邹钧 - 上海海洋大学 - 水产与生命学院

个人简介

邹钧，男，出生年月，1966年12月；籍贯，湖南；博士，特聘教授，博士生导师。水产动物生理与医学系。上海市高校水产动物免疫与疫病生态防控重点创新团队负责人。2004年获国家自然科学基金委海外青年合作基金资助、入选2012年福建省“闽江学者”、 2015年上海市“高层次人才”、2018年湖南省“百人计划”。2003-2017年任苏格兰鱼类研究中心科研主任，2018年受聘于上海海洋大学水产与生命学院。长期从事鱼类免疫学、病害防控和抗病育种研究。聚焦研究鱼类细胞因子的结构、功能与作用机制，首次发现了鱼类白细胞介素1、伽马干扰素和防御素；开创性地提出了脊椎动物干扰素系统的演化假说。在Science China: Life Sciences、 Journal of Immunology、Journal of Virology、PLOS Pathogens等期刊发表SCI论文160余篇，参编3部英文编著和1部大学本科教材，论文引用达12000余次。教育背景 1983-1987，北京大学、生物化学，理学学士； 1987-1990，中国科学院大学、鱼类遗传与育种，理学硕士； 1992-1998，University of Aberdeen、动物学，哲学博士教学工作情况主讲研究生课程：Molecular Immunology（全英语）、比较免疫学、鱼类免疫学、水产动物医学前沿课程。主持和参与的科教项目 [1] 国家自然科学基金区域创新发展联合重点项目，青鱼I型干扰素在抗病毒天然免疫中的机理研究，U21A20268, 2022-01至2025-12，262万元，参与。 [2] 国家自然科学基金重点基金，草鱼CD4 T辅助（Th）细胞免疫系统及其应答病毒感染的分子机理研究，32030112，2021-01至2025-12，285万元，主持。 [3] 科技部重点研发计划“蓝色粮仓科技创新”重点专项“重要水产养殖生物抗病和抗逆性状的遗传基础与调控机制”-课题二“淡水鱼类抗病与抗逆性状形成的分子机理”-子课题，虹鳟传染性胰坏死病毒感染的分子基础，2018YFD0900302-4，2018-12至2022-12，74万元，主持。 [4] 上海市科委国际科技合作基金项目，19390743100，鱼类抗菌肽的挖掘与潜在产业应用，2019-11至2021-10，30万元，主持。 [5] 国家自然科学基金委员会，中国与葡萄牙科技基金会合作研究项目，41761134050，鱼类免疫在极端环境下的进化，2017-01至2019-12，251万元，参与。 [6] 国家自然科学基金国际重大合作项目，31320103913，鱼类伽马干扰素的分泌调控、信号传导及其免疫功能研究，2014-01至2018-12，270万元，参与。 [7] 国家自然科学基金海外青年合作基金，30428024，RNAi转基因鱼，2005-01至2007-12,40万元，主持。申请和授权专利情况 [1] 邹钧，季宁，王俊亚，黄文吉，分泌抗传染性胰腺坏死病毒VP2单克隆抗体的杂交瘤细胞株、单克隆抗体和应用。发明专利号申请号：202211039158.0。 [2] 邹钧，张艳维，高谦，王俊亚，覃钰婷，王邦杰，草鱼CD3e杂交瘤细胞株及单克隆抗体和应用。发明专利号申请号：202211038897.8。专著和教材 [1]参编《水产动物免疫学》，农业出版社，2021。 [2] 参编《The evolution of the Immune System: Conservation and Diversification》，Academic Press，2016。 [3]参编《Immunobiology of the Shark》，CRC Press Taylors & Francis Group，2015。 [4]参编《Fish Defenses, Vol 1: Immunology》，Science Publishers，2009。

