个人简介

1961 - 1968 Studies in Chemistry at the University of Kiel and Freiburg 31.3.1966 Diploma in Chemistry 15.7.1968 Ph.D. under the guidance of Prof. Dr. B. Franck "Untersuchungen zur gezielten Oxidation von Laudanosolin-Derivaten" (Selective Oxidation of Laudanosolin-Derivatives). 15.9.1969-14.9.1971 Research Associate with Prof. Dr. G. Buechi at the Massachusetts 1974 Research Associate with Prof. Dr. A.R. Battersby at the University of Cambridge, England 9.7.1975 Habilitation at the University of Muenster. Thesis: "Secologanin, Schluesselverbindung in der Biosynthese der Indol-, Ipecacuanha- und Cinchona-Alkaloide. Untersuchungen zur Biogenese und Synthese" (Secologanin, Key Intermediate in the Biosynthesis of Indole-Ipecacuanha and Cinchona-Alkaloids. Biogenesis and Synthesis). Appointment as "Privatdozent" 1977 Professor at the University of Dortmund. 1978 - 2012 (2008) Professor (Chair) and Director of the Institute of Organic Chemistry at the Georg-August-University in Göttingen 1983 - 1987 and 1991 - 1995 Dean and Vice Dean of the Faculty of Chemistry at the Georg-August University of Göttingen since 2012 Distinguished Research Professor of the State of Lower Saxony

研究领域

Development of efficient/stereoselective and environmentally friendly synthetic procedures and their use in the synthesis of natural products and their analogues as well as other bioactive compounds and materials. Design of new drugs for a selective treatment of cancer using tumour-specific antibodies/enzymes and prodrugs.

The focus of our research lies in synthetic organic as well as biomolecular and medicinal chemistry. We develop new synthetic methods which are highly selective and efficient as well as ecologically and economically benign. Thus, we have introduced the concept of domino reactions and used it in the synthesis of natural products as alkaloids, steroids, terpenes, antibiotics, cytotoxic compounds, spinosyns and carbohydrates. In addition, also materials especially molecular switches are prepared using this approach. Domino reactions allow the formation of complex structures starting from simple substrates in a straight forward way. Moreover, we have developed a highly selective procedure for the allylation of aldehydes and ketones to give enantiopure homo-allylic ethers. In our work in the field of a selective cancer therapy we develop new glycosidic prodrugs which can be used in the prodrug monotherapy (PMT) and antibody directed enzyme prodrug therapy (ADEPT). In the latter approach a conjugate of a tumour-selective monoclonal antibody and an enzyme which liberates a highly cytotoxic compound from a non-toxic prodrug is used. In addition, also photocleavable prodrugs and antibody drug conjugates (ADCs) are developed.

近期论文

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L.F. Tietze, M. Müller, S.-C. Duefert, K. Schmuck, I. Schuberth Photoactivatable Prodrugs of Highly Potent Duocarmycin Analogues for a Selective Cancer Therapy. Chem. Eur. J. 2013, 19, 1726-1731. Online L.F. Tietze, S.-C. Duefert, J. Clerc, M. Bischoff, C. Maaß, D. Stalke Total Synthesis of Linoxepin through a Palladium-Catalyzed Domino Reaction. Angew. Chem. 2013, 125, 3273-3276; Angew. Chem., Int. Ed. 2013, 52, 3191-3194. Online L.F. Tietze, T. Hungerland, C. Eichhorst, A. Düfert, C. Maaß, D. Stalke Efficient Synthesis of Helical Tetrasubstituted Alkenes as Potential Molecular Switches: A Two-Component Palladium-Catalyzed Triple Domino Process. Angew. Chem. 2013, 125, 3756-3759; Angew. Chem., Int. Ed. 2013, 52, 3668-3671. Online L.F. Tietze, S. Jackenkroll, C. Raith, D.A. Spiegl, J.R. Reiner, M.C. Ochoa Campos Enantioselective Total Synthesis of (-)-Diversonol. Chem. Eur. J. 2013, 19, 4876-4882. Online L.F. Tietze, S.A. Sieber Duocarmycin Analogues without a DNA-Binding Indole Unit Associate with Aldehyde Dehydrogenase 1A1 and not DNA: A Reply. Angew. Chem. 2013, 125, 5557-5559; Angew. Chem., Int. Ed. 2013, 52, 5447-5449. Online L.F. Tietze, L. Ma, J.R. Reiner, S. Jackenkroll, S. Heidemann Enantioselective Total Synthesis of (-)-Blennolide A. Chem. Eur. J. 2013, 19, 8610-8614. Online T. Wirth, G.F. Pestel, V. Ganal, T. Kirmeier, I. Schuberth, T. Rein, L.F. Tietze, S.A. Sieber The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity. Angew. Chem. 2013, 125, 7059-7063; Angew. Chem., Int. Ed. 2013, 52, 6921-6925. Online L.F. Tietze, S. Dietz, N. Schützenmeister, S. Biller, J. Hierold, T. Scheffer, M.M. Baag Selective Glycosylation with the Amino Sugar D-Forosamine for the Synthesis of Spinosyns and Its Analogues. Eur. J. Org. Chem. 2013, 7305-7312. Online L.F. Tietze, T. Hungerland, J. Ammermann, C. Eichhorst, S.O. Reichmann, D. Stalke A facile synthesis of 3-substituted benzofurans and indoles through a palladium-catalyzed domino carbopalladation/CH-activation/isomerization process. Ind. Chem. Soc. 2013, 90, 1537-1555. K.-C. Chen, K. Schmuck, L.F. Tietze, S.R. Roffler Selective Cancer Therapy by Extracellular Activation of a Highly Potent Glycosidic Duocarmycin Analogue. Mol. Pharmaceutics 2013, 10, 1773-1782. Online L.F. Tietze, L. Ma, S. Jackenkroll, J.R. Reiner, J. Hierold, B. Gnanaprakasam, S. Heidemann The Paecilin Puzzle - Enantioselective Synthesis of the Proposed Structures of Paecilin A and B. Heterocycles 2014, 88, 1101-1119. Online L.F. Tietze, S.-C. Düfert, J. Hierold Domino Reactions in the Total Synthesis of Natural Products in "Domino Reactions: Concepts for Efficient Organic Synthesis" (Ed.: L.F. Tietze) Wiley-VCH, Weinheim, 2014, p. 523-578. L.F. Tietze, S. Jackenkroll, J. Hierold, L. Ma, B. Waldecker A Domino Approach to the Enantioselective Total Syntheses of Blennolide C and Gonytolide C. Chem. Eur. J. 2014, 20, 8628-8635. Online L.F. Tietze, C. Eichhorst, T. Hungerland, M. Steinert A Fast Way to Fluorescence: A Fourfold Domino Reaction to Condensed Polycyclic Compounds. Chem. Eur. J. 2014, 20, 12553-12558. Online L.F. Tietze, J. Clerc, S. Biller, S.-C. Duefert, M. Bischoff Enantioselective Total Synthesis of the Lignan (+)-Linoxepin. Chem. Eur. J. 2014, 20, 17119–17124. Online L.F. Tietze, C. Eichhorst An efficient Domino Sonogashira/double Carbopalladation/C-H-Activation Reaction leading to Fluorescent Polycyclic Aromatic Hydrocarbons. Heterocycles 2015, 90, 919-927. Online L.F. Tietze, T. Eicher, U. Diederichsen, A. Speicher, N. Schützenmeister Reactions and Syntheses in the Organic Chemistry Laboratory, 2nd Edition (completely revised and updated), Wiley-VCH, Weinheim, 2015.