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个人简介

2008年于西北大学化学系获理学学士学位。2014年5月于中国科学院大连化物所获理学博士学位,并应聘到中国科学院大连化物所工作,2016年6月任副研究员,2022年7月任研究员。一直从事膜蛋白质样品预处理和分离分析新方法及蛋白质相互作用组方面的研究。主要包括:系统研究了离子液体与膜蛋白质相互作用机理,发展了基于离子液体的膜蛋白质样品预处理方法,显著提高了蛋白质组定性定量的覆盖深度;建立了基于活细胞中原位化学交联的蛋白质复合物结构分析方法,为实现蛋白质时空动态的相互作用和功能精准解析提供了关键技术。作为课题负责人承担2018年国家重点研发计划“蛋白质机器的动态结构的原位捕获和分析方法”,作为项目负责人承担了国家基金委面上基金2项、青年基金1项等。2018年入选大连市青年科技之星,2020年入选中国科学院青年创新促进会。担任中国蛋白质组学会以及中国计算蛋白质组学会青年委员、中科院青年促进会沈阳分会委员等。已在Angew. Chem., Hepatology, Anal. Chem., Mol. Cell. Proteomic等期刊发表论文40余篇,其中含第一或通讯作者(含共同)发表论文20篇;申请发明专利38项,授权专利17项。

研究领域

一直从事膜蛋白质样品预处理和分离分析新方法及蛋白质相互作用组方面的研究。主要包括:系统研究了离子液体与膜蛋白质相互作用机理,发展了基于离子液体的膜蛋白质样品预处理方法,显著提高了蛋白质组定性定量的覆盖深度;建立了基于活细胞中原位化学交联的蛋白质复合物结构分析方法,为实现蛋白质时空动态的相互作用和功能精准解析提供了关键技术。

