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个人简介

教育经历 1.1999.04-2005.03,美国俄勒冈健康科学大学,免疫学博士后 2.1994.08-1999.06,中国科学院上海药物研究所,药理学博士 3.1990.09-1994.06,山东大学,微生物学系,理学学士 工作经历 1.2015.05-至今, 中国科学院上海药物研究所,课题组长、研究员 2.2014.05-2015.04,美国礼来制药公司,生物药物发现研究中心,咨询科学家 3.2009.01-2014.04,美国礼来制药公司,生物药物发现研究中心,资深科学家 4.2005.04-2009.02,美国俄勒冈健康科学大学,神经免疫,助理教授

研究领域

基于噬菌体展示技术和单细胞技术的单克隆抗体药物的发现、筛选和改良; 新型抗体化学药物偶联体(ADC)药物的构建和表征; 双特异性抗体药物的构建和表征

抗体药物

近期论文

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1. Bodhankar, S., Wang, C., Vandenbark, A.A., and Offner, H. 2011. Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells. Eur. J. Immunol. 41:1165. 2. Wang, C., Li, Y., Proctor, T. M., Vandenbark, A. A. and Offner H. 2010. Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis. J. Neurosci. Res. 88:7. 3. Wang, C., Dehghani, B., Li, Y., Kaler, L. J., Vandenbark, A. A., and Offner H., 2009. Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1. Immunology 126:329. 4. Wang, C., Dehghani, B., Li, Y., Kaler, L. J., Proctor, T., Vandenbark, A. A. and Offner, H. 2009. Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1. J. Immunol. 182:3294. 5. Offner, H., Sinha, S., Wang, C., Burrows, G. G., and Vandenbark. A. A., 2008. Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis. Rev. Neurosci. 19:327. 6. Wang, C., Dehghani, B., Magrisso, I. J., Rick, E. A., Bonhomme, E., Cody, D. B., Elenich, L. A., Subramanian, S., Murphy, S. J., Kelly, M. J., Rosenbaum, J. S., Vandenbark, A. A. and Offner H. 2008. GPR30 contributes to estrogen-induced thymic atrophy. Mol. Endocrinol. 22:636. 7. Wang, C., Gold, B.G., Kaler, L.J., Yu, X., Afentoulis, M.E., Burrows G.G., Vandenbark, A.A., Bourdette, D.N., Offner, H. 2006. Antigen-specific therapy promotes repair of myelin and axonal damage in established EAE. J. Neurochem. 98: 1816. 8. Wang, C., Chou, Y. C., Rich, C. M., Link, J.M., Afentoulisa, M. E., van Noort, J. M., Wawrousekd, E. F., Offner, H., Vandenbarka, A. A. 2006. αB-crystallin-reactive T cells from knockout mice are not encephalitogenic. J. Neruoimmunol. 176: 51. 9. Offner, H., Subramanian, S., Parker, S.M., Wang, C., Afentoulis, M. E., Lewis, A., Vandenbark, A. A. and Hurn P. D. 2006. Splenic atrophy in experimental stroke is accompanied by increased Treg cells and circulating macrophages. J. Immunol. 176: 6523. 10. Offner, H., Subramanian, S., Wang, C., Afentoulis, M. E., Vandenbark, A. A., Huan, J., and Burrows, G. G. 2005. Treatment of passive EAE in SJL mice with a recombinant TCR ligand induces high levels of IL-13. J.Immunol. 175: 4103. 11. Wang, C., Buck, D. C., Yang, R, Macey, T. A., and Neve, K. A. 2005. Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases. J.Neurochem. 93: 899. 12. Chou, Y. K., Burrows, G. G., LaTocha, D., Wang, C., Subramanian, S., Bourdette, D. N., and Vandenbark, A. A. 2004. CD4 T-cell epitopes of human alpha B-crystallin. J.Neurosci.Res. 75: 516. 13. Wang, C., Mooney, J. L., Meza-Romero, R., Chou, Y. K., Huan, J., Vandenbark, A. A., Offner, H., and Burrows, G. G. 2003. Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation. J.Immunol. 171: 1934. 14. Vandenbark, A. A., Rich, C., Mooney, J., Zamora, A., Wang, C., Huan, J., Fugger, L., Offner, H., Jones, R., and Burrows, G. G. 2003. Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice. J.Immunol. 171: 127. 15. Burrows G. G., Chou Y. K., Wang C, Chang J. W., Finn T. P., Culbertson N. E., Kim J, Bourdette D. N., Lewinsohn D. A., Lewinsohn D. M., Ikeda M, Yoshioka T, Allen C. N., Offner H, Vandenbark A. A. 2001. Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells. J Immunol 167: 4386. 16. Wang C, Zhou D. H., Chen J, Chi Z. Q. 1999. Leucine-2-alanine enkephalin induced delta opioid receptors internalization expressed stably in CHO cells. Acta Pharmacol Sin. 20: 491. 17. Wang C, Zhou D. H., Chen Z. J., Wei Q, Chen J, Li G. F., Pei G, Chi Z. Q. 1998. The C-truncated delta-opioid receptor underwent agonist-dependent activation and desensitization. Biochem Biophys Res Commun 249: 321. 18. Wang C, Zhou D. H., Chen J, Li G. F., Pei G., Chi Z. Q. 1997. Binding properties of C-truncated delta opioid receptors. Acta Pharmacol Sin 18: 337. 19. Wei Q, Zhou D. H., Shen Q. X., Wang C, Pei G, Chi Z. Q. 1998. Human mu-opioid receptor overexpressed in baculovirus system and its pharmacological characterizations. Acta Pharmacol Sin 19: 218. 20. Zhu X. L., Wang C, Chen Z. J., Wu Y. L., Zhou D. H., Pei G. 1997. The carboxyl terminus mouse delta-opioid receptor is not required for agonist-dependent activation. Biochem Biophys Res Commun 232: 513.

学术兼职

1、美国免疫学学会会员 2、国家“十三五”新药创制重大专项生物技术药物评审专家 3、国家“十二五”新药创制重大专项生物技术药物验收和评估专家

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