai L, Peng C, Montellier E, Lu Z, Chen Y, Ishii H, Debernardi A, Buchou T, Rousseaux S, Jin F, Sabari BR, Deng Z, Allis CD, Ren B, Khochbin S, Zhao Y. Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. Nat Chem Biol 2014; doi: 10.1038 3. Park, J., Chen, Y., Tishkoff, D. X., Peng, C., Tan, M., Dai, L., Xie, Z., Zhang, Y., Zwaans, B. M., Skinner, M. E., Lombard, D. B., and Zhao, Y. SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Mol Cell 2013; 50, 919-930 4. Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., Rosenbaum, M., Zhao, Y., Gu, W., Farmer, S. R., and Accili, D. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma. Cell 2012; 150, 620-632 5. Li, T., Kon, N., Jiang, L., Tan, M., Ludwig, T., Zhao, Y., Baer, R., and GU, W. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 2012; 149, 1269-1283 6. Choi, M. C., Cohen, T. J., Barrientos, T., Wang, B., Li, M., Simmons, B. J., Yang, J. S., Cox, G. A., Zhao, Y., and Yao, T. P. A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program. Mol cell 2012; 47, 122-132 7. Chen, Y., Zhao, W., Yang, J. S., Cheng, Z., Luo, H., Lu, Z., Tan, M., Gu, W., and Zhao, Y. Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics 2012; 11, 1048-1062 8. Peng, C., Lu, Z., Xie, Z., Cheng, Z., Chen, Y., Tan, M., Luo, H., Zhang, Y., He, W., Yang, K., Zwaans, B. M., Tishkoff, D., Ho, L., Lombard, D., He, T. C., Dai, J., Verdin, E., Ye, Y., and Zhao, Y. The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics 2011; 10, M111 012658 9. Tan, M., Luo,H., Lee, S., Jin, F., Yang, J.-S., Montellier, E., Buchou,T., Cheng, Z., Rousseaux, S., Rajagopal, N., Lu, Z., Ye, Z., Zhu, Q., Wysocka, J., Ye, Y., Khochbin, S., Ren, B., Zhao, Y., Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 2011; 146, 1016-1028 10. Lu, J., Lin, Y., Sheu, J., Wu, J., Lee, F., Chen, Y., Lin, M., Chiang, F., Tai, T., Berger, S.L., Zhao, Y., Tsai, K., Zhu, H., Chuang, L., Boeke, J.D., A protein acetylation-phosphorylation signaling cascade coordinates growth and lifespan. Cell 2011; 146, 969-979 11. Zhang, Z., Tan, M., Xie, Z., Dai, L., Chen, Y., and Zhao, Y., Identification of lysine succinylation as a new post-translational modification. Nature Chem Biol 2011; 7(1): p. 58-63 12. Bajpai, R., Chen, D.A., Rada-Iglesias, A., Zhang, J., Xiong, Y., Helms, J., Chang, C.P., Zhao, Y., Swigut, T., and Wysocka, J., CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature 2010; 463: p.958-62 13. Chen, Y., Chen, W., Cobb, M.H. and Zhao, Y., PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites. Proc Natl Acad Sci USA 2009; 106(3): p. 761-6 14. Cheng, Z., Tang, Y., Chen, Y., Kim, S., Liu, H., Li, S.S., Gu, W. and Zhao, Y., Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics 2009; 8(1): p. 45-52 15. Lin, Y.Y., Lu, J.Y., Zhang, J., Walter, W., Dang, W., Wan, J., Tao, S.C., Qian, J., Zhao, Y., Boeke, J.D., Berger, S.L. and Zhu, H., Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell 2009; 136(6): p. 1073-84 16. Peng, J.C., Valouev, A., Swigut, T., Zhang, J., Zhao, Y., Sidow, A. and Wysocka, J., Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 2009; 139(7): p. 1290-302 17. Zhang, J., Sprung, R., Pei, J., Tan, X., Kim, S., Zhu, H., Liu, C.F., Grishin, N.V. and Zhao, Y., Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteomics 2009; 8(2): p. 215-25

学术兼职

美国人类蛋白质组组织（US HUPO）理事会成员美国人类蛋白质组组织（US HUPO）教育委员会成员美国人类蛋白质组组织（US HUPO）提名委员会成员人类蛋白质组计划质谱核心委员会主席（Mass Spectrometry Pillar Committee, International Human Proteome Project）《Molecular & Cellular Proteomics》和《 Clinical Proteomics》杂志编委质谱美籍华人社团理事会成员质谱美籍华人社团会员委员会主席