Barman, Ishan - Johns Hopkins University - Department of Mechanical Engineering

个人简介

Ishan Barman is an Associate Professor in the Department of Mechanical Engineering at Johns Hopkins University with joint appointments in the Departments of Oncology and Radiology and Radiological Science. He graduated from the Indian Institute of Technology (IIT), Kharagpur, before moving to Massachusetts Institute of Technology (MIT) for his M.S. and Ph.D. During his doctoral research, he investigated non-invasive blood glucose sensing using vibrational spectroscopy under Professor Michael Feld. He leads an interdisciplinary research group that is focused on the development of cutting-edge biophotonics technologies with the goal of disease detection at early, manageable stages, monitoring therapeutic effects and treatment outcomes, and guiding interventions. The optical tools generated from these investigations have been leveraged in diverse biomedical environments including in automated recognition of biopsy specimen, real-time diagnosis of middle ear pathology, and as a customized monoclonal antibody identification platform.

研究领域

Non-invasive, early disease detection and monitoring of treatment response and resistance A new window into single cell analysis Poking, prodding and squishing cells Imaging with nanostructures

近期论文

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Liang L, Zheng P, Jia S, Ray K, Chen Y, Barman I, "Plasmonic Nanodiamonds", Nano Letters. 2023, DOI: 10.1021/acs.nanolett.3c01514 Anantha P, Liu Z, Raj P, Barman I, "Optical diffraction tomography and Raman spectroscopy reveal distinct cellular phenotypes during white and brown adipocyte differentiation". Biosensors and Bioelectronics. 2023,115388 Tanwar S, Wu L, Zahn N, Raj P, Ghaemi B, Chatterjee A, Bulte JWM, Barman I, “Targeted enzyme activity imaging with quantitative phase microscopy” Nano Letters 2023, 23, 4602-4608 Kim JH, Zhang C, Sperati CJ, Bagnasco SM, Barman I. "Non-Perturbative Identification and Subtyping of Amyloidosis in Human Kidney Tissue with Raman Spectroscopy and Machine Learning". Biosensors. 2023; 13(4):466. https://doi.org/10.3390/bios13040466 Zheng P, Liang L, Arora S, Ray K, Semancik S, Barman I, "Pyramidal Hyperbolic Metasurfaces Enhance Spontaneous Emission of Nitrogen-Vacancy Centers in Nanodiamond", Adv. Optical Mater. 2023, 2202548. https://doi.org/10.1002/adom.202202548 Mukhopadhyaya T, Lee T D, Ganley C, Tanwar S, Raj P, Li L, Song Y, Clancy P, Barman I, Thon S, Katz H E “ Stable High-Conductivity Ethylenedioxythiophene Polymers via Borane-Adduct Doping” Advanced Functional Materials 2022, 2208541. Liu Z, Parida S, Wu S, Sears CL, Sharma D, Barman I, “Label-free vibrational and quantitative phase microscopy reveals remarkable pathogen-induced morpho-molecular divergence in tumor-derived cells”, ACS Sensors, 10.1021/acssensors.2c00232, 2022. Tanwar S, Kim JH, Bulte JWM, Barman I, “Surface-enhanced Raman scattering (SERS): An emerging tool for sensing cellular function”, WIREs: Nanomedicine & Nanobiotechnology, e1802, doi: 10.1002/wnan.1802, 2022. Mussi V, Fasolino I, Paria D, Simone SD, Caporali M, Serrano-Ruiz M, Ambrosio L, Barman I*, Raucci MG*, Convertino A*, “Label-free morpho-molecular imaging for studying