Roelfes, Gerard - University of Groningen - Stratingh Institute for Chemistry

个人简介

Gerard Roelfes obtained his MSc and PhD (2000) from the University of Groningen, the Netherlands. His PhD research (supervisor Prof. Ben L. Feringa) was on synthetic models for non-heme iron oxygenases, which was a joint project with Unilever Research (Dr. R. Hage) and the group of Prof. Lawrence Que Jr. (Univ. Minnesota), in whose lab he carried out part of the work. After his PhD he went for a post-doc with Prof. Donald Hilvert in the Laboratorium fur Organische Chemie of the ETH-Zurich (Switzerland), where he worked on synthetic strategies towards seleno-proteins, using a combination of chemical and biological methods. In 2003 he returned to the University of Groningen as a junior research group leader. He became Assistant Professor in 2006, Associate Professor in 2010 and since 2015 is Full Professor of Biomolecular Chemistry & Catalysis.

研究领域

bio-inspired catalysis and chemical biology

近期论文

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In vivo Biocatalytic Cascades Featuring an Artificial-Enzyme-Catalyzed New-to-Nature Reaction L. Ofori Atta, Z. Zhou and G. Roelfes Angewandte Chemie International Edition, 2023, 62, e202214191 Boron catalysis in a designer enzyme L. Longwitz, R.B. Leveson-Gower, H.J. Rozeboom, A.-M.W.H. Thunnissen and G. Roelfes Nature, 2024, online Computation-guided engineering of distal mutations in an artificial enzyme F. Casilli, M. Canyelles-Niño, G. Roelfes and L. Alonso-Cotchico Faraday Discussions, 2024, accepted Selective aza-Michael addition to dehydrated amino acids in natural antimicrobial peptides M. Vargiu, Y. Xu, O.P. Kuipers and G. Roelfes ChemBioChem, 2024, 25, e202400043 Biocatalytic Friedel-Crafts reactions R.B. Leveson Gower and G.Roelfes ChemCatChem, 2022, 14, e202200636 Tandem Friedel-Crafts Alkylation/Enantioselective Protonation by Artificial Enzyme Iminium Catalysis R.B. Leveson-Gower, R. de Boer and G. Roelfes ChemCatChem, 2022, 14, e202101875 Supramolecular Assembly of DNA - and Protein-Based Artificial Metalloenzymes G. Roelfes in Supramolecular Catalysis, new directions and developments, 2022, Wiley-VCH, 561-572 Synergistic Catalysis of Tandem Michael Addition / Enantioselective Protonation Reactions by an Artificial Enzyme Z. Zhou and G. Roelfes ACS Catalysis, 2021, 11, 9366-9369 Repurposed and artificial heme enzymes for cyclopropanation reactions G. Roelfes Journal of Inorganic Biochemistry, 2021, 222, 111523 Chemogenetic Tags with Probe Exchange for Live-Cell Fluorescence Microscopy A. Iyer, M. Baranov , A.J. Foster, S. Chordia, G. Roelfes, R. Vlijm, G. van den Bogaart, and B. Poolman ACS Chemical Biology, 2021, 16, 891–904 In Vivo Assembly of Artificial Metalloenzymes and Application in Whole‐Cell Biocatalysis - VIP paper S. Chordia, S. Narasimhan, A. Lucini Paioni, M. Baldus and G. Roelfes Angewandte Chemie International Edition, 2021, 60, 5913-5920 Unlocking Iminium Catalysis in Artificial Enzymes to Create a Friedel-Crafts Alkylase R.B. Leveson-Gower, Z. Zhou, I. Drienovská and G. Roelfes ACS Catalysis, 2021, 11, 6763–6770 Merging whole-cell biosynthesis of styrene and transition-metal catalyzed derivatization reactions R.V. Maaskant, S. Chordia and G. Roelfes ChemCatChem, 2021, 13, 1607-1613 Rapid and selective chemical editing of Ribosomally synthesized and Post-translationally modified Peptides (RiPPs) via Cu(II)-catalyzed β-borylation of dehydroamino acids R.H. de Vries, J.H. Viel, O.P Kuipers and G. Roelfes Angewandte Chemie International Edition, 2021, 60, 3946-3950 A Water-Soluble Iridium Photocatalyst for Chemical Modification of Dehydroalanines in Peptides and Proteins R.C.W. van Lier, A.D. de Bruijn and G. Roelfes Chemistry, A European Journal, 2021, 27, 1430-1437 Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme L. Villarino, S. Chordia, L. Alonso-Cotchico, E. Reddem, Z. Zhou, A.-M.W.H. Thunnissen, J.D. Maréchal and G. Roelfes ACS Catalysis, 2020, 10, 11783-11790 Novel modifications of nonribosomal peptides from Brevibacillus laterosporus MG64 and investigation of their mode of action Z. Li, R.H. de Vries, P. Chakraborty, C. Song, X. Zhao, D.-J. Scheffers, G. Roelfes, and O.P. Kuipers Applied and Environmental Microbiology, 2020, 86, e01981-20 Cu(II)-Catalyzed β-Silylation of Dehydroalanine Residues in Peptides and Proteins R.H. de Vries and G. Roelfes Chemical Communications, 2020, 56, 1058 - 11061 Unexpected catalytic activity of the regulatory protein QacR C. Gutiérrez de Souza, L. Alonso-Cotchico, M. Bersellini and G. Roelfes ChemRxiv, 2020, preprint Characterization of two relacidines belonging to a novel class of circular lipopeptides that act against Gram-negative bacterial pathogens Z. Li, P. Chakraborty, R.H. de Vries, C. Song, X. Zhao, G. Roelfes, D.-J. Scheffers and O.P. Kuipers Environmental Microbiology, 2020, 22, 5125-5136 A hydroxyquinoline-based unnatural amino acid for the design of novel artificial metalloenzymes I. Drienovská, R.A. Scheele, C. Gutiérrez de Souza and G. Roelfes ChemBioChem, 2020, 21, 3077-3081 Impact of binding to the Multidrug Resistant Regulator protein LmrR on the photo-physics and -chemistry of photosensitizers S.H. Mejías, G. Roelfes and W.R. Browne Physical Chemistry Chemical Physics, 2020, 22, 12228-12238 Artificial Metalloenzymes based on TetR Proteins and Cu(II) for Enantioselective Friedel-Crafts Alkylation Reactions C. Gutiérrez de Souza, M. Bersellini and G. Roelfes ChemCatChem, 2020, 12, 3190-3194