王慧婧 - 四川大学 - 华西药学院

个人简介

2008.09-2012.06 四川大学华西药学院理学学士 2012.09-2017.06 重庆大学创新药物研究中心工学博士（导师：秦勇教授） 2017.09-2019.12 美国加州大学圣地亚哥分校（UCSD）博士后（导师：Dionicio Siegel教授） 2020.04-至今四川大学华西药学院药物化学系，副研究员

研究领域

1.具有重要生理活性的天然产物全合成 2.活性小分子的结构修饰、构效关系研究及先导化合物的发现

近期论文

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Huijing Wang, Qiuyan Dong, Qinxia Xie, Pei Tang*. Asymmetric synthesis of ABC tricyclic systems in Daphniphyllum alkaloid. Chin. Chem. Lett. 2020, 31, 685-688. Huijing Wang, Matthew J. Kolar, Tina Chang, José Rizo, Srihari Konduri, Clare McNerlin, Alan Saghatelian, and Dionicio Siegel*. Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids. Org. Lett. 2019, 21, 8080−8084. Huijing Wang, Tina Chang, Srihari Konduri, Jianbo Huang, Alan Saghatelian, Dionicio Siegel*. Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA. J. Antibiot. 2019, 72 (6), 498− 506. Yi Luo, Lingmei Guo, Xinling Yu, Haosheng Ding, Huijing Wang*, and Yong Wu*. Cp*IrIII-Catalyzed [3+2] Annulations of N-Aryl-2- aminopyrimidines with Sulfoxonium Ylides to Access 2-Alkyl Indoles Through C–H Bond Activation. Eur. J. Org. Chem. 2019, 3203–3207. Yan-zhao Liu, Yao Hu, Guang-hui Lv, Rui-fang Nie, Yao Peng, Chen Zhang, Song-yang Lv, Li Hai, Hui-jing Wang*, and Yong Wu*. Synthesis of 1,2-Benzothiazines via C−H Activation/Cyclization in a Recyclable, Mild System. ACS Sustainable Chem. Eng. 2019, 7, 13425−13429. Huijing Wang, Pei Tang, Qilong Zhou, Dan Zhang*, Zhitao Chen, Hongxiu Huang, Yong Qin*. One-Pot Synthesis of Multisubstituted Butyrolactonimidates: Total Synthesis of (-)-Nephrosteranic Acid, J. Org. Chem. 2015, 80, 2494-2505. (Featured Article). Hongxiu Huang, Huijing Wang (co-first author), Ling Tan, Shuqing Wang, Pei Tang, Hao Song*, Xiao-Yu Liu, Dan Zhang, Yong Qin*. Asymmetric Michael Addition Induced by (R)-tert-Butanesulfinamide and Synthesis of Chiral Pyrazolidinone Derivatives, J. Org. Chem. 2016, 81, 10506-10516. Huijing Wang, Dan Zhang*, Fusheng Wang, Yi Wu, Hao Song. Synthesis and Anticholinesterase Activity of (-)-Physostigmine, Analogues with Modifications at C3a and C5, Chem. Res. Chin. Univ. 2013, 29, 888-893. Lingmei Guo, Baolan Tang, Ruifang Nie, Yanzhao Liu, Shan Lv, Huijing Wang, Li Guo, Li Hai*, and Yong Wu*. C–H alkenylation/cyclization and sulfamidation of 2-phenylisatogens using N-oxide as a directing group. Chem.Commun. 2019, 55, 10623−10626. Matthew J. Kolar, Srihari Konduri, Tina Chang, Huijing Wang, Clare McNerlin, Lena Ohlsson, Magnus Härröd, Dionicio Siegel*, and Alan Saghatelian*. Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals. J. Biol. Chem. 2019, 294 (27), 10698−10707. Fei Xue, Tao Xiao, Huijing Wang, Dan Zhang*, Hao Song, Yong Qin*. Synthesis of chiral trans-fused 2-methyl-5-hydroxyldecahydroquinoline, Tetrahedron, 2015, 71, 5640-5643. Xiaobei Wang, Dongliang Xia, Wenfang Qin, Ruijie Zhou, Xiaohan Zhou, Qilong Zhou, Wentao Liu, Xiang Dai, Huijing Wang, Shuqing Wang, Ling Tan, Dan Zhang, Hao Song, Xiao-Yu Liu, Yong Qin*. A radical cascade enabling collective syntheses of divergent natural products, Chem 2017, 2, 803-816. Qilong Zhou, Huijing Wang, Pei Tang, Hao Song, Yong Qin*. Total Synthesis of Lignan Lactone (-)-Hinokinin, Nat. Prod. Bioprospect. 2015, 5, 255-261.