个人简介

教育与工作经历 曾在西北农业大学读本科、硕士、博士学位，香港大学动物学系博士后，曾去美国康涅犾格大学与荷兰瓦格宁根大学高访。 目前在南京农业大学动物科技学院任教。 奖励及荣誉 二级教授、钟山学者首席教授，师德标兵；主持的《动物繁殖学》分别获首批国家级一流本科课程（2020）及国家精品（2010）、首批精品资源共享课程（2016）；主持获省部级科研、教学二等奖2项；参与获国家教学成果2等奖1项、省级科技进步2等奖2项；获校级教学成果特等、1等、2等各1项。 承担科研项目 目前承担的主要项目有：主持国家重点研发计划项目：山羊规模化高效安全养殖关键技术集成与示范。主持国家自然科学基金面上项目2项。国家肉羊产业技术体系岗位科学家项目。江苏现代农业（肉羊）产业技术体系集成创新中心项目；江苏省农业重大新品种创制计划等。

研究领域

动物胚胎工程；动物生殖调控；羊业科学

动物遗传育种与繁殖；动物生物工程；养殖

近期论文

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发表论文350多篇，其中SCI 文章150多篇，近几年发表的重要论文如下： 2021 Mingtian Deng #, Yongjie Wan#, Zifei Liu1, Cai Yu1, Baobao Chen, Yanli Zhang*, Feng Wang*, Long non-coding RNA lnc_3712 impedes nuclear reprogramming via repressing Kdm5b，Molecular Therapy-Nucleic Acids，2021，24：54-66 Xiaolei Yao,XiaoXiao Gao, Yongjin Bao, Jinyu Yang, Xiaodan Li, M.A.EI-Samahy,Zhibo Wang, Guomin Zhang, Yanli Zhang, Wujun Liu, Feng Wang*，LncRNA FDNCR promotes apoptosis of granulosa cells by targeting the miR-543-3p/DCN/TGF-β signaling pathway in Hu sheep，Molecular Therapy - Nucleic Acids，2021，24：223-240 Kaiping Deng,Yixuan Fan,Yaxu Liang,Yu Cai,Guomin Zhang,Mingtian Deng,Zhibo Wang,Jiawei Lu,Jianfe Shi,Haifeng Zhang,Yanli Zhang*,Feng Wang*, FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway,Molecular Therapy - Nucleic Acids，accept Kaiping Deng, Zhen Zhang, Yaxu Liang, Yixuan Fan, Feng Wang*，FTO regulates myoblast proliferation by controlling CCND1 expression via m6A-YTHDF2-denpent manner，Experimental Cell Research，2021,40：112524 Li,Xiaodan; Yao,Xiaolei; Xie,Haiqiang; Gao,Xiaoxiao; Deng,Kaiping; Bao,Yongjin; Feng,Wang*，SPATA6 promotes proliferation, testosterone production, and inhibits apoptosis in Hu sheep Leydig cells，Theriogenology, 2021,166：9-20 Yu Cai#, Mingtian Deng#, Qifan Zhang, Zifei Liu, Liang Wang, Wenwen Sheng, Yanli Zhang, Peihua You, Ziyu Wang*,Feng Wang*，Effects of dietary betaine supplementation on biochemical parameters of blood and testicular oxidative stress in Hu sheep，Theriogenology,2021,164:65-73 Xiaolei Yao,M.A. EI-Samahy,Shenhua Xiao,Zhibo Wang,Fanxing Meng,Xiaodan Li,Yongjin Bao,Yanli Zhang,Ziyu Wang,Yixuan Fan,Feng Wang*, CITED4 mediates proliferation, apoptosis and steroidogenesis of Hu sheep granulosa cells in vitro, Reproduction，2021,161:255-267 2020 Zifei Liu#, Guomin Zhang#，Mingtian Deng,Hua Yang,Jing Pang,Yu Cai,Yongjie Wan* and Feng Wang*，Inhibition of lysine-specific histone demethylase 1A results in meiotic aberration during oocyte maturation in vitro in goats，Theriogenology，2020，143：168-178 Kaiping Deng，Caifang Ren，yixuan Fan，Zifei Liu，Guomin Zhang，Peihua You，Feng Wang*，miR-27a is an important adipogenesis regulator associated with differential lipid accumulation between intramuscular and subcutaneous adipose tissues of sheep，Domestic Animal Endocrinology，2020,71:106393 Mingtian Deng，Baobao Chen，Zifei Liu，Yongjie Wan，Hua Yang，Yu Cai，Jianguo Zhou，Yanli Zhang，Feng Wang*，Aberrant DNA and histone methylation during zygotic