个人简介

教育与工作经历 2004年9月-2009年6月，南京农业大学，动物医学专业攻读本科 2009年9月-2011年6月，南京农业大学，临床兽医专业攻读硕士 2011年9月-2014年12月，南京农业大学，临床兽医专业攻读博士 2015年3月-至今，在南京农业大学动物科技学院任教 奖励及荣誉 2019 教育部自然科学二等奖（5/5）；2020年，动科院教师教学比赛“二等奖”；2021年，动科院优秀毕业论文指导教师 参加学术团体及任职情况 张羽，2014年12月获南京农业大学临床兽医学博士学位，2015年03月至今在南京农业大学动物科技学院任教。主要开展哺乳动物卵母细胞质量控制与分子调控的机制研究，包括环境内分泌干扰物对卵母细胞成熟质量的影响及卵母细胞内部分子调控机制。首次报道了内分泌干扰物MEHP侵害猪卵母细胞成熟并探索了其保护措施；同时探明了膜泡运输蛋白RAB35和蛋白激酶PKD1调控卵母细胞成熟质量的机制。相关研究在学科权威期刊Molecular Human Reproduction和Biology of Reproduction上发表，2篇论文当选当期封面文章。 承担科研项目 1. 中央高校基本科研业务费，KYYZ202102, PKD1介导的抗氧化参与藏猪卵母细胞高原低氧适应的机制研究，2021/01/01-2021/12/31，5万元，主持 2. 国家自然科学基金青年基金项目，31601204，Rab35对小鼠卵母细胞成熟过程中极性形成的调控及机制，2017/01-2019/12，22万元，主持。 3. 江苏省自然科学基金青年基金项目，BK20150674，Daam1在猪卵母细胞不均等分裂过程中的功能及机制，2015/07-2018/06，20万元，主持 4. 中国博士后科学基金面上资助，2015M580441，Daam1对猪卵母细胞成熟过程中极性形成的调控及机制，2015/12-2017/11，8万元，主持 5. 江苏省博士后科研资助计划，1501065B、Rab35对卵母细胞纺锤体迁移和极体排出的功能及机制，2015/08/25-2017/08/24，4万元，主持 6. 南京农业大学专任教师科研启动费，802558，2015/10-2017/10，1万元，主持 7. 中央高校基本科研业务费，KJQN201703， Rab35对小鼠卵母细胞成熟过程中极性形成的调控及机制，2016/01-2018/12，10万元，主持 8. 博士后国际交流计划学术交流项目，2015，3万元，主持

