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Crystal Structure of the Commercial Herbicide, Amidosulfuron, in Complex with Arabidopsis thaliana Acetohydroxyacid Synthase Cheng, Yan, Lonhienne, Thierry, Garcia, Mario. D., Williams, Craig M., Schenk, Gerard and Guddat, Luke W. (2023). Crystal Structure of the Commercial Herbicide, Amidosulfuron, in Complex with Arabidopsis thaliana Acetohydroxyacid Synthase. Journal of Agricultural and Food Chemistry, 71 (13), 5117-5126. doi: 10.1021/acs.jafc.2c08528
Kinetico-Mechanistic Studies on a Reactive Organocopper(II) Complex: Cu–C Bond Homolysis versus Heterolysis Gonzálvez, Miguel A., Williams, Craig M., Martínez, Manuel and Bernhardt, Paul V. (2023). Kinetico-Mechanistic Studies on a Reactive Organocopper(II) Complex: Cu–C Bond Homolysis versus Heterolysis. Inorganic Chemistry, 62 (11), 4662-4671. doi: 10.1021/acs.inorgchem.3c00127
Multitargeted Opioid Ligand Discovery as a Strategy to Retain Analgesia and Reduce Opioid-Related Adverse Effects Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2023). Multitargeted Opioid Ligand Discovery as a Strategy to Retain Analgesia and Reduce Opioid-Related Adverse Effects. Journal of Medicinal Chemistry, 66 (6), 3746-3784. doi: 10.1021/acs.jmedchem.2c01695
seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe)Xue, Yongbo, Savchenko, Andrei I., Agnew-Francis, Kylie A., Miles, Jared A., Holt, Tina, Lu, Hieng, Chow, Sharon, Forster, Paul I., Boyle, Glen M., Ross, Benjamin P., Fischer, Katja, Kutateladze, Andrei G. and Williams, Craig M. (2023). seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe). Journal of Natural Products, 86 (3), 490-497. doi: 10.1021/acs.jnatprod.2c01037
A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase Jin, Da-Yun, Chen, Xuejie, Liu, Yizhou, Williams, Craig M., Pedersen, Lars C., Stafford, Darrel W. and Tie, Jian-Ke (2023). A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase. Nature Communications, 14 (1) 828. doi: 10.1038/s41467-023-36446-8
Structural Reassignment of Two Polyenol Natural Products Kutateladze, Andrei G., Bates, Roderick W., Elyashberg, Mikhail and Williams, Craig M. (2023). Structural Reassignment of Two Polyenol Natural Products. European Journal of Organic Chemistry, 26 (9) e202201316. doi: 10.1002/ejoc.202201316
Chiral Auxiliary-Directed Site-Selective Deprotonation of the Cubane Skeleton Takebe, Hiyori, Yoshino, Nana, Shimada, Yukako, Williams, Craig M. and Matsubara, Seijiro (2023). Chiral Auxiliary-Directed Site-Selective Deprotonation of the Cubane Skeleton. Organic Letters, 25 (1), 27-30. doi: 10.1021/acs.orglett.2c03659
1-Azahomocubane Fahrenhorst-Jones, Tyler, Marshall, David L., Burns, Jed. M., Pierens, Gregory K., Hormann, Robert E., Fisher, Allison M., Bernhardt, Paul V., Blanksby, Stephen J., Savage, G. Paul, Eaton, Philip E. and Williams, Craig M. (2023). 1-Azahomocubane. Chemical Science, 14 (11), 2821-2825. doi: 10.1039/d3sc00001j
Unearthing the Subtleties of Rhodium(II)-Catalyzed Carbenoid Cycloadditions to Furans with an N-Sulfonyl-1,2,3-triazole Probe Bettencourt, Christian J., Krainz, Tanja, Chow, Sharon, Parr, Brendan T., Tracy, William F., Bernhardt, Paul V., Davies, Huw M. L. and Williams, Craig M. (2022). Unearthing the Subtleties of Rhodium(II)-Catalyzed Carbenoid Cycloadditions to Furans with an N-Sulfonyl-1,2,3-triazole Probe. Organic Letters, 24 (50), 9290-9295. doi: 10.1021/acs.orglett.2c03869