genome activation in goat cloned embryos，Theriogenology，2020，148：27-36 Yaxu Liang, Yongjin Bao, Xiaoxiao Gao, Kaiping Deng, Shiyu An, Zhibo Wang, Xinai Huang, Dong Liu, Zhinan Liu, Feng Wang*，YX Fan*，Effects of spirulina supplementation on lipid metabolism disorder, oxidative stress caused by high-energy dietary in Hu sheep，Meat Science，2020，164：108094 Yixuan.Fan,Yaxu Liang,Kaiping Deng,Zhen Zhang,Guomin Zhang,Yanli Zhang,Feng Wang*, Analysis of DNA Methylation Profiles during sheep Skeletal Muscle Development Using Whole-genome Bisulfite Sequencing，BMC genomics，2020，21:327 https://doi.org/10.1186/s12864-020-6751-5 Yu Cai,Mingtian Deng,Zifei Liu,Guomin Zhang，Jing Pang，Shiyu An，Zhibo Wang，Yanli Zhang,Feng Wang*，EZH2 expression and its role in spermatogonial stem cell self-renewal in goats.Theriogenology,2020，155：222-231 Caifang Ren,Kaiping Deng,Zhibo Wang,Mingtian Deng,Yixuan Fan,Yanli Zhang,Jianyu Ma, Shuting Wang,Zifei Liu,Feng Wang*,Reinterpreting sheep muscle strand-specific RNA sequencing data showing extensive 3’UTR extensions，Animal Genetics，2020，51：788-798。 Mingtian Deng，Guomin Zhang; Yu Cai; Zifei Liu; Yanli Zhang; Fanxing Meng; Feng Wang; Yongjie Wan*，DNA methylation dynamics during zygotic genome activation in goat，Theriogenology，2020，156：144-154 Xiaoxiao Gao, Xiaolei Yao, Zhibo Wang, Xiaohe Li, Xiaodan Li, Shiyu An, Guo-Min Zhang, Feng Wang*，Long non-coding RNA366.2 controls endometrial epithelial cell proliferation and migration by upregulating WNT6 as a ceRNA of miR-1576 in sheep uterus，JCP，BBA - Gene Regulatory Mechanisms，2020，1863：194606 Xiaolei Yao#;Zibo Wang#;Xiaoxiao Gao;Xiaodan Li;Hua Yang;EI-Samahy M.A;Yongjin Bao; Shenhua Xiao;Fanxing Meng;Feng Wang*，Unconservative_15_2570409 suppress progesterone receptor expression in granulosa cells of Hu sheep，Theriogenology，2020，157：303-31 Guo-Min Zhang; Yi-Xuan Guo; Chun-Yu Cheng; El-Samahy M. A.; Ran Tong; Xiao-Xiao Gao; Kai-Ping Deng; Feng Wang*; Zhi-hai Lei*，Arginine infusion rescues ovarian follicular development in feed-restricted Hu sheep during the luteal phase，Theriogenology，2020，158：75-83 Mingtian Deng, Baobao Chen, Yongjie Wan, Zifei Liu, Yu Cai, Guoming Zhang, Yixuan Fan, YANLI ZHANG* and Feng Wang*，YTHDF2 regulates maternal transcriptome degradation and embryo development in goat，Frontiers in Cell and Developmental Biology，10.3389/fcell.2020.580367 2019 Yi-Xuan Guo#,Guo-Min Zhang#, Xiao-Lei Yao, Ran Tong,Chun-Yu Cheng,Ting-Ting Zhang, Shu-Ting Wang,Hua Yang,Feng Wang*，Effects of nitric oxide on steroidogenesis and apoptosis in goat luteinized granulosa cells，Theriogenology，2019，126：55-62 Guo-Min Zhang,Ting-Ting Zhang,Shi-Yu An,M.A.El-Samahy,Hua Yang,Yong-Jie Wan,Fan-Xing Meng,Shen-Hua Xiao,Feng Wang∗,Zhi-Hai Lei∗,Expression of Hippo signaling pathway components in Hu sheep male reproductive tract and spermatozoa, Theriogenology，2019，126：239-248 Guo-Min Zhang, Shi-Yu An, M. A. El-Samahy, Yan-Li Zhang, Yong-Jie