黄锐敏 - 中国科学院上海药物研究所 -

个人简介

教育经历： 1999.9–2004.7 中科院生物化学与细胞生物学研究所，细胞生物学，博士 1994.9–1999.7 中国科学技术大学，生物科学，学士工作经历： 2016．3-至今中科院上海药物研究所,研究员 2004．10–2016.3 美国纪念斯隆凯特琳癌症研究中心，历任博士后，Senior Research Scientist等职务

研究领域

1.肿瘤分子影像学研究 2.肿瘤相关基因功能研究

近期论文

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1.Huang R, Harmsen S, Samii JM, Karabeber H, Pitter KL, Holland EC, Kircher MF. High precision imaging of microscopic spread of glioblastomas with a targeted SERRS nanoprobe. Theranostics (in press). 2.Spaliviero M*, Harmsen S*, Huang R*, Wall MA, Eastham JA, Touijer KA, Scardino PT, Kircher MF. Detection of Lymph Node Metastases with SERRS Nanoparticles. Mol Imaging Biol (Epub ahead of print). 3.Harmsen S*, Huang R*, Wall MA, Karabeber H, Samii JM, Spaliviero M, White JR, Monette S, O’Connor R, Pitter KL, Sastra SA, Saborowski M, Holland EC, Singer S, Olive KP, Lowe SW, Blasberg RG, Kircher MF. Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging. (Sci Trans Med, 7(271), 271ra7, 2015; Cover Story Article). 4.Zhuang J, Lu Q, Shen B, Huang X, Shen L, Zheng X, Huang R, Yan J, Guo H. TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT. Sci Rep, 5, 11924, 2015. 5.Karabeber H, Huang R, Iacono P, Samii JM, Pitter K, Holland EC, Kircher MF. Guiding brain tumor resection using surface-enhanced Raman scattering nanoparticles and a hand-held Raman scanner. ACS Nano, 8(10), 9755-66, 2014. (Cover Story Article) 6.Zhang H*, Huang R*, Cheung NK, Guo H, Zanzonico PB, Thaler HT, Lewis JS, Blasberg RG. Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clin Cancer Res, 20(8), 2182-91, 2014. 7.Zhang H, Huang R, Pillarsetty N, Thorek DL, Vaidyanathan G, Serganova I, Blasberg RG, Lewis JS. Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter. Eur J Nucl Med Mol Imaging, 41(2), 322-32, 2014. 8.Hou Z, Zhao W, Zhou J, Shen L, Zhan P, Xu C, Chang C, Bi H, Zou J, Yao X, Huang R, Yu L, Yan J. A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival. Int J Biochem Cell Biol, 53C, 380-8, 2014. 9.Zhao W, Chang C, Cui Y, Zhao X, Yang J, Shen L, Zhou J, Hou Z, Zhang Z, Ye C, Hasenmayer D, Perkins R, Huang X, Yao X, Yu L, Huang R, Zhang D, Guo H, Yan J. Steroid Receptor Coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of Hypoxia Inducible Factor 1α. J Biol Chem, 289(16), 11219-29, 2014. 10.Surriga O, Rajasekhar VK, Ambrosini G, Dogan Y, Huang R, Schwartz GK. Crizotinib, a c-Met inhibitor, prevents metastasis in a metastatic uveal melanoma model. Mol Cancer Ther, 12(12), 2817-26, 2013. 11.Huang R, Vider J, Kovar JL, Olive DM, Mellinghoff IK, Mayer-Kuckuk P, Kircher MF, Blasberg RG. Integrin αvβ3-targeted IRDye 800CW near-infrared imaging of glioblastoma. Clin Cancer Res, 18(20), 5731-40, 2012. 12.Kircher MF, de la Zerda A, Jokerst JV, Zavaleta CL, Kempen PJ, Mittra E, Pitter K, Huang R, Campos C, Habte F, Sinclair R, Brennan CW, Mellinghoff IK, Holland EC, Gambhir SS. A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. Nature Med, 18(5), 829-34, 2012. 13.Huang R, Cheung NK, Vider J, Cheung IY, Gerald WL, Tickoo SK, Holland EC, Blasberg RG. MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas. FASEB J, 25(12), 4138-49, 2011. 14.Huang R, Vider J, Serganova I, Blasberg RG. ATP-binding cassette transporters modulate both coelenterazine- and D-luciferin- based bioluminescence imaging. Mol Imaging, 10(3), 215-26, 2011. 15.Moroz MA, Huang R, Kochetkov T, Shi W, Thaler H, de Stanchina E, Gamez I, Ryan RP, Blasberg RG. Comparison of corticotropin-releasing factor, dexamethasone, and temozolomide: treatment efficacy and toxicity in U87 and C6 intracranial gliomas. Clin Cancer Res, 17(10), 3282-92, 2011. 16.Mo W, Zhang L, Yang G, Zhai J, Hu Z, Chen Y, Chen X, Hui L, Huang R, Hu G. Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma. Mol Cell, 31(5), 695-707, 2008. 17.Huang R, Xing Z, Luan Z, Wu T, Wu X, Hu G. A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas. Cancer Res, 63(13), 3375-82, 2003. 18.Huang R, Wu T, Xu L, Liu A, Ji Y, Hu G. Upstream binding factor up-regulated in hepatocellular carcinoma is related to the survival and cisplatin-sensitivity of cancer cells. FASEB J, 16(3), 293-301, 2002.