研究领域

卵子成熟与胚胎发育

动物遗传育种与繁殖

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhang Y, Wan X, Wang HH, Pan MH, Pan ZN, Sun SC*. RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis. Mol Hum Reprod. 2019, 25(7):359-372. 2. Zhang Y, Wu LL, Wan X, Wang HH, Li XH, Pan ZN, Sun SC*. Loss of PKC mu function induces cytoskeletal defects in mouse oocyte meiosis. J Cell Phyisol. 2019, 234(10):18513-18523. 3. Zhang Y, Wang HH, Wan X, Xu Y, Pan MH, Sun SC*. Inhibition of protein kinase D disrupts spindle formation and actin assembly during porcine oocyte maturation. Aging. 2018, 10(12):3736-44. 4. Zhang Y, Wang T, Lan M, Sun SC*. Melatonin protects oocytes from MEHP exposure-induced meiosis defects in porcine. Biol Reprod. 2018, 98(3): 286-298. 5. Zhang Y, Wang QC, Liu J, Xiong B, Cui XS, Kim NH, Sun SC*. The Small GTPase CDC42 regulates actin dynamics during porcine oocyte maturation. J Reprod Dev. 2017, 63(5): 505-510. 6. Lu YJ#; Zhang Y#, Pan MH, Kim NH, Sun SC*, Cui XS*. Daam1 regulates fascin for actin assembly in mouse oocyte meiosis. Cell Cycle, 2017, 16(14): 1350-1356. 7. Ma RJ#, Li HR#, Zhang Y#, Lin Y, Qiu XH, Xie M, Yao B*. The toxic effects and possible mechanisms of Brusatol on mouse oocytes. PloS One, 2017, 12(5): e0177844. 8. Zhang Y#, Zhu CC#, Sun SC. Cyclin B3: an anaphase onset controller in meiosis. Cell Cycle, 2015, 14(19): 3013. 9. Zhang Y, Wang F, Niu YJ, Liu HL, Rui R, Cui XS, Kim NH, Sun SC*. Formin mDia1, a downstream molecule of FMNL1, regulates Profilin1 for actin assembly and spindle organization during mouse oocyte meiosis. BBA Mol Cell Res. 2015, 1853(2): 317-27. 10. Zhang Y, Duan X, Cao R, Liu HL, Cui XS, Kim NH, Rui R, Sun SC*. Small GTPase RhoA regulates cytoskeleton dynamics during porcine oocyte maturation and early embryo. Cell Cycle. 2014, 13(21): 3390-403. 11. Zhang Y, Liu J, Peng X, Zhu CC, Han J, Luo J, Rui R*. KIF20A Regulates Porcine Oocyte Maturation and Early Embryo Development. PLoS One. 2014, 9(7): e102898. 12. Zhang Y, Wang QC, Han J, Cao R, Cui XS, Kim NH, Rui R, Sun SC*. Involvement of Dynamin 2 in actin-based polar body extrusion during porcine oocyte maturation. Mol Reprod Dev. 2014, 81(8):725-34. 13. Zhang Y, Duan X, Xiong B, Cui XS, Kim NH, Rui R, Sun SC*. ROCK inhibitor Y-27632 prevents porcine oocyte maturation. Theriogenology. 2014, 82(1):49-56. 其他论文： 14. Pan ZN, Pan MH, Sun MH, Li XH, Zhang Y, Sun SC*. RAB7 GTPase regulates actin dynamics for DRP1-mediated mitochondria function and spindle migration in mouse oocyte meiosis. FASEB J. 2020, 34(7): 9615-9627. 15. Pan MH, Wan X, Wang HH, Pan ZN, Zhang Y, Sun SC*. FMNL3 regulates FASCIN for actin-mediated spindle migration and cytokinesis in mouse oocytes. Biol Reprod. 2020, 102(6): 1203-1212. 16. Lan M, Zhang Y, Wan X, Pan MH, Xu Y, Sun SC*. Melatonin ameliorates ochratoxin A-induced oxidative stress and apoptosis in porcine oocytes. Environ Pollut. 2020. 256:113374. 17. Wang QC, Wan X, Jia RX, Xu Y, Liu X, Zhang Y, Sun SC*. Inhibition of N-WASP affects actin-mediated cytokinesis during porcine oocyte maturation. Theriogenology. 2020, 144:132-138. 18. Wang HH, Zhang Y, Tang F, Pan MH, Wan X, Li XH, Sun SC*. Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics. Development. 2019. 146(3): dev171280. 19. Pan ZN, Lu Y, Tang F, Pan MH, Wan X, Lan M, Zhang Y, Sun SC*. RAB8A GTPase regulates spindle migration and Golgi apparatus distribution via ROCK-mediated actin assembly in mouse oocyte meiosis. Biol Reprod. 2019, 100(3):711-720. 20. Duan X, Zhang HL, Pan MH, Zhang Y, Sun SC*. Vesicular transport protein Arf6 modulates cytoskeleton dynamics for polar body extrusion in mouse oocyte meiosis. BBA-Mol Cell Res. 2018, 1865(2):455-462. (IF=5.3) 21. Tang F, Pan MH, Wan X, Lu Y, Zhang Y, Sun SC*. Kif18a regulates Sirt2-mediated tubulin acetylation for spindle organization during mouse oocyte meiosis. Cell Div. 2018, 13:9. 22. Liu J, Wang QC, Duan X, Cui XS, Kim NH, Zhang Y, Sun SC*. Profilin 1 plays feedback role on actin-mediated polar body extrusion in mouse oocytes. Reprod Fertil Dev. 2018, 30(5):752-58. 23. Pan MH, Wang F, Lu Y, Tang F, Duan X, Zhang Y, Xiong B, Sun SC*. FHOD1 regulates cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell division. J Cell Physiol. 2018, 233(3):2270-2278. 24. Duan X, Zhang Y, Chen KL, Zhang HL, Wu LL, Liu HL, Wang ZB, Sun SC*. The small GTPase RhoA regulates the LIMK1/2-cofilin pathway to modulate cytoskeletal dynamics in oocyte meiosis. J Cell Physiol. 2018, 233(8):6088-97. 25. Tang F, Pan MH, Lu Y, Wan X, Zhang Y, Sun SC*. Involvement of Kif4a in spindle formation and chromosome segregation in mouse oocytes. Aging Dis. 2018, 9(4):623-633. 26. Wan X, Zhang Y, Lan M, Pan MH, Tang F, Zhang HL, Ou XH*, Sun SC*. Meiotic arrest and spindle defects are associated with altered KIF11 expression in porcine oocytes. Environ Mol Mutagen. 2018, 59(9):805-812. 27. Duan X, Zhang HL, Pan MH, Zhang Y, Sun SC*. Vesicular transport protein Arf6 modulates cytoskeleton dynamics for polar body extrusion in mouse oocyte meiosis. BBA-Mol Cell Res. 2017: S0167-4889(17)30315-4. 28. Han J, Wang QC, Zhu CC, Liu J, Zhang Y, Cui XS, Kim NH, Sun SC*. Deoxynivalenol exposure induces autophagy/apoptosis and epigenetic modification changes during porcine oocyte maturation. Toxicol Appl Pharmacol. 2016, 300:70-76. 29. Ma R, Zhang Y, Zhang L, Han J, Rui R*. Sirt1 protects pig oocyte against in vitro aging. Anim Sci J. 2015, (9): 826-32. 30. Wang QC, Liu J, Wang ZB, Zhang Y, Duan X, Cui XS, Kim NH, Sun SC*. Dynamin 2 regulates actin-mediated spindle migration in mouse oocytes. Biol Cell. 2014,106 (6): 193-202 . 31. Duan X, Chen KL, Zhang Y, Cui XS, Kim NH, Sun SC*. ROCK inhibition prevents mouse early embryo development. Histochem Cell Biol. 2014, 142(2): 227-233. 32. Wang F, An GY, Zhang Y, Liu HL, Cui XS, Kim NH, Sun SC*. Arp2/3 complex inhibition prevents meiotic maturation in porcine oocytes. PLoS One. 2014, 9(1): e87700.