the differential interaction of black phosphorus with tumor cells”, Nanomaterials, 2022 (accepted). Zheng P, Wu L, Raj P, Mizutani T, Szabo M, Hanson WA, Barman I, “A dual-modal single-antibody plasmonic spectro-immunoassay for detection of small molecules”, Small, 18, 2200090, 2022. Paria D, Kwok KS, Raj P, Zheng P, Gracias DH, Barman I, “Label-free spectroscopic SARS-CoV‑2 detection on versatile nanoimprinted substrates”, Nano Letters, 22(9), 3620–3627, 2022. (Selected as Supplementary Cover) Tanwar S, Paidi SK, Prasad R, Pandey R, Barman I, “Advancing Raman spectroscopy from research to clinic: Translational potential and challenges” Spectrochimica Acta Part A: Molecular and Biomolecular spectroscopy 2021, 260, 119957 Zheng P, Raj P, Mizutani T, Szabo M, Hanson WA, Barman I, “Plexcitonic quasi-bound states in the continuum”, Small, 17(39), 2102596, 2021 Ahmed I, Ma V, Liu Y, Khan M, Liu Z, Zhang C, Paidi S, Manno F, Amjad N, Manno S, Ahmed R, Law A, Raza F, Ali A, Zhang Y, Cho W, Barman I, Alda M, Bergink V, Lau C, “Lithium from breast-milk inhibits thyroid iodine uptake and hormone production, which are remedied by maternal iodine supplementation”, Bipolar Disorders, 23(6), 615-625, 2021. Narayanan N, Kim JH, Santhakumar H, Joseph M, Karunakaran V, Shamjith S, Saranya G, Sujai P, Jayasree R, Barman I, Maiti KK, “Nanotheranostic Probe Built on Methylene Blue Loaded Cucurbituril [8] and Gold Nanorod: Targeted Phototherapy in Combination with SERS Imaging on Breast Cancer Cells”, Journal of Physical Chemistry B, 125 (49), 13415–13424, 2021. Paidi SK, Troncoso JR, Raj P, Diaz PM, Ivers JD, Lee DE, Avaritt NL, Gies A, Quick CM, Byrum SD, Tackett AJ, Rajaram N, Barman I, “Raman spectroscopy and machine learning reveals early tumor microenvironmental changes induced by immunotherapy”, Cancer Research, 81(22), 5745-5755, 2021. Yuan Y, Raj P, Zhang J, Siddhanta S, Barman I*, Bulte JWM*, “Furin-mediated self-assembly of olsalazine nanoparticles for targeted Raman imaging of tumors”, Angewandte Chemie Intl. Ed. (accepted), 133(8), 3969-3973, 2021. (Selected as Hot Paper and Front Cover) Sarkar A, Paria D, Barman I, Gracias D, “Controlled nanoscale cracking of graphene ribbons by polymer shrinkage”, ACS Applied Nano Materials, 4 (2), 1529–1539, 2021. Zheng P, Kang J, Paria D, Kang J, Barman I, “Molecular radiative energy shifts under strong oscillating fields”, Small, 17 (3), 2007244, 2021. Mussi V, Ledda M, Polese D, Maiolo L, Paria D, Barman I, Lolli MG, Lisi A, Convertino A, “Silver-coated silicon nanowire platform discriminates genomic DNA from normal and malignant human epithelial cells using label-free Raman spectroscopy”, Materials Science and Engineering C, 122, 111951, 2021. Sarkar A, Paria D, Barman I, Gracias D, “Controlled nanoscale cracking of graphene ribbons by polymer shrinkage”, ACS Applied Nano Materials, 4 (2), 1529–1539, 2021. Yuan Y, Raj P, Zhang J, Siddhanta S, Barman I*, Bulte JWM*, “Furin-mediated self-assembly of olsalazine nanoparticles for targeted Raman imaging of tumors”, Angewandte Chemie Intl. Ed. (accepted), 133(8), 3969-3973, 2021. (Selected as Hot Paper and Front Cover) Mussi V, Ledda M, Polese D, Maiolo L, Paria D, Barman I, Lolli MG, Lisi A, Convertino A, “Silver-coated silicon