研究领域

鱼类免疫因子结构和功能，宿主与病原互作机制，鱼类抗病遗传机制与抗病育种，疫苗与免疫制剂作用机理，免疫系统起源与演化。

近期论文

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[1] W. Huang, X. Zhao, N. Ji, J. Guo, J. Feng, K. Chen, Y. Wu, J. Wang, H. Feng, J. Zou. IRF2 cooperates with phosphoprotein of spring viremia of carp virus to suppress antiviral response in zebrafish, J Virol. 96 (2022) e0131422. [2] X. Zhu, J. Wang, Z. Jia, J. Feng, B. Wang, Z. Wang, Q. Liu, K. Wu, W. Huang, X. Zhao, H. Dang, J. Zou, Novel dimeric architecture of an IFN-γ-related cytokine provides insights into subfunctionalization of type II IFNs in teleost fish, J Immunol 209 (11) (2022) 2203-2214. [3] Z. Wang, J. Xu, J. Feng, K. Wu, K. Chen, Z. Jia, X. Zhu, W. Huang, X. Zhao, Q. Liu, B. Wang, X. Chen, J. Wang, J. Zou, Structural and functional analyses of type I IFNa shed light into its interaction with multiple receptors in fish, Front Immunol 13 (2022) 862764. [4] X. Zhao, W. Huang, Y. Shi, J. Guo, H. Xiao, N. Ji, J. Feng, H. Dang, J. Zou, PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish, Frontiers in Immunology 13 (2022) 979919. [5] X. Zhao, W. Huang, J. Guo, N. Ji, J. Feng, Y. Shi, K. Chen, J. Zou, PLAAT1 promotes p53 degradation via autophagy-lysosome pathway in zebrafish, Fish Shellfish Immunol 125 (2022) 48-53. [6] J. Wang, Z. Jia, H. Dang, J. Zou, Meteorin-like/Meteorin-β upregulates proinflammatory cytokines via NF-κB pathway in grass carp Ctenopharyngodon idella, Dev Comp Immunol 127 (2022) 104289. [7] B. Wang, Y. Qin, Z. Sun, X. Zhu, Z. Jia, K. Chen, D. Liu, J. Wang, J. Zou, Production and characterization of monoclonal antibodies against grass carp CD4-1 and CD4-2, Aquaculture and Fisheries (2022). [8] Y. Wu, Y. Yang, H. Dang, H. Xiao, W. Huang, Z. Jia, X. Zhao, K. Chen, N. Ji, J. Guo, Z. Qin, J. Wang, J. Zou, Molecular identification of Klebsiella pneumoniae and expression of immune genes in infected spotted gar Lepisosteus oculatus, Fish Shellfish Immunol 119 (2021) 220-230. [9] Z. Sun, Y. Qin, D. Liu, B. Wang, Z. Jia, J. Wang, Q. Gao, J. Zou, Y. Pang, The evolution and functional characterization of CXC chemokines and receptors in lamprey, Dev Comp Immunol 116 (2021) 103905. [10] K. Chen, J. Tian, J. Wang, Z. Jia, Q. Zhang, W. Huang, X. Zhao, Z. Gao, Q. Gao, J. Zou, Lipopolysaccharide-induced TNFα factor (LITAF) promotes inflammatory responses and activates apoptosis in zebrafish Danio rerio, Gene 780 (2021) 145487. [11] Y. Qin, Z. Sun, W. Wang, J. Xu, B. Wang, Z. Jia, X. Li, J. Wang, Q. Gao, X. Chen, J. Zou, Characterization of CD3γ/δ+ cells in grass carp (Ctenopharyngodon idella), Dev Comp Immunol 114 (2021) 103791. [12] W. Wei, J. Wang, Q. Min, Z. Jia, K. Chen, H. Feng, J. Zou, CCL19 variants mediate chemotactic response via CCR7 in grass carp Ctenopharyngodon idella, Dev Comp Immunol 122 (2021) 104127. [13] Z. Jia, J. Wang, K. Chen, Q. Zhang, Z. Sun, Z. Hassan, H. Feng, J. Zou, Identification and expression analysis of group II C-type lectin domain containing receptors in grass carp Ctenopharyngodon idella, Gene 789 (2021) 