Hamad, Abdel R. - Johns Hopkins University

个人简介

Dr. Abdel R Hamad is an Associate Professor of Pathology and Medicine. Dr. Hamad earned his B.V.Sc and M.V.Sc in veterinary medicine from the University of Khartoum and his Ph.D in immunology from the University of Colorado Health Science Center. He completed his postdoctoral training here at Johns Hopkins University School of Medicine and joined the Faculty in 2002.

研究领域

Dr. Hamad’s research is focused on understanding pathophysiological roles of non-conventional immune lymphocytes in the regulation of autoimmunity, particularly type 1 diabetes (T1D), obesity and type 2 diabetes. He is also actively studying the role of non-conventional T cells in the regulation of immune responses to ischemia reperfusion injury (IRI).

近期论文

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Chunfa Jie, R Ahmed, ARA Hamad. Expression of unique gene signature distinguishes TCRαβ+/BCR+ dual expressers from CD3+CD14+ doublets. Cytometry Part A 101 (4), 283-289 –published April 2022. doi: 10.1002/cyto.a.24542 Rizwan Ahmed, Kusuma Ananth, Zahra Omidian, Neha Majety, Hao Zhang, Abdel Rahim A Hamad. Detection, sorting, and immortalization of dual expresser lymphocytes from human peripheral blood samples. STAR protocols 2 (4), 100925- December 2021. doi: 10.1016/j.xpro.2021.100925. Jaiswal AK, Sadasivam M, Aja S, Hamad ARA. Lack of Syndecan-1 produces significant alterations in whole-body composition, metabolism and glucose homeostasis in mice. World J Diabetes. 2020 Apr 15;11(4):126-136. doi: 10.4239/wjd.v11.i4.126. Gong J, Noel S, Hsu J, Bush EL, Arend LJ, Sadasivam M, Lee SA, Kurzhagen JT, Hamad ARA, Rabb H. TCR+CD4-CD8- (double negative) T cells protect from cisplatin-induced renal epithelial cell apoptosis and acute kidney injury. Am J Physiol Renal Physiol. 2020 Apr 13;. doi: 10.1152/ajprenal.00033.2020. Gharaie Fathabad S, Kurzhagen JT, Sadasivam M, Noel S, Bush E, Hamad ARA, Rabb H. T Lymphocytes in Acute Kidney Injury and Repair. Semin Nephrol. 2020 Mar;40(2):114-125. doi: 10.1016/j.semnephrol.2020.01.003. Review Lee SA, Noel S, Kurzhagen JT, Sadasivam M, Pierorazio PM, Arend LJ, Hamad AR, Rabb H. CD4+ T Cell-Derived NGAL Modifies the Outcome of Ischemic Acute Kidney Injury. J Immunol. 2020 Feb 1;204(3):586-595. doi: 10.4049/jimmunol.1900677. Sadasivam M, Noel S, Rabb H, Hamad ARA. Renal double negative T cells: increasing importance in health and disease. Ann Transl Med. 2020 Feb;8(4):143. doi: 10.21037/atm.2019.11.51. Giwa AM, Ahmed R, Omidian Z, Majety N, Karakus KE, Omer SM, Donner T, Hamad ARA. Current understandings of the pathogenesis of type 1 diabetes: Genetics to environment. World J Diabetes. 2020 Jan 15;11(1):13-25. doi: 10.4239/wjd.v11.i1.13. Review Hsu J, Krishnan A, Lee SA, Dodd-O JM, Kim BS, Illei P, Yarnoff K, Hamad AA, Rabb H, Bush EL. CD3+CD4-CD8- Double-negative αβ T cells attenuate lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2019 Nov 2;. doi: 10.1016/j.jtcvs.2019.09.188. Hamad ARA, Sadasivam M, Rabb H. Hybrid lipids, peptides, and lymphocytes: new era in type 1 diabetes research. J Clin Invest. 2019 Aug 5;130:3527-3529. doi: 10.1172/JCI130313. Ahmed R, Omidian Z, Giwa A, Cornwell B, Majety N, Bell DR, Lee S, Zhang H, Michels A, Desiderio S, Sadegh-Nasseri S, Rabb H, Gritsch S, Suva ML, Cahan P, Zhou R, Jie C, Donner T, Hamad ARA. A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen. 2019 May 30;177(6):1583-1599.e16. doi: 10.1016/j.cell.2019.05.007. Omidian Z, Ahmed R, Giwa A, Donner T, Hamad ARA. IL-17 and limits of success. Cell Immunol. 2019 May;339:33-40. doi: 10.1016/j.cellimm.2018.09.001. Epub 2018 Sep 17. Review. Sadasivam M, Noel S, Lee SA, Gong J, Allaf ME, Pierorazio P, Rabb H, Hamad ARA. Activation and Proliferation of PD-1+ Kidney Double-Negative T Cells Is Dependent on Nonclassical MHC Proteins and IL-2. J Am Soc Nephrol. 2019 Feb;30(2):277-292. doi: 10.1681/ASN.2018080815. Gong J, Noel S, Pluznick JL, Hamad ARA, Rabb H. Gut Microbiota-Kidney Cross-Talk in Acute Kidney Injury. Semin Nephrol. 2019 Jan;39(1):107-116. doi: 10.1016/j.semnephrol.2018.10.009. Review.