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Inhibition of mitochondrial metabolism by (−)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells 2023 | RSC Medicinal Chemistry Gialelis, Timothy L., Wang, Zifei, Homer, Joshua A., Yang, Wen-Hsuan, Chung, Taemoon, Hu, Qingting, Smedley, Christopher J., Pawar, Nitin J., Upadhyay, Nitinkumar S., Tuveson, David A., Lyons, Scott K., Lukey, Michael J., Moses, John E.
Shapeshifting Antibiotics: Bullvalene Linked Vancomycin Dimers are Effective Against Multidrug-Resistant Gram-Positive Bacteria 21 Apr 2022 | American Chemical Society (ACS)Ottonello, Alessandra, Wyllie, Jessica, Yahiaoui, Oussama, Murray, Ewan, Williams, Paul, Bolla, Jani, Robinson, Carol, Fallon, Thomas, Soares da Costa, Tatiana, Moses, John
Accelerated SuFEx Click Chemistry For Modular Synthesis 9 Nov 2021 | Angewandte Chemie International Edition Smedley, Christopher, Homer, Joshua, Gialelis, Timothy, Barrow, Andrew, Koelln, Rebecca, Moses, John
SuFExable polymers with helical structures derived from thionyl tetrafluoride.16 Aug 2021 | Nature Chemistry Li, Suhua, Li, Gencheng, Gao, Bing, Pujari, Sidharam, Chen, Xiaoyan, Kim, Hyunseok, Zhou, Feng, Klivansky, Liana, Liu, Yi, Driss, Hafedh, Liang, Dong-Dong, Lu, Jianmei, Wu, Peng, Zuilhof, Han, Moses, John, Sharpless, K
Aminium cation-radical catalysed selective hydration of (E)-aryl enynes.22 Jun 2021 | Chemical Communications Giel, Marie-Claire, Barrow, Andrew, Smedley, Christopher, Lewis, William, Moses, John
Smedley, C. J*.; Homer, J. A*.; Gialelis, T. L.*; Barrow, A. S.; Koelln, R. A.; Moses J. E., Accelerated SuFEx click chemistry for modular synthesis, Angew. Chem. Int. Ed. 2021. DOI: 10.1002/anie.202112375R1 (*Contributed equally) (used Mass Spec at Cold Spring Harbor Lab.)
Li, S.; Li, G.; Gao, B.; Pujari, S. P.; Chen, X.; Kim, H.; Zhou, F.; Klivansky, L. M.; Liu, Y.; Driss, H.; Liang, D.-D.; Lu, J.; Wu, P.; Zuilhof, H.; Moses, J.; Sharpless, K. B., SuFExable polymers with helical structures derived from thionyl tetrafluoride, Nat. Chem., 2021, 13, 858–867.
Giel M.-C., Barrow A.S., Smedley C.J., Lewis W., Moses J.E., Aminium cation-radical catalysed selective hydration of (E)-aryl enynes, ChemComm., 2021, doi: 10.1039/d1cc02257a. Epub ahead of print. PMID: 34159967.
Smedley, C.J., Li, G., Barrow, A. S., Gialelis, T. L., Giel, M.-C., Ottonello, A., Cheng, Y., Kitamura, S., Wolan, D. W., Sharpless, K. B. and Moses, J. E., Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs, Angew. Chem. Int. Ed., 2020, DOI:10.1002/anie.202003219
Giel, M.-C., Smedley, C. J., Mackie, E. R. R., Guo, T., Dong, J., Soares da Costa, T. P. and Moses, J. E., Metal-Free Synthesis of Functional 1-Substituted-1,2,3-Triazoles from Ethenesulfonyl Fluoride and Organic Azides, Angew. Chem. Int. Ed., 2020, 59, 1181, DOI:10.1002/anie.201912728
Zheng, Q., Woehl, J. L., Kitamura, S., Santos-Martins, D., Smedley, C. J., Li, G., Forli, S., Moses, J. E., Wolan, D. W. and Sharpless, K. B., SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase, Proc. Natl. Acad. Sci. U.S.A., 2019, 116, 18808, DOI:10.1073/pnas.1909972116
Barrow, A. S., Smedley, C. J., Zheng, Q., Li, S., Dong, J. and Moses, J. E., The growing applications of SuFEx click chemistry, Chem. Soc. Rev., 2019, 48, 4731, DOI:10.1039/C8CS00960K
Liu, F., Wang, H., Li, S., Bare, G. A. L., Chen, X., Wang C., Moses J. E., Wu, P. and Sharpless, K. B., Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins Angew. Chem. Int. Ed., 2019, 58, 8029, DOI:10.1002/anie.201902489
