张占军 - 北京师范大学 - 认知神经科学与学习国家重点实验室

个人简介

教育经历 2002/09–2005/07，北京中医药大学，医学博士 1999/09–2002/07，天津中医药大学，医学硕士工作经历 2017/03-至今，北京师范大学认知神经科学与学习国家重点实验室，副主任 2013/10-至今，北京师范大学老年脑健康研究中心，创始主任 2010/12-2016/12，北京师范大学脑与认知科学研究院，副院长 2013/07至今，北京师范大学认知神经科学与学习国家重点实验室，教授 2007/09-2013/07，北京师范大学认知神经科学与学习国家重点实验室，副教授 2005/09-2007/09，北京师范大学，博士后

研究领域

主要从事人类高级认知功能的衰退规律及其脑机制研究，多年来专注于老年脑健康领域。中国老龄人口庞大，老年痴呆疾病的早诊早防,大脑健康促进成为影响国民健康和社会经济发展的重大课题。而针对中国人群本土化的认知老化常模、测评工具、认知康复等关键技术的缺失都极大阻碍了疾病的防治，而构建高标准、多维度、纵向的中国老年人群队列成为解决上述问题的关键。早在2008年，带领团队发起了BABRI北京老年脑健康促进计划(Beijing Aging Brain Rejuvenation Initiative )历经10余年潜心研究，针对社区认知障碍早期筛查瓶颈问题，建立了脑健康体检（痴呆风险筛查）技术平台，在全国多个医院、社区推广使用，大大提高了痴呆风险的知晓率，极大促进了对于认知障碍相关疾病“早知道、早发现、早预警和早干预”的全病程管理

