呼庆勋 - 上海大学

个人简介

呼庆勋，副教授，硕士生导师。2016年获复旦大学博士学位，2020年在华盛顿大学完成博士后研究工作，回国后被聘为上海大学医学院副教授。主要从事线粒体代谢实时成像监测与精准调控，一方面致力于发展新型遗传编码的荧光探针，用于在时间和空间尺度上解析生理病理情况下心血管系统的复杂功能；另一方面，借助先进的工具建立单细胞高通量筛选分析系统，为心血管疾病的诊治提供新理论和新方法。近年研究成果在Cell Metabolism，Circulation Research，Developmental Cell, Cell Reports Methods, Redox Biology（3篇）和Antioxidants and Redox Signaling等主流期刊发表学术论文。已授权国际PCT专利2项和中国发明专利4项。入选上海市人才计划，主持国家自然科学基金青年项目1项，荣获上海药学科技二等奖和美国心脏协会New Investigator Travel Award。研究成果在国内外产生重要影响，近500个实验室应用相关技术成果或重要发现从事科学研究并发表顶级期刊。培养的研究生多人次获得学业奖学金和企业冠名奖学金。本实验室研究生将接受生化分子、蛋白设计、细胞功能和动物药效评价等实验技术的全面培训，热忱欢迎有志于从事科学研究的优秀同学加入本课题组！典型举例 NAD(H)是细胞中重要的辅酶和核心代谢物，不仅参与能量代谢及氧化还原反应，还直接调控多种关键酶活性。NAD(H)系列荧光探针的开发为高时空分辨监测其在生理病理情况下的代谢规律提供了强有力的研究工具（Cell Metabolism, 2015; Developmental cell, 2020; Cell Reports Methods, 2021）。线粒体动力学对维持线粒体稳态起着至关重要的作用。首次鉴定了线粒体分裂蛋白Drp1翻译后修饰新形式（乙酰化和硫巯基化）并揭示其在心脏疾病中信号传导机制。（Circulation Research, 2020; Redox Biology, 2022）。硫化氢（H2S）是继NO和CO之后的第三种气体信号分子，在心血管系统中发挥着尤为重要的关键调控作用。获得了一种缓慢释放H2S新型供体，具有促进血管新生、增强血管舒张和抑制心力衰竭的保护作用，对揭示H2S生物学功能、加速H2S相关药物开发具有重要意义（Antioxidants & Redox Signaling, 2016; Oxidative Medicine and Cellular Longevity, 2016; Redox Biology, 2018）。

研究领域

1. 新型成像技术的开发及在体应用 2. 线粒体功能调控的代谢新机制 3. 心血管疾病的干预新策略

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Dan Wu, Bo Tan, Yuanyuan Sun, Qingxun Hu*, Cystathionine γ lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction. Redox Biology. 2022, 58, 102519. 2. Qingxun Hu#, Dan Wu#, Matthew Walker, Pei Wang, Rong Tian*, and Wang Wang*, Genetically encoded biosensors for evaluating NAD+/NADH ratio in cytosolic and mitochondrial compartments. Cell Reports Methods, 2021,1, 100116. 3. Qingxun Hu, Huiliang Zhang, Nicolás Gutiérrez Cortés, Dan Wu, Pei Wang, Jing Zhang, Julie A. Mattison, Eric Smith, Lisa F. Bettcher, Mingyi Wang, Edward G. Lakatta, Shey-Shing Sheu, Wang Wang*, Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction. Circulation Research, 2020, 126, 456–470. 4. Yejun Zou#, Aoxue Wang#, Li Huang#, Xudong Zhu#, Qingxun Hu#, Yinan Zhang, Xianjun Chen, Fengwen Li, Qiaohui Wang, Hu Wang, Renmei Liu, Fangting Zuo, Ting Li, Jing Yao, Yajie Qian, Mei Shi, Xiao Yue, Weicai Chen, Zhuo Zhang, Congrong Wang, Yong Zhou, Linyong Zhu, Zhenyu Ju, Joseph Loscalzo, Yi Yang*, Yuzheng Zhao*. Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor. Developmental Cell, 2020, 53, 240-252. 5. Dan Wu#, Qingxun Hu#, Ying Xiong, Deqiu Zhu, Yicheng Mao* and Yi Zhun Zhu*, Novel H2S-NO hybrid molecule (ZYZ-803) promoted synergistic effects against heart failure. Redox Biology, 2018, 15, 243-252. 6. Dan Wu#, Qingxun Hu#, Bo Tan, Peter Rose, Deqiu Zhu, Yi Zhun Zhu*, Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II. Redox Biology, 2018, 19, 250-262. 7. Qingxun Hu#, Dan Wu#, Fenfen Ma, Suna Yang, Bo Tan, Hong Xin, Xianfeng Gu, Xu Chen, Siyao Chen, Yicheng Mao and Yi Zhun Zhu*. Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide–Nitric Oxide Hybrid Molecule. Antioxidants & Redox Signaling, 2016, 25, 498-514. 8. Yuzheng Zhao, Qingxun Hu, Feixiong Cheng, Ni Su, Aoxue Wang, Yejun Zou, Hanyang Hu, Xianjun Chen, Hai-Meng Zhou, Xinzhi Huang, Kai Yang, Qian Zhu, Xue Wang, Jing Yi, Linyong Zhu, Xuhong Qian, Lixin Chen, Yun Tang, Joseph Loscalzo and Yi Yang*. SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents. Cell Metabolism, 2015, 21, 777–789.

学术兼职

Fronters in Cardiovascular Medicine 客座编辑