Wan，Zi-Yu Wang, Shen-Hua Xiao, Fan-Xing Meng, Feng Wang*, Zhi-Hai Lei*，Suppression of miR-1197-3p attenuates H2O2 induced apoptosis of goat luteinized granulosa cells via targeting PPARGC1A，Theriogenology，2019，132:72-82 Kaiping Deng, Caifang Ren, Yixuan Fan, Jing Pang, Guomin Zhang, Yanli Zhang, Pei-Hua You and Feng Wang*，YAP1 regulates PPARG and RXR alpha expression to affect the proliferation and differentiation of ovine preadipocyte，Journal of Cellular Biochemistry，2019;120:19578-19589 Yi xuan Fan,Caifang Ren,Guomin Zhang, Kaiping Deng，Fanxing Meng，Feng wang*，Effects of algae dietary supplementation on fatty acid composition and the expression of genes involved in lipid metabolism in Hu sheep managed under intensive finishing systems，Meat Science，2019，157：107872 Xiao-Xiao Gao, Qi-Fan Zhang, Ming Zhu, Xiao-He Li, Yi-Xuan Guo, Jing Pang，Zi-Fei Liu, Pei-Hua You, Guo-Min Zhang, Feng Wang*，Effects of L-Arginine on endometrial estrogen receptor α/β and progesterone receptor expression in nutrient-restricted Hu sheep，Theriogenology，2019，138:137-144 2018 Guo-Min Zhang，Ting-Ting Zhang, Yu-Hang Jin, Jian-Ling Liu, Yi-Xuan Guo, Yi-Xuan Fan, M.A. El-Samahy. Fan-Xing Meng,Feng Wang*, Zhi-Hai Lei*，Effect of caloric restriction and subsequent re-alimentation on oxidative stress in the liver of Hu sheep ram lambs，Animal Feed Science and Technology, 2018，237：68-77 Yi-Xuan Guo, Hai-Tao Nie, Chen-Jie Xu, Guo-Min Zhang, Ling-Wei Sun,Ting-Ting Zhang, Zhen Wang, Xu Feng, Pei-Hua You, Feng Wang*，Effects of nutrient restriction and arginine treatment on oxidative stress in the ovarian tissue of ewes during the luteal phase，Theriogenology，2018，113：127-136 Xiaolei Yao，Mohmed El-samahy, Lijie Fan，Linfeng Zheng，Yuyue Jin，Jing pang，Guomin Zhang，Zifei Liu，Feng Wang*,In vitro influence of Selenium on the proliferation of and steroidogenesis in goat luteinized granulosa cells，Theriogenology，2018，114：70-80 Mingtian Deng, Zifei Liu, Caifang Ren, Guomin Zhang, Jing Pang, Yanli Zhang, Feng Wang*，Yongjie Wan*, Long noncoding RNAs exchange during zygotic genome activation in goat，Biology of Reproduction，2018，99：707-717 Xiaoxiao Gao，Xiaohe Li，Qifan Zhang，Ming Zhu，Yixuan Guo，Kaiping Deng，Guomin Zhang，Feng Wang*，Effects of L-arginine on endometrial microvessel density in underfed Hu sheep，Theriogenology，2018，119：252-258 2017 Lingwei Sun; Yixuan Guo; Yixuan Fan; Haitao Nie; Ruocheng Wang; Feng Wang*，Metabolic profiling of stages of healthy pregnancy in Hu sheep using nuclear magnetic resonance (NMR)，Theriogenology，2017，92：121-128 Xiaolei Yao, Hua Yang, Yanli Zhang, Caifang Ren, Haitao Nie, Yixuan Fan, Wenjun Zhou, Shuting Wang, Xu Feng, Feng Wang*，Characterization of GALNTL5 gene sequence and expression in ovine testes and sperm，Theriogenology，2017，95：54-61 Yi-Xuan Guo, Hai-Tao Nie, Ling-Wei Sun , Guo-Min Zhang, Kai-Ping Deng, Yi-Xuan Fan, Feng Wang*，Effects of diet and arginine treatment during the luteal phase