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Wenlong Zheng#, Zhongji Pu#, Lanxin Xiao,Gang Xu, Lirong Yang, Haoran Yu*, Jianping Wu*. Mutability-Landscape-Guided Engineering of l-Threonine Aldolase Revealing the Prelog Rule in Mediating Diastereoselectivity of C-C Bond Formation. Angewandte Chemie International Edition, 2022.11.11 https://doi.org/10.1002/ange.202213855 (IF 16.823 )
Kudakwashe Nyandoro, Charles M. G. Lamb, Haoran Yu, Jian Shi and Derek Macmillan*. Investigation of acyl transfer auxiliary-assisted glycoconjugation for glycoprotein semi-synthesis. Organic & Biomolecular Chemistry, 2022. DOI: 10.1039/d2ob01633h
Ziyuan Wang, Haisheng Zhou*, Haoran Yu, Zhongji Pu, Jinling Xu, Hongyu Zhang, Jianping Wu, and Lirong Yang*. Computational Redesign of the Substrate Binding Pocket of Glutamate Dehydrogenase for Efficient Synthesis of Noncanonical L‑Amino Acids. ACS Catalysis, 2022, 12, 13619-13629 (IF 13.7)
Wenlong Zheng, Zhongji Pu, Lanxin Xiao, Gang Xu, Li-Rong Yang, Haoran Yu*, Jianping Wu*. Substrate access path-guided engineering of L-threonine aldolase for improving diastereoselectivity. Chemical Communications. 2022.06.24 https://doi.org/10.1039/D2CC02644A (IF 6.222)
Xiumiao Yao, Tingting Kang, Zhongji Pu, Tao Zhang, Jianping Lin, Lirong Yang, Haoran Yu*, and Mianbin Wu*. Sequence and Structure-Guided Engineering of Urethanase from Agrobacterium tumefaciens d3 for Improved Catalytic Activity. Journal of Agricultural and Food Chemistry, 2022. https://doi.org/10.1021/acs.jafc.2c01406 (IF 5.279)
Yun Feng, Zhongji Pub, Li Zhu, Mianbin Wu, Lirong Yang, HaoranYu*, Jianping Lin*. Enhancing the thermostability of D-allulose 3-epimerase from Clostridium cellulolyticum H10 via a dual-enzyme screening system. Enzyme and Microbial Technology, 2022. https://doi.org/10.1016/j.enzmictec.2022.110054 (IF 3.493)
Zhonglang Yu#, Haoran Yu#, Jinling Xu, Zhe Wang, Ziyuan Wang, Tingting Kang, Kaitong Chen, Zhongji Pu, Jianping Wu, Li-Rong Yang, Gang Xu*. Enhancing Thermostability of Lipase from Pseudomonas alcaligenes for producing L-menthol by the CREATE Strategy. Catalysis Science & Technology, 2022. https://doi.org/10.1039/D2CY00082B (IF 6.119)
Haoran Yu*, Shuang Ma, Yiwen Li, Paul A. Dalby*. Hot spots-making directed evolution easier. Biotechnology Advances, 2022. https://doi.org/10.1016/j.biotechadv.2022.107926 (IF 17.681)
Ke Liu, Haoran Yu, Guoyun Sun, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv*, Long Liu*. Semi-rational design of L-amino acid deaminase for production of pyruvate and D-alanine by Escherichia coli whole-cell biocatalyst. Amino Acids, 2021. https://doi.org/10.1007/s00726-021-03067-8
Cheng Zhang, Nuria Codina, Jiazhi Tang, Haoran Yu, Nesrine Chakroun, Frank Kozielski, Paul A. Dalby*. Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation. Computational and Structural Biotechnology Journal, 2021. DOI: 10.1016/j.csbj.2021.05.005.
Zhonglang Yu, Haoran Yu, Haibin Tang, Zhe Wang, Jianping Wu, Lirong Yang, Gang Xu*. Site‐specifically Incorporate Non‐Canonical Amino Acids into Pseudomonas alcaligenes Lipase to Hydrolyze L‐ menthol propionate among the Eight Isomers. ChemCatChem, 2021.
Wenlong Zheng, Haoran Yu, Sai Fang, Kaitong Chen, Zhe Wang, Xiuli Cheng, Gang Xu*, Lirong Yang, and Jianping Wu*. Directed Evolution of l-Threonine Aldolase for the Diastereoselective Synthesis of β-Hydroxy-α-amino Acids. ACS Catalysis, 2021, 11, XXX, 3198–3205
Jinling Xu, Haisheng Zhou*, Haoran Yu, Tong Deng, Ziyuan Wang, Hongyu Zhang, Jianping Wu, Lirong Yang*. Computational design of highly stable and soluble alcohol dehydrogenase for NADPH regeneration. Bioresour. Bioprocess, 8, 12 (2021).
Haoran Yu, Paul A Dalby*. A beginner's guide to molecular dynamics simulations and the identification of cross-correlation networks for enzyme engineering. Methods in Enzymology, 2020.
Haoran Yu, Roberto Icken Hernandez Lopez, David Steadman, Daniel Mendez-Sanchez, Sally Higson, Armando Cazares-Korner, Tom D. Sheppard, John M Ward, Helen C Hailes, Paul A Dalby*. Engineering transketolase to accept both unnatural donor and acceptor substrates and produce α-hydroxyketones. The FEBS Journal, 2020, 287 (9): 1758-1776. （IF:5.54）
Haoran Yu, Paul A. Dalby*. Exploiting correlated molecular-dynamics networks to counteract enzyme activity-stability trade-off. Proceedings of the National Academy of Sciences, 2018, 115 (52): E12192- E12200. (IF 11.205)
Haoran Yu, Paul A. Dalby*. Coupled molecular dynamics mediate long and short-range epistasis between mutations that affect stability and aggregation kinetics. Proceedings of the National Academy of Sciences, 2018, 115 (47) : E11043-E11052. (IF 11.205)
Lin Liu, Haoran Yu, Kun Du, Zhiyan Wang, Yiru Gan, He Huang*. Enhanced trypsin thermostability in Pichia pastoris through truncating the flexible region. Microbial cell factories, 2018, 17 (1): 165-174.
Cheng Zhang, Maariyah Samad, Haoran Yu, Nesrine Chakroun, David Hilton, and Paul A. Dalby*. Computational-design to reduce conformational flexibility and aggregation rates of an antibody Fab fragment. Molecular pharmaceutics, 2018, 15 (8): 3079-3092.
Haoran Yu, Yihan Yan, Cheng Zhang, Paul A. Dalby*. Two strategies to engineer flexible loops for improved enzyme thermostability. Scientific Reports 7, Article number: 41212 (2017) doi:10.1038/srep41212.
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