145668. [14] Z. Hassan, J. Wang, Y. Qin, W. Wang, Q. Liu, L. Lei, Z. Sun, Y. Yang, K. Wu, X. Zhu, Z. Wang, H. Feng, J. Zou, Functional characterization of an interleukin 20 like homologue in grass carp Ctenopharyngodon idella, Fish Shellfish Immunol 115 (2021) 43-57. [15] W. Wang, J. Wang, L. Lei, J. Xu, Y. Qin, Q. Gao, J. Zou, Characterisation of IL-15 and IL-2Rβ in grass carp: IL-15 upregulates cytokines and transcription factors of type 1 immune response and NK cell activation, Fish Shellfish Immunol 107 (Pt A) (2020) 104-117. [16] J. Wang, W. Wang, J. Xu, Z. Jia, Q. Liu, X. Zhu, C. Xia, J. Zou, Structural insights into the co-evolution of IL-2 and its private receptor in fish, Dev Comp Immunol115 (2020) 103895. [17] Y. Yang, J. Wang, J. Xu, Q. Liu, Z. Wang, X. Zhu, X. Ai, Q. Gao, X. Chen, J. Zou, Characterization of IL-22 bioactivity and IL-22-positive cells in grass carp Ctenopharyngodon idella, Front Immunol 11 (2020) 586889. [18] Z. Gan, S. Chen, B. Huang, J. Zou, P. Nie, Fish type I and type II interferons: composition, receptor usage, production and function, Reviews in Aquaculture 12 (2020) 773–804. [19] X. Jiang, J. Wang, S. Wan, Y. Xue, Z. Sun, X. Cheng, Q. Gao, J. Zou, Distinct expression profiles and overlapping functions of IL-4/13A and IL-4/13B in grass carp (Ctenopharyngodon idella), Aquaculture and Fisheries 5 (2020) 72-79. [20] X. Cheng, X. Jiang, Y. Song, J. Gao, Y. Xue, Z. Hassan, Q. Gao, J. Zou, Identification and modulation of expression of a TNF receptor superfamily member 25 homologue in grass carp (Ctenopharyngodon idella), Aquaculture and Fisheries 5 (2020) 28-35. [21] C. Zhang, Q. Zhang, J. Wang, J. Tian, Y. Song, H. Xie, M. Chang, P. Nie, Q. Gao, J. Zou, Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish, Fish Shellfish Immunol 94 (2019) 685-696. [22] Y. Xue, X. Jiang, J. Gao, X. Li, J. Xu, J. Wang, Q. Gao, J. Zou, Functional characterisation of interleukin 34 in grass carp Ctenopharyngodon idella, Fish Shellfish Immunol 92 (2019) 91-100. [23] A.K. Redmond, J. Zou, C.J. Secombes, D.J. Macqueen, H. Dooley, Discovery of all three types in cartilaginous fishes enables phylogenetic resolution of the origins and evolution of interferons, Front Immunol 10 (2019) 1558. [24] F. Liu, N.C. Bols, P.H. Pham, C.J. Secombes, J. Zou, Evolution of IFN subgroups in bony fish - 1:Group I-III IFN exist in early ray-finned fish, with group II IFN subgroups present in the Holostean spotted gar, Lepisosteus oculatus, Fish Shellfish Immunol 95 (2019) 163-170. 25] J. Wang, T. Wang, O. Benedicenti, C. Collins, K. Wang, C.J. Secombes, J. Zou, Characterisation of ZBTB46 and DC-SCRIPT/ZNF366 in rainbow trout, transcription factors potentially involved in dendritic cell maturation and activation in fish, Dev Comp Immunol 80 (2018) 2-14. [26] C.J. Secombes, J. Zou, Evolution of interferons and interferon receptors, Front Immunol 8 (2017) 209. [27] J. Zou, C.J. Secombes, The Function of Fish Cytokines, Biology (Basel) 5(2) (2016). [28 J. Zou, B. Gorgoglione, N.G. Taylor, T. Summathed, P.T. Lee, A. Panigrahi, C. Genet, Y.M. Chen, T.Y. Chen, M. Ul