近期论文

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Caishui Yang, Xin Li, Junying Zhang, Yaojing Chen, He Li, Dongfeng Wei, Peng Lu, Ying Liang, Zhen Liu, Ni Shu, Fang Wang, Qing Guan, Wuhai Tao, Qingshan Wang, Jianjun Jia, Lin Ai, Ruixue Cui, Yanping Wang, Dantao Peng, Wei Zhang, Kewei Chen, Xiaomin Wang, Jizong Zhao, Yongyan Wang, Qi Dong, Jun Wang, Zhanjun Zhang, Beijing Aging Brain Rejuvenation Initiative workgroup; Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative[J]. Alzheimer's and Dementia, 2021(1). 中国老年学和老年医学学会脑认知与健康分会, 中国老年医学学会认知障碍分会, 中国医师协会神经内科医师分会认知障碍疾病专业委员会, 等. 中国数字化记忆门诊临床应用专家共识（2021） [J] . 中华医学杂志, 2021, 101(45) : 3712-3717. Yiru Yang; Chenlong Lv; He Li; Kewei Chen; Xin Li; Yaojing Chen; Junying Zhang; Dongfeng Wei; Peng Lu; Jun Wang; Zhanjun Zhang; Community-based Model for Dementia Risk Screening: The Beijing Aging Brain Rejuvenation Initiative (BABRI) Brain Health System, Journal of the American Medical Directors Association, 2021, S1525-8610(20): 1-7. Chen Yaojing, Dang Mingxi, Zhang Zhanjun. Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease: a systematic review of symptom-general and –specific lesion patterns[J]. Molecular Neurodegeneration, 2021, 16(1). Sang Feng, Chen Yaojing, Chen Kewei, Dang Mingxi, Gao Shudan, Zhang Zhanjun. Sex Differences in Cortical Morphometry and White Matter Microstructure During Brain Aging and Their Relationships to Cognition. Cerebral Cortex. 2021 Jun. DOI: 10.1093/cercor/bhab155. Qiuhui Bi; Wenxiao Wang; Na Niu; He Li; Yezhou Wang; Weijie Huang; Kewei Chen; Kai Xu; Junying Zhang; Yaojing Chen; Dongfeng Wei; Ruixue Cui; Ni Shu; Zhanjun Zhang; Relationship between the disrupted topological efficiency of the structural brain connectome and glucose hypometabolism in normal aging, Neuroimage, 2021, 226(117591): 1-9. 张占军等. "社区老年脑健康体检与痴呆风险筛查体系构建与实践——北京方案." 科学通报 65.14(2020):9. Weiyi Zeng; Yaojing Chen; Zhibao Zhu; Shudan Gao; Jianan Xia; Xiaochun Chen; Jianjun Jia; Zhanjun Zhang; Severity of white matter hyperintensities: Lesion patterns, cognition, and microstructural changes, Journal of Cerebral Blood Flow & Metabolism, 2020, 40(12): 2454-2463. Li, Xin; Xia, Jianan; Ma, Chao; Chen, Kewei; Xu, Kai; Zhang, Junying; Chen, Yaojing; Li, He; Wei, Dongfeng; Zhang, Zhanjun; Accelerating Structural Degeneration in Temporal Regions and Their Effects on Cognition in Aging of MCI Patients, Cerebral Cortex, 2020, 30(1): 326-338. Li, Xin; Wang, Yezhou; Wang, Wenxiao; Huang, Weijie; Chen, Kewei; Xu, Kai; Zhang, Junying; Chen, Yaojing; Li, He; Wei, Dongfeng; Shu, Ni; Zhang, Zhanjun; Age-Related Decline in the Topological Efficiency of the Brain Structural Connectome and Cognitive Aging, Cerebral Cortex, 2020, 30(8): 4651-4661. Gao, Shudan; Chen, Yaojing; Sang, Feng; Yang, Yiru; Xia, Jianan; Li, Xin; Zhang, Junying; Chen, Kewei; Zhang, Zhanjun; White Matter Microstructural Change Contributes to Worse Cognitive Function in Patients With Type 2 Diabetes, Diabetes, 2019, 68(11): 2085-2094. 陈姚静; 徐凯; 杨财水; 李馨; 李鹤; 张俊英; 卫东锋; 夏佳楠; 陶伍海; 卢朋; 王君; 舒妮; 彭丹涛; 贾建军; 张巍; 崔瑞雪; 王燕平; 关青; 罗跃嘉; 王芳; 王青山; 陈克伟; 王晓民; 赵继宗; 王永炎; 张占军; 优雅地老去——北京BABRI老年脑健康计划, 中国科学:生命科学, 2018, (07): 721-734. Liu, Zhen; Dai, Xiangwei; Tao, Wuhai; Liu, Huilan; Li, He; Yang, Caishui; Zhang, Junying; Li, Xin; Chen, Yaojing; Ma, Chao; Pei, Jing; Mao, Haohao; Chen, Kewei; Zhang, Zhanjun; APOE influences working memory in non-demented elderly through an interaction with SPON1 rs2618516 , Human Brain Mapping, 2018, 39(7): 2859-2867. Liu, Zhen; Dai, Xiangwei; Zhang, Junying; Li, Xin; Chen, Yaojing; Ma, Chao; Chen, Kewei; Peng, Dantao; Zhang, Zhanjun; The Interactive Effects of Age and PICALM rs541458 Polymorphism on Cognitive Performance, Brain Structure, and Function in Non-demented Elderly , Molecular Neurobiology, 2018, 55(2): 1271-1283. Chen, Yaojing; Liu, Zhen; Zhang, Junying; Chen, Kewei; Yao, Li; Li, Xin; Gong, Gaolang; Wang, Jun; Zhang, Zhanjun; Precuneus degeneration in nondemented elderly individuals with APOE varepsilon4: Evidence from structural and functional MRI analyses, Hum Brain Mapp, 2017, 38(1): 271-282. Ma Chao; Zhang Yangjun; Li Xin; Zhang Junying; Chen Kewei; Liang Ying; Chen Yaojing; Liu Zhen; Zhang Zhanjun; Is there a significant interaction effect between apolipoprotein E rs405509 T/T and epsilon 4 genotypes on cognitive impairment and gray matter volume?, European Journal of Neurology, 2016, 23(9): 1415-1425. Chen, Yaojing; Wang, Ailin; Tang, Jinfu; Wei, Dongfeng; Li, Peng; Chen, Kewei; Wang, Yongyan; Zhang, Zhanjun; Association of White Matter Integrity and Cognitive Functions in Patients With Subcortical Silent Lacunar Infarcts, Stroke, 2015, 46(4): 1123-1126. Li, Xin; Liang, Ying; Chen, Yaojing; Zhang, Junying; Wei, Dongfeng; Chen, Kewei; Shu, Ni; Reiman, Eric M.; Zhang, Zhanjun; Disrupted Frontoparietal Network Mediates White Matter Structure Dysfunction Associated with Cognitive Decline in Hypertension Patients, Journal of Neuroscience, 2015, 35(27): 10015-10024. Chen, Yaojing; Liu, Zhen; Zhang, Junying; Xu, Kai; Zhang, Sisi; Wei, Dongfeng; Zhang, Zhanjun; Altered Brain Activation Patterns Under Different Working Memory Loads in Patients With Type 2 Diabetes, Diabetes Care, 2014, 37(12): 3157-3163. Chen, Yaojing; Chen, Kewei; Zhang, Junying; Li, Xin; Shu, Ni; Wang, Jun; Zhang, Zhanjun; Reiman, Eric M.; Disrupted Functional and Structural Networks in Cognitively Normal Elderly Subjects with the APOE epsilon 4 Allele, Neuropsychopharmacology, 2015, 40(5): 1181-1191.