Que, Emily - The University of Texas at Austin

个人简介

ACS Division of Inorganic Chemistry Young Investigator Award, 2010

研究领域

Research in the Que lab centers lies at the interface of bioinorganic chemistry and chemical biology, with an emphasis on chemical synthesis of new molecular tools that will be characterized in the test tube and in biological settings ranging from isolated proteins, cell culture, and whole organisms. Two major areas of the lab include the development of chemical tools to probe cellular metal homeostasis and the development of novel MRI contrast agents for molecular imaging.

近期论文

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Que, E.L.; Bleher, R.; Duncan, F.E.; Kong, B.Y.; Gleber, S.C.; Vogt, S.; Chen, S.; Garwin, S.A.; Bayer, A.R.; Dravid, V.P.; Woodruff, T.K.; O'Halloran, T.V. "Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks," Nature Chem. 2014, doi:10.1038/nchem.2133. Kong, B.Y.; Duncan, F.E.; Que, E.L.; Kim, A.M.; O'Halloran, T.V.; Woodruff, T.K. "Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition," Mol. Hum. Reprod. 2014, 20, 1077-1089. Ya, R.; Que, E.L.; O'Halloran, T.V.; Woodruff, T.K. "Zinc as a key meiotic cell-cycle regulator in the mammalian oocyte," In Zinc Signals in Cellular Functions and Disorders. Fukada, T., Kambe, T., Eds; Springer: Japan, 2014, 315-343. Yong, Y.P.; Gleber, S.C.; O'Halloran, T.V.; Que, E.L.; Bleher, R.; Vogt, S.; Woodruff, T.K.; Jacobsen, C. "Low-dose X-ray fluorescence tomography images using differential phase contrast," J. Synchrotron Radiat. 2014, 21, 229-234. Marvin, R. G.; Wolford, J. L.; Kidd, M. J.; Murphy, S.; Ward, J.; Que, E. L.; Mayer, M. L.; Penner-Hahn, J. E.; Jaldar, K.; O’Halloran, T. V. “Fluxes in ‘Free’ and Total Zinc are Essential for Progression of Intraerythrocytic Stages of Plasmodium falciparum,” Chem. Biol. 2012, 19, 731-741. PMCID: PMC3601789 Que, E. L.; New, E. J.; Chang, C. J. “A Cell-Permeable Gadolinium Contrast Agent for Magnetic Resonance Imaging of Copper in a Menkes Disease Model,” Chem. Sci. 2012, 3, 1829-1834. Que, E. L.; Chang, C. J. “Responsive Magnetic Resonance Imaging Contrast Agents as Chemical Sensors for Metals in Biology and Medicine,” Chem. Soc. Rev. 2010, 39, 51-60. Que, E. L.; Gianolio, E.; Baker, S. L.; Aime, S.; Chang, C.J. “A Copper-Activated Magnetic Resonance Imaging Contrast Agent with Improved Turn-On Relaxivity Response and Anion Compatibility,” Dalton Trans. 2010, 39, 469-476. Que, E. L.; Gianolio, E.; Baker, S. L.; Wong, A. P.; Aime, S.; Chang, C.J. “Copper Responsive Magnetic Resonance Imaging Contrast Agents,” J. Am. Chem. Soc. 2009, 131, 8527-8536. Que, E. L.; Domaille, D. W.; Chang, C. J. "Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging," Chem. Rev. 2008, 108, 1517-1549. Domaille, D. W.; Que, E. L.; Chang, C. J. "Synthetic Fluorescent Sensors for Studying the Cell Biology of Metals," Nat. Chem. Biol. 2008, 4, 168-175. Que, E. L.; Chang, C. J. "A Smart Magnetic Resonance Contrast Agent for Selective Copper Sensing," J. Am. Chem. Soc. 2006, 128, 15942-15943. Chastek, T.T.; Que, E.L.; Jarzombeck, P.; Macosko, C.W.; Stein, A. "Synthesis of lamellar isobutyl silicates and dispersion in polypropylene melts," J. Appl. Polymer Sci. 2007, 105, 1456-1465. Jensen, M.P.; Que, E.L.; Shan, X.; Rybak-Akimova, E.; Que, L. Jr. "Spectroscopic and kinetic studies of the reaction of [Cu(I)(6-PhTPA)]+ with O2," Dalton Trans. 2006, 29, 3523-3527. Chastek, T.T.; Que, E.L.; Shore, J.S.; Lowy, R.J. III; Macosko, C.; Stein, A. "Hexadecyl-functionalized lamellar mesostructured silicates and aluminosilicates designed for polymer-clay nanocomposites. Part I. Clay synthesis and structure," Polymer, 2005, 46, 4421-4430. Jensen, M.P.; Lange, S.J.; Mehn, M.P.; Que, E.L.; Que, L. Jr. "Biomimetic aryl hydroxylation derived from alkyl hydroperoxide at a nonheme iron center. Evidence for an Fe(IV)=O oxidant," J. Am. Chem. Soc. 2003, 125, 2113-2128.