王贝贝 - 北京师范大学 - 先进材料研究中心

个人简介

学习经历 2003.09-2007.07，中国石油大学（北京），应用化学专业学士学位 2007.09-2012.07，复旦大学，物理化学专业，博士学位工作经历 2012.07-2015.05，密歇根州立大学，生物化学与分子生物学系，博士后 2015.06-2017.11，卡尔加里大学，生物科学系，博士后 2017.11-2021.09，电子科技大学，生命科学与技术学院，副教授 2021.09至今，北京师范大学，先进材料研究中心副教授获奖情况 2020国际基因工程机器大赛iGEM (UESTC-software)主教练（Gold Prize, nominated for Best of Software） 2019国际基因工程机器大赛iGEM (UESTC-software)主教练 (Gold Prize, Best of Software) 2018国际基因工程机器大赛iGEM (UESTC-software)主教练 (Gold Prize, Best of Software, nominated for Best of Product Design) 2020年电子科技大学优秀班主任 Alberta Innovates Health Solutions (AIHS) fellowship, Canada

研究领域

王贝贝博士使用多种计算模拟方法研究从分子尺度到细胞尺度的生物学现象，从而在微观现象和宏观现象之间架起桥梁。我们创建脂质分子，DNA，RNA和蛋白质的最新计算模型，以研究其结构-动力学-功能之间的关系。

近期论文

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Beibei Wang*, Huayi Yang, Jianan Sun, Chuhao Dou, Jian Huang, and Fengbiao Guo. BioMaster: an integrated database and analytic platform to provide comprehensive information about BioBrick parts. Front. Microbiol. 2021. https://doi.org/10.3389/fmicb.2021.593979 Beibei Wang, Rachel E. Sexton, Michael Feig*. Kinetics of nucleotide entry into RNA polymerase active site provides mechanism for efficiency and fidelity. BBA Gene Regulatory Mechanisms 2017 1860, 482-490. Beibei Wang, Joshua Francis, Monika Sharma, Sean M. Law, Alexander V. Predeus, Michael Feig*. Long-Range Signaling in MutS and MSH Homologs via Switching of Dynamic Communication Pathways. PLoS Comput. Biol. 2016 12(10): e1005159. Beibei Wang, Jingwei Weng, Wenning Wang*. Substrate binding accelerates the conformational transition and substrate extrusion in multidrug efflux transporter AcrB. Front. Microbiol. 2015, 6, 302. Beibei Wang, Kristopher Opron, Zachary F. Burton, Robert I. Cukier, Michael Feig*. Five checkpoints maintaining the fidelity of transcription by RNA polymerases in structural and energetic details. Nucleic Acid Res. 2015, 43, 1133-1146. Beibei Wang, Jingwei Weng, Wenning Wang*. Multiple conformational states and gate opening of outer membrane protein TolC revealed by MD simulations. Proteins, 2014, 82, 2169-2179. Beibei Wang, Michael Feig, Robert I. Cukier, Zachary F. Burton*. Computational simulation strategies for analysis of multi-subunit RNA polymerases. Chem. Rev. 2013, 113, 8546-8566. Beibei Wang, Alexander V. Predeus, Zachary F. Burton, Michael Feig*. Energetic and Structural Details of the Trigger-Loop Closing Transition in RNA Polymerase II. Biophys. J. 2013, 105, 767-775. Beibei Wang, Jingwei Weng, Kangnian Fan, Wenning Wang*. Inter-domain flexibility and pH-induced conformational changes of AcrA revealed by molecular dynamics simulations. J. Phys. Chem. B, 2012, 116, 3411-3420. Beibei Wang, Jingwei Weng, Kangnian Fan, Wenning Wang*. Elastic network model-based normal mode analysis reveals the conformational couplings in the tripartite AcrAB-TolC multidrug efflux complex. Proteins, 2011, 79, 2936-2945.