nanowire platform discriminates genomic DNA from normal and malignant human epithelial cells using label-free Raman spectroscopy”, Materials Science and Engineering C, 122, 111951, 2021. Wrobel M, Kim JH, Raj P, Barman I, Smulko J, “Utilizing pulse dynamics for non-invasive Raman spectroscopy of blood analytes”, Biosensors and Bioelectronics, 180, 113115, 2021. Rex R, Siddhanta S, Barman I, “Role of aqueous-phase calcination in synthesis of ultra-stable dye-embedded fluorescent nanoparticles for cellular probing”, Applied Spectroscopy, 75(8), 1012-1021, 2021. Tanwar S, Paidi SK, Pandey R, Barman I, “Advancing Raman spectroscopy from research to clinic: Translational potential and challenges”, Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy (invited article), 260, 119957, 2021 Liang L, Zheng P, Zhang C, Barman I, “A programmable DNA-silicification-based nanocavity for single-molecule plasmonic sensing”, Advanced Materials, 33 (7), 2005133, 2021. Paria D, Convertino A, Raj P, Glunde K, Chen Y, Barman I, “Nanowire assisted mechanotyping of cellular metastatic potential”, Advanced Functional Materials, 2101638, 2021. Zhang C, Siddhanta S, Paria D, Li Y, Zheng C, Barman I, “Spectroscopy assisted label-free molecular analysis of live cell surface with vertically aligned plasmonic nanopillars”, Small, 17 (21), 2100161, 2021. Ayyappan V, Chang A, Zhang C, Paidi SK, Bordett R, Liang T, Barman I, Pandey R, “Identification and staging of B-cell acute lymphoblastic leukemia using quantitative phase imaging and machine learning”, ACS Sensors, 5 (10), 3281–3289, 2020. Ahmed I, Khan MS, Paidi SK, Liu Z, Zhang C, Liu Y, Baloch GA, Law AWL, Zhang Y, Barman I, Lau C, “Laser induced breakdown spectroscopy with machine learning reveals lithium-induced electrolyte imbalance in the kidneys”, Journal of Pharmaceutical and Biomedical Analysis, 194, 113805, 2020. Ayyappan V, Chang A, Zhang C, Paidi SK, Bordett R, Liang T, Barman I, Pandey R, “Identification and staging of B-cell acute lymphoblastic leukemia using quantitative phase imaging and machine learning”, ACS Sensors, 5 (10), 3281–3289, 2020. Liu Z, Lee S-J, Park S, Konstantopoulos K, Glunde K, Chen Y, Barman I, “Cancer cells display increased migration and deformability in pace with metastatic progression”, FASEB Journal, 34(7), 9307-9315, 2020. [Huang Z, Siddhanta S], Zheng G, Kickler T, Barman I, “Rapid, label-free optical spectroscopy platform for diagnosis of heparin-induced thrombocytopenia”, Angewandte Chemie Intl. Ed., 59(15), 5972-5978, 2020. Zheng P, Paria D, Wang H, Li M, Barman I, “Optical properties of symmetry-breaking tetrahedral nanoparticle”, Nanoscale, 12, 832-842, 2020. Tsui SM, Ahmed R, Amjad N, Ahmed I, Yang J, Manno F, Barman I, Shih W-C, Lau C, “Single red blood cell analysis reveals elevated hemoglobin in poikilocytes”, Journal of Biomedical Optics, 25(1):1-13, 2020. Li M, Paidi SK, Sakowski E, Preheim S, Barman I, “Ultrasensitive detection of hepatotoxic microcystin production from cyanobacteria using surface-enhanced Raman scattering (SERS) immunosensor”, ACS Sensors, 4(5), 1203- 1210, 2019. Yuan Y, Zhang J, Qi X, Li S, Liu G, Siddhanta S, Barman I, Song X, McMahon MT, Bulte JWM, “Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced MR