个人简介
Tao grew up in Huaian, Jiangsu province, China. When he was exposed to chemistry in high school, he knew he found his career. Tao studied general chemistry at Nanjing University, China, and then learned fluorescence from Prof. Yun-Bao Jiang at Xiamen University, China. He traveled to Georgia, US, and spent five years in studying peptide self-assembly in Prof. Vincent P. Conticello's lab at Emory University. After finishing his PhD study, Tao went to the west coast, where he started a brand-new exploration in making biomimetic polymers with Pro. Ting Xu at University of California, Berkeley. Now, at Xiamen University, Tao’s group develops strategies to control the composition, shape, and dynamics of synthetic peptide assemblies. They seek to create smart supramolecular machineries that recognize and sense biological signals and events within the nanometer to micrometer size regime.
研究领域
We are a dynamic assembly of chemists, biologists, physicists, and engineers, who are fascinated by how nature derives functions from structures within the nanometer to micrometer size regime. We seek to understand the fundamental rules underlying biomacromolecular recognition, assembly, and function, by designing synthetic biomimetic systems using peptides, nucleic acids, and synthetic polymers. We also approach disease-related biological issues by developing real-time sensing and imaging strategies in order to address challenges in diagnostics and therapeutics.
RESEARCH AREAS
Controlled multi-component peptide assembly
Multivalent cancer cell recognition
In situ imaging of biological events
近期论文
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Dan Cheng; Fan Jia; Yunbao Jiang; Vincent P. Conticello*; Tao Jiang*, Assembly of peptide nanostructures with controllable physical dimensions. Nano Research 2024, 17, 151–161.
Xin Chen; Cai Xia; Pan Guo; Chenru Wang; Xiaobing Zuo; Yun-Bao Jiang; Tao Jiang*, Preserving structurally labile peptide nanosheets after molecular functionalization of the self-assembling peptides. Angewandte Chemie International Edition 2024, 63, e202315296.
Pan Guo; Xingjing Zhang; Jingsheng Chen; Xiaoyong Chen; Yun-baoJiang; TaoJiang*, On-Demand Elongation of Peptide Nanofibrils at Cellular Interfaces to Modulate Cell−Cell Interactions. Nano Letters 2024.
Xiaoyong Chen; Di Wang; Yun-Bao Jiang; Tao Jiang*, Design of Cell-Specific Targeting Peptides for Cancer Therapy. Targets 2024, 2(3), 186-201.
Dan Cheng; Xin Chen; Weijia Zhang; Pan Guo; Wenhui Xue; Junfan Xia; Siyu Wu; Junhui Shi; Dan Ma; Xiaobing Zuo; Bin Jiang; Shaowei Li; Ningshao Xia; Yunbao Jiang; Vincent P. Conticello; Tao Jiang, Design of Multicomponent Peptide Fibrils with Ordered and Programmable Compositional Patterns. Angewandte Chemie-International Edition 2023.
Zhiyuan Ruan; Shuni Li; Alexandra Grigoropoulos; Hossein Amiri; Shayna L. Hilburg; Haotian Chen; Ivan Jayapurna; Tao Jiang; Zhaoyi Gu; Alfredo Alexander-Katz; Carlos Bustamante; Haiyan Huang; Ting Xu, Population-based heteropolymer design to mimic protein mixtures. Nature 2023, 615 (7951), 251-258.
Dan Cheng; Fan Jia; Yunbao Jiang; Vincent P. Conticello; Tao Jiang, Assembly of Peptide Nanostructures with Controllable Physical Dimensions. submitted
Qingqing Fang; Pan Guo; Yiting Zeng; Chenru Wang; Tao Jiang; Yunbao Jiang, Design of high-avidity multivalent ligand structures that target cells with high ligand economy. Chemical Communications 2022, 58 (70), 9802-9805.
Pan Guo; Di Wang; Shumin Zhang; Dan Cheng; Siyu Wu; Xiaobing Zuo; Yunbao Jiang; Tao Jiang, Reassembly of Peptide Nanofibrils on Live Cell Surfaces Promotes Cell-Cell Interactions. submitted.
