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个人简介

Craig M. Williams was born in Adelaide, Australia. He received his B.Sc. (Hons) degree in chemistry in 1994 from Flinders University. In 1997, he was awarded his Ph.D. in organic chemistry from the same institution under the supervision of Professor Rolf H. Prager. He undertook post-doctoral studies as an Alexander von Humboldt Fellow working with Professor Armin de Meijere at the Georg-August-Universität, Göttingen, Germany, from 1997 to 1999. In early 1999, he accepted a second post-doctoral fellowship at the Australian National University with Professor Lewis N. Mander. Professor Williams has held an academic position at the University of Queensland since 2000, and during this time has won a number of awards including a Thieme Chemistry Journals Award in 2007, an Australian Research Council Future Fellowship award in 2011, and the Award for Outstanding Contribution to Research (SCMB, UQ, 2019).

研究领域

The Williams research group explores numerous interests within the discipline of organic chemistry (e.g. medicinal chemistry, fundamental molecules, natural productisolation, microelectronics, drug and agrichemical development, impact sensitive molecules) enabled by organic synthesis refined through the construction of biologically active complex natural products (diterpenes, polyketides, alkaloids), and designs synthetic methodology to assist in this endeavour (synthetic transformations and reagents). Professor Williams especially enjoys teaching whole molecule retrosynthesis to undergraduate and post-graduate students.

近期论文

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Crystal Structure of the Commercial Herbicide, Amidosulfuron, in Complex with Arabidopsis thaliana Acetohydroxyacid Synthase Cheng, Yan, Lonhienne, Thierry, Garcia, Mario. D., Williams, Craig M., Schenk, Gerard and Guddat, Luke W. (2023). Crystal Structure of the Commercial Herbicide, Amidosulfuron, in Complex with Arabidopsis thaliana Acetohydroxyacid Synthase. Journal of Agricultural and Food Chemistry, 71 (13), 5117-5126. doi: 10.1021/acs.jafc.2c08528 Kinetico-Mechanistic Studies on a Reactive Organocopper(II) Complex: Cu–C Bond Homolysis versus Heterolysis Gonzálvez, Miguel A., Williams, Craig M., Martínez, Manuel and Bernhardt, Paul V. (2023). Kinetico-Mechanistic Studies on a Reactive Organocopper(II) Complex: Cu–C Bond Homolysis versus Heterolysis. Inorganic Chemistry, 62 (11), 4662-4671. doi: 10.1021/acs.inorgchem.3c00127 Multitargeted Opioid Ligand Discovery as a Strategy to Retain Analgesia and Reduce Opioid-Related Adverse Effects Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2023). Multitargeted Opioid Ligand Discovery as a Strategy to Retain Analgesia and Reduce Opioid-Related Adverse Effects. Journal of Medicinal Chemistry, 66 (6), 3746-3784. doi: 10.1021/acs.jmedchem.2c01695 seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe)Xue, Yongbo, Savchenko, Andrei I., Agnew-Francis, Kylie A., Miles, Jared A., Holt, Tina, Lu, Hieng, Chow, Sharon, Forster, Paul I., Boyle, Glen M., Ross, Benjamin P., Fischer, Katja, Kutateladze, Andrei G. and Williams, Craig M. (2023). seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe). Journal of Natural Products, 86 (3), 490-497. doi: 10.1021/acs.jnatprod.2c01037 A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase Jin, Da-Yun, Chen, Xuejie, Liu, Yizhou, Williams, Craig M., Pedersen, Lars C., Stafford, Darrel W. and Tie, Jian-Ke (2023). A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase. Nature Communications, 14 (1) 828. doi: 10.1038/s41467-023-36446-8 Structural Reassignment of Two Polyenol Natural