imaging and tumor therapy”, Nature Materials, 18, 1376-1383, 2019. Zhang C, Springall JS, Wang X, Barman I, “Rapid, quantitative determination of aggregation and particle formation for antibody drug conjugate therapeutics with label-free Raman spectroscopy”, Analytica Chimica Acta, 1081, 138-145, 2019. [Zhang C, Paria D], Semancik S, Barman I, “Composite-scattering plasmonic nanoprobes for label-free, quantitative biomolecular sensing”, Small, 15(38):e1901165, 2019. [Siddhanta S, Bhattacharjee S], Harrison SM, Scholz D, Barman I, “Shedding light on the trehalose-enabled mucopermeation of nanoparticles with label-free Raman spectroscopy”, Small, 15(33):e1901679, 2019. Li M, Paidi SK, Sakowski E, Preheim S, Barman I, “Ultrasensitive detection of hepatotoxic microcystin production from cyanobacteria using surface-enhanced Raman scattering (SERS) immunosensor”, ACS Sensors, 4(5), 1203- 1210, 2019. Yuan Y, Zhang J, Qi X, Li S, Liu G, Siddhanta S, Barman I, Song X, McMahon MT, Bulte JWM, “Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced MR imaging and tumor therapy”, Nature Materials, 18, 1376-1383, 2019. Zhang C, Springall JS, Wang X, Barman I, “Rapid, quantitative determination of aggregation and particle formation for antibody drug conjugate therapeutics with label-free Raman spectroscopy”, Analytica Chimica Acta, 1081, 138-145, 2019. Li M, Paidi SK, Sakowski E, Preheim S, Barman I, “Ultrasensitive detection of hepatotoxic microcystin production from cyanobacteria using surface-enhanced Raman scattering (SERS) immunosensor”, ACS Sensors, 4(5), 1203- 1210, 2019. Paidi SK, Diaz PM, Dadgar S, Jenkins SV, Quick CM, Griffin RJ, Dings RPM, Rajaram N, Barman I, “Label-free Raman spectroscopy reveals signatures of radiation resistance in the tumor microenvironment”, Cancer Research, 79(8), 2054-2064, 2019. Karandikar S, Zhang C, Meiyappan A, Barman I, Finck C, Srivastava PK, Pandey R, “Reagent-free and rapid assessment of T cell activation state using diffraction phase microscopy and deep learning”, Analytical Chemistry, 91(5), 3405-3411, 2019. Junjuri R, Zhang C, Barman I, Manoj Kumar G, “Identification of post-consumer plastics using laser-induced breakdown spectroscopy”, Polymer Testing, 76, 101-108, 2019. Pandey R, Zhou R, Bordett R, Hunter C, Glunde K, Barman I, Valdez TA, Finck C, “Integration of diffraction phase microscopy and Raman imaging for label-free morpho-molecular assessment of live cells”, Journal of Biophotonics, e201800291, 2018. [Pandey R, Zhang C], Kang JW, Desai PM, Dasari RR, Barman I*, Valdez TA*, “Differential diagnosis of otitis media with effusion using label-free Raman spectroscopy: a pilot study”, Journal of Biophotonics, 11(6):e201700259, 2018. [Rizwan A, Paidi SK, Zheng C], Cheng M, Fan Z, Barman I*, Glunde K*, “Mapping the genetic basis of microcalcifications and their role in metastasis”, Scientific Reports, 8:11067, 2018. Huang S, Pandey R, Barman I, Kong J, Dresselhaus M, “Raman enhancement of blood constituent proteins using graphene”, ACS Photonics, 5(8), 2978–2982, 2018. Huang Z, Nagpal A, Siddhanta S, Barman I, “Leveraging coffee ring effect on plasmonic paper substrate for sensitive analyte detection using Raman spectroscopy”, Journal of Raman Spectroscopy, DOI: 10.1002/jrs.5415, 