Structural basis of resistance to herbicides that target acetohydroxyacid synthase Lonhienne, Thierry, Cheng, Yan, Garcia, Mario D., Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2022). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nature Communications, 13 (1) 3368, 3368. doi: 10.1038/s41467-022-31023-x
Wasabi (Eutrema japonicum) Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats Thomaz, Fernanda Santos, Tan, Yuen P., Williams, Craig M., Ward, Leigh C., Worrall, Simon and Panchal, Sunil K. (2022). Wasabi (Eutrema japonicum) Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats. Foods, 11 (21) 3435, 3435. doi: 10.3390/foods11213435
Reassignment of improbable natural products identified through chemical principle screening Elyashberg, Mikhail, Novitskiy, Ivan M., Bates, Roderick W., Kutateladze, Andrei G. and Williams, Craig M. (2022). Reassignment of improbable natural products identified through chemical principle screening. European Journal of Organic Chemistry, 2022 (34) e202200572, 1-9. doi: 10.1002/ejoc.202200572
Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain Kong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic and Medicinal Chemistry, 69 116889, 1-10. doi: 10.1016/j.bmc.2022.116889
Photochemical generation of the 2-azabicyclo[4.2.0]octa-4,7-diene skeleton Fahrenhorst-Jones, Tyler, Savage, G. Paul and Williams, Craig M. (2022). Photochemical generation of the 2-azabicyclo[4.2.0]octa-4,7-diene skeleton. Australian Journal of Chemistry, 75 (11), 884-887. doi: 10.1071/ch22139
Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development Shah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development. Frontiers in Plant Science, 13 909073. doi: 10.3389/fpls.2022.909073
Toward the total synthesis of alpkinidine: Michael addition to isoquinolinetrione CE ring-system synthons Buccini, Marco, Dhoro, Francis, Tham, Louisa, Skelton, Brian W., Williams, Craig M. and Piggott, Matthew J. (2022). Toward the total synthesis of alpkinidine: Michael addition to isoquinolinetrione CE ring-system synthons. ACS Omega, 7 (23), 19093-19105. doi: 10.1021/acsomega.2c02117
Toward the total synthesis of alpkinidine: synthesis of haloquinone CE ring system synthons and attempted nucleophilic bisannulation Buccini, Marco, Tham, Louisa, Dhoro, Francis, Skelton, Brian W., Williams, Craig M. and Piggott, Matthew J. (2022). Toward the total synthesis of alpkinidine: synthesis of haloquinone CE ring system synthons and attempted nucleophilic bisannulation. ACS Omega, 7 (23), 19080-19092. doi: 10.1021/acsomega.2c02116
Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K‐dependent carboxylation Chen, Xuejie, Furukawa, Natsuko, Jin, Da‐Yun, Liu, Yizhou, Stafford, Darrel W., Williams, Craig M., Suhara, Yoshitomo and Tie, Jian‐Ke (2022). Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K‐dependent carboxylation. The FEBS Journal, 289 (9), 2613-2627. doi: 10.1111/febs.16291
The (±)-6-Aza[1.0]triblattane skeleton: contraction beyond the Wilder–Culberson ring system Fahrenhorst-Jones, Tyler, Bernhardt, Paul V., Savage, G. Paul and Williams, Craig M. (2022). The (±)-6-Aza[1.0]triblattane skeleton: contraction beyond the Wilder–Culberson ring system. Organic Letters, 24 (3) acs.orglett.1c04240, 903-906. doi: 10.1021/acs.orglett.1c04240
Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2022). Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources. Journal of Medicinal Chemistry, 65 (3) acs.jmedchem.0c01915, 1612-1661. doi: 10.1021/acs.jmedchem.0c01915