Products Kutateladze, Andrei G., Bates, Roderick W., Elyashberg, Mikhail and Williams, Craig M. (2023). Structural Reassignment of Two Polyenol Natural Products. European Journal of Organic Chemistry, 26 (9) e202201316. doi: 10.1002/ejoc.202201316 Chiral Auxiliary-Directed Site-Selective Deprotonation of the Cubane Skeleton Takebe, Hiyori, Yoshino, Nana, Shimada, Yukako, Williams, Craig M. and Matsubara, Seijiro (2023). Chiral Auxiliary-Directed Site-Selective Deprotonation of the Cubane Skeleton. Organic Letters, 25 (1), 27-30. doi: 10.1021/acs.orglett.2c03659 1-Azahomocubane Fahrenhorst-Jones, Tyler, Marshall, David L., Burns, Jed. M., Pierens, Gregory K., Hormann, Robert E., Fisher, Allison M., Bernhardt, Paul V., Blanksby, Stephen J., Savage, G. Paul, Eaton, Philip E. and Williams, Craig M. (2023). 1-Azahomocubane. Chemical Science, 14 (11), 2821-2825. doi: 10.1039/d3sc00001j Unearthing the Subtleties of Rhodium(II)-Catalyzed Carbenoid Cycloadditions to Furans with an N-Sulfonyl-1,2,3-triazole Probe Bettencourt, Christian J., Krainz, Tanja, Chow, Sharon, Parr, Brendan T., Tracy, William F., Bernhardt, Paul V., Davies, Huw M. L. and Williams, Craig M. (2022). Unearthing the Subtleties of Rhodium(II)-Catalyzed Carbenoid Cycloadditions to Furans with an N-Sulfonyl-1,2,3-triazole Probe. Organic Letters, 24 (50), 9290-9295. doi: 10.1021/acs.orglett.2c03869 Structural basis of resistance to herbicides that target acetohydroxyacid synthase Lonhienne, Thierry, Cheng, Yan, Garcia, Mario D., Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2022). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nature Communications, 13 (1) 3368, 3368. doi: 10.1038/s41467-022-31023-x Wasabi (Eutrema japonicum) Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats Thomaz, Fernanda Santos, Tan, Yuen P., Williams, Craig M., Ward, Leigh C., Worrall, Simon and Panchal, Sunil K. (2022). Wasabi (Eutrema japonicum) Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats. Foods, 11 (21) 3435, 3435. doi: 10.3390/foods11213435 Reassignment of improbable natural products identified through chemical principle screening Elyashberg, Mikhail, Novitskiy, Ivan M., Bates, Roderick W., Kutateladze, Andrei G. and Williams, Craig M. (2022). Reassignment of improbable natural products identified through chemical principle screening. European Journal of Organic Chemistry, 2022 (34) e202200572, 1-9. doi: 10.1002/ejoc.202200572 Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain Kong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic and Medicinal Chemistry, 69 116889, 1-10. doi: 10.1016/j.bmc.2022.116889 Photochemical generation of the 2-azabicyclo[4.2.0]octa-4,7-diene skeleton Fahrenhorst-Jones, Tyler, Savage, G. Paul and Williams, Craig M. (2022). Photochemical generation of the 2-azabicyclo[4.2.0]octa-4,7-diene skeleton. Australian Journal of Chemistry, 75 (11), 884-887. doi: 10.1071/ch22139 Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development Shah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development. Frontiers in Plant Science, 13 909073. doi: 10.3389/fpls.2022.909073 Toward the total synthesis of alpkinidine: Michael addition to isoquinolinetrione CE ring-system synthons Buccini, Marco, Dhoro, Francis, Tham, Louisa, Skelton, Brian W., Williams, Craig M. and Piggott, Matthew J. (2022). Toward the total synthesis of alpkinidine: Michael addition to isoquinolinetrione CE ring-system synthons. ACS Omega, 7 (23), 19093-19105. doi: 10.1021/acsomega.2c02117 Toward the total synthesis of alpkinidine: synthesis of haloquinone CE ring system synthons and attempted nucleophilic bisannulation Buccini, Marco, Tham, Louisa, Dhoro, Francis, Skelton, Brian W., Williams, Craig M. and Piggott, Matthew J. (2022). Toward the total synthesis of alpkinidine: synthesis of haloquinone CE ring system synthons and attempted nucleophilic bisannulation. ACS Omega, 7 (23), 19080-19092. doi: 10.1021/acsomega.2c02116 Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K‐dependent carboxylation Chen, Xuejie, Furukawa, Natsuko, Jin, Da‐Yun, Liu, Yizhou, Stafford, Darrel W., Williams, Craig M., Suhara, Yoshitomo and Tie, Jian‐Ke (2022). Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K‐dependent carboxylation. The FEBS Journal, 289 (9), 2613-2627. doi: 10.1111/febs.16291 The (±)-6-Aza[1.0]triblattane skeleton: contraction beyond the Wilder–Culberson ring system Fahrenhorst-Jones, Tyler, Bernhardt, Paul V., Savage, G. Paul and Williams, Craig M. (2022). The (±)-6-Aza[1.0]triblattane skeleton: contraction beyond the Wilder–Culberson ring system. Organic Letters, 24 (3) acs.orglett.1c04240, 903-906. doi: 10.1021/acs.orglett.1c04240 Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2022). Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources. Journal of Medicinal Chemistry, 65 (3) acs.jmedchem.0c01915, 1612-1661. doi: 10.1021/acs.jmedchem.0c01915 Organocopper(II) complexes: new catalysts for carbon–carbon bond formation via electrochemical atom transfer radical addition (eATRA) Gonzálvez, Miguel A., Su, Chuyi, Williams, Craig M. and Bernhardt, Paul V. (2022). Organocopper(II) complexes: new catalysts for carbon–carbon bond formation via electrochemical atom transfer radical addition (eATRA). Chemical Science, 13 (35), 10506-10511. doi: 10.1039/d2sc03418b Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes Cullen, Jason K., Boyle, Glen M., Yap, Pei-Yi, Elmlinger, Stefan, Simmons, Jacinta L., Broit, Natasa, Johns, Jenny, Ferguson, Blake, Maslovskaya, Lidia A., Savchenko, Andrei I., Mirzayans, Paul Malek, Porzelle, Achim, Bernhardt, Paul V., Gordon, Victoria A., Reddell, Paul W., Pagani, Alberto, Appendino, Giovanni, Parsons, Peter G. and Williams, Craig M. (2021). Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes. Scientific Reports, 11 (1) 207, 207. doi: 10.1038/s41598-020-80397-9 Tandem oxidation-dehydrogenation of (hetero)arylated primary alcohols via perruthenate catalysis Bettencourt, Christian J., Chow, Sharon, Moore, Peter W., Read, Christopher D. G., Jiao, Yanxiao, Bakker, Jan Peter, Zhao, Sheng, Bernhardt, Paul V. and Williams, Craig M. (2021). Tandem oxidation-dehydrogenation of (hetero)arylated primary alcohols via perruthenate catalysis. Australian Journal of Chemistry, 74 (9), 652-659. doi: 10.1071/ch21137 Unmasking inherent chirality within the cubane skeleton Yoshino, Nana, Kato, Yumi, Shimada, Yukako, Williams, Craig M. and Matsubara, Seijiro (2021). Unmasking inherent chirality within the cubane skeleton. Israel Journal of Chemistry, 61 (7-8), 380-386. doi: 10.1002/ijch.202100013 Comprehensive computational investigation of the Barton–Kellogg reaction for both alkyl and aryl systems Burns, Jed M., Clark, Timothy and Williams, Craig M. (2021). Comprehensive computational investigation of the Barton–Kellogg reaction for both alkyl and aryl systems. The Journal of Organic Chemistry, 86 (11) acs.joc.1c00506, 1-14. doi: 10.1021/acs.joc.1c00506 Experimental and theoretical approaches for the development of 4H-Chromene derivatives as inhibitors of tyrosinase Canavieira, Luciana Morais, Brasil, Edikarlos Macedo, Silva, Thiago de Melo e, Borges, Rosivaldo dos Santos, Silva, José Rogério Araújo, Lameira, Jerônimo, Bernhardt, Paul V., Williams, Craig M. and Alves, Cláudio Nahum (2021). Experimental and theoretical