余洛汀 - 四川大学 - 生物治疗国家重点实验室

个人简介

余洛汀，生物治疗国家重点实验室，教授，博士生导师。2007年毕业于四川大学，获应用化学专业博士学位。近年承担了多项国家新药创制重大专项、国家重点研发计划课题和国家自然科学基金面上项目，以及多项企业新药开发项目。迄今已获四个1类新药临床批件（其中已进临床三期）。还有多个处于不同研发阶段有潜力的候选新药在加速研发中。已申请数十项专利，发表百篇科研论文。曾获得 “药明康德生命化学奖”和“四川大学产学研合作杰出贡献奖”，入选四川省学术技术带头人、省卫生健康领军人才和江苏省双创人才，并任四川省药学会化学药生物药专委会副主任、省医药行业协会副秘书长、高新区专家联合会副会长等多个社团职务。

研究领域

余洛汀课题主要从事药物化学、化学生物学、制药工程专业领域研究。课题组由数十名涉及多个专业背景的师生组成，针对人类重大疾病开展创新药物研发，主要是化学小分子靶向新药，包括抗肿瘤、感染性肝病、传染病、抗耐药菌等新药开发

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Liu Z, Hu X, Wang Q, Wu X, Zhang Q, Wei W, Su X, He H, Zhou S, Hu R, Ye T, Zhu Y, Wang N, Yu L. Design and Synthesis of EZH2-Based PROTACs to Degrade the PRC2 Complex for Targeting the Noncatalytic Activity of EZH2. J Med Chem. 2021 Mar 11;64(5):2829-2848. Zhang Q , Hu X , Li L , Zhang L , Wan G , Feng Q , Zhu Y , Wang N , Liu Z , Yu L . The discovery of SKLB-0335 as a paralog-selective EZH2 covalent inhibitor. Chem Commun. 2021 Mar 25;57(24):3006-3009. Xia Y, Xu F, Xiong M, Yang H, Lin W, Xie Y, Xi H, Xue Q, Ye T, Yu L. Repurposing of antipsychotic trifluoperazine for treating brain metastasis, lung metastasis and bone metastasis of melanoma by disrupting autophagy flux. Pharmacol Res. 2021 Jan;163:105295. Zuo W, Zhu Y, Liu Z, Xia Y, Xu Y, Peng C, Yu L, Wang N. BRD4 inhibition sensitizes aggressive non-Hodgkin lymphomas to PI3Kδ inhibitors by suppressing PI3K reactivation and c-MYC expression. Am J Cancer Res. 2021 Jan 1;11(1):215-235. Xu Y, Wang Q, Xiao K, Liu Z, Zhao L, Song X, Hu X, Feng Z, Gao T, Zuo W, Zeng J, Wang N, Yu L. Novel Dual BET and PLK1 Inhibitor WNY0824 Exerts Potent Antitumor Effects in CRPC by Inhibiting Transcription Factor Function and Inducing Mitotic Abnormality. Mol Cancer Ther. 2020 Jun;19(6):1221-1231. Xue Q, Liu Z, Feng Z, Xu Y, Zuo W, Wang Q, Gao T, Zeng J, Hu X, Jia F, Zhu Y, Xia Y, Yu L. Penfluridol: An antipsychotic agent suppresses lung cancer cell growth and metastasis by inducing G0/G1 arrest and apoptosis. Biomed Pharmacother. 2020 Jan;121:109598. Zhang Q, Hu X, Wan G, Wang J, Li L, Wu X, Liu Z, Yu L. Discovery of 3-(((9H-purin-6-yl)amino)methyl)-4,6-dimethylpyridin-2(1H)-one derivatives as novel tubulin polymerization inhibitors for treatment of cancer. Eur J Med Chem. 2019 Dec 15;184:111728. Tao X, Wang N, Wang J, Fu Z, Gu Z, Zhang Y, Chen S, Wang L, Yu L. Preclinical evaluation of Amphihevir, a first-in-class clinical Hepatitis C virus NS4B inhibitor. Antimicrob Agents Chemother. 2019 Sep 16;63(12):e01237-19. Shi Y, Wang Q, Rong J, Ren J, Song X, Fan X, Shen M, Xia Y, Wang N, Liu Z, Hu Q, Ye T, Yu L. Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis. Eur J Med Chem. 2019 Oct 1;179:182-195. Hu QF, Gao TT, Shi YJ, Lei Q, Liu ZH, Feng Q, Chen ZJ, Yu LT. Design, synthesis and biological evaluation of novel 1-phenyl phenanthridin-6(5H)-one derivatives as anti-tumor agents targeting TOPK. Eur J Med Chem. 2019 Jan 15;162:407-422. Gao T, Hu Q, Hu X, Lei Q, Feng Z, Yu X, Peng C, Song X, He H, Xu Y, Zuo W, Zeng J, Liu Z, Yu L. Novel selective TOPK inhibitor SKLB-C05 inhibits colorectal carcinoma growth and metastasis. Cancer Lett. 2019 Mar 31;445:11-23. Lei Q, Xiong L, Xia Y, Feng Z, Gao T, Wei W, Song X, Ye T, Wang N, Peng C, Li Z, Liu Z, Yu L. YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect. Cell Death Dis. 2018 Oct 18;9(11):1066. Feng Z, Xia Y, Gao T, Xu F, Lei Q, Peng C, Yang Y, Xue Q, Hu X, Wang Q, Wang R, Ran Z, Zeng Z, Yang N, Xie Z, Yu L. The antipsychotic agent trifluoperazine hydrochloride suppresses triple-negative breast cancer tumor growth and brain metastasis by inducing G0/G1 arrest and apoptosis. Cell Death Dis. 2018 Sep 26;9(10):1006. Wang NY, Xu Y, Zuo WQ, Xiao KJ, Liu L, Zeng XX, You XY, Zhang LD, Gao C, Liu ZH, Ye TH, Xia Y, Xiong Y, Song XJ, Lei Q, Peng CT, Tang H, Yang SY, Wei YQ, Yu LT. Discovery of imidazo[2,1-b]thiazole HCV NS4B inhibitors exhibiting synergistic effect with other direct-acting antiviral agents. J Med Chem. 2015 Mar 26;58(6):2764-78.