Organocopper(II) complexes: new catalysts for carbon–carbon bond formation via electrochemical atom transfer radical addition (eATRA) Gonzálvez, Miguel A., Su, Chuyi, Williams, Craig M. and Bernhardt, Paul V. (2022). Organocopper(II) complexes: new catalysts for carbon–carbon bond formation via electrochemical atom transfer radical addition (eATRA). Chemical Science, 13 (35), 10506-10511. doi: 10.1039/d2sc03418b
Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes Cullen, Jason K., Boyle, Glen M., Yap, Pei-Yi, Elmlinger, Stefan, Simmons, Jacinta L., Broit, Natasa, Johns, Jenny, Ferguson, Blake, Maslovskaya, Lidia A., Savchenko, Andrei I., Mirzayans, Paul Malek, Porzelle, Achim, Bernhardt, Paul V., Gordon, Victoria A., Reddell, Paul W., Pagani, Alberto, Appendino, Giovanni, Parsons, Peter G. and Williams, Craig M. (2021). Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes. Scientific Reports, 11 (1) 207, 207. doi: 10.1038/s41598-020-80397-9
Tandem oxidation-dehydrogenation of (hetero)arylated primary alcohols via perruthenate catalysis Bettencourt, Christian J., Chow, Sharon, Moore, Peter W., Read, Christopher D. G., Jiao, Yanxiao, Bakker, Jan Peter, Zhao, Sheng, Bernhardt, Paul V. and Williams, Craig M. (2021). Tandem oxidation-dehydrogenation of (hetero)arylated primary alcohols via perruthenate catalysis. Australian Journal of Chemistry, 74 (9), 652-659. doi: 10.1071/ch21137
Unmasking inherent chirality within the cubane skeleton Yoshino, Nana, Kato, Yumi, Shimada, Yukako, Williams, Craig M. and Matsubara, Seijiro (2021). Unmasking inherent chirality within the cubane skeleton. Israel Journal of Chemistry, 61 (7-8), 380-386. doi: 10.1002/ijch.202100013
Comprehensive computational investigation of the Barton–Kellogg reaction for both alkyl and aryl systems Burns, Jed M., Clark, Timothy and Williams, Craig M. (2021). Comprehensive computational investigation of the Barton–Kellogg reaction for both alkyl and aryl systems. The Journal of Organic Chemistry, 86 (11) acs.joc.1c00506, 1-14. doi: 10.1021/acs.joc.1c00506
Experimental and theoretical approaches for the development of 4H-Chromene derivatives as inhibitors of tyrosinase Canavieira, Luciana Morais, Brasil, Edikarlos Macedo, Silva, Thiago de Melo e, Borges, Rosivaldo dos Santos, Silva, José Rogério Araújo, Lameira, Jerônimo, Bernhardt, Paul V., Williams, Craig M. and Alves, Cláudio Nahum (2021). Experimental and theoretical approaches for the development of 4H-Chromene derivatives as inhibitors of tyrosinase. Molecular Simulation, 47 (9), 762-770. doi: 10.1080/08927022.2021.1926455
The future of retrosynthesis and synthetic planning: algorithmic, humanistic or the interplay? Williams, Craig M. and Dallaston, Madeleine A. (2021). The future of retrosynthesis and synthetic planning: algorithmic, humanistic or the interplay?. Australian Journal of Chemistry, 74 (5), 291-326. doi: 10.1071/ch20371
A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase Chen, Xuejie, Liu, Yizhou, Furukawa, Natsuko, Jin, Da‐Yun, Paul Savage, G., Stafford, Darrel W., Suhara, Yoshitomo, Williams, Craig M. and Tie, Jian‐Ke (2021). A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase. Journal of Thrombosis and Haemostasis, 19 (3), 689-700. doi: 10.1111/jth.15209
Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch Pilkington, Rowan L., Dallaston, Madeleine A., Savage, G. Paul, Williams, Craig M. and Polyzos, Anastasios (2021). Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch. Reaction Chemistry and Engineering, 6 (3), 486-493. doi: 10.1039/d0re00442a
Corrigendum to: Ranking Oxidant Sensitiveness: A Guide for Synthetic Utility (Chemistry – A European Journal, (2019), 25, 41, (9614-9618), 10.1002/chem.201902036) Dallaston, Madeleine A., Bettencourt, Christian J., Chow, Sharon, Gebhardt, Joshua, Spangler, Jordan, Johnston, Martin R., Wall, Craig, Brusnahan, Jason S. and Williams, Craig M. (2020). Corrigendum to: Ranking Oxidant Sensitiveness: A Guide for Synthetic Utility (Chemistry – A European Journal, (2019), 25, 41, (9614-9618), 10.1002/chem.201902036). Chemistry - A European Journal, 26 (59) chem.202004223, 13532-13532. doi: 10.1002/chem.202004223
Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials Tse, Edwin G., Houston, Sevan D., Williams, Craig M., Savage, G. Paul, Rendina, Louis M., Hallyburton, Irene, Anderson, Mark, Sharma, Raman, Walker, Gregory S., Obach, R. Scott and Todd, Matthew H. (2020). Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials. Journal of Medicinal Chemistry, 63 (20) acs.jmedchem.0c00746, 11585-11601. doi: 10.1021/acs.jmedchem.0c00746
Synthetic tigliane intermediates engage thiols to induce potent cell line selective anti‐cancer activity Chow, Sharon, Krainz, Tanja, Bettencourt, Christian J., Broit, Natasa, Ferguson, Blake, Zhu, Mingzhao, Hull, Kenneth G., Pierens, Gregory K., Bernhardt, Paul V., Parsons, Peter G., Romo, Daniel, Boyle, Glen M. and Williams, Craig M. (2020). Synthetic tigliane intermediates engage thiols to induce potent cell line selective anti‐cancer activity. Chemistry: A European Journal, 26 (59) chem.202003221, 13372-13377. doi: 10.1002/chem.202003221
Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229
Squaramides as bioisosteres in contemporary drug design Agnew-Francis, Kylie A. and Williams, Craig M. (2020). Squaramides as bioisosteres in contemporary drug design. Chemical Reviews, 120 (20) acs.chemrev.0c00416, 11616-11650. doi: 10.1021/acs.chemrev.0c00416
EBC‐232 and 323: a structural conundrum necessitating unification of five in silico prediction and elucidation methods Maslovskaya, Lidia A., Savchenko, Andrei I., Krenske, Elizabeth H., Chow, Sharon, Holt, Tina, Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G., Boyle, Glen M., Kutateladze, Andrei G. and Williams, Craig M. (2020). EBC‐232 and 323: a structural conundrum necessitating unification of five in silico prediction and elucidation methods. Chemistry – A European Journal, 26 (51) chem.202001884, 11862-11867. doi: 10.1002/chem.202001884
Cubane, Bicyclo[1.1.1]pentane and Bicyclo[2.2.2]octane: Impact and Thermal Sensitiveness of Carboxyl-, Hydroxymethyl- and Iodo-substituents Dallaston, Madeleine A., Houston, Sevan D. and Williams, Craig M. (2020). Cubane, Bicyclo[1.1.1]pentane and Bicyclo[2.2.2]octane: Impact and Thermal Sensitiveness of Carboxyl-, Hydroxymethyl- and Iodo-substituents. Chemistry - A European Journal, 26 (52) chem.202001658, 11966-11970. doi: 10.1002/chem.202001658
Structures of fungal and plant acetohydroxyacid synthases Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3
Cubane chirality via substitution of a “hidden” regular tetrahedron Yoshino, Nana, Kato, Yumi, Mabit, Thibaud, Nagata, Yuuya, Williams, Craig M., Harada, Mei, Muranaka, Atsuya, Uchiyama, Masanobu and Matsubara, Seijiro (2020). Cubane chirality via substitution of a “hidden” regular tetrahedron. Organic Letters, 22 (11) acs.orglett.0c01142, 4083-4087. doi: 10.1021/acs.orglett.0c01142
