刘臻 - 北京生命科学研究所 -

个人简介

刘臻博士教育经历 Education 2015.8-2019.8 化学博士, 美国斯克里普斯研究所 (TSRI) 导师：Prof. Keary M. Engle 2015.8-2019.8 Ph.D. in Chemistry, The Scripps Research Institute, US. Supervisor: Prof. Keary M. Engle 2011.9–2015.6 化学学士, 北京大学化学与分子工程学院导师：王剑波教授，张艳教授 2011.9–2015.6 Bachelor in Chemistry, College of Chemistry and Molecular Engineering, Peking University, China Supervisors: Prof. Jianbo Wang and Prof. Yan Zhang 工作经历 Professional Experience 2022.9至今研究员，北京生命科学研究所 2022.9–present Assistant Investigator, NIBS, Beijing 2020.9–2022.8，副研究员（博士后），美国加州理工学院导师：Prof. Frances H. Arnold 2020.9–2022.8 Postdoctoral Research Associate, California Institute of Technology, Frances H. Arnold laboratory, US 2019.9–2020.8，助理研究员（博士后），美国加州理工学院导师：Prof. Frances H. Arnold 2019.9–2020.8 Postdoctoral Research Fellow, California Institute of Technology, Frances H. Arnold laboratory, US 研究概述 Research Description 酶是自然界各类生命体中的催化剂，是多种生理过程赖以维系的重要组分。人类在很早的时代就开始利用生物催化来进行社会生产，一个典型的例子就是我国古代的酿造工艺。近几十年来，随着定向进化以及多种分子生物学技术的飞速发展，科学家对于酶催化剂的改造能力得到了空前的提高，使得我们不仅可以快速地优化酶的天然活性，拓宽底物范围，甚至可以赋予他们未知的催化性能。这一进步极大地拓宽了生物催化在有机合成以及药物研发领域的应用范围和发展前景。我们在北京生命科学研究所（NIBS）的实验室将围绕着发展高效新颖的生物催化反应为中心展开，研究目标在于解决化学合成和药物开发过程中的难题，降低生产成本，推动这些新方法的工业化应用。课题组的研究方向主要有以下三个方面：一．通过定向进化或理性设计等手段发展非天然的高效酶促反应；二．发展多步酶催化或酶催化-化学反应相结合的串联过程以实现活性有机小分子的高效合成；三．发展绿色经济的过渡金属催化的有机反应方法学。我们实验室欢迎所有对有机化学，酶催化以及化学生物学感兴趣的科研工作者加入到我们的团队，来共同解决合成化学以及酶学领域中的现有难题。实验室的训练将使你对多个学科有所了解，为你未来的学术发展或者科研工作打下坚实的基础。

近期论文

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1. Liu, Z.†; Qin, Z.-Y.†; Zhu L.; Athavale, S. V.; Sengupta, A.; Jia, Z.-J.; Garcia-Borràs, M.; Houk, K. N.; Arnold, F. H. “An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes,” J. Am. Chem. Soc. 2022, 144, 80–85. (†Authors contributed equally) 2. Liu, Z.; Calvó-Tusell, C.; Zhou, A. Z.; Chen, K.; Garcia-Borràs, M.; Arnold, F. H. “Dual-Function Enzyme Catalysis for Enantioselective Carbon–Nitrogen Bond Formation,” Nat. Chem. 2021, 13, 1166–1172. 3. Athavale, S. V.†; Gao, S.†; Liu, Z.; Mallojjala, S. C.; Hirschi, J. S.; Arnold, F. H. “Biocatalytic, Intermolecular C–H Bond Functionalization for the Synthesis of Enantioenriched Amides,” Angew. Chem. Int. Ed. 2021, 60, 24864–24869. (†Authors contributed equally) 4. Liu, Z.; Arnold, F. H. “New-to-nature Chemistry from Old Protein Machinery: Carbene and Nitrene Transferases,” Curr. Opin. Biotechnol. 2021, 69, 43–51. 5. Wang, X.; Li, Z.-Q.; Mai, B. K.; Gurak, J. A., Jr.; Xu, J. E.; Tran, V. T.; Ni, H.-Q.; Liu, Z.; Liu, Z.; Yang, K. S.; Xiang, R.; Liu, P.; Engle, K. M. “Controlling Cyclization Pathways in Palladium(II)-catalyzed Intramolecular Alkene Hydro-functionalization via Substrate Directivity,” Chem. Sci. 2020, 11, 11307–11314. 