戴辉雄 - 中国科学院上海药物研究所 -

个人简介

教育背景 2004-09--2007-07 中国科学院上海有机化学研究所博士 2001-09--2004-07 南开大学硕士 1997-09--2001-07 南昌大学学士工作简历 2012-07~2016-02,中国科学院上海有机化学研究所, 副研究员 2009-12~2012-07,美国Scipps研究所, 研究助理 2007-12~2009-12,美国德州大学, 博士后 2004-09~2007-07,中国科学院上海有机化学研究所, 博士 2001-09~2004-07,南开大学, 硕士 1997-09~2001-07,南昌大学, 学士

研究领域

目前主要致力于开发新型的官能团转化方法，用于天然产物和药物分子的结构修饰，从而发展出高效的先导化合物的优化策略，更好地服务于新药研发。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Fused-ring α-pyrones from intramolecular C–H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者铑催化吲哚C（4）—H选择性活化构建氮杂-螺4，5吲哚骨架, Construction of Aza-spiro4,5indole Scaffolds via Rhodium-Catalyzed Regioselective C(4)—H Activation of Indole, 化学学报, 2022, 第 5 作者 Functionalized styrene synthesis via palladium-catalyzed C-C cleavage of aryl ketones, TETRAHEDRON LETTERS, 2022, 通讯作者 Enones as Alkenyl Reagents via Ligand-Promoted C-C Bond Activation, ACS CATALYSIS, 2022, 通讯作者 Rhodium-Catalyzed C-H Activation of Indoles for the Construction of Spiroindole Scaffolds, SYNTHESIS-STUTTGART, 2022, 通讯作者 Homologation of aryl ketones to long-chain ketones and aldehydes via C–C bond cleavage, ISCIENCE, 2022, 第 5 作者 Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C-C Bond Activation, JOURNAL OF ORGANIC CHEMISTRY, 2022, 通讯作者 Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters, Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters, CHINESE CHEMICAL LETTERS, 2021, 通讯作者 Construction of 2-alkynyl aza-spiro4,5indole scaffolds via sequential C-H activations for modular click chemistry libraries, CHEMICAL COMMUNICATIONS, 2021, 通讯作者 C3-Arylation of indoles with aryl ketones via C-C/C-H activations, CHEMICAL COMMUNICATIONS, 2021, 通讯作者 Copper-mediated ortho C-H primary amination of anilines, TETRAHEDRON LETTERS, 2021, 通讯作者 Palladium/Norbornene-Catalyzed Decarbonylative Difunctionalization of Thioesters, JACS AU, 2021, 第 10 作者 Pd-Catalyzed Asymmetric Dearomatization of Indoles via Decarbonylative Heck-Type Reaction of Thioesters, ORGANIC LETTERS, 2021, 通讯作者 Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination, ORGANIC LETTERS, 2021, 通讯作者 Ligand-Promoted Alkynylation of Aryl Ketones: A Practical Tool for Structural Diversity in Drugs and Natural Products, ACS CATALYSIS, 2021, 通讯作者 Copper-Mediated ortho-C-H Amination Using DMF as the Amine Source, ORGANIC LETTERS, 2021, 通讯作者 Enones as Alkenyl Reagents via Ligand-Promoted C-C Bond Activation, ACS CATALYSIS, 2021, 第 6 作者 Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings, ORGANIC LETTERS, 2021, 通讯作者 Pd-Catalyzed Asymmetric Acyl-Carbamoylation of an Alkene to Construct an alpha-Quaternary Chiral Cycloketone, ORGANIC LETTERS, 2021, 通讯作者 Copper mediated C(sp(2))-H amination and hydroxylation of phosphinamides, CHEMICAL COMMUNICATIONS, 2020, 通讯作者 Copper-mediated C-H thiolation of (hetero)arenes using weakly coordinating directing group, TETRAHEDRON LETTERS, 2020, 通讯作者 Palladium-catalyzed meta-CsbndH bond iodination of arenes with I2, CHINESE CHEMICAL LETTERS, 2020, 通讯作者 Palladium-Catalyzed, Copper(I)-Promoted Methoxycarbonylation of Arylboronic Acids with O-Methyl S-Aryl Thiocarbonates, JOURNAL OF ORGANIC CHEMISTRY, 2020, 通讯作者 Cu(II) Mediated beta-C-H Alkynylation of Acrylamides with Terminal Alkynes, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 通讯作者 Synthesis of Trifluoromethylarenes via Nickel-Mediated C-O Bond Activation of Phenol Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 通讯作者铜参与的烯基酰胺β-碳氢键与端炔的炔基化反应（英文）, 有机化学, 2020, 第 5 作者铜参与的烯基酰胺β-碳氢键与端炔的炔基化反应, Cu(II)-Mediatedβ-C—H Alkynylation of Acrylamides with Terminal Alkynes, 有机化学, 2020, 第 5 作者 Transformations of Aryl Ketones via Ligand-Promoted C-C Bond Activation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 通讯作者 Synthesis of Axially Chiral Olefin-Oxazoline Ligands via Pd-Catalyzed Multiple C-H Functionalization, ORGANIC LETTERS, 2020, 通讯作者 Copper-mediated CsbndH thiolation of (hetero)arenes using weakly coordinating directing group, TETRAHEDRON LETTERS, 2020, 通讯作者 Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature, TETRAHEDRON LETTERS, 2020, 通讯作者 Palladium-catalyzed meta-C—H bond iodination of arenes with I2, Palladium-catalyzed meta-C-H bond iodination of arenes with I-2, CHINESE CHEMICAL LETTERS, 2020, 通讯作者 Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines, ORGANIC LETTERS, 2020, 通讯作者镍介导的苯酚衍生物碳氧键活化合成三氟甲基芳烃, Synthesis of Trifluoromethylarenes via Nickel-Mediated C-O Bond Activation of Phenol Derivatives, 有机化学, 2020, 第 2 作者 Remote Para-C-H Acetoxylation of Electron-Deficient Arenes, ORGANICLETTERS, 2019, 通讯作者 Palladium-catalyzed intramolecular CsbndH acylation of indoles with thioester, TETRAHEDRON LETTERS, 2019, 通讯作者 Copper-catalyzedα-selective C–H trifluoromethylation of acrylamides with TMSCF3, Copper-catalyzed α-selective C–H trifluoromethylation of acrylamides with TMSCF3, 中国化学快报:英文版, 2019, 通讯作者 Copper-catalyzed alpha-selective C-H trifluoromethylation of acrylamides with TMSCF3, CHINESE CHEMICAL LETTERS, 2019, 通讯作者 coppercatalyzedselectivechtrifluoromethylationofacrylamideswithtmscf3, CHINESECHEMICALLETTERS, 2019, 通讯作者 Palladium-Catalyzed Remote meta-C-H Bond Deuteration of Arenes Using a Pyridine Template, ORGANIC LETTERS, 2019, 通讯作者 Efficient Synthesis of Spirooxindole Pyrrolones by a Rhodium(III)-Catalyzed C-H Activation/Carbene Insertion/Lossen Rearrangement Sequence, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 通讯作者 Cu-Mediated C-H Thioetherification of Arenes at Room Temperature, ORGANIC LETTERS, 2019, 通讯作者 Palladium-catalyzed intramolecular C-H acylation of indoles with thioester, TETRAHEDRON LETTERS, 2019, 通讯作者