Löffler, Felix - Max Planck Institute of Colloids and Interfaces -

研究领域

Microarrays enable rapid high-throughput approaches to disease research, diagnostics, as well as materials discovery. The goal of our group is to generate highly complex microarrays, offering a multitude of different biomolecules or materials. With such arrays, we want to advance screening technology and find e.g. novel biomarkers for disease diagnostics or advanced materials for catalytic applications. Our highly interdisciplinary research topics cover many different aspects of high-density arrays, their production technology, as well as their applications. Technology Development & Applications Laser-induced transfer for surface patterning Our current research focuses on laser patterning technology. The approach unites the advantages of lithographic precision with rapid prototyping of recent 3d printing technology. Exploiting this patterning technology, we strive to synthesize many different molecules and materials in a novel solid material-based organic synthesis approach. Combining our expertise in organic chemistry, materials science, and surface patterning with novel research questions, we can synthetically create the whole genomic information of a pathogen or generate new catalysts.

近期论文

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Zhang, J.; Liu, Y.; Njel, C.; Ronneberger, S.; Tarakina, N. V.; Löffler, F. F.: An all-in-one nanoprinting approach for the synthesis of a nanofilm library for unclonable anti-counterfeiting applications. Nature Nanotechnology (2023) Liu, Y.; Zhu, X.; Wei, Z.; Wu, K.; Zhang, J.; Mutti, F. G.; Zhang, H.; Löffler, F. F.; Zhou, J.: Multi-channel lanthanide nanocomposites for customized synergistic treatment of orthotopic multi-tumor cases. Angewandte Chemie International Edition, e202303570 (2023) Ronneberger, S.; Zhang, J.; Liu, Y.; Löffler, F. F.: Solid ink laser patterning for high-resolution information labels with supervised learning readout. Advanced Functional Materials, 2210116 (2023) Eickelmann, S.; Moon, S.; Liu, Y.; Bitterer, B.; Ronneberger, S.; Bierbaum, D.; Breitling, F.; Löffler, F. F.: Assessing polymer-surface adhesion with a polymer collection. Langmuir 38 (7), pp. 2220 - 2226 (2022) Fathi, A.; Dahlke, C.; Krähling, V.; Kupke, A.; Okba, N. M. A.; Raadsen, M. P.; Heidepriem, J.; Müller, M. A.; Paris, G.; Lassen, S. et al.: Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome. Nature Communications 13, 4182 (2022) Hepp, M.; Wang, H.; Derr, K.; Delacroix, S.; Ronneberger, S.; Loeffler, F. F.; Butz, B.; Strauss, V.: Trained laser-patterned carbon as high-performance mechanical sensors. npj flexible electronics 6, 3 (2022) Paris, G.; Bierbaum, D.; Paris, M.; Mager, D.; Loeffler, F. F.: Development and experimental assessment of a model for the material deposition by laser-induced forward transfer. Applied Sciences 12 (3), 1361 (2022) Paris, G.; Heidepriem, J.; Tsouka, A.; Liu, Y.; Mattes, D. S.; Pinzón Martín, S.; Dallabernardina, P.; Mende, M.; Lindner, C.; Wawrzinek, R. et al.: Automated laser-transfer synthesis of high-density microarrays for infectious disease screening. Advanced Materials 34 (12), 2200359 (2022) Tsouka, A.; Dallabernardina, P.; Mende, M.; Sletten, E. T.; Leichnitz, S.; Bienert, K.; Le Mai Hoang, K.; Seeberger, P. H.; Löffler, F. F.: VaporSPOT: parallel synthesis of oligosaccharides on membranes. Journal of the American Chemical Society 144 (43), pp. 19832 - 19837 (2022) Zhang, J.; Liu, Y.; Ronneberger, S.; Tarakina, N. V.; Merbouh, N.; Löffler, F. F.: Nanolayer laser absorber for femtoliter chemistry in polymer reactors. Advanced Materials 34 (8), 2108493 (2022) Dallabernardina, P.; Benazzi, V.; Laman, J. D.; Seeberger, P. H.; Löffler, F. F.: Automated glycan assembly of peptidoglycan backbone fragments. Organic & Biomolecular Chemistry 19 (45), pp. 9829 - 9832 (2021) Eickelmann, S.; Ronneberger, S.; Zhang, J.; Paris, G.; Löffler, F. F.: Alkanes as intelligent surface