Hassan, S.M. Mughal, P. Boudinot, C.J. Secombes, Salmonids have an extraordinary complex type I IFN system: characterization of the IFN locus in rainbow trout oncorhynchus mykiss reveals two novel IFN subgroups, J Immunol 193(5) (2014) 2273-86. [29] J. Chen, Q. Xu, T. Wang, B. Collet, Y. Corripio-Miyar, S. Bird, P. Xie, P. Nie, C.J. Secombes, J. Zou, Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish, Dev Comp Immunol 41(2) (2013) 137-52. [30] M.X. Chang, J. Zou, P. Nie, B. Huang, Z. Yu, B. Collet, C.J. Secombes, Intracellular interferons in fish: a unique means to combat viral infection, PLoS Pathog 9(11) (2013) e1003736. [31] J. Zou, C.J. Secombes, Teleost fish interferons and their role in immunity, Dev Comp Immunol 35(12) (2011) 1376-87. [32] M. Chang, B. Collet, P. Nie, K. Lester, S. Campbell, C.J. Secombes, J. Zou, Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss), J Virol 85(16) (2011) 8403-12. [33] Z. Qi, P. Nie, C.J. Secombes, J. Zou, Intron-containing type I and type III IFN coexist in amphibians: refuting the concept that a retroposition event gave rise to type I IFNs, J Immunol 184(9) (2010) 5038-46. [34] J. Zou, M. Chang, P. Nie, C.J. Secombes, Origin and evolution of the RIG-I like RNA helicase gene family, BMC Evol Biol 9 (2009) 85. [35] M. Chang, P. Nie, B. Collet, C.J. Secombes, J. Zou, Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts, Immunogenetics 61(4) (2009) 315-25. [36] J. Zou, C. Tafalla, J. Truckle, C.J. Secombes, Identification of a second group of type I IFNs in fish sheds light on IFN evolution in vertebrates, J Immunol 179(6) (2007) 3859-71. [37] J. Zou, C. Mercier, A. Koussounadis, C. Secombes, Discovery of multiple beta-defensin like homologues in teleost fish, Mol Immunol 44(4) (2007) 638-47. [38] J. Zou, A. Carrington, B. Collet, J.M. Dijkstra, Y. Yoshiura, N. Bols, C. Secombes, Identification and bioactivities of IFN-gamma in rainbow trout Oncorhynchus mykiss: the first Th1-type [39] J. Zou, Y. Yoshiura, J.M. Dijkstra, M. Sakai, M. Ototake, C. Secombes, Identification of an interferon gamma homologue in Fugu, Takifugu rubripes, Fish Shellfish Immunol 17(4) (2004) 403-9. [40] J. Zou, T. Wang, I. Hirono, T. Aoki, H. Inagawa, T. Honda, G.I. Soma, M. Ototake, T. Nakanishi, A.E. Ellis, C.J. Secombes, Differential expression of two tumor necrosis factor genes in rainbow trout, Oncorhynchus mykiss, Dev Comp Immunol 26(2) (2002) 161-72. [41] J. Zou, P.S. Grabowski, C. Cunningham, C.J. Secombes, Molecular cloning of interleukin 1beta from rainbow trout Oncorhynchus mykiss reveals no evidence of an ice cut site, Cytokine 11(8) (1999) 552-60. [42] J. Zou, C. Cunningham, C.J. Secombes, The rainbow trout Oncorhynchus mykiss interleukin-1 beta gene has a differ organization to mammals and undergoes incomplete splicing, Eur J Biochem 259(3) (1999) 901-8.

学术兼职

现为水产学会鱼病专业委员会副主任委员和水产学会水产动物免疫专业委员会委员、国际发育与比较免疫学会亚洲分会理事、美国免疫学家协会和美国微生物协会会员；担任Fish and Shellfish Immunology和Aquaculture and Fisheries副主编，Developmental and Comparative Immunology、Fish and Shellfish Immunology Reports、水产学报和水生生物学报编委。