Qin, Tian - The University of Texas at Dallas

个人简介

Tian was born in Chongqing and grew up in Chengdu, China. He completed his undergraduate studies in chemistry at University of Science and Technology of China. In 2009, Tian relocated to Boston University, Boston, to begin his PhD with Prof. John Porco. Tian’s graduate work focused on synthesis of complex and bioactive natural products, particularly in tetrahydroxanthone family natural products. In 2015, after PhD graduation, Tian started his postdoctoral training in the laboratory of Prof. Phil Baran at Scripps Research focused on the development of synthetically useful radical cross couplings. Tian joined the faculty at UT Southwestern in September 2018, and Tian’s lab will focus on chemical synthesis concerning about efficiency and selectivity control.

研究领域

Synthetic organic chemistry enables the biomedical sciences and plays a crucial, irreplaceable role in drug development. Research in Qin's lab will focus on the development of novel synthetic transformations and strategies that will allow access to bioactive, complex natural products and efficient synthesis of pharmaceuticals and their derivatives.

近期论文

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Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates.Yang, Y.*; Tsien, J.*; Dykstra, R.; Chen, S.-J.; Merchant, R. R.; Hughes, J. M. E.; Peters, B. K.; Gutierrez, O.; Qin, T. Nat. Chem. 2023, ASAP. Control of the antitumour activity and specificity of CAR T cells via organic adapters covalently tethering the CAR to tumour cells. Stepanov, A. V.; Xie, J.; Zhu, Q.; Shen, Z.; Su, W.; Kuai, L.; Soll, R.; Shaver, G.; Douthit, L.; Zhang, D.; Kalinin, R.; Xiang, F.; Zhao, Y.; Qin, T.; Baran, P. S.; Gabibov, A. G.; Bushnell, D.; Neri, D.; Kornberg, R. D.; Lerner, R. Nat. Biomed. Eng., 2023, ASAP. Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer.. Li, P.*; Zhen, Y.*; Kim, C.*; Liu, Z.; Hao, J.; Deng, H.; Deng, H., Min, Z.; Wang, X.; Qin, T.; Yu, Y. Sci. Adv., 2023, 9, eadg775. Synthesis of nimbolide and its analogues and their application as poly(ADP-ribose)polymerase-1 trapping inducers. Deng, H.*; Deng, H.*; Kim, C.; Li, P.; Wang, X.; Yu, Y.; Qin, T. Nat. Synth. 2023, ASAP. Uncanonical Semi-reduction of Quinolines and Isoquinolines via Regioselective HAT-promoted Hydrosilylation. Hu, C.; Vu, C.; Merchant, R. R.; Chen, S.; Hughes, J. M. E.; Peters, B. K.; Qin, T. J. Am. Chem. Soc. 2023, 145, 25–31. Alkyl sulfinates as cross-coupling partners for programmable and stereospecific installation of C(sp3) bioisosteres. Min, Z.*; Tsien, J.*; Dykstra, R.; Hughes, J. M. E.; Peters, B. K.; Merchant, R. R.; Gutierrez, O.; Qin, T. Nat. Chem. 2023, 15, 550–559. Mutations Linked to Neurological Disease Enhance Self-association of Low-complexity Protein Sequences. Zhou, X.; Sumrow, L.; Tashiro, K.; Sutherland, L.; Liu, D.; Qin, T.; Kato, M.; Liszczak, G.; McKnight, S. Science 2022, 377, eabn5582. Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis. Wang, Z.; Cheong, M. C.; Tsien, J.; Deng, H.; Qin, T.; Stoltzufs, J.; Jaleta, T.; Li, X.; Lok, J.; Kiewer, S.; Mangelsdorf, D., eLife 2021, 10:e73535. An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates. Yang, Y.*; Tsien, J.*; Hughes, J. M. E.; Peters, B. K.; Merchant, R. R.; Qin, T., Nat. Chem. 2021, 13, 950–955 Practical and Modular Construction of C(sp3)-Rich Alkyl Boron Compounds. Yang, Y.*; Tsien, J.*; Ben David, A.; Hughes, J. M. E.; Merchant, R. R.; Qin, T., J. Am. Chem. Soc. 2021, 143, 471–480. Sulfur (IV)-mediated Heterocycle Cross-Couplings. Zhou, M., Tsien, J., Qin, T., Angew. Chem. Int. Ed. 2020, 59, 7372–7376. Mycobacterium tuberculosis sulfolipid-1 activates nociceptive neurons and induces cough. Ruhl, C.R., Pasko, B.L., Khan, H.S., Kindt, L.M., Stamm, C.E., Franco, L.H., Hsia, C., Zhou, M., Davis, C.R., Qin, T., Gautron, L., Burton, M., Mejia, G.L., Naik, D.K., Dussor, G., Price, T.J., Shiloh, M.U. Cell 2020, 181, 293–305. A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines. Ni, S.; Padial, N. M.; Kingston, C.; Vantourout, J. C.; Schmitt, D. C.; Edwards, J. T.; Kruszyk, M.; Merchant, R. R.; Mykhailiuk, P. K.; Sanchez, B.; Yang, S.; Perry, M.; Gallego, G. M.; Mousseau, J. J.; Collins, M. R.; Cherney, R. J.; Lebed, P. S.; Chen, J. S.; Qin, T.; Baran, P. S. J. Am. Chem. Soc. 2019, 141, 6726–6739. Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids. Shang, M.*; Feu, K. S.*; Vantourout, J. C.; Barton, L. M.; Osswald, H. L.; Kato, N.; Gagaring, K.; McNamara, C. W.; Chen, G.; Hu, L.; Ni, S.; Fernández-Canelas, P.; Chen, M.; Merchant, R. R.; Qin, T.; Schreiber, S.; Melillo, B.; Yu, J.-Q.; Baran, P. S. Prod. Nat. Acad. Sci. 2019, 116, 8721-8727. Quaternary Centers by Nickel‐Catalyzed Cross‐Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents. Chen, T.-G.; Zhang, H.; Mykhailiuk, P.K.; Merchant, R.R.; Smith, C.A.; Qin, T.; Baran, P.S. Angew. Chem. Int. Ed. 2019, 58, 2454–2458. A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling. Ni, S.; Garrido-Castro, A. F.; Merchant, R. R.; deGruyter, J. N.; Schmitt, D. C.; Mousseau, J. J.; Gallego, G. M.; Yang, S.; Collins, M. R.; Qiao, J. X.; Yeung, K.–S.; Langley, D. R.; Poss, M. A.; Scola, P. M.; Qin, T.; Baran, P. S. Chem. Int. Ed. Angew. Chem. Int. Ed., 2018, 55, 14560–14565. Cu-Catalyzed Decarboxylative Borylation. Wang, J.*; Shang, M.*; Lundberg, H.; Feu, K. S.; Hecker, S. J.; Qin, T.; Blackmond, D. G.; Baran, P. S. ACS Catal., 2018, 8, 9537–9542. Building C(sp3)-rich Complexity by Combining Cycloaddition and C–C Cross Coupling Reactions. Chen, T.–G.*; Barton, L.*; Lin, Y.*; Tsien, J.; Kossler, D.; Bastida, I.; Asai, S.; Bi, C.; Chen, J. S.; Shan, D.; Fang, H.; Fang, F. G.; Choi, H.; Hawkins, L.; Qin, T.; Baran, P. S. Nature, 2018, 560, 350–354. Kinetically Guided Radical-based Synthesis of C(sp3)–C(sp3) Linkages on DNA. Wang, J.*; Lundberg, H.*; Asai, S.; Martín-Acosta, P.; Chen, J. S.; Brown, S.; Farrell, W.; Dushin, R. G.; O’Donnell, C. J.; Ratnayake, A. S.; Richardson, P.; Liu, Z.; Qin, T.; Blackmond, D. G.; Baran, P. S. Nat. Acad. Sci., 2018, 115, E6404–E6410. Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling. Wu, X.*; Iwata, T.*; Scharf, A.; Qin, T.; Reichl, K.D.; Porco, J. A., Jr., J. Am. Chem. Soc., 2018, 140, 5969–5975. Modular Radical Cross-Coupling with Sulfones Enables Access to sp3-rich (Fluoro)alkylated Scaffolds. Merchant, R. R.*; Edwards, J. T.*; Qin, T. *; Kruszyk, M. M.; Bi, C.; Che, G.; Bao, D.-H.; Qiao, W.; Sun, L.; Collins, M. R.; Gallego, G. M.; Mousseau, J. J.; Nuhant, P.; Baran, P. S. Science, 2018, 360, 75–80. CITU: A Peptide and Decarboxylative Coupling Reagent. deGruyter, J. N.*; Malins, L. R. *; Wimmer, L.; Clay, K. J.; Lopez-Ogalla, J.; Qin, T.; Cornella, J.; Liu, Z.; Che, G.; Bao, D.; Stevens, J. M.; Qiao, J.; Allen, M. P. Poss, M. A.; Baran, P. S. Org. Lett., 2017, 19, 6196-6199. Decarboxylative Alkynylation. Smith, J. M.*; Qin, T.*; Merchant, R. R.; Edwards, J. T.; Malins, L. R.; Liu, Z.; Che, G.; Shen, Z.; Shaw, S. A.; Eastgate, M. D.; Baran, P. S. Angew. Chem. Int. Ed., 2017, 56, 11906–11910. Decarboxylative Alkenylation. Edwards, J. T.*; Merchant, R.*; McClymont, K. S.; Knouse K. W.; Qin, T.; Malins, L. R.; Vokits, B.; Shaw, S. A.; Bao, D.-H.; Wei, F.-L.; Zhou, T.; Eastgate, M. D.; Baran, P. S. Nature, 2017, 545, 213–218. Fe-Catalyzed C–C Bond Construction from Olefins via Radicals. Lo, J. C.; Kim, D.; Pan, C.-M.; Edwards, J. T.; Yabe, Y.; Gui, J.; Qin, T.; Gutiérrez, S.; Giacoboni, J.; Smith, M. W.; Holland, P. L.; Baran, P. S., Am. Chem. Soc., 2017, 139, 2484–2503. Ni-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms. Qin, T.; Malins, L. R.; Edwards, J. T.; Merchant, R. R.; Novak, A. J. E.; Zhong, J. Z.; Mills, R. B.; Yan, M.; Yuan, C.; Eastgate, M. D.; Baran, P. S., Angew. Chem. Int. Ed., 2017, 56, 260-265.