Smedley, C. J., Zheng, Q., Gao, B., Li, S., Molino, A., Duivenvoorden, H. M., Parker, B. S., Wilson, D. J. D., Sharpless, K. B. and Moses, J. E., Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides, Angew. Chem. Int. Ed., 2019, 58, 4552, DOI:10.1002/anie.201813761
Randall, J. D., Eyckens, D. J., Stojcevski, F., Francis, P. S., Doeven, E. H., Barlow, A. J., Barrow, A. S., Arnold, C. L., Moses, J. E. and Henderson, L. C., Modification of Carbon Fibre Surfaces by Sulfur-Fluoride Exchange Click Chemistry, ChemPhysChem, 2018, 19, 3176, DOI:10.1002/cphc.201800789
Smedley, C. J., Stanley P. A., Qazzaz, M. E., Prota, A. E., Olieric, N., Collins, H., Eastman, H., Barrow, A. S., Lim, K.-H., Kam, T.-S., Smith, B. J., Duivenvoorden, H. M., Parker, B. S., Bradshaw, T. D., Steinmetz, M. O. and Moses, J. E., Sustainable Syntheses of Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site, Sci. Rep., 2018, 8, 10617, DOI:10.1038/s41598-018-28880-2
Sharma, P., Bhat, S., Prabhath, R. M. R.,Molino, A., Nauha, E., Wilson, D. J. D. and Moses, J. E., Synthesis of 1,2,4-Triazol-3-imines via Selective Stepwise Cycloaddition of Nitrile Imines with Organo-Cyanamides, Org. Lett., 2018, 20, 4263, DOI:10.1021/acs.orglett.8b01673
Gahtory, D., Sen, R., Pujari, S., Li, S., Zheng, Q., Moses, J. E., Sharpless, K. B. and Zuilhof, H., Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms, Chem. Eur. J., 2018, 24, 10550, DOI:10.1002/chem.201802356
Smedley, C. J., Giel, M.-C., Molino, A., Barrow, A. S., Wilson, D. J. D. and Moses, J. E., 1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry, Chem. Commun., 2018, 54, 6020. DOI:10.1039/c8cc03400a
Jenner, M., Kosol, S., Griffiths, D., Prasongpholchai, P., Manzi, L., Barrow, A. S., Moses, J. E., Oldham, N. J., Lewandowski, J. R. and Challis, G. L., Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases, Nat. Chem. Bio., 2018, 14, 270. DOI:10.1038/nchembio.2549
Gao, B., Li, S., Wu, P., Moses, J. E. and Sharpless K. B., SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides and Sulfonimidates, Angew. Chem. Int. Ed., 2018, 57, 1939. DOI:10.1002/ange.201712145
Powell, K. J., Richens, J. L., Bramble, J. P., Han L. -C., Sharma, P., O’Shea P. and Moses, J. E., Photochemical activity of membrane-localised polyketide derived marine natural products, Tetrahedron, 2017, 74, 1191. Invited special edition highlighting chemical biology in Australia. DOI:10.1016/j.tet.2017.10.056
Manzi, L., Barrow, A. S., Hopper, J. T. S., Kleanthous, C., Robinson, C. V., Moses, J.E. and Oldham N.J., Carbene footprinting reveals binding interfaces of a multimeric membrane spanning protein, Angew. Chem. Int. Ed., 2017, 56, 14873. DOI:10.1002/anie.201708254
Smedley, C. J., Barrow, A. S., Spiteri, C., Giel, M.-C., Sharma, P. and Moses, J. E., Frontispiece: Sulfur-Fluoride Exchange (SuFEx)-Mediated Synthesis of Sterically Hindered and Electron-Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates, Chem Eur J., 2017, 23, 9990. DOI:10.1002/chem.201701552
Li, S., Wu, P., Moses, J. E. and Sharpless, K. B. Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub, Angew. Chem. Int. Ed., 2017, 56, 2903. DOI:10.1002/anie.201611048
Han, L. -C., Stanley, P. A., Wood, P., Bradshaw, T. D. and Moses, J.E., Horner–Wadsworth–Emmons approach to piperlongumine analogues with potent anti-cancer activity, Org. Biomol. Chem., 2016, 14, 7585.