近期论文

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Jing Chen#, Qun Zhao#*, Hang Gao, Lili Zhao, Huiying Chu, Yichu Shan, Zhen Liang, Yukui Zhang, Lihua Zhang*, A Glycosidic-Bond-Based Mass-Spectrometry-Cleavable Cross-linker Enables In Vivo Cross-linking for Protein Complex Analysis, Angewandte Chemie International Edition, 2023, 62: e202212860. Beirong Zhang#, Zhou Gong#*, Lili Zhao, Yuxin An, Hang Gao, Jing Chen, Zhen Liang, Maili Liu, Yukui Zhang, Qun Zhao,* and Lihua Zhang*, Decoding Protein Dynamics in Cells Using Chemical Cross-Linking and Hierarchical Analysis. Angewandte Chemie International Edition, 2023, e202301345. Yuwan Chen, Wen Zhou, Yufei Xia, Weijie Zhang, Qun Zhao, Xinwei Li, Hang Gao, Zhen Liang, Guanghui Ma, Kaiguang Yang*, Lihua Zhang*, Yukui Zhang, Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria, Nature Communications, 2023, 14: 3882. Baofu Ma, Jianyu Han, Qun Zhao, Bo Jiang, Zhixin Zhang*, Baofeng Zhao*, Zhen Liang, Yukui Zhang, Lihua Zhang*, Platinum Engineering on Nanoceria Surface toward High Catalytic Activity for Inducing Tumor Cell Apoptosis and Inhibiting Migration, Acs Sustainable Chemistry & Engineering, 2023, 11: 6163-6172. Xinwei Li, Yuwan Chen, Jing Jiang, Wen Zhou, Hang Gao, Qun Zhao, Zhen Liang, Xupeng Cao*, Kaiguang Yang*, Lihua Zhang*, and Yukui Zhang, Crosslinker Nanocarriers Delivery to Chloroplasts for In Vivo Mapping of Photosynthetic Membrane Protein Complexes in Living Chlamydomonas reinhardtii Cells, Analytical Chemistry, 2023, 95: 9555-9563. Beirong Zhang, Hang Gao, Zhou Gong, Lili Zhao, Bowen Zhong, Zhigang Sui, Zhen Liang, Yukui Zhang, Qun Zhao*, and Lihua Zhang*, Improved Cross-Linking Coverage for Protein Complexes Containing Low Levels of Lysine by Using an Enrichable Photo-Cross-Linker, Analytical Chemistry, 2023, 95: 9445-9452. Li Guan*, Yanyan Zhou, Xiao Li, Yongbao Mao, Anyang Li, Yile Fu, Wen Liu, Sheying Dong, Zhen Liang, Yukui Zhang, Qun Zhao*, and Lihua Zhang*, ON-OFF Fluorescent Cyanine Dye Based on a Benzothiophenyl Rotor Enables Selective Illumination of G-Quadruplexes in Mitochondria, Analytical Chemistry, 2023, 95: 9288-9296. Bowen Zhong, Yuxin An, Hang Gao, Lili Zhao, Xiao Li, Zhen Liang, Yukui Zhang, Qun Zhao*, Lihua Zhang*, In vivo cross-linking-based affinity purification and mass spectrometry for targeting intracellular protein-protein interactions, Analytica Chimica Acta, 2023, 1265: 341273. Zuoling Wen, Yuebin Zhang, Beirong Zhang, Yumo Hang, Li Xu, Yangsheng Chen, Qunhui Xie, Qun Zhao, Lihua Zhang, Guohui Li, Bin Zhao, Fei Sun*, Yujia Zhai*, Yun Zhu*, Cryo-EM structure of the cytosolic AhR complex, Structure, 2023, 31: 295-308. Huan Feng#, Qun Zhao#, Beirong Zhang, Hang Hu, Meng Liu, Kaifeng Wu, Xiaosong Li, Xin Zhang*, Lihua Zhang*, Yu Liu*, Enabling Photo-Crosslinking and Photo-Sensitizing Properties for Synthetic Fluorescent Protein Chromophores. Angewandte Chemie International Edition, 2022, e202215215. Shen Chen#, Liping Chen#, Lizhu Ye#, Yue Jiang, Qiong Li, Haiyan Zhang, Rui Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Qun Zhao, Jianhui Liu, Gangfeng Ouyang, Michael Aschnerf, Yuxin Zheng, Lihua Zhang, Wen Chen*, Daochuan Li*, PP2A-mTOR-p70S6K/4E-BP1 Axis Regulates M1 Polarization of Pulmonary Macrophages and Promotes Ambient Particulate Matter Induced Mouse Lung Injury, Journal of Hazardous Materials, 2022, 424: 127624. Hongwei Chu#, Qun Zhao#, Ju Liu, Kaiguang Yang, Yanlei Wang, Jianhui Liu, Kun Zhang, Baofeng Zhao*, Hongyan He*, Yong Zheng, Shijun Zhong, Zhen Liang, Lihua Zhang*, Yukui Zhang, Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes, Analytical Chemistry, 2022, 94: 758-767. Yuxin An, Qun Zhao*, Hang Gao, Lili Zhao, Xiao Li, Xiaodan Zhang, Zhen Liang, Lihua Zhang*, Yukui Zhang, Selective Removal of Unhydrolyzed Monolinked Peptides from Enriched Crosslinked Peptides To Improve the Coverage of Protein Complex Analysis, Analytical Chemistry, 2022, 94: 3904-3913. Hongwei Chu#, Qun Zhao*#, Yichu Shan#, Shen Zhang, Zhigang Sui, Xiao Li, Fei Fang, Baofeng Zhao*, Shijun Zhong, Zhen Liang, Lihua Zhang*, Yukui Zhang, All-Ion Monitoring-Directed Low-Abundance Protein