Kalparinol, a Salvialane (Isodaucane) sesquiterpenoid derived from native Australian dysphania species that suggests a putative biogenetic link to zerumbone Tan, Yuen Ping, Savchenko, Andrei I., Agnew-Francis, Kylie A., Boyle, Glen M., Bernhardt, Paul V., Fraser, James A. and Williams, Craig M. (2020). Kalparinol, a Salvialane (Isodaucane) sesquiterpenoid derived from native Australian dysphania species that suggests a putative biogenetic link to zerumbone. Journal of Natural Products, 83 (5) acs.jnatprod.9b01039, 1473-1479. doi: 10.1021/acs.jnatprod.9b01039
EBC-342: A novel tetrahydrofuran moiety containing casbane from the Australian rainforest Maslovskaya, Lidia A., Savchenko, Andrei I., Krenske, Elizabeth H., Chow, Sharon, Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G., Boyle, Glen M. and Williams, Craig M. (2020). EBC-342: A novel tetrahydrofuran moiety containing casbane from the Australian rainforest. European Journal of Organic Chemistry, 2020 (8), 1042-1045. doi: 10.1002/ejoc.202000017
Humulene diepoxides from the Australian arid zone herb Dysphania: assignment of aged hops constituents Tan, Yuen Ping, Agnew‐Francis, Kylie A., Hofmann, Julian, Savchenko, Andrei I., Lafontaine, Scott R., Boyle, Glen M., Bernhardt, Paul V., Fraser, James A., Shellhammer, Thomas H. and Williams, Craig M. (2020). Humulene diepoxides from the Australian arid zone herb Dysphania: assignment of aged hops constituents. Chemistry: A European Journal, 26 (7) chem.201904420, 1653-1660. doi: 10.1002/chem.201904420
Rearrangement-free hydroxylation of methylcubanes by a cytochrome P450: the case for dynamical coupling of C–H abstraction and rebound Sarkar, Md. Raihan, Houston, Sevan D., Savage, G. Paul, Williams, Craig M., Krenske, Elizabeth H., Bell, Stephen G. and De Voss, James J. (2019). Rearrangement-free hydroxylation of methylcubanes by a cytochrome P450: the case for dynamical coupling of C–H abstraction and rebound. Journal of the American Chemical Society, 141 (50) jacs.9b08064, 19688-19699. doi: 10.1021/jacs.9b08064
En route to D-ring inverted phorbol esters Chow, Sharon, Krainz, Tanja, Bernhardt, Paul V. and Williams, Craig M. (2019). En route to D-ring inverted phorbol esters. Organic Letters, 21 (21) acs.orglett.9b03379, 8761-8764. doi: 10.1021/acs.orglett.9b03379
Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon Tan, Yuen P., Xue, Yongbo, Savchenko, Andrei I., Houston, Sevan D., Modhiran, Naphak, McMillan, Christopher L. D., Boyle, Glen M., Bernhardt, Paul V., Young, Paul R., Watterson, Daniel and Williams, Craig M. (2019). Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon. Journal of Natural Products, 82 (10) acs.jnatprod.9b00522, 2828-2834. doi: 10.1021/acs.jnatprod.9b00522
1,4-Diazacubane crystal structure rectified as piperazinium Arachchige, Kasun S. Athukorala, Fahrenhorst-Jones, Tyler, Burns, Jed M., AL-Fayaad, Hydar A., Behera, Jogendra N., Rao, C. N. R., Clegg, Jack K. and Williams, Craig M. (2019). 1,4-Diazacubane crystal structure rectified as piperazinium. Chemical Communications, 55 (78), 11751-11753. doi: 10.1039/c9cc06272f
Contemplating 1,2,4-thiadiazole-inspired cyclic peptide mimics: a computational investigation Xie, Sida, Bernhardt, Paul V., Gahan, Lawrence R. and Williams, Craig M. (2019). Contemplating 1,2,4-thiadiazole-inspired cyclic peptide mimics: a computational investigation. Australian Journal of Chemistry, 72 (11), 894-899. doi: 10.1071/CH19248
