个人简介
王涛 博士
北京生命科学研究所高级研究员
教育经历
2006年 美国约翰霍普金斯大学医学院生物化学系，博士
Ph. D., Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD, USA
2000年 北京大学生物化学系，硕士
M.S., Biochemistry Department, Peking University, Beijing, P. R. China
1997年 南开大学生物化学及分子生物学系，学士
B.S., Biochemistry and Molecular Biology Department, Nankai University, Tianjin, P. R. China
工作经历
2018- 北京生命科学研究所高级研究员
Associate Investigator, National Institute of Biological Sciences, Beijing, China
2012-2018 北京生命科学研究所研究员
Assistant Investigator, National Institute of Biological Sciences, Beijing, China
2007-2011 美国Fred Hutchinson癌症研究中心，博士后
Postdoctoral Fellow, Division of Basic Science Fred Hutchinson Cancer Research Center, Seattle, WA, USA
2006-2007 美国约翰霍普金斯大学，博士后
Postdoctoral Fellow, Department of Biological Chemistry, Johns Hopkins University, Baltimore, USA
研究概述
细胞内各个细胞器包括内质网、线粒体和胞浆都存在质量控制机制，破坏质量控制的任何环节都会影响细胞稳态，是细胞功能丧失。我们的实验室致力于以果蝇模型为主研究细胞器内质量控制的分子机制；各个质量控制系统之间的协调互作以维持细胞健康。
1. 线粒体运输协同线粒体自噬维持了神经元轴突中线粒体稳态，对神经元的生长和生理功能维持至关重要。围绕线粒体的质量控制机制，我们的实验室致力于揭示线粒体选择性顺行和逆行运输的分子机制；线粒体自噬及调控网络，并在果蝇、小鼠、以及人源细胞等多种研究模式中研究线粒体质量控制对神经元生理功能维持的生理意义。
2. 细胞磷脂代谢依赖于线粒体和内质网之间的脂质双向交换，多种磷脂如磷脂酰乙醇胺的缺乏引起多重应激信号。我们实验室致力于探索线粒体和内质网之间脂质双向交换的分子机制和生理功能，进而对细胞器之间如何协同反应以对抗各种压力。
3. 诸如多聚谷氨酰胺病等主要神经退行性疾病都与错误折叠蛋白质的聚集有关。我们实验室利用胞浆和内质网错误折叠蛋白质引发神经元退变的果蝇模型，深入探讨细胞如何感知错误折叠蛋白质，错误折叠蛋白在聚集前和聚集后的清除的机制，以及生物体如何在蛋白高度聚集时引发细胞死亡并清除异常细胞。
近期论文
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1. Xie J., Han Y. and Wang T.* 2021. RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. PLoS Genet. 17(5):e1009558.
2. Han Y., Zhuang N. and Wang T.* 2021. Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila. Cell Reports. 34(12):108875 (cover article).
3. Xu J., Zhao H. and Wang T.* 2020. Suppression of retinal degeneration by two novel ERAD ubiquitin E3 ligases SORDD1/2 in Drosophila. PLoS Genet. 16(11):e1009172.
4. Zhao H. and Wang T.* 2020. PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila. PLoS Genet. 16(10):e1009070.
5. Xiong L., Zhang L., Yang Y., Li N., Lai W., Wang F., Zhu X. and Wang T.*. 2020. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Cell Death Differ. 27(2): 646-661.
6. Xu Y. and Wang T.* 2019. LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision. Cell Rep. 27(5):1327-1333.
7. Zhao H., Wang J. and Wang T.* 2018. The V-ATPase V1 subunit A1 Is required for rhodopsin anterograde trafficking in Drosophila. Mol. Biol. Cell. 29(13):1640-1651. (cover article).
8. Ren S., Huang Z., Jiang Y. and Wang T.* 2018. dTBC1D7 regulates systemic growth independently of TSC through insulin signaling. J. Cell Biol. 217(2):517-526.
