蔡涛 - 北京生命科学研究所 -

个人简介

蔡涛博士核酸测序中心主任核酸测序中心测序技术在近些年有着飞速的发展，新测序技术可以提供海量信息，在基因组学，转录组学以及表观遗传学中被广泛使用，新测序技术为模式生物以及肿瘤的研究提供便利。测序中心拥有AB 3730xl DNA analyzer 和Illumina Genome Analyzer IIx，提供的服务包括传统Sanger法测序，高通量测序以及高通量测序数据的后续分析。测序中心将与各个实验室合作使用测序技术来解决具体的生物学问题，并拓展测序技术的应用领域。

近期论文

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1. T. Cai, J.F. Dufour, B. Muellhaupt, T. Gerlach, M. Heim, D. Moradpour, A. Cerny, R. Malinverni, V. Kaddai, M. Bochud, et al., Viral Genotype-Specific Role of PNPLA3, PPARG, MTTP and IL28B in Hepatitis C Virus-Associated Steatosis. J Hepatol, 2011. 2. Rauch, A., Z. Kutalik, P. Descombes, T. Cai, J. Di Iulio, T. Mueller, M. Bochud, M. Battegay, E. Bernasconi, J. Borovicka, et al., Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology, 2010. 138(4): p. 1338-45, 1345 e1-7. 3. Wei, B.*, T. Cai*, R. Zhang*, A. Li, N. Huo, S. Li, Y.Q. Gu, J. Vogel, J. Jia, Y. Qi, et al., Novel microRNAs uncovered by deep sequencing of small RNA transcriptomes in bread wheat (Triticum aestivum L.) and Brachypodium distachyon (L.) Beauv. Funct Integr Genomics, 2009. * co-first authors 4. Bochud, P.Y., T. Cai, K. Overbeck, M. Bochud, J.F. Dufour, B. Mullhaupt, J. Borovicka, M. Heim, D. Moradpour, A. Cerny, et al., Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C. J Hepatol, 2009.51(4): p. 655-66. 5. Mi, S.*, T. Cai*, Y. Hu, Y. Chen, E. Hodges, F. Ni, L. Wu, S. Li, H. Zhou, C. Long, et al., Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide.Cell, 2008. 133(1): p. 116-27. * co-first authors 6. Wu, J., X. Mao, T. Cai, J. Luo, and L. Wei, KOBAS server: a web-based platform for automated annotation and pathway identification. Nucleic Acids Res, 2006. 34(Web Server issue): p. W720-4. 7. T. Cai, X. Mao, S. Li, and L. Wei, Genome comparison using Gene Ontology (GO) with statistical testing. BMC Bioinformatics, 2006. 7: p. 374. 8. Mao, X.*, T. Cai*, J.G. Olyarchuk, and L. Wei, Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary. Bioinformatics, 2005. 21(19): p. 3787-93. * co-first authors 9. Yu, Z., T. Li, T. Cai, J. Zhao, and J. Luo, [MGAP-A microbe genome annotation platform]. Wei Sheng Wu Xue Bao, 2003. 43(6): p. 805-8. 10. Chen, Y.J., G. Gao, Y.M. Bao, R. Lopez, J.M. Wu, T. Cai, Z.Q. Ye, X.C. Gu, and J.C. Luo, [Initial analysis of complete genome sequences of SARS coronavirus]. Yi Chuan Xue Bao, 2003. 30(6): p. 493-500. 11.Tao, W., C.H. Yan, T. Cai, S. Hao, and Z.H. Zhai, Structural components of the nuclear body in nuclei of Allium cepa cells. Cell Res, 2001. 11(1): p. 68-73.