approaches for the development of 4H-Chromene derivatives as inhibitors of tyrosinase. Molecular Simulation, 47 (9), 762-770. doi: 10.1080/08927022.2021.1926455 The future of retrosynthesis and synthetic planning: algorithmic, humanistic or the interplay? Williams, Craig M. and Dallaston, Madeleine A. (2021). The future of retrosynthesis and synthetic planning: algorithmic, humanistic or the interplay?. Australian Journal of Chemistry, 74 (5), 291-326. doi: 10.1071/ch20371 A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase Chen, Xuejie, Liu, Yizhou, Furukawa, Natsuko, Jin, Da‐Yun, Paul Savage, G., Stafford, Darrel W., Suhara, Yoshitomo, Williams, Craig M. and Tie, Jian‐Ke (2021). A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase. Journal of Thrombosis and Haemostasis, 19 (3), 689-700. doi: 10.1111/jth.15209 Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch Pilkington, Rowan L., Dallaston, Madeleine A., Savage, G. Paul, Williams, Craig M. and Polyzos, Anastasios (2021). Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch. Reaction Chemistry and Engineering, 6 (3), 486-493. doi: 10.1039/d0re00442a Corrigendum to: Ranking Oxidant Sensitiveness: A Guide for Synthetic Utility (Chemistry – A European Journal, (2019), 25, 41, (9614-9618), 10.1002/chem.201902036) Dallaston, Madeleine A., Bettencourt, Christian J., Chow, Sharon, Gebhardt, Joshua, Spangler, Jordan, Johnston, Martin R., Wall, Craig, Brusnahan, Jason S. and Williams, Craig M. (2020). Corrigendum to: Ranking Oxidant Sensitiveness: A Guide for Synthetic Utility (Chemistry – A European Journal, (2019), 25, 41, (9614-9618), 10.1002/chem.201902036). Chemistry - A European Journal, 26 (59) chem.202004223, 13532-13532. doi: 10.1002/chem.202004223 Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials Tse, Edwin G., Houston, Sevan D., Williams, Craig M., Savage, G. Paul, Rendina, Louis M., Hallyburton, Irene, Anderson, Mark, Sharma, Raman, Walker, Gregory S., Obach, R. Scott and Todd, Matthew H. (2020). Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials. Journal of Medicinal Chemistry, 63 (20) acs.jmedchem.0c00746, 11585-11601. doi: 10.1021/acs.jmedchem.0c00746 Synthetic tigliane intermediates engage thiols to induce potent cell line selective anti‐cancer activity Chow, Sharon, Krainz, Tanja, Bettencourt, Christian J., Broit, Natasa, Ferguson, Blake, Zhu, Mingzhao, Hull, Kenneth G., Pierens, Gregory K., Bernhardt, Paul V., Parsons, Peter G., Romo, Daniel, Boyle, Glen M. and Williams, Craig M. (2020). Synthetic tigliane intermediates engage thiols to induce potent cell line selective anti‐cancer activity. Chemistry: A European Journal, 26 (59) chem.202003221, 13372-13377. doi: 10.1002/chem.202003221 Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229 Squaramides as bioisosteres in contemporary drug design Agnew-Francis, Kylie A. and Williams, Craig M. (2020). Squaramides as bioisosteres in contemporary drug design. Chemical Reviews, 120 (20) acs.chemrev.0c00416, 11616-11650. doi: 10.1021/acs.chemrev.0c00416 EBC‐232 and 323: a structural conundrum necessitating unification of five in silico prediction and elucidation methods Maslovskaya, Lidia A., Savchenko, Andrei I., Krenske, Elizabeth H., Chow, Sharon, Holt, Tina, Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G., Boyle, Glen M., Kutateladze, Andrei G. and Williams, Craig M. (2020). EBC‐232 and 323: a structural conundrum necessitating unification of five in silico prediction and elucidation methods. Chemistry – A European Journal, 26 (51) chem.202001884, 11862-11867. doi: 10.1002/chem.202001884 Cubane, Bicyclo[1.1.1]pentane and Bicyclo[2.2.2]octane: Impact and