thermometers: a facile approach to characterize short-lived temperature gradients on the micrometer scale. Advanced Materials Interfaces 8 (3), 2001626 (2021) Heidepriem, J.; Dahlke, C.; Kobbe, R.; Santer, R.; Koch, T.; Fathi, A.; Silva Seco, B. M.; Ly, M. L.; Schmiedel, S.; Schwinge, D. et al.: Longitudinal development of antibody responses in COVID-19 patients of different severity with ELISA, peptide, and glycan arrays: an immunological case series. Pathogens 10 (4), 438 (2021) Ilic, I.; Tsouka, A.; Perovic, M.; Hwang, J.; Heil, T.; Löffler, F. F.; Oschatz, M.; Antonietti, M.; Liedel, C.: Sustainable cathodes for lithium-ion energy storage devices based on tannic acid—toward ecofriendly energy storage. Advanced Sustainable Systems 5 (1), 2000206 (2021) Liu, Y.; Seeberger, P. H.; Merbouh, N.; Löffler, F. F.: Position matters: fluorescent positional isomers for reversible multichannel encryption devices. Chemistry – A European Journal 27 (65), pp. 16098 - 16102 (2021) Löffler, F. F.; Viana, I. F. T.; Fischer, N.; Coêlho, D. F.; Silva, C. S.; Purificação, A. F.; Araújo, C. M. C. S.; Leite, B. H. S.; Durães-Carvalho, R.; Magalhães, T. et al.: Identification of a Zika NS2B epitope as a biomarker for severe clinical phenotypes. RSC Medicinal Chemistry 12 (9), pp. 1525 - 1539 (2021) Tsouka, A.; Hoetzel, K.; Mende, M.; Heidepriem, J.; Paris, G.; Eickelmann, S.; Seeberger, P. H.; Lepenies, B.; Löffler, F. F.: Probing multivalent carbohydrate-protein interactions with on-chip synthesized glycopeptides using different functionalized surfaces. Frontiers in Chemistry 9, 766932 (2021) Zhang, J.; Zou, Y.; Eickelmann, S.; Njel, C.; Heil, T.; Ronneberger, S.; Strauß, V.; Seeberger, P. H.; Savateev, A.; Löffler, F. F.: Laser-driven growth of structurally defined transition metal oxide nanocrystals on carbon nitride photoelectrodes in milliseconds. Nature Communications 12, 3224 (2021) Delacroix, S.; Zieleniewska, A.; Ferguson, A. J.; Blackburn, J. L.; Ronneberger, S.; Löffler, F. F.; Strauß, V.: Using carbon laser patterning to produce flexible, metal-free humidity sensors. ACS Applied Electronic Materials 2 (12), pp. 4146 - 4154 (2020) Heidepriem, J.; Krähling, V.; Dahlke, C.; Wolf, T.; Klein, F.; Addo, M. M.; Becker, S.; Löffler, F. F.: Epitopes of naturally acquired and vaccine-induced anti-Ebola virus glycoprotein antibodies in single amino acid resolution. Biotechnology Journal 15 (9), 2000069 (2020) Heiss, K.; Heidepriem, J.; Fischer, N.; Weber, L. K.; Dahlke, C.; Jaenisch, T.; Löffler, F. F.: Rapid response to pandemic threats: immunogenic epitope detection of pandemic pathogens for diagnostics and vaccine development using peptide microarrays. Journal of Proteome Research 19 (11), pp. 4339 - 4354 (2020) Mende, M.; Tsouka, A.; Heidepriem, J.; Paris, G.; Mattes, D. S.; Eickelmann, S.; Bordoni, V.; Wawrzinek, R.; Fuchsberger, F. F.; Seeberger, P. H. et al.: On-chip neo-glycopeptide synthesis for multivalent glycan presentation. Chemistry – A European Journal 26 (44), pp. 9954 - 9963 (2020) Paris, G.; Klinkusch, A.; Heidepriem, J.; Tsouka, A.; Zhang, J.; Mende, M.; Mattes, D.; Mager, D.; Riegler, H.; Eickelmann, S. et al.: Laser-induced forward transfer of soft material nanolayers with millisecond pulses shows contact-based material deposition. Applied Surface Science 508, 144973 (2020) Zhang, J.; Gim, S.; Paris, G.; Dallabernardina, P.; Schmitt, C. N. Z.; Eickelmann, S.; Löffler, F. F.: Ultrasonic-assisted synthesis of highly defined silver nanodimers by self-assembly for improved surface-enhanced Raman spectroscopy. Chemistry – A European Journal 26 (6), pp. 1243 - 1248 (2020) Aeinehvand, M. M.; Weber, L.; Jiménez, M.; Palermo, A.; Bauer, M.; Löffler, F. F.; Ibrahim, F.; Breitling, F.; Korvink, J.; Madou, M. et al.: Elastic reversible valves on centrifugal microfluidic platforms. Lab on a Chip 19 (6), pp. 1090 - 1100 (2019) Eickelmann, S.; Tsouka, A.; Heidepriem, J.; Paris, G.; Zhang, J.; Molinari, V.; Mende, M.; Löffler, F. F.: A low-cost laser-based nano-3D polymer printer for rapid surface patterning and chemical synthesis of peptide and glycan microarrays. Advanced Materials Technologies 4 (11), 1900503 (2019) Foertsch, T. C.; Davis, A. T.; Popov, R.; von Bojničić-Kninski, C.; Held, F. E.; Tsogoeva, S. B.; Löffler, F. F.; Nesterov-Mueller, A.: Spatial modes of laser-induced mass transfer in micro-gaps. Applied Sciences 9 (7), 1303 (2019) Jaenisch, T.; Heiss, K.; Fischer, N.; Geiger, C.; Bischoff, F. R.; Moldenhauer, G.; Rychlewski, L.; Sié, A.; Coulibaly, B.; Seeberger, P. H. et al.: High-density peptide arrays help to identify linear immunogenic B-cell epitopes in individuals naturally exposed to malaria infection. Molecular and Cellular Proteomics 18 (4), pp. 642 - 656 (2019) Mattes, D. S.; Streit, B.; Bhandari, D. R.; Greifenstein, J.; Foertsch, T. C.; Münch, S. W.; Ridder, B.; Bojničić‐Kninski, C. v.; Nesterov‐Mueller, A.; Spengler, B. et al.: Combinatorial Synthesis of Peptoid Arrays via Laser‐Based Stacking of Multiple Polymer Nanolayers. Macromolecular Rapid Communications 40 (6), 18000533 (2019) Mende, M.; Bordoni, V.; Tsouka, A.; Löffler, F. F.; Delbianco, M.; Seeberger, P. H.: Multivalent glycan arrays. Faraday Discussions 219, pp. 9 - 32 (2019) Paris, G.; Heidepriem, J.; Tsouka, A.; Mende, M.; Eickelmann, S.; Löffler, F. F.: Automated laser-assisted synthesis of microarrays for infectious disease research. Microfluidics, BioMEMS, and Medical Microsystems XVII 10875, 108750C (2019) Atwater, J.; Mattes, D. S.; Streit, B.; von Bojničić‐Kninski, C.; Löffler, F. F.; Breitling, F.; Fuchs, H.; Hirtz, M.: Combinatorial synthesis of macromolecular arrays by microchannel cantilever spotting (µCS). Advanced Materials 30 (31), 1801632 (2018) Fühner, V.; Heine, P.; Helmsing, S.; Goy, S.; Heidepriem, J.; Löffler, F. F.; Dübel, S.; Gerhard, R.; Hust, M.: Development of neutralizing and non-neutralizing antibodies targeting known and novel epitopes of TcdB of Clostridioides difficile. Frontiers in Microbiology 9, 2908 (2018) Mattes, D. S.; Rentschler, S.; Foertsch, T. C.; Münch, S. W.; Löffler, F. F.; Nesterov-Mueller, A.; Bräse, S.; Breitling, F.: A trifunctional linker for purified 3D assembled peptide structure arrays. Small Methods 2 (2), 1700205 (2018) Palermo, A.; Weber, L. K.; Rentschler, S.; Isse, A.; Sedlmayr, M.; Herbster, K.; List, V.; Hubbuch, J.; Löffler, F. F.; Nesterov-Müller, A. et al.: Identification of a Tetanus Toxin Specific Epitope in Single Amino Acid Resolution. Biotechnology Journal 12 (10), 1700197 (2017) Freire, M. C. L. C.; Pol-Fachin, L.; Coêlho, D. F.; Viana, I. F. T.; Magalhães, T.; Cordeiro, M. T.; Fischer, N.; Löffler, F. F.; Jaenisch, T.; Franca, R. F. et al.: Mapping putative B-cell Zika virus NS1 epitopes provides molecular basis for anti-NS1 antibody discrimination between Zika and dengue viruses. ACS Omega 2 (7), pp. 3913 - 3920 (2017) von Bojnicic-Kninski, C.; Popov, R.; Dörsam, E.; Löffler, F. F.; Breitling, F.; Nesterov-Mueller, A.: Combinatorial particle patterning. Advanced Functional Materials 27 (42), 1703511 (2017) Weber, L. K.; Isse, A.; Rentschler, S.; Kneusel, R. E.; Palermo, A.; Hubbuch, J.; Nesterov-Mueller, A.; Breitling, F.; Löffler, F. F.: Antibody Fingerprints in Lyme Disease Deciphered with High Density Peptide Arrays. Engineering in Life Sciences 17 (10), pp. 1078 - 1087 (2017) Weber, L. K.; Palermo, A.; Kügler, J.; Armant, O.; Isse, A.; Rentschler, S.; Jaenisch, T.; Hubbuch, J.; Dübel, S.; Nesterov-Mueller, A. et al.: Single amino acid fingerprinting of the human antibody repertoire with high density peptide arrays. Journal of Immunological Methods 443, pp. 45 - 54 (2017) von Bojnicic-Kninski, C.; Bykovskaya, V.; Maerkle, F.; Popov, R.; Palermo, A.; Mattes, D. S.; Weber, L. K.; Ridder, B.; Foertsch, T. C.; Welle, A. et al.: Selective Functionalization of Microstructured Surfaces by Laser-Assisted Particle Transfer. Advanced Functional Materials 26 (39), pp. 7067 - 7073 (2016)