个人简介
陆一鸣,博士,教授,担任同济大学附属第十人民医院兼职PI(研究员),八加一药业股份有限公司创新药物研究中心首席科学家,中国药学会生化与生物技术药物专业委员会委员,国家卫生健康委医药卫生科技发展研究中心“新型冠状病毒肺炎治疗药物咨询专家组”专家,国家自然科学基金、“重大新药创制”国家科技重大专项、上海市自然科学基金、北京市自然科学基金评审专家。主持 “重大新药创制”国家科技重大专项2项、国家重点研究计划(子课题)1项、国家自然科学基金3项、上海市科委“科技创新行动计划”生物医药领域科技支撑项目2项、上海市教委创新项目重点项目1项等共12项,副主编、参编专著5部,国家发明专利6项(PCT 2项),获得2016年度上海市技术发明三等奖(第2)。
参编著作
1. 《药学分子生物学》,中国医药科技出版社,2017,参编
2. 《疫苗工程》,华东理工大学出版社,2009,副主编
3. 《医学分子遗传学》,科学出版社,2009,副主编
4. 《医学遗传学》,科学出版社,2009,参编
5. 《染色体、基因与疾病》,科学出版社,2008,参编
6. 《现代生物工程》,科学出版社,2007,参编
研究领域
1. 海洋生物功能分子的发现及创新药物的研究开发;
2. 药物新靶标的发现与确证
抗炎免疫药物药理、分子药理学
近期论文
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1. ChuanZhang#,An Li#, RuinaWang#, Yan Cao, Han Jiang, Songying Ouyang, Xingyuan Ma*, YimingLu* . Recombinant expression, purification and bioactivitycharacterization of extracellular domain of human tumor necrosis factor receptor 1, Protein Expression and Purification,2019,155,21-26
2. An Li#, Chuan Zhang#, Jie Wang#, Junjie Wang, Hailong Jiang, Jianzhong Li, Xingyuan Ma*, Wen Zhang*, Yiming Lu*.Cloning, expression, purification and bioactivity evaluation of a thrombin-like enzyme from Deinagkistrodon acutus venom gland library. Biotechnol Lett 2018 ;40(1):93-102.
3. Yan Huang#, Jie Wang#, Fuao Cao#,Hailong Jiang, An Li, Jianzhong Li, Lei Qiu, Hao Shen, Wenjun Chang, Chuanxiang Zhou*, Yamin Pan*,Yiming Lu*. SHP2 associates with nuclear localization of STAT3: the significance in progression and prognosis of colorectal cancer. Scientific Reports, 2017, DOI:10.1038/s41598-017-17604-7
4. Guosheng Wu#, Junjie Wang#, Pengfei Luo#, An Li, Song Tian, Hailong Jiang, Yongjun Zheng, Feng Zhu* , Yiming Lu* and Zhaofan Xia* . Hydrostatin-SN1, a sea snake-derived bioactive peptide, reduces inflammation in a mouse model of acute lung injury. Frontiers in Pharmacology. 2017,8:246.doi: 10.3389/fphar.2017.00246.
5. Wang, Ningyuan(#),Huang, Yan(#),Li, An(#),Jiang, Hailong,Wang, Jie,Li, Jianzhong,Qiu, Lei,Li, Ka(*),Lu, Yiming(*).Hydrostatin-TL1, an Anti-Inflammatory Active Peptide from the Venom Gland of Hydrophis cyanocinctus in the South China Sea. International Journal of Molecular Sciences, 2016, DOI:10.3390/ijms17111940.
6. Zheng, Zengjie(#),Jiang, Hailong(#),Huang, Yan(#),Wang, Jie,Qiu, Lei,Hu, Zhenlin,Ma, Xingyuan(*),Lu, Yiming(*).Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis. Scientific Reports, 2016, DOI:10.1038/srep25672.
7. Li, Hongjiao(#),Lu, Yiming(#),Xiang, Jingjie,Jiang, Hailong,Zhong, Yanqiang(*),Lu, Ying(*).Enhancement of immunogenic response and protection in model rats by CSTM nanoparticles anticaries DNA vaccine. Nanomedicine, 2016 ,11(11):1407-16.