个人简介
丁海涛 副研究员
教育背景
2004.09-2010.12 浙江大学 博士
2000.09-2004.06 安徽大学 学士
工作经历
2022.01-至今 上海交通大学海洋学院 副研究员
2015.04-至今 中国极地研究中心 助理研究员/副研究员
2011.10-2015.03 浙江大学 博士后/助理研究员
科研项目
1. 国家自然科学基金面上项目,北极海单胞菌β-1,3-半乳糖苷酶的立体选择性催化机制及其生态学意义,2021/01-2024/12,主持
2. 国家重点研发计划子课题,极地微生物新型生物制品的研制及其应用潜力评价,2018/08-2021/12,主持
3. 国家自然科学基金青年基金,NAD(P)+-依赖型葡萄糖脱氢酶底物识别分子机制研究,2013/01-2015/12,主持
研究领域
1. 极地微生物酶资源挖掘与应用
2. 极地微生物对气候变化的响应
近期论文
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1. Wang Y, Wang P, Cao HY, Ding HT, Su HN, Liu SC, Liu G, Zhang X, Li CY, Peng M, Li F, Li S, Chen Y, Chen XL, Zhang YZ. Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis. Nat Commun. 2022 13(1):566.
2. Zhang, Y.; Ding, H. T.; Jiang, W. X.; Zhang, X.; Cao, H. Y.; Wang, J. P.; Li, C. Y.; Huang, F.; Zhang, X. Y.; Chen, X. L.; Zhang, Y. Z.; Li, P. Y. Active site architecture of an acetyl xylan esterase indicates a novel cold adaptation strategy. J. Biol. Chem. 2021, 100841.
3. Xu, F.; Chen, X.; Sun, X.; Dong, F.; Li, C.; Li, P..; Ding, H.; Chen, Y.; Zhang, Y.; Wang, P. Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the Arctic. J. Biol. Chem. 2020, jbc. RA120. 015106.
4. Tang, B.; Yang, J.; Chen, X.; Wang, P.; Zhao, H.; Su, H.; Li, C.; Yu, Y.; Zhong, S.; Wang, L.; Lidbury, I.; Ding, H.; Wang, M.; McMinn, A.; Zhang, X.; Chen, Y.; Zhang, Y. A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria. Nat. Commun. 2020, 11, 285. 3.
5. Liu, K.; Ding, H.; Yu, Y.; Chen, B. A Cold-Adapted Chitinase-Producing Bacterium from Antarctica and Its Potential in Biocontrol of Plant Pathogenic Fungi. Mar. Drugs 2019, 17, 695.
6. Ding, H.; Luo, W.; Yu, Y.; Chen, B. Construction of a Robust Cofactor Self-Sufficient Bienzyme Biocatalytic System for Dye Decolorization and its Mathematical Modeling. Int. J. Mol. Sci. 2019, 20, 6104.
7. Ding, H.; Zhou, L.; Zeng, Q.; Yu, Y.; Chen, B. Heterologous expression of a thermostable β-1,3-galactosidase and its potential in synthesis of galactooligosaccharides. Mar. Drugs 2018, 16, 415.
8. Ding, H.; Zeng, Q.; Zhou, L.; Yu, Y.; Chen, B. Biochemical and structural insights into a novel thermostable β-1, 3-galactosidase from Marinomonas sp. BSi20414. Mar. Drugs 2017, 15, 13.