吴基培 - 香港中文大学

个人简介

Education 1990-1993 D.Phil. in Chemistry Balliol College, University of Oxford 1988-1990 M.Phil. in Chemistry The Chinese University of Hong Kong 1984-1988 B.Sc. (Hons.) in Chemistry, First Class Chung Chi College, The Chinese University of Hong Kong Positions Since 2002 Professor, Department of Chemistry, The Chinese University of Hong Kong Since 2002 Warden, Pentecostal Mission Hall Complex (High Block) Chung Chi College, The Chinese University of Hong Kong 2017-2021 Pro-Vice-Chancellor/Vice-President, The Chinese University of Hong Kong 2019-2020 Acting University Dean of Students, The Chinese University of Hong Kong 2011-2017 Associate Vice-President, The Chinese University of Hong Kong 2009-2017 University Dean of Students, The Chinese University of Hong Kong 2004-2008 Associate Dean (Student Affairs), Faculty of Science, The Chinese University of Hong Kong 2002-2005 Part-Time Professor, Fuzhou University, China 2001-2004 Associate Director, Applied Chemistry with Management Studies Programme, The Chinese University of Hong Kong 1997-2000 Part-Time Lecturer, School of Pharmacy, The Chinese University of Hong Kong 1994-2002 Lecturer in Chemistry, The Chinese University of Hong Kong 1993-1994 Research Fellow in Chemistry, California Institute of Technology, USA

研究领域

Our current research interests lie in the chemistry of various functional dyes, particularly phthalocyanines and boron dipyrromethene derivatives, focusing on their synthesis, supramolecular chemistry, bioconjugation, bioorthogonal chemistry and applications in photodynamic therapy, photothermal therapy, bioimaging, fluorescence sensing, logic devices and renewable energy production. The ongoing projects include: A. Design and preparation of multifunctional molecular and nano-photoresponsive agents for targeted phototherapies B. Use of supramolecular and bioorthogonal chemistry for advanced theranostic applications C. Development of efficient peptide and protein conjugation methods D. Development of molecular-based fluorescent sensors and logic devices E. Synthetic studies and applications of low-symmetry phthalocyanines F. Exploration of phthalocyanine-based materials for CO2 fixation, water splitting and batteries