QuantificationReveals CALB2 as a Key Promoter in Hepatocellular CarcinomaMetastasis, Analytical Chemistry, 2022, 94: 6102-6111. Hang Gao, Lili Zhao, Bowen Zhong, Beirong Zhang, Zhou Gong, Baofeng Zhao, Yi Liu, Qun Zhao*, Lihua Zhang*, Yukui Zhang, In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker, Analytical Chemistry, 2022, 94: 7551-7558. Yuxin An, Qun Zhao*, Zhou Gong, Lili Zhao, Yi Li, Zhen Liang, Peng Zou, Yukui Zhang, Lihua Zhang*, Suborganelle-Specific Protein Complex Analysis Enabled by in Vivo Cross-Linking Coupled with Proximal Labeling, Analytical Chemistry, 2022, 94: 12051-12059. Hang Gao, Qun Zhao*, Zhou Gong, Bowen Zhong, Jing Chen, Zhigang Sui, Xiao Li, Zhen Liang, Yukui Zhang, Lihua Zhang*, Alkynyl-Enrichable Carboxyl-Selective Crosslinkers to Increase the Crosslinking Coverage for Deciphering Protein Structures, Analytical Chemistry, 2022, 94: 12398-12406. Di Shen#, Wenhan Jin#, Qun Zhao#, Mengdie Wang, Beirong Zhang, Huan Feng, Wang Wan, Yulong Bai, Haochen Lyu, Jialu Sun, Lihua Zhang*, and Yu Liu*, Covalent Solvatochromic Proteome Stress Sensor Based on the Schiff Base Reaction, Analytical Chemistry, 2022, 94: 14143-14150. Yuwen Chen#, Yuxin An#, Zhongpeng Dai, Yi Liu, Zhen Liang, Qun Zhao*, Lihua Zhang*, Yukui Zhang, Highly Selective Enrichment of Surface Proteins from Living Cells by Photo-crosslinking Probe Enabled In-depth Analysis of Surfaceome, Analytica Chimica Acta, 2022, 1203: 339694. Lili Zhao#, Bowen Zhong#, Yuxin An, Weijie Zhang, Hang Gao, Xiaodan Zhang, Zhen Liang, Yukui Zhang, Qun Zhao*, Lihua Zhang*, Enhanced protein–protein interaction network construction promoted by in vivo cross-linking with acid-cleavable click-chemistry enrichment, Frontiers in Chemistry, 2022, 10: 994572. Liping Chen#, Ping Guo#, Wenxue Li#, Xinhang Jiang, Qun Zhao, Daochuan Li, Qing Wang, Yongmei Xiao, Xiumei Xing, Yaqin Pang, Michael Aschner, Lihua Zhang*, Wen Chen*, Protein Phosphatase 2A Regulates Cytotoxicity and Drug Resistance by Dephosphorylating AHR and MDR1, Journal of Biological Chemistry, 2022, 298: 101918. Wang Wan#, Qun Zhao#, Biao Jing#, Congcong Peng, Mengdie Wang, Yanan Huang, Wenhan Jin, Bowen Zhong, Zhenduo Zhang, Xuepeng Dong, Zhenming Gao*, Lihua Zhang*, Yu Liu*, Interrogating the impact of aggregation-induced emission nanoparticles on in vitro protein stability, ex vivo protein homeostasis, and in vivo biocompatibility, AGGREGATE, 2022, e274. Lili Zhao, Zhou Gong, Qun Zhao*, Lihua Zhang*, Yukui Zhang, Deciphering In-vivo Cross-linking Mass Spectrometry Data for Dynamic Protein Structure Analysis, Chemical Research in Chinese Universities, 2022, 38: 758-762. Liping Chen#, Ping Guo#, Wenxue Li#, Fei Fang#, Wei Zhu, Junling Fan, Fangping Wang, Yuanyuan Gao, Qun Zhao, Qing Wang, Yongmei Xiao, Xiumei Xing, Daochuan Li, Tieliu Shi, Dianke Yu, Michael Aschner, Lihua Zhang*, Wen Chen*, Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis, Hepatology, 2021, 73: 1551-1569. Wang Wan, Yanan Huang, Qiuxuan Xia, Yulong Bai, Yuwen Chen, Wenhan Jin, Mengdie Wang, Di Shen, Haochen Lyu, Yuqi Tang, Xuepeng Dong, Zhenming Gao, Qun Zhao, Lihua Zhang, Yu Liu*, Covalent Probes for Aggregated Protein Imaging via Michael Addition,Angewandte Chemie-International Edition, 2021, 60: 11335-11343. Hongwei Chu, Changqing Wu, Qun Zhao, Rui Sun, Kuo Yang, Baofeng Zhao*, Yang Liu, Zhen Liang, Shijun Zhong, Lihua Zhang*, Yukui Zhang, Quantitative Proteomics Identifies FOLR1 to Drive Sorafenib Resistance via Activating Autophagy in Hepatocellular Carcinoma Cells, Carcinogenesis, 2021, 42: 753-761. Lili Zhao, Qun Zhao*, Yichu Shan, Fei Fang, Weijie Zhang, Baofeng Zhao, Xiao Li, Zhen Liang, Lihua Zhang*, Yukui Zhang, Smart Cutter: An Efficient Strategy for Increasing the Coverage of Chemical Cross-Linking Analysis, Analytical Chemistry, 2020, 92: 1097-1105. Fei Fang, Qun Zhao, Huiying Chu, Mingwei Liu, Baofeng Zhao, Zhen Liang, Lihua Zhang*, Guohui Li*, Liming Wang, Jun Qin, Yukui Zhang, Molecular Dynamics Simulation-assisted Ionic Liquid Screening for Deep Coverage Proteome Analysis, Molecular & Cellular Proteomics, 2020, 19: 1724-1737.

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