Qingqing Fang; Yan Xu; Xiaosheng Yan; Tao Jiang ; Yunbao Jiang, Synthetic approaches to metal-coordination-directed macrocyclic complexes. Frontiers in Chemistry 2022, 10.
Yan Xu; Xiaosheng Yan; Sibo Zhang; Shaowei Li; Ningshao Xia; Tao Jiang; Zhao Li; Yunbao Jiang, Nanospheres from coordination polymers of Ag+ with a highly hydrophilic thiol ligand formed in situ from dynamic covalent binding and a hydrophobic thiol. New Journal of Chemistry 2021, 45 (42), 19957-19962.
Tao Jiang; Aaron Hall; Marco Eres; Zahra Hemmatian; Baofu Qiao; Yun Zhou; Zhiyuan Ruan; Andrew D. Couse; William T. Heller; Haiyan Huang; Monica Olvera de la Cruz; Marco Rolandi; Ting Xu, Single-chain heteropolymers transport protons selectively and rapidly. Nature 2020, 577 (7789), 216-220.
Brian Panganiban; Baofu Qiao; Tao Jiang; Christopher DelRe; Mona M. Obadia; Nguyen Trung Dac; Anton A. A. Smith; Aaron Hall; Izaac Sit; Marquise G. Crosby; Patrick B. Dennis; Eric Drockenmuller; Monica Olvera de la Cruz; Ting Xu, Random heteropolymers preserve protein function in foreign environments. Science 2018, 359 (6381), 1239-1243.
Tao Jiang; Vincent P. Conticello, Programmable Fabrication of Multilayer Collagen Nanosheets of Defined Composition. In Peptide Self-Assembly: Methods and Protocols, Nilsson, B. L.; Doran, T. M., Eds. Springer New York: New York, NY, 2018; pp 221-232.
Tao Jiang; Elizabeth L. Magnotti; Vincent P. Conticello, Geometrical frustration as a potential design principle for peptide-based assemblies. Interface Focus 2017, 7 (6).
Tao Jiang; Travis A. Meyer; Charles Modlin; Xiaobing Zuo; Vincent P. Conticello; Yonggang Ke, Structurally Ordered Nanowire Formation from Co-Assembly of DNA Origami and Collagen-Mimetic Peptides. Journal of the American Chemical Society 2017, 139 (40), 14025-14028.
Tao Jiang; Owen A. Vail; Zhigang Jiang; Xiaobing Zuo; Vincent P. Conticello, Rational Design of Multilayer Collagen Nanosheets with Compositional and Structural Control. Journal of the American Chemical Society 2015, 137 (24), 7793-7802.
Tao Jiang; Daiping Guo; Qian Wang; Xin Wu; Zhao Li; Zhenhua Zheng; Boyuan Yin; Lin Xia; Jixian Tang; Wenxin Luo; Ningshao Xia; Yunbao Jiang, Developing a genetically encoded green fluorescent protein mutant for sensitive light-up fluorescent sensing and cellular imaging of Hg(II). Analytica Chimica Acta 2015, 876, 77-82.
Tao Jiang; Chunfu Xu; Xiaobing Zuo; Vincent P. Conticello, Structurally Homogeneous Nanosheets from Self-Assembly of a Collagen-Mimetic Peptide. Angewandte Chemie-International Edition 2014, 53 (32), 8367-8371.(Hot Paper)
Tao Jiang; Chunfu Xu; Yang Liu; Zheng Liu; Joseph S. Wall; Xiaobing Zuo; Tianquan Lian; Khalid Salaita; Chaoying Ni; Darrin Pochan; Vincent P. Conticello, Structurally Defined Nanoscale Sheets from Self-Assembly of Collagen-Mimetic Peptides. Journal of the American Chemical Society 2014, 136 (11), 4300-4308.
Paolo Anzini; Chunfu Xu; Spencer Hughes; Elizabeth Magnotti; Tao Jiang; Lars Hemmingsen; Borries Demeler; Vincent P. Conticello, Controlling Self-Assembly of a Peptide-Based Material via Metal-Ion Induced Registry Shift. Journal of the American Chemical Society 2013, 135 (28), 10278-10281.
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