个人简介
孙晓东,副教授,硕士研究生导师
2000-2013年本、硕、博就读和工作于南开大学,2013-2015年于美国 Vanderbilt University 和 Georgia Institute of Technology 从事博士后研究。2015年引进至四川大学华西基础医学与法医学院。
以第一/共同第一作者或通讯作者在 Proc Natl Acad Sci U S A, Signal Transduct Target Ther, Protein Cell, Theranostics, J Clin Transl Hepatol 等期刊发表研究论文20余篇。获四川省学术和技术带头人后备人选(2021),四川大学优秀教师(2018),四川大学好未来优秀学者(2018)等称号奖项。
承担本科生“药理学”,硕士研究生和博士研究生“分子药理学”、“临床药理学”等课程教学工作。
主持国家自然科学基金面上项目1项、省部级基金项目2项以及其他科研基金项目多项。
主要研究方向及领域:
建设“代谢药理学”科研团队,应用包括代谢异常疾病动物模型和细胞模型等完备的科研体系,从事激素调控代谢的机制研究,从代谢异常引起的氧化应激器官损伤和免疫调节角度,探寻肿瘤、脂肪肝和糖尿病等疾病的分子机制及药物机理。
科研团队现有高级职称2人,中级、初级职称及研究生10余人。人才培养目标:培养生物医学及药学领域的优秀青年科研/研发人才,为他们打好学术基础,并在他们的职业发展中持续提供支持,使他们成为大健康领域的顶尖人才!
近期论文
查看导师新发文章
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1. YH Wang, YL Wang, F Li, J Zou, XQ Li, MX Xu, DJ Yu, YJ Ma, W Huang, XD Sun*, YY Zhang*. Psoralen suppresses lipid deposition by alleviating insulin resistance and promoting autophagy in oleate-induced L02 cells. Cells, 2022; 11(7): 11071067.
2. J Zou, MX Xu, F Li, YH Wang, XQ Li, DJ Yu, YJ Ma, YY Zhang*, and XD Sun*. Icaritin alleviates docetaxel-induced skin injury by suppressing reactive oxygen species via estrogen receptors. Thorac Cancer, 2022; 13(2): 190-201.
3. Y Yang, Y Wu, J Zou, YH Wang, MX Xu, W Huang, DJ Yu, L Zhang, YY Zhang*, XD Sun*. Naringenin attenuates non-alcoholic fatty liver disease by enhancing energy expenditure and regulating autophagy via AMPK. Front Pharmacol, 2021; 12: 687095.
4. Y Wu, Y Yang, F Li, J Zou, YH Wang, MX Xu, YL Wang, RX Li, YT Sun, S Lu, YY Zhang*, XD Sun*. Icaritin attenuates lipid accumulation by increasing energy expenditure and autophagy regulated by phosphorylating AMPK. J Clin Transl Hepatol, 2021; 9(3): 373-383.
5. YL Wang, J Wu, RX Li, YT Sun, YJ Ma, CY Zhao, J Zou, YY Zhang*, XD Sun*. A double-edged sword: the Kelch-like ECH-associated protein 1-nuclear factor erythroid-derived 2-related factor 2-antioxidant response element pathway targeted pharmacological modulation in nonalcoholic fatty liver disease. Curr Opin Pharmacol, 2021; 60: 281-290.
6. CC Tao, Y Yang, F Li, L Qiao, Y Wu, XD Sun, YY Zhang*, CL Li*. Cloning short DNA into plasmids by one‐step PCR. Thoracic Cancer, 2020; 11: 3409-3415.
7. CC Tao, Y Wu, X Gao, L Qiao, Y Yang, F Li, J Zou, YH Wang, SY Zhang, CL Li, YY Zhang*, XD Sun*. The antitumor effects of icaritin against breast cancer is related to estrogen receptors. Curr Mol Med, 2020; 21(1): 73-85.
8. J Yao, F Yang, X Sun, S Wang, N Gan, Q Liu, D Liu, X Zhang, D Niu, Y Wei, C Ma, ZQ Luo, Q Sun, and D Jia. Mechanism of inhibition of retromer transport by the bacterial effector RidL. Proc Natl Acad Sci U S A, 2018; 115(7): E1446-E1454.
9. Y Liu, W Ren, Y Bai, L Wan, X Sun, Y Liu, W Xiong, YY Zhang*, LM Zhou*. Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis. J Nat Med, 2018; 72(2): 481-492.
10. X Liu, Y Li, X Sun, Y Muftuoglu, B Wang, T Yu, Y Hu, L Ma, M Xiang, G Guo, C You, X Gao, and Y Wei. Powerful anti-colon cancer effect of modified nanoparticle-mediated IL-15 immunogene therapy through activation of the host immune system. Theranostics, 2018; 8(13): 3490-3503.
学术兼职
担任中国药理学会化疗药理专委会委员,中国抗癌协会肿瘤胃肠病学专委会、肿瘤标志专委会委员,四川省药理学学会抗肿瘤药物专委会委员,四川省抗癌协会肿瘤标志专委会委员等。