Thermal Sensitiveness of Carboxyl-, Hydroxymethyl- and Iodo-substituents Dallaston, Madeleine A., Houston, Sevan D. and Williams, Craig M. (2020). Cubane, Bicyclo[1.1.1]pentane and Bicyclo[2.2.2]octane: Impact and Thermal Sensitiveness of Carboxyl-, Hydroxymethyl- and Iodo-substituents. Chemistry - A European Journal, 26 (52) chem.202001658, 11966-11970. doi: 10.1002/chem.202001658 Structures of fungal and plant acetohydroxyacid synthases Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3 Cubane chirality via substitution of a “hidden” regular tetrahedron Yoshino, Nana, Kato, Yumi, Mabit, Thibaud, Nagata, Yuuya, Williams, Craig M., Harada, Mei, Muranaka, Atsuya, Uchiyama, Masanobu and Matsubara, Seijiro (2020). Cubane chirality via substitution of a “hidden” regular tetrahedron. Organic Letters, 22 (11) acs.orglett.0c01142, 4083-4087. doi: 10.1021/acs.orglett.0c01142 Kalparinol, a Salvialane (Isodaucane) sesquiterpenoid derived from native Australian dysphania species that suggests a putative biogenetic link to zerumbone Tan, Yuen Ping, Savchenko, Andrei I., Agnew-Francis, Kylie A., Boyle, Glen M., Bernhardt, Paul V., Fraser, James A. and Williams, Craig M. (2020). Kalparinol, a Salvialane (Isodaucane) sesquiterpenoid derived from native Australian dysphania species that suggests a putative biogenetic link to zerumbone. Journal of Natural Products, 83 (5) acs.jnatprod.9b01039, 1473-1479. doi: 10.1021/acs.jnatprod.9b01039 EBC-342: A novel tetrahydrofuran moiety containing casbane from the Australian rainforest Maslovskaya, Lidia A., Savchenko, Andrei I., Krenske, Elizabeth H., Chow, Sharon, Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Parsons, Peter G., Boyle, Glen M. and Williams, Craig M. (2020). EBC-342: A novel tetrahydrofuran moiety containing casbane from the Australian rainforest. European Journal of Organic Chemistry, 2020 (8), 1042-1045. doi: 10.1002/ejoc.202000017 Humulene diepoxides from the Australian arid zone herb Dysphania: assignment of aged hops constituents Tan, Yuen Ping, Agnew‐Francis, Kylie A., Hofmann, Julian, Savchenko, Andrei I., Lafontaine, Scott R., Boyle, Glen M., Bernhardt, Paul V., Fraser, James A., Shellhammer, Thomas H. and Williams, Craig M. (2020). Humulene diepoxides from the Australian arid zone herb Dysphania: assignment of aged hops constituents. Chemistry: A European Journal, 26 (7) chem.201904420, 1653-1660. doi: 10.1002/chem.201904420 Rearrangement-free hydroxylation of methylcubanes by a cytochrome P450: the case for dynamical coupling of C–H abstraction and rebound Sarkar, Md. Raihan, Houston, Sevan D., Savage, G. Paul, Williams, Craig M., Krenske, Elizabeth H., Bell, Stephen G. and De Voss, James J. (2019). Rearrangement-free hydroxylation of methylcubanes by a cytochrome P450: the case for dynamical coupling of C–H abstraction and rebound. Journal of the American Chemical Society, 141 (50) jacs.9b08064, 19688-19699. doi: 10.1021/jacs.9b08064 En route to D-ring inverted phorbol esters Chow, Sharon, Krainz, Tanja, Bernhardt, Paul V. and Williams, Craig M. (2019). En route to D-ring inverted phorbol esters. Organic Letters, 21 (21) acs.orglett.9b03379, 8761-8764. doi: 10.1021/acs.orglett.9b03379 Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon Tan, Yuen P., Xue, Yongbo, Savchenko, Andrei I., Houston, Sevan D., Modhiran, Naphak, McMillan, Christopher L. D., Boyle, Glen M., Bernhardt, Paul V., Young, Paul R., Watterson, Daniel and Williams, Craig M. (2019). Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon. Journal of Natural Products, 82 (10) acs.jnatprod.9b00522, 2828-2834. doi: 10.1021/acs.jnatprod.9b00522 1,4-Diazacubane crystal structure rectified as piperazinium Arachchige, Kasun S. Athukorala, Fahrenhorst-Jones, Tyler, Burns, Jed M., AL-Fayaad, Hydar A., Behera, Jogendra N., Rao, C. N. R., Clegg, Jack K. and Williams, Craig M. (2019). 1,4-Diazacubane crystal structure rectified as piperazinium. Chemical Communications, 55 (78), 11751-11753. doi: 10.1039/c9cc06272f Contemplating 1,2,4-thiadiazole-inspired cyclic peptide mimics: a computational investigation Xie, Sida, Bernhardt, Paul V., Gahan, Lawrence R. and Williams, Craig M. (2019). Contemplating 1,2,4-thiadiazole-inspired cyclic peptide mimics: a computational investigation. Australian Journal of Chemistry, 72 (11), 894-899. doi: 10.1071/CH19248 Ranking oxidant sensitiveness: a guide for synthetic utility Dallaston, Madeleine A., Bettencourt, Christian J., Chow, Sharon, Gebhardt, Joshua, Spangler, Jordan, Johnston, Martin R., Wall, Craig, Brusnahan, Jason S. and Williams, Craig M. (2019). Ranking oxidant sensitiveness: a guide for synthetic utility. Chemistry - A European Journal, 25 (41), 9614-9618. doi: 10.1002/chem.201902036 The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement Houston, Sevan D., Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A., Sykes, Melissa L., Stok, Jeanette E., Farfan Soto, Clementina, Burns, Jed M., Bernhardt, Paul V., De Voss, James J., Boyle, Glen M., Smith, Maree T., Tsanaktsidis, John, Savage, G. Paul, Avery, Vicky M. and Williams, Craig M. (2019). The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic and Biomolecular Chemistry, 17 (28), 6790-6798. doi: 10.1039/c9ob01238a Thermal and sensitiveness determination of cubanes: towards cubane‐based fuels for infrared countermeasures Dallaston, Madeleine A., Brusnahan, Jason S., Wall, Craig and Williams, Craig M. (2019). Thermal and sensitiveness determination of cubanes: towards cubane‐based fuels for infrared countermeasures. Chemistry: A European Journal, 25 (35) chem.201901086, 8344-8352. doi: 10.1002/chem.201901086 Determining the necessity of phenyl ring π-character in warfarin Xing, Hui, Houston, Sevan D., Chen, Xuejie, Jin, Da-Yun, Savage, G. Paul, Tie, Jian-Ke and Williams, Craig M. (2019). Determining the necessity of phenyl ring π-character in warfarin. Bioorganic and Medicinal Chemistry Letters, 29 (15), 1954-1956. doi: 10.1016/j.bmcl.2019.05.039 Reassignments and corroborations of oxo‐bridged natural products directed by OSE and DU8+ NMR computation Kutateladze, Andrei G., Krenske, Elizabeth H. and Williams, Craig M. (2019). Reassignments and corroborations of oxo‐bridged natural products directed by OSE and DU8+ NMR computation. Angewandte Chemie, 131 (21) ange.201902777, 7181-7186. doi: 10.1002/ange.201902777 Nitric oxide modulates μ‐opioid receptor function in vitro Huang, Lillian, Wyse, Bruce D., Williams, Craig M. and Smith, Maree T. (2019). Nitric oxide modulates μ‐opioid receptor function in vitro. Clinical and Experimental Pharmacology and Physiology, 46 (7) 1440-1681.13091, 676-685. doi: 10.1111/1440-1681.13091 Stachyonic acid: a dengue virus inhibitor from Basilicum polystachyon Tan, Yuen P., Houston, Sevan D., Modhiran, Naphak, Savchenko, Andrei I., Boyle, Glen M., Young, Paul R., Watterson, Daniel and Williams, Craig M. (2019). Stachyonic acid: a dengue virus inhibitor from Basilicum polystachyon. Chemistry – A European Journal, 25 (22) chem.201900591, 5664-5667. doi: 10.1002/chem.201900591 Cyclooctatetraene: a bioactive cubane paradigm complement Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst-Jones, Tyler, Kuo, Andy, Murray, Cody-Ellen P., Conn, Kyna-Anne, Jaeschke, Kara N., Jin, Da-Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian-Ke and Williams, Craig