个人简介
学习经历
2019.11 - 2021.04 斯坦福大学,医学院放射系分子影像中心,博士后,合作导师:Jianghong Rao
2014.09 - 2019.07 北京师范大学,化学学院,博士 (药物化学与分子工程),导师:崔孟超
2010.09 - 2014.07 兰州大学,核科学与技术学院,学士 (放射化学)
博士期间从事靶向于阿尔茨海默症患者脑内Aβ斑块和Tau蛋白的近红外荧光以及放射性分子探针开发。通过药物化学手段筛选出性质优良的Aβ荧光探针,并实现了Aβ和Tau蛋白的多光谱成像,为阿尔茨海默多靶点联合诊断提供了新思路。通过先导化合物筛选,化学修饰和生物性质评价得到的两个[F-18]标记的Tau蛋白正电子药物S16以及Aβ探针91通过了中国人民解放军总医院伦理委员会的审查,临床上完成超过二百多个病例与健康对照检查,从基础研究到临床转化迈出了重要一步。
博后期间从事肿瘤免疫治疗成像,通过结合分子自组装,生物自发光,生物正交反应等手段用于生物成像及治疗。
奖励荣誉
2019 原子高科优秀博士生
2018、2017、2015 研究生国家奖学金
近期论文
查看导师最新文章
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Kaixiang Zhou, Chang Yuan et al. Environment-Sensitive Based Near-Infrared Probe for Fluorescent Discrimination of Aβ and Tau Fibrils in AD Brain. Journal of Medicinal Chemistry, 2019, 62, 6694-6704.
Kaixiang Zhou, Hongcun Bai et al. Smart D-π-A Type Near-Infrared Aβ Probes: Effects of a Marked π Bridge on Optical and Biological Properties. Analytical Chemistry, 2017, 89, 9432–9437
Kaixiang Zhou, Hualong Fu et al. The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques. Chemical Communications, 2015, 51, 11665-11668.
Kaixiang Zhou, Fan Yang et al. Synthesis and Evaluation of Fluorine-18 Labeled 2-Phenylquinoxaline Derivatives as Potential Tau Imaging Agents. Molecular Pharmaceutics, 2021, 18, 1176-1195.
Kaixiang Zhou, Yuying Li et al. Structure-Property Relationships of Polyethylene Glycol Modified Fluorophore as Near-Infrared Aβ Imaging Probes. Analytical Chemistry, 2018, 90, 8576–8582.
Huiya Tan1, Kaixiang Zhou1 et al. Dual-functional red-emitting fluorescent probes for imaging beta-amyloid plaques and viscosity. Sensors and Actuators B: Chemical, 2019, 298, 126903. (1co-first author)