近期论文

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“Dual Cathepsin B and Glutathione-Activated Dimeric and Trimeric Phthalocyanine-Based Photodynamic Molecular Beacons for Targeted Photodynamic Therapy”, L. K. B. Tam, L. Yu, R. C. H. Wong, W.-P. Fong, D. K.P. Ng* and P.-C. Lo,* J. Med. Chem., 2021, 64, 17455-17467. “Glutathione-Degradable Polydopamine Nanoparticles as a Versatile Platform for Fabrication of Advanced Photosensitizers for Anticancer Therapy”, G. Dai, C. K.K. Choi, C. H. J. Choi, W.-P. Fong and D. K. P. Ng,* Biomater. Sci., 2022, 10,189-201. “A Self-Assembled Subphthalocyanine-Based Nanophotosensitiser for Photodynamic Therapy”, N. M. Casellas, G. Dai, E. Y. Xue, A. Fonseca, D. K. P.Ng,* M. García-Iglesias* and T. Torres,* Chem. Commun., 2022, 58, 669-672. “Site-Specific Displacement-Driven Activation of Supramolecular Photosensitizing Nanoassemblies for Antitumoral Photodynamic Therapy”, E. Y.Xue, C. Yang, W.-P. Fong and D. K. P. Ng,* ACS Appl. Mater. Interfaces, 2022,14, 14903-14915. “Comparison of the In Vitro Photodynamic Activity of the C1 and C1 Anomers of a Glucosylated Boron Dipyrromethene”, J. Xiong, K.-W. Yeung, C. T.T. Wong, W.-P. Fong* and Dennis K. P. Ng,* Colorants, 2022, 1, 193-207. “[3+1] Mixed Cyclization: A Synthetic Route to Prepare Low-Symmetry Phthalocyanines”, J. Y. M. Chan and D. K. P. Ng,* J. Org. Chem., 2022, 87,7213-7218. “Porphyrin-Based Supramolecular Nanofibres as a Dynamic and Activatable Photosensitiser for Photodynamic Therapy”, N. M. Casellas, G. Dai, E. Y. Xue, M.J. Vicente-Arana, D. K. P. Ng,* T. Torres* and M. García-Iglesias,* Biomater.Sci., 2022, 10, 3259-3267. “Specific Activation of Photosensitizer with Extrinsic Enzyme for Precisive Photodynamic Therapy”, J. Xiong, J. C. H. Chu, W.-P. Fong, C. T. T. Wong* and D. K. P. Ng,* J. Am. Chem. Soc., 2022, 144, 10647-10658. “Phenanthrodiazaporphyrins: 1,10-Phenanthroline-Embedded Diazaporphyrin Analogues”, J. Y. M. Chan, Y. Okada, S. Yoshida, T. Kawata, N. Kobayashi* and D. K. P. Ng,* Bull. Chem. Soc. Jpn., 2022, 95, 1325-1331. “A Tumor-Targeting Dual-Stimuli-Activatable Photodynamic Molecular Beacon for Precise Photodynamic Therapy”, L. K. B. Tam, L. He, D. K. P. Ng,* P. C. K.Cheung and P.-C. Lo,* Chem. Eur. J., 2022, 28, e202201652. “A Tetrazine-Responsive Isonitrile-Caged Photosensitiser for Site-Specific Photodynamic Therapy”, J. Xiong, E. Y. Xue, Q. Wu, P.-C. Lo* and D. K. P.Ng,* J. Controlled Release, 2023, 353, 663-674. “Toward Precise Antitumoral Photodynamic Therapy Using a Dual ReceptorMediated Bioorthogonal Activation Approach”, J. C. H. Chu, C. T. T. Wong and D. K. P. Ng,* Angew. Chem. Int. Ed., 2023, 62, e202214473. “Synthesis, Cellular Uptake, and Photodynamic Activity of Oligogalactosyl Zinc(II) Phthalocyanines”, J. Xiong, E. Y. Xue and D. K. P. Ng,* ChemPlusChem,2023, 88, e202200285 with a front cover in that issue and a Cover Profile ine202200406. "Glycosylated BODIPY-Incorporated Pt(II) Metallacycles for Targeted and Synergistic Chemo-Photodynamic Therapy", G. Durán-Sampedro, E. Y. Xue, M.Moreno-Simoni, C. Paramio, T. Torres,* D. K. P. Ng* and G. de la Torre,* J. Med.Chem., 2023, 66, 3448-3459. “Sodium-Coordinated Polymeric Phthalocyanines as Stable High-Capacity Organic Anodes for Sodium-Ion Batteries”, J. Lee, Y. Kim, S. Park, K. H. Shin, G.Jang, M. J. Hwang, D. Kim, K.-A. Min, H. S. Park, B. Han,* D. K. P. Ng* and L.Y. S. Lee,* Energy Environ. Mater., 2023, 6, e12468. "Selective Photodynamic Eradication of Senescent Cells with a β-GalactosidaseActivated Photosensitiser", J. Xiong, Y.-K. Cheung, W.-P. Fong, C. T. T. Wong and Dennis K. P. Ng,* Chem. Commun., in press. “An Enzyme-Responsive Double-Locked Photodynamic Molecular Beacon for Targeted Photodynamic Anticancer Therapy”, L. K. B. Tam, J. C. H. Chu, C.Yang, P. C. K. Cheung, D. K. P. Ng* and P.-C. Lo,* J. Am. Chem. Soc., in press. "Polymeric Phthalocyanine-Based Nanosensitizers for Enhanced Photodynamic and Sonodynamic Therapies", S. Liu, J. Ma, E. Y. Xue, Y. Zheng, W. Song, D. K.P. Ng,* A. Wang* and N. Zheng,* Adv. Healthcare Mater., submitted. "Design and Synthesis of a NAD(P)H:quinone Oxidoreductase 1-Activatable Photosensitiser for Controlled Photodynamic Therapy", E. Y. Xue, F. Kang, Y. Zhou and D. K. P. Ng,* Chem. Commun., submitted.(257) "Assembling Artificial Photosynthetic Models in Water Using -CyclodextrinConjugated Phthalocyanines as Building Blocks", X.-F. Chen, H. B. Gobeze,Francis D’Souza* and Dennis K. P. Ng,* Chem. Eur. J., submitted.