M. (2019). Cyclooctatetraene: a bioactive cubane paradigm complement. Chemistry: A European Journal, 25 (11), 2729-2734. doi: 10.1002/chem.201806277 Cubanes in medicinal chemistry Reekie, Tristan A., Williams, Craig M., Rendina, Louis M. and Kassiou, Michael (2019). Cubanes in medicinal chemistry. Journal of Medicinal Chemistry, 62 (3) acs.jmedchem.8b00888, 1078-1095. doi: 10.1021/acs.jmedchem.8b00888 Enantioselective synthesis of (R)-2-cubylglycine including unprecedented rhodium mediated C–H insertion of cubane Houston, Sevan D., Chalmers, Benjamin A., Savage, G. Paul and Williams, Craig M. (2019). Enantioselective synthesis of (R)-2-cubylglycine including unprecedented rhodium mediated C–H insertion of cubane. Organic & Biomolecular Chemistry, 17 (5), 1067-1070. doi: 10.1039/c8ob02959h New Halimanes from the Australian rainforest plant Croton Insularis Maslovskaya, Lidia A., Savchenko, Andrei I., Gordon, Victoria A., Reddell, Paul W., Pierce, Carly J., Boyle, Glen M., Parsons, Peter G. and Williams, Craig M. (2019). New Halimanes from the Australian rainforest plant Croton Insularis. European Journal of Organic Chemistry, 2019 (5), 1058-1060. doi: 10.1002/ejoc.201801548 Cyclooctatetraenes through valence isomerization of cubanes: scope and limitations Houston, Sevan D., Xing, Hui, Bernhardt, Paul V., Vanden Berg, Timothy J., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2019). Cyclooctatetraenes through valence isomerization of cubanes: scope and limitations. Chemistry: A European Journal, 25 (11), 2735-2739. doi: 10.1002/chem.201805124 New casbanes and the first trans‐cyclopropane seco‐casbane from the Australian rainforest plant croton insularis Maslovskaya, Lidiya A., Savchenko, Andrei I., Pierce, Carly J., Boyle, Glen M., Gordon, Victoria A., Reddell, Paul W., Parsons, Peter G. and Williams, Craig M. (2019). New casbanes and the first trans‐cyclopropane seco‐casbane from the Australian rainforest plant croton insularis. Chemistry - A European Journal, 25 (6), 1525-1534. doi: 10.1002/chem.201804904 Synthesis of the seco-limonoid BCD ring system identifies a Hsp90 chaperon machinery (p23) inhibitor Pinkerton, David M., Chow, Sharon, Eisa, Nada H., Kainth, Kashish, Vanden Berg, Timothy J., Burns, Jed M., Guddat, Luke W., Savage, G. Paul, Chadli, Ahmed and Williams, Craig M. (2019). Synthesis of the seco-limonoid BCD ring system identifies a Hsp90 chaperon machinery (p23) inhibitor. Chemistry - A European Journal, 25 (6), 1451-1455. doi: 10.1002/chem.201805420 A protocol for an iodine-metal exchange reaction on cubane using lithium organozincates Kato, Yumi, Williams, Craig M., Uchiyama, Masanobu and Matsubara, Seijiro (2019). A protocol for an iodine-metal exchange reaction on cubane using lithium organozincates. Organic Letters, 21 (2), 473-475. doi: 10.1021/acs.orglett.8b03721 Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research McAlpine, James B., Chen, Shao-Nong, Kutateladze, Andrei, MacMillan, John B., Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A., Biavatti, Maique W., Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S., Capon, Robert J., Choi, Young H., Coppage, David, Crews, Phillip, Crimmins, Michael T., Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M., Garson, Mary J., Genta-Jouve, Grégory, Gerwick, William H., Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M., Hunter, Luke, Jeannerat, Damien, Ji, Nai-Yun ... Pauli, Guido F. (2019). Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36 (1), 248-249. doi: 10.1039/c8np90041h Cover Feature: Hydrogen-Bonding Interactions in the Ley-Griffith Oxidation: Practical Considerations for the Synthetic Chemist (Eur. J. Org. Chem. 2-3/2019) Moore, Peter W., Zerk, Timothy J., Burns, Jed M., Bernhardt, Paul V. and Williams, Craig M. (2018). Cover Feature: Hydrogen-Bonding Interactions in the Ley-Griffith Oxidation: Practical Considerations for the Synthetic Chemist (Eur. J. Org. Chem. 2-3/2019). European Journal of Organic Chemistry, 2019 (2-3), 230-230. doi: 10.1002/ejoc.201801822 Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A. and Guddat, Luke W. (2018). Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proceedings of the National Academy of Sciences of the United States of America, 115 (41), E9649-E9658. doi: 10.1073/pnas.1809422115 Hydrogen-bonding interactions in the Ley-Griffith oxidation: practical considerations for the synthetic chemist Moore, Peter W., Zerk, Timothy J., Burns, Jed M., Bernhardt, Paul V. and Williams, Craig M. (2018). Hydrogen-bonding interactions in the Ley-Griffith oxidation: practical considerations for the synthetic chemist. European Journal of Organic Chemistry, 2019 (2-3), 303-308. doi: 10.1002/ejoc.201800860 The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research McAlpine, James B., Chen, Shao-Nong, Kutateladze, Andrei, MacMillan, John B., Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A., Biavatti, Maique W., Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S., Capon, Robert J., Choi, Young H., Coppage, David, Crews, Phillip, Crimmins, Michael T., Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M., Garson, Mary J., Genta-Jouve, Grégory, Gerwick, William H., Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M., Hunter, Luke, Jeannerat, Damien, Ji, Nai-Yun ... Pauli, Guido F. (2018). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36 (1), 35-107. doi: 10.1039/c7np00064b Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675) Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161 Developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer Xie, Sida, Savchenko, Andrei I., Krenske, Elizabeth H., Grange, Rebecca L., Gahan, Lawrence R. and Williams, Craig M. (2018). Developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer. European Journal of Organic Chemistry, 2018 (25), 3265-3270. doi: 10.1002/ejoc.201800449 Front cover: developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer (Eur. J. Org. Chem. /2018) Xie, Sida, Savchenko, Andrei I., Krenske, Elizabeth H., Grange, Rebecca L., Gahan, Lawrence R. and Williams, Craig M. (2018). Front cover: developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer (Eur. J. Org. Chem. /2018). European Journal of Organic Chemistry, 2018 (25), 3246-3246. doi: 10.1002/ejoc.201800902 Heteroatom-Interchanged Isomers of Lissoclinamide 5: Copper(II) Complexation, Halide Binding, and Biological Activity Xie, Sida, Savchenko, Andrei I., Kerscher, Marion, Grange, Rebecca L., Krenske, Elizabeth H., Harmer, Jeffrey R., Bauer, Michelle J., Broit, Natasa, Watters, Dianne J., Boyle, Glen M., Bernhardt, Paul V., Parsons, Peter G., Comba, Peter, Gahan, Lawrence R. and Williams, Craig M. (2018). Heteroatom-Interchanged Isomers of Lissoclinamide 5: Copper(II) Complexation, Halide Binding, and Biological Activity. European Journal of Organic Chemistry, 2018 (12), 1465-1476. doi: 10.1002/ejoc.201701659 ATP3 and MTP3: easily prepared stable perruthenate salts for oxidation applications in synthesis Moore, Peter W., Read, Christopher D. G., Bernhardt, Paul V. and Williams, Craig M. (2018). ATP3 and MTP3: easily prepared stable perruthenate salts for oxidation applications in synthesis. Chemistry: A European Journal, 24 (18), 4556-4561. doi: 10.1002/chem.201800531

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