on ovarian NO/PGC-1a signaling in ewes，Theriogenology，2017，96：76-84 Yanli Zhang, Hua Yang, Le Han, Fengzhe Li, Tingting Zhang, Jing Pang, Xu Feng，Caifang Ren, Shengyong Mao, Feng Wang*，Long noncoding RNA expression profile changes associated with dietary energy in the sheep testis during sexual maturation，Sci Rep.2017,12;7(1):5180-5192 Zhang, Yanli，Han, Le; Yang, Hua; Pang, Jing; Li, Peizhen; Zhang, Guomin; Li, Fengzhe; Wang, Feng*, Bisphenol A affects cell viability involved in autophagy and apoptosis in goat testis sertoli cell，Environmental Toxicology and Pharmacology，2017，55：137-147 Yanli Zhang，Fengzhe Li，Xu Feng，Hua Yang，Aoxiang Zhu，Jing Pang，Le Han，Tingting Zhang，Xiaolei Yao，Feng Wang *，Genome-wide Analysis of DNA Methylation Profiles on Sheep ovaries Associated with Prolificacy Using Whole-genome Bisulfite Sequencing，BMC Genomics，2017 Oct 2;18(1):759. doi: 10.1186/s12864-017-4068-9 2016 Feifei Luo, Ruoxin Jia, Shijia Ying, Ziyu Wang, Feng Wang*。Analysis of Genes that Influence Sheep Follicular Development by Different Nutrition Levels during the Luteal Phase using Expression Profiling. Animal Genetics，2016,47：354-364 Hao Zhang, Lingwei Sun, Ziyu Wang, Mingtian Deng, Guoming Zhang. Rihong Guo, Tiewei Ma, and Feng Wang*，Dietary N-carbamylglutamate and Rumen-protected L-Arginine Supplementation ameliorate Fetal growth restriction in undernourished ewes. Journal of Animal Science,2016，94：2072-2085 Rihong Guo#, Yongjie Wan#, Dan Xu, Libin Cui , Mingtian Deng , Guoming Zhang. Ruoxin Jia, Wenjun Zhou, Zhen Wang, Kaiping Deng, Mingrui Huang, Feng Wang*, Yanli Zhang*,Generation and evaluation of Myostatin Knock-out Rabbits and Goat Using CRISPR/Cas9 system, Scientific Reports, 2016, 6:29855 Hao Zhang, Lingwei Sun, Ziyu Wang, Mingtian Deng, Haitao Nie, Guoming Zhang, Tiewei Ma and Feng Wang*. N-carbamylglutamate and L-arginine improved maternal and placental development in underfed ewes, Reproduction，2016，151：623–635 Guomin Zhang; Mingtian Deng; Yanli Zhang; Yixuan Fan; Yongjie Wan; Haitao Nie; Ziyu Wang; Feng Wang*; Zhihai Lei*. Effect of PGC-1α overexpression or silencing on mitochondrial apoptosis of goat luteinized granulosa cells. Journal of Bioenergetics and Biomembranes,2016，48:493-507 出版教材、著作30多部，其中主编、副主编如下： 1.主编《动物繁殖学》，中国农业大学出版社，2012.05，北京 2.第一主编《动物繁殖学实验教程》，（第二版），中国农业大学出版社，2017.07，北京 3.第一主编《牛羊繁殖学》，中国农业出版社，2003.12，北京 4.主编《羊业科学研究进展(2015)》,中国农业科学技术出版社, 2015.10,北京 5.第二主编《肉用山羊养殖与疫病防治新技术》，中国农业科学技术出版社, 2015.12,北京 6.第三主编《肉羊标准化高效养殖关键技术》，江苏凤凰科技出版社，2016,10,南京 7.主编《高产奶牛养殖7日通》，中国农业出版社，2004.01，北京 8.主编《高产奶牛绿色养殖新技术》，中国农业出版社，2003.07，北京 9.主编《肉牛绿色养殖新技术》，中国农业出版社，2003.05，北京 10.主编《无公害牛奶生产技术》,云南科技出版社，2002.12，昆明 11.主编《肉羊饲养新技术》，中国农业科学技术出版社，2013.04，北京 12.副主编《动物繁殖技术》，中国农业出版社，2010.06，北京

学术兼职

国家肉羊体系岗位专家兼室主任；江苏省家畜胚胎工程实验室主任、省肉羊体系首席专家、省肉羊育种协作组首席专家。中国畜牧兽医学会动物繁殖学分会副理事长、养羊学分会常务理事；中国农学会秸秆资源综合利用分会常务理事，全国草食动物健康生产科技创新联盟常务理事。第二届全国畜牧业标准化技术委员会委员，江苏省畜牧业标准化技术委员会委员。江苏省第三届畜禽资源委员会委员兼羊业分会主任委员。江苏省畜牧业协会常务理事、兼羊业分会副会长及秘书长。