陈苏仁 - 北京师范大学 - 生命科学学院

个人简介

2009年内蒙古大学生命科学学院本科毕业后，保送进入中国科学院动物研究所（干细胞与生殖生物学国家重点实验室）硕博连读，导师为我国著名生殖生物学家刘以训院士，博士毕业后留所先后任助理研究员和副研究员。2019年入职北京师范大学生命科学学院，任副教授、博士生导师、课题组长，研究方向为精子生物学和男性不育遗传学。学术成果以通讯作者（含共同）在Human Reproduction Update, Science Advances, eBioMedicine, Cell Reports和Development等国际一流学术期刊上。入选中国科协青年人才托举工程”，获得国家重点研发计划和国家自然科学基金等资助。受聘为全国研究生教育评估监测专家库专家，国家自然科学基金函审专家，北京市科学技术委员会、中关村科技园区管理委员会科技项目评审专家库专家。目前担任SCI期刊BMC Molecular and Cell Biology编委（Associate editor）。承担本科生《生殖的奥秘—生殖生物学与医学》、《带你了解遗传病—医学遗传学》和研究生《生殖生物学与医学》等课程，荣获北京师范大学优秀新生导师称号。

研究领域

生殖遗传学。利用临床男性不育患者（如无精症、弱精症和畸形精子症等）样本开展全外显子测序，发掘致病基因变异；应用透射电镜等高分辨率成像技术研究精子结构缺陷；并构建致病突变的基因敲除 /点突变小鼠深入揭示发病机理。生殖遗传研究面向人民生命健康，将有望为男性不育患者的基因诊断、辅助生殖治疗和遗传咨询提供重要理论依据。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Molecular genetics of infertility: Loss-of-function mutations in humans and corresponding knockout/mutated mice Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice Loss-of-function mutations in CEP78 cause male infertility in humans and mice CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile men The mutation c.346-1G > A in SOHLH1 impairs sperm production in the homozygous but not in the heterozygous condition CD83, a Novel MAPK Signaling Pathway Interactor, Determines Ovarian Cancer Cell Fate Mechanisms of Long Non-Coding RNAs in Cancers and Their Dynamic Regulations An exploration of the role of Sertoli cells on fetal testis development using cell ablation strategy Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell Biologic response of sperm and seminal plasma to transient testicular heating Testicular germ cell tumor: a comprehensive review Distinct Metabolic Features of Seminoma and Embryonal Carcinoma Revealed by Combined Transcriptome and Metabolome Analyses Recent advances in the regulation of testicular germ cell tumors by microRNAs Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I CRISPR/Cas9-mediated genome editing induces gene knockdown by altering the pre-mRNA splicing in mice A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth GATA4 is a negative regulator of contractility in testicular peritubular myoid cells Selective deletion of WLS in peritubular myoid cells does not affect spermatogenesis or fertility in mice Role of WNT signaling in epididymal sperm maturation Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in an in vitro goat spermatogonial stem cell differentiation culture system Regulation of blood–testis barrier assembly in vivo by germ cells EZH2 deletion promotes spermatogonial differentiation and apoptosis Requirement for CCNB1 in mouse spermatogenesis Melatonin promotes sheep Leydig cell testosterone secretion in a co-culture with Sertoli cells Merotelic kinetochore attachment in oocyte meiosis II causes sister chromatids segregation errors in aged mice Focuses on the impact of Zika virus infection on the male reproductive tract The control of male fertility by spermatid-specific factors: Searching for contraceptive targets from spermatozoon's head to tail Elevated intracellular pH appears in aged oocytes and causes oocyte aneuploidy associated with the loss of cohesion in mice Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models Selective deletion of Smad4 in postnatal germ cells does not affect spermatogenesis or fertility in mice: Deletion of Smad4 in germ cells using Ngn3-Cre and Stra8-Cre Letter: Myh11-Cre is not limited to peritubularmyoid cells and interaction between Sertoli and peritubular myoid cells needs investigation Sodium–hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility Melatonin promotes development of haploid germ cells from early developing spermatogenic cells of Suffolk sheep under in vitro condition Androgen receptor in Sertoli cells regulates DNA double-strand break repair and chromosomal synapsis of spermatocytes partially through intercellular EGF-EGFR signaling Testis Cord Maintenance in Mouse Embryos: Genes and Signaling Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling Wt1 deficiency causes undifferentiated spermatogonia accumulation and meiotic progression disruption in neonatal mice The Heat-Induced Reversible Change in the Blood-Testis Barrier (BTB) Is Regulated by the Androgen Receptor (AR) via the Partitioning-Defective Protein (Par) Polarity Complex in the Mouse Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration The Wilms Tumor Gene, Wt1, Maintains Testicular Cord Integrity by Regulating the Expression of Col4a1 and Col4a2 Serine protease and ovarian paracrine factors in regulation of ovulation