6. Liu, Z.; Chen, J.; Lu, H.-X.; Li, X.; Gao, Y.; Coombs, J. R.; Goldfogel, M.; Engle, K. M. “Pd(0)-Catalyzed Directed syn-1,2-Carboboration and -Silyation: Alkene Scope, Applications in Dearmoatization, and Stereocontrol via a Chiral Auxiliary,” Angew. Chem. Int. Ed. 2019, 58, 17068–17073. 7. Liu, Z.; Gao, Y.; Zeng, T.; Engle, K. M. “Transition-Metal-Catalyzed 1,2-Carboboration of Alkenes: Strategies, Mechanisms, and Stereocontrol,” Isr. J. Chem. 2020, 60, 219–229. 8. Liu, Z.; Li, X.; Zeng, T.; Engle, K. M. “Directed, Palladium(II)-Catalyzed Enantioselective anti-Carboboration of Alkenyl Carbonyl Compounds,” ACS Catal. 2019, 9, 3260–3265. 9. Zeng, T.; Liu, Z.; Schmidt, M. A.; Eastgate, M. D.; Engle, K. M. “Directed, Palladium(II)-Catalyzed Intermolecular Aminohydroxylation of Alkenes Using a Mild Oxidation System,” Org. Lett. 2018, 20, 3853–3857. 10. Gao, D.-W.; Xiao, Y.; Liu, M.; Liu, Z.; Karunananda, M. K.; Chen, J. S.; Engle, K. M. “Catalytic, Enantioselective Synthesis of Allenyl Boronates,” ACS Catal. 2018, 8, 3650–3654. 11. Liu, Z.; Ni, H.-Q.; Zeng, T.; Engle, K. M. “Catalytic Carbo- and Aminoboration of Alkenyl Carbonyl Compounds via Five- and Six-Membered Palladacycles,” J. Am. Chem. Soc. 2018, 140, 3223–3227. 12. Liu, Z.; Wang, Y.; Wang, Z.; Zeng, T.; Liu, P.; Engle, K. M. “Catalytic Intermolecular Carboamination of Unactivated Alkenes via Directed Aminopalladation,” J. Am. Chem. Soc. 2017, 139, 11261–11270. 13. Derosa, J.; Cantu, A. L.; Boulous, M. N.; O’Duill, M. L.; Turnbull, J. L.; Liu, Z.; De La Torre, D. M.; Engle, K. M. “Directed Palladium(II)-Catalyzed anti-Hydrochlorination of Unactivated Alkynes with HCl,” J. Am. Chem. Soc. 2017, 139, 5183–5193. 14. Liu, Z.; Zeng, T.; Yang, K. S.; Engle, K. M. “β,γ-Vicinal Dicarbofunctionalization of Alkenyl Carbonyl Compounds via Directed Nucleopalladation,” J. Am. Chem. Soc. 2016, 138, 15122–15125. 15. Yang, K. S.; Gurak, J. A., Jr.; Liu, Z.; Engle, K. M. “Catalytic, Regioselective Hydrocarbofunctionalization of Unactivated Alkenes with Diverse C–H Nucleophiles,” J. Am. Chem. Soc. 2016, 138, 14705–14712. 16. Liu, Z.; Derosa, J.; Engle, K. M. “Palladium(II)-Catalyzed Regioselective syn-Hydroarylation of Disubstituted Alkynes Using a Removable Directing Group,” J. Am. Chem. Soc. 2016, 138, 13076–13081. 17. Gurak, J. A., Jr.; Yang, K. S.; Liu, Z.; Engle, K. M. “Directed, Regiocontrolled Hydroamination of Unactivated Alkenes via Protodepalladation,” J. Am. Chem. Soc. 2016, 138, 5805–5808. 