Ranking oxidant sensitiveness: a guide for synthetic utility Dallaston, Madeleine A., Bettencourt, Christian J., Chow, Sharon, Gebhardt, Joshua, Spangler, Jordan, Johnston, Martin R., Wall, Craig, Brusnahan, Jason S. and Williams, Craig M. (2019). Ranking oxidant sensitiveness: a guide for synthetic utility. Chemistry - A European Journal, 25 (41), 9614-9618. doi: 10.1002/chem.201902036
The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement Houston, Sevan D., Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A., Sykes, Melissa L., Stok, Jeanette E., Farfan Soto, Clementina, Burns, Jed M., Bernhardt, Paul V., De Voss, James J., Boyle, Glen M., Smith, Maree T., Tsanaktsidis, John, Savage, G. Paul, Avery, Vicky M. and Williams, Craig M. (2019). The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic and Biomolecular Chemistry, 17 (28), 6790-6798. doi: 10.1039/c9ob01238a
Thermal and sensitiveness determination of cubanes: towards cubane‐based fuels for infrared countermeasures Dallaston, Madeleine A., Brusnahan, Jason S., Wall, Craig and Williams, Craig M. (2019). Thermal and sensitiveness determination of cubanes: towards cubane‐based fuels for infrared countermeasures. Chemistry: A European Journal, 25 (35) chem.201901086, 8344-8352. doi: 10.1002/chem.201901086
Determining the necessity of phenyl ring π-character in warfarin Xing, Hui, Houston, Sevan D., Chen, Xuejie, Jin, Da-Yun, Savage, G. Paul, Tie, Jian-Ke and Williams, Craig M. (2019). Determining the necessity of phenyl ring π-character in warfarin. Bioorganic and Medicinal Chemistry Letters, 29 (15), 1954-1956. doi: 10.1016/j.bmcl.2019.05.039
Reassignments and corroborations of oxo‐bridged natural products directed by OSE and DU8+ NMR computation Kutateladze, Andrei G., Krenske, Elizabeth H. and Williams, Craig M. (2019). Reassignments and corroborations of oxo‐bridged natural products directed by OSE and DU8+ NMR computation. Angewandte Chemie, 131 (21) ange.201902777, 7181-7186. doi: 10.1002/ange.201902777
Nitric oxide modulates μ‐opioid receptor function in vitro Huang, Lillian, Wyse, Bruce D., Williams, Craig M. and Smith, Maree T. (2019). Nitric oxide modulates μ‐opioid receptor function in vitro. Clinical and Experimental Pharmacology and Physiology, 46 (7) 1440-1681.13091, 676-685. doi: 10.1111/1440-1681.13091
Stachyonic acid: a dengue virus inhibitor from Basilicum polystachyon Tan, Yuen P., Houston, Sevan D., Modhiran, Naphak, Savchenko, Andrei I., Boyle, Glen M., Young, Paul R., Watterson, Daniel and Williams, Craig M. (2019). Stachyonic acid: a dengue virus inhibitor from Basilicum polystachyon. Chemistry – A European Journal, 25 (22) chem.201900591, 5664-5667. doi: 10.1002/chem.201900591
Cyclooctatetraene: a bioactive cubane paradigm complement Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst-Jones, Tyler, Kuo, Andy, Murray, Cody-Ellen P., Conn, Kyna-Anne, Jaeschke, Kara N., Jin, Da-Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian-Ke and Williams, Craig M. (2019). Cyclooctatetraene: a bioactive cubane paradigm complement. Chemistry: A European Journal, 25 (11), 2729-2734. doi: 10.1002/chem.201806277
Cubanes in medicinal chemistry Reekie, Tristan A., Williams, Craig M., Rendina, Louis M. and Kassiou, Michael (2019). Cubanes in medicinal chemistry. Journal of Medicinal Chemistry, 62 (3) acs.jmedchem.8b00888, 1078-1095. doi: 10.1021/acs.jmedchem.8b00888