2018. Pandey R, Singh SP, Zhang C, Horowitz GL, Lue N, Galindo L, Dasari RR, Barman I, “Label-free spectrochemical probe for determination of hemoglobin glycation in clinical blood samples”, Journal of Biophotonics, 11(10):e201700397, 2018. Faraz M, Abbasi A, Naqvi FK, Khare N, Prasad R, Barman I, Pandey R, “Polyindole/CdS nanocomposite based turn-on, multi-ion fluorescence sensor for detection of Cr3+, Fe3+ and Sn2+ ions”, Sensors and Actuators: B. Chemical, 269, 195-202, 2018. Sperati CJ, Zhang C, Delsante M, Gupta R, Bagnasco S, Barman I, “Raman spectroscopy for the diagnosis of intratubular triamterene crystallization”, Kidney International Reports, 3(4), 997-1003, 2018. [Pandey R, Zhang C], Kang JW, Desai PM, Dasari RR, Barman I*, Valdez TA*, “Differential diagnosis of otitis media with effusion using label-free Raman spectroscopy: a pilot study”, Journal of Biophotonics, 11(6):e201700259, 2018. [Zhang C, Winnard Jr. PT], Dasari S, Kominsky SL, Doucet M, Jayaraman S, Raman V*, Barman I*, “Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations”, Chemical Science, 9, 743 – 753, 2018. Huang Z, Siddhanta S, Zhang C, Kickler T, Zheng G, Barman I, “Painting and heating: A non-conventional, scalable route to sensitive biomolecular analysis with plasmon-enhanced spectroscopy”, Journal of Raman Spectroscopy, 48, 1365–1374, 2017. Singh SP, Kang S, Kang JW, So PTC, Dasari RR, Yaqoob Z, Barman I, “Label-free characterization of UV radiation-induced changes in skin fibroblasts with Raman spectroscopy and quantitative phase microscopy”, Scientific Reports, 7:10829, 2017. [Rizwan A, Paidi SK, Zheng C], Cheng M, Fan Z, Barman I*, Glunde K*, “Mapping the genetic basis of microcalcifications and their role in metastasis”, Scientific Reports, 8:11067, 2018. Huang S, Pandey R, Barman I, Kong J, Dresselhaus M, “Raman enhancement of blood constituent proteins using graphene”, ACS Photonics, 5(8), 2978–2982, 2018. Huang Z, Nagpal A, Siddhanta S, Barman I, “Leveraging coffee ring effect on plasmonic paper substrate for sensitive analyte detection using Raman spectroscopy”, Journal of Raman Spectroscopy, DOI: 10.1002/jrs.5415, 2018. Pandey R, Singh SP, Zhang C, Horowitz GL, Lue N, Galindo L, Dasari RR, Barman I, “Label-free spectrochemical probe for determination of hemoglobin glycation in clinical blood samples”, Journal of Biophotonics, 11(10):e201700397, 2018. Faraz M, Abbasi A, Naqvi FK, Khare N, Prasad R, Barman I, Pandey R, “Polyindole/CdS nanocomposite based turn-on, multi-ion fluorescence sensor for detection of Cr3+, Fe3+ and Sn2+ ions”, Sensors and Actuators: B. Chemical, 269, 195-202, 2018. Sperati CJ, Zhang C, Delsante M, Gupta R, Bagnasco S, Barman I, “Raman spectroscopy for the diagnosis of intratubular triamterene crystallization”, Kidney International Reports, 3(4), 997-1003, 2018. [Pandey R, Zhang C], Kang JW, Desai PM, Dasari RR, Barman I*, Valdez TA*, “Differential diagnosis of otitis media with effusion using label-free Raman spectroscopy: a pilot study”, Journal of Biophotonics, 11(6):e201700259, 2018. [Zhang C, Winnard Jr. PT], Dasari S, Kominsky SL, Doucet M, Jayaraman S, Raman V*, Barman I*, “Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations”, Chemical Science, 9, 743 – 753, 2018.