Qing, Yujia - University of Oxford - Department of Chemistry

个人简介

Yujia graduated in 2012 with a BSc in Chemistry from the University of Sheffield. Later, she moved to the University of Oxford to complete her MSc in Pharmacology. In 2014, Yujia joined the group of Prof. Hagan Bayley where she completed a DPhil in Chemical Biology and then undertook postdoctoral research. In 2019, Yujia received the Reaxys PhD Prize and the Dream Chemistry Award. In 2020, Yujia started her Glasstone Research Fellowship in Science and joined Magdalen College as a Fellow by Examination. In 2022, Yujia was appointed as an Associate Professor of Organic Chemistry and Tutorial Fellow at Lady Margaret Hall.

研究领域

The investigation of chemistry at the single-molecule level provides reaction details that are masked in ensemble experiments. The use of engineered protein nanopores as nanoreactors allows individual bond-making and bond-breaking events to be monitored in real time, which modulate the voltage-driven ionic current through a pore. Yujia’s research focuses on studying single-molecule chemistry, particularly that of polymers, under nanopore confinement. The chemical insights gained at the molecular level has been applied to construct a mobile molecule, which can move biopolymers within a nanopore sensor for sequence analysis. In parallel, Yujia is interested in engineering protein nanoreactors to achieve vectorial catalysis.

近期论文

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Nanopore-based technologies beyond DNA sequencing.November 2022 | Journal article | Nature nanotechnology Enzyme-less DNA base identification by chemical stepping in a nanopore October 2021 | Journal article | Journal of the American Chemical Society Single‐molecule observation of intermediates in bioorthogonal 2‐cyanobenzothiazole chemistry August 2020 | Journal article | Angewandte Chemie (International ed. in English) Single‐molecule observation of intermediates in bioorthogonal 2‐cyanobenzothiazole chemistry August 2020 | Journal article | Angewandte Chemie Direct detection of molecular intermediates from first-passage times May 2020 | Journal article | Science Advances Catalytic site-selective substrate processing within a tubular nanoreactor November 2019 | Journal article | Nature Nanotechnology Single-molecule kinetics of growth and degradation of cell-penetrating poly(disulfide)s April 2019 | Journal article | Journal of the American Chemical Society Single-molecule observation of the intermediates in a catalytic cycle November 2018 | Journal article | Journal of the American Chemical Society Directional control of a processive molecular hopper August 2018 | Journal article | Science Single-molecule determination of the isomers of D-glucose and D-fructose that bind to boronic acids January 2018 | Journal article | Angewandte Chemie International Edition Bioorthogonal cycloadditions with sub-millisecond intermediates. January 2018 | Journal article | Angewandte Chemie International Edition Rates and stoichiometries of metal ion probes of cysteine residues within ion channels. July 2013 | Journal article | Biophysical journal