9. Han Y., Xiong L., Xu Y., Tian T. and Wang T.* 2017. The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila. Elife. 6:e29146.
10. Zhuang N., Li L., Chen S. and Wang T.* 2016. PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control. Cell Death Dis. 7(12):e2501.
11. Huang Z., Ren S., Jiang Y. and Wang T.* 2016. PINK1 and Parkin cooperatively protect neurons against constitutively active TRP channel-induced retinal degeneration in Drosophila. Cell Death Dis. 7:e2179
12. Xu Y. and Wang T.* 2016. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. J Cell Sci. 15;129(2):394-405.
13. Xu Y., An F., Borycz J.A., Borycz J., Meinertzhagen I.A. and Wang T.* 2015. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors. PLoS Genet. 11(12):e1005764.
14. Kuo Y., Hang H., Cai T. and Wang T.* 2015. Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila. Sci. Rep. 5:10339.
15. Huang Y., Xie J. and Wang T.* 2015. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila. PLoS One. 10(12):e0144925.
16. Wu K., Liu J., Zhuang N. and Wang T.* 2014. UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease. FASEB Journal. 28(12):5111-21
17. Kuo Y., Ren S., Lao U., Edgar B.A., Wang T.* 2013. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. Cell Death Dis. 3;4:e833.
18. Wang T.*, Blumhagen R., Lao U. Kuo Y. and Edgar B.A. 2012. LST8 regulates cell growth via Target-of-Rapamycin Complex2. Mol. Cell. Biol. 32(12):2203-2213 (cover article).
19. Wang T., WangX., Ni J., Von Lintig J. and Montell C.* 2012. The Drosophila visual cycle and de novo chromophore synthesis depends on rdhB. J Neurosci. 32: 3485-3491.
20. Wang X., Wang T., Jiao Y., Von Lintig J. and Montell C.* 2010. Requirement for an Enzymatic Visual Cycle in Drosophila. Curr. Biol. 20:93-102 (equal contribution of first two authors)
21. Wang T.* and Edgar B.A.* 2010. TOR signaling and cell death. The Enzymes. 28: 217-244 (Book Chapter)
22. Wang T., Lao U. and Edgar B.A. 2009. TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease. J. Cell Biol. 186: 703-711
23. Wang T., Wang X., Xie Q. and Montell C.* 2008. The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron. 57, 56-68 (Cover article).
24. Liu Z., Wang X., Yu Y., Li X., Wang T., Jiang H., Ren Q., Jiao Y., Sawa A., Moran T., Ross CA., Montell C. and Smith W.W.* 2008. A Drosophila model for LRRK2-linked parkinsonism. Proc. Natl. Acad. Sci. USA. 105, 2693-2698
25. Wang T. and Montell C.* 2007. Phototransduction and retinal degeneration in Drosophila. Pflugers Arch. 454, 821-847. (review)
26. Liu C-H. Wang T. Postma M. Obukhov A.G. Montell C. and Hardie R.C.* 2007. In vivo identification and manipulation of the Ca2+ selectivity filter in the Drosophila TRP channel. J Neurosci. 27, 604-615 (equal contribution of first two authors).
27. Wang T., Jiao Y. and Montell C.* 2007. Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. J Cell Biol. 177, 305-316.
28. Wang T. and Montell C.* 2006. A PI Synthase Required for a Sustained Light Response. J Neurosci. 26, 12816-12825.
29. Wang T., Jiao Y. and Montell C.* 2005. Dissecting independent channel and scaffolding roles of the Drosophila TRP channel. J. Cell Biol. 171, 685-694.
30. Wang T. and Montell C.* 2005. Rhodopsin formation in Drosophila is dependent on the PINTA retinoid binding protein. J. Neurosci. 25, 5187-5194 (Cover article).
31. Wang T., Xu H., Oberwinkler J., Gu Y., Hardie R.C. and Montell C.* 2005. Light-activation, adaptation and cell survival functions of the Na+/Ca2+ exchanger, CalX Neuron 45, 367-378.
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