Silverman, S. M., Sharpless, K. B. and Moses, J. E., Click Chemistry Synthesis of [1,2,3]-Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE, Chem. Eur. J., 2016, 23, 79.
Manzi, L., Barrow, A. S., Scott, D., Layfield, R., Wright, T. G., Moses, J. E. and Oldham, N. J., Carbene Footprinting Accurately Maps Binding Sites in Protein-Ligand and Protein-Protein Interactions, Nat. Commun., 2016, 7, 13288.
Zhang, E., Tang, J., Li, S., Wu, P., Moses, J. E. and Sharpless, K. B., Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates, Chem. Eur. J., 2016, 22, 5692.
Barrow, A. S. and Moses, J. E., Synthesis of Sulfonyl Azides via Lewis Base Activation of Sulfonyl Fluorides and Trimethylsilyl Azide, Synlett, 2016, 27, 1840.
Bhat, S. V., Robinson, D., Sharma, P. and Moses, J. E., Synthesis of Oxadiazol-5-imines via the Cyclizative Capture of in situ Generated Cyanamide Ions and Nitrile Oxides, Org. Lett., 2016, 18, 1100.
Stanley, P. A., Spiteri, C., Moore, J. C., Barrow, A. S., Sharma, P. and Moses, J. E., Biomimetic Approaches Towards The Synthesis of Complex Dimeric Natural Products, Curr. Pharm. Des., 2016, 22, 1628.
Roe, S., Gunaratnam, M., Spiteri, C., Sharma, P., Alharthy, R. D., Neidle, S. and Moses, J. E., Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors, Org. Biomol. Chem., 2015, 13, 8500.
Cousins, A. R. O., Ritson, D., Sharma, P., Stevens, M. F. G., Searle, M. F. and Moses, J. E., Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences, Chem. Commun., 2014, 50, 15202.
Moore, J. C., Davies, E. S., Walsh, D. A., Sharma, P. and Moses, J. E., Formal Synthesis of Kingianin A based upon a Novel Electrochemically-induced Radical Cation Diels–Alder Reaction, Chem. Commun., 2014, 50, 12523.
Powell, K. J., Han, L. –C., Sharma, P. and Moses, J. E., Chemoselective Palladium-Catalyzed Cyanation of Alkenyl Halides, Org. Lett., 2014, 16, 2158.
Dempster, S., Harper, S., Moses, J. E. and Dreveny, I., Structural characterisation of the apo-form and NADH binary complex of human lactate dehydrogenase, Acta Crystallographica Section D, 2014, 70, 1484.
Borreguero, A. M., Carmona, M. S., Sharma, P., Spiteri, C., Martínez-Velencoso, M., Rodríguez, J. F. and Moses, J. E., A novel ‘click-chemistry’ approach to flame retardant polyurethanes. React. Funct, Polym., 2013, 73, 1207.
Carbone, G., Burnley, J. and Moses, J. E., A catalytic and tert-butoxide ion-mediated amidation of aldehydes with para-nitro azides, Chem. Commun., 2013, 49, 2759.
Burnley, J., Carbone, G. and Moses, J. E., Catalytic Reduction of ortho- and para-Azidonitrobenzenes via tert-Butoxide Ion Mediated Electron Transfer, Synlett, 2013, 24, 652.
Powell, K. J., Sharma, P., Richens, J. L., Davis, B. M., O’Shea, P. and Moses, J. E., Interactions of Marine-Derived gamma-Pyrone Natural Products with Phospholipid Membranes Phys. Chem. Chem. Phys., 2012, 14, 14489.
Ritson, D. J. and Moses J. E., A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design, synthesis and biophysical evaluation, Tetrahedron, 2012, 7, 197.
Awaad, A. S., Al-Jaber, N. A., Moses, J. E., El-Meligy, R. M. and Zain, M. E., Antiulcerogenic Activities of the Extracts and Isolated Flavonoids of Euphorbia cuneata Vahl, Phytother. Res., 2013, 27, 126.
Spiteri, C. and Moses, J. E., Continuous Flow Synthesis of Secondary Amides by Tandem Azidation-Amidation of Anilines, Synlett, 2012, 23, 1546.
Awaad A. S., Al-Jaber N. A., Soliman, G. A., Al-Outhman M. R., Zain M. E., Moses J. E. and El-Meligy R. M., New Biological Activities of Casimiroa edulis Leaf Extract and Isolated Compounds, Phytother. Res., 2012, 26, 452.
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