18. Liu, Z.; Xia, Y.; Feng, S.; Zhang, Y.; Wang, J. “Rh(I)-Catalyzed Coupling of 2-Bromoethyl Aryldiazoacetates with Tertiary Propargyl Alcohols through Carbene Migratory Insertion,” Org. Chem. Front. 2016, 3, 1691–1698. 19. Feng, S.; Mo, F.; Xia, Y.; Liu, Z.; Liu, Z.; Zhang, Y.; Wang, J. “Rhodium(I)-Catalyzed C–C Bond Activation of Siloxyvinylcyclopropanes with Diazoesters,” Angew. Chem. Int. Ed. 2016, 55, 15401–15405. 20. Xia, Y.; Ge, R.; Chen, L.; Liu, Z.; Xiao, Q.; Zhang, Y.; Wang, J. “Palladium-Catalyzed Oxidative Cross-Coupling of Conjugated Enynones with Organoboronic Acids,” J. Org. Chem. 2015, 80, 7856–7864. 21. Xia, Y.; Liu, Z.; Ge, R.; Xiao, Q.; Zhang, Y.; Wang, J. “Pd-Catalyzed Cross-Coupling of Terminal Alkynes with Ene-Yne-Ketones: Access to Conjugated Enynes via Metal Carbene Migratory Insertion,” Chem. Commun. 2015, 51, 11233–11235. 22. Liu, Z.; Xia, Y.; Feng, S.; Wang, S.; Qiu, D.; Zhang, Y.; Wang, J. “Rh(I)-Catalyzed Stille-Type Coupling of Diazoesters with Aryl Trimethylstannanes,” Aust. J. Chem. 2015, 68, 1379–1384. 23. Xia, Y.; Feng, S.; Liu, Z.; Zhang, Y.; Wang, J. “Rh(I)-Catalyzed Sequential C(sp)–C(sp3) and C(sp3)–C(sp3) Bond Formation through Carbene Migratory Insertion,” Angew. Chem. Int. Ed. 2015, 54, 7891–7894. 24. Xia, Y.; Liu, Z.; Feng, S.; Ye, F.; Zhang, Y.; Wang, J. “Rh(I)-Catalyzed Cross-Coupling of α-Diazoesters with Arylsiloxanes,” Org. Lett. 2015, 17, 956–959. 25. Xia, Y.; Liu, Z.; Feng, S.; Zhang, Y.; Wang, J. “Ir(III)-Catalyzed Aromatic C–H Bond Functionalization via Metal Carbene Migratory Insertion,” J. Org. Chem. 2015, 80, 223–236. 26. Xia, Y.; Xia, Y.; Liu, Z.; Zhang, Y.; Wang, J. “Palladium-Catalyzed Cross-Coupling Reaction of Diazo Compounds and Vinyl Boronic Acids: An Approach to 1,3-Diene Compounds,” J. Org. Chem. 2014, 79, 7711–7717. 27. Xia, Y.; Xia, Y.; Ge, R.; Liu, Z.; Xiao, Q.; Zhang, Y.; Wang, J. “Oxidative Cross-Coupling of Allenyl Ketones and Organoboronic Acids: Expeditious Synthesis of Highly Substituted Furans,” Angew. Chem. Int. Ed. 2014, 53, 3917–3921. 28. Xia, Y.; Liu, Z.; Liu, Z.; Ge, R.; Ye, F.; Hossain, M.; Zhang, Y.; Wang, J. “Formal Carbene Insertion into C–C Bond: Rh(I)-Catalyzed Reaction of Benzocyclobutenols with Diazoesters,” J. Am. Chem. Soc. 2014, 136, 3013–3015. 29. Xia, Y.; Qu, S.; Xiao, Q.; Wang, Z.-X.; Qu, P.; Chen, Li.; Liu, Z.; Tian, L.; Huang, Z.; Zhang, Y.; Wang, J. “Palladium-Catalyzed Carbene Migratory Insertion Using Conjugated Ene-Yne-Ketones as Carbene Precursors” J. Am. Chem. Soc. 2013, 135, 13502–13511.