Enantioselective synthesis of (R)-2-cubylglycine including unprecedented rhodium mediated C–H insertion of cubane Houston, Sevan D., Chalmers, Benjamin A., Savage, G. Paul and Williams, Craig M. (2019). Enantioselective synthesis of (R)-2-cubylglycine including unprecedented rhodium mediated C–H insertion of cubane. Organic & Biomolecular Chemistry, 17 (5), 1067-1070. doi: 10.1039/c8ob02959h
New Halimanes from the Australian rainforest plant Croton Insularis Maslovskaya, Lidia A., Savchenko, Andrei I., Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Boyle, Glen M., Parsons, Peter G. and Williams, Craig M. (2019). New Halimanes from the Australian rainforest plant Croton Insularis. European Journal of Organic Chemistry, 2019 (5), 1058-1060. doi: 10.1002/ejoc.201801548
Cyclooctatetraenes through valence isomerization of cubanes: scope and limitations Houston, Sevan D., Xing, Hui, Bernhardt, Paul V., Vanden Berg, Timothy J., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2019). Cyclooctatetraenes through valence isomerization of cubanes: scope and limitations. Chemistry: A European Journal, 25 (11), 2735-2739. doi: 10.1002/chem.201805124
New casbanes and the first trans‐cyclopropane seco‐casbane from the Australian rainforest plant croton insularis Maslovskaya, Lidiya A., Savchenko, Andrei I., Pierce, Carly J., Boyle, Glen M., Gordon, Victoria A., Reddell, Paul W., Parsons, Peter G. and Williams, Craig M. (2019). New casbanes and the first trans‐cyclopropane seco‐casbane from the Australian rainforest plant croton insularis. Chemistry - A European Journal, 25 (6), 1525-1534. doi: 10.1002/chem.201804904
Synthesis of the seco-limonoid BCD ring system identifies a Hsp90 chaperon machinery (p23) inhibitor Pinkerton, David M., Chow, Sharon, Eisa, Nada H., Kainth, Kashish, Vanden Berg, Timothy J., Burns, Jed M., Guddat, Luke W., Savage, G. Paul, Chadli, Ahmed and Williams, Craig M. (2019). Synthesis of the seco-limonoid BCD ring system identifies a Hsp90 chaperon machinery (p23) inhibitor. Chemistry - A European Journal, 25 (6), 1451-1455. doi: 10.1002/chem.201805420
A protocol for an iodine-metal exchange reaction on cubane using lithium organozincates Kato, Yumi, Williams, Craig M., Uchiyama, Masanobu and Matsubara, Seijiro (2019). A protocol for an iodine-metal exchange reaction on cubane using lithium organozincates. Organic Letters, 21 (2), 473-475. doi: 10.1021/acs.orglett.8b03721
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research McAlpine, James B., Chen, Shao-Nong, Kutateladze, Andrei, MacMillan, John B., Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A., Biavatti, Maique W., Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S., Capon, Robert J., Choi, Young H., Coppage, David, Crews, Phillip, Crimmins, Michael T., Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M., Garson, Mary J., Genta-Jouve, Grégory, Gerwick, William H., Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M., Hunter, Luke, Jeannerat, Damien, Ji, Nai-Yun ... Pauli, Guido F. (2019). Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36 (1), 248-249. doi: 10.1039/c8np90041h
Cover Feature: Hydrogen-Bonding Interactions in the Ley-Griffith Oxidation: Practical Considerations for the Synthetic Chemist (Eur. J. Org. Chem. 2-3/2019) Moore, Peter W., Zerk, Timothy J., Burns, Jed M., Bernhardt, Paul V. and Williams, Craig M. (2018). Cover Feature: Hydrogen-Bonding Interactions in the Ley-Griffith Oxidation: Practical Considerations for the Synthetic Chemist (Eur. J. Org. Chem. 2-3/2019). European Journal of Organic Chemistry, 2019 (2-3), 230-230. doi: 10.1002/ejoc.201801822
Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A. and Guddat, Luke W. (2018). Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proceedings of the National Academy of Sciences of the United States of America, 115 (41), E9649-E9658. doi: 10.1073/pnas.1809422115
Hydrogen-bonding interactions in the Ley-Griffith oxidation: practical considerations for the synthetic chemist Moore, Peter W., Zerk, Timothy J., Burns, Jed M., Bernhardt, Paul V. and Williams, Craig M. (2018). Hydrogen-bonding interactions in the Ley-Griffith oxidation: practical considerations for the synthetic chemist. European Journal of Organic Chemistry, 2019 (2-3), 303-308. doi: 10.1002/ejoc.201800860
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research McAlpine, James B., Chen, Shao-Nong, Kutateladze, Andrei, MacMillan, John B., Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A., Biavatti, Maique W., Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S., Capon, Robert J., Choi, Young H., Coppage, David, Crews, Phillip, Crimmins, Michael T., Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M., Garson, Mary J., Genta-Jouve, Grégory, Gerwick, William H., Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M., Hunter, Luke, Jeannerat, Damien, Ji, Nai-Yun ... Pauli, Guido F. (2018). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36 (1), 35-107. doi: 10.1039/c7np00064b
Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675) Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161
Developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer Xie, Sida, Savchenko, Andrei I., Krenske, Elizabeth H., Grange, Rebecca L., Gahan, Lawrence R. and Williams, Craig M. (2018). Developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer. European Journal of Organic Chemistry, 2018 (25), 3265-3270. doi: 10.1002/ejoc.201800449
Front cover: developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer (Eur. J. Org. Chem. /2018) Xie, Sida, Savchenko, Andrei I., Krenske, Elizabeth H., Grange, Rebecca L., Gahan, Lawrence R. and Williams, Craig M. (2018). Front cover: developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer (Eur. J. Org. Chem. /2018). European Journal of Organic Chemistry, 2018 (25), 3246-3246. doi: 10.1002/ejoc.201800902
Heteroatom-Interchanged Isomers of Lissoclinamide 5: Copper(II) Complexation, Halide Binding, and Biological Activity Xie, Sida, Savchenko, Andrei I., Kerscher, Marion, Grange, Rebecca L., Krenske, Elizabeth H., Harmer, Jeffrey R., Bauer, Michelle J., Broit, Natasa, Watters, Dianne J., Boyle, Glen M., Bernhardt, Paul V., Parsons, Peter G., Comba, Peter, Gahan, Lawrence R. and Williams, Craig M. (2018). Heteroatom-Interchanged Isomers of Lissoclinamide 5: Copper(II) Complexation, Halide Binding, and Biological Activity. European Journal of Organic Chemistry, 2018 (12), 1465-1476. doi: 10.1002/ejoc.201701659
ATP3 and MTP3: easily prepared stable perruthenate salts for oxidation applications in synthesis Moore, Peter W., Read, Christopher D. G., Bernhardt, Paul V. and Williams, Craig M. (2018). ATP3 and MTP3: easily prepared stable perruthenate salts for oxidation applications in synthesis. Chemistry: A European Journal, 24 (18), 4556-4561. doi: 10.1002/chem.201800531