个人简介
蔺辉星,江苏省科技副总。2004-2009 年,南京农业大学动物医学专业,本科;2009-2014 年,南京农业大学预防兽医学专业,硕博连读研究生。2014-2018 年南京农业大学动物医学院师资博士后。2018 年至今,南京农业大学动物医学院预防兽医系讲师。2020 年受聘为硕士研究生指导教师。主要从事猪消化系统和呼吸系统疫病致病机制及免疫防控研究。主持国家自然科学基金青年科学基金、中国博士后科学基金特别资助等科研项目 8 项,在 Vaccine、Journalof Proteome Research、Veterinary Research 等期刊发表第一作者或通讯作者论文18 篇,其中 SCI 论文 13 篇,参编 Springer 出版社英文著作 1 部。申报国家发明专利 10 项,其中 4 项已获授权。
主持科研项目:
1. 猪痘病毒 SPV009 蛋白抑制宿主免疫应答的分子机制,国家自然科学基金青年科学基金项目,2018-2020。
2. 动物源新型冠状病毒检测,中国博士后科学基金特别资助,2020-2022。
3. 猪腹泻综合防控技术研究,江苏省产学研合作项目,2020-2021。
4. 猪病毒性腹泻新型疫苗研发,江苏省“校企联盟”合作项目,2021-2025。
5. 猪病毒性腹泻多联乳酸杆菌载体疫苗研发,江苏省“校企联盟”合作项目,2016-2019。
6. PEDV 和 TGEV 二联重组猪痘活载体疫苗的研制,江苏省普通高校研究生科研创新计划,2012-2013。
7. 猪痘病毒抑制宿主免疫应答的分子机制,中央高校基本科研业务费项目,2018-2020。
8. IEC-2 细胞自噬对 PEDV 复制的影响机制,中央高校基本科研业务费自主创新项目,2018-2019。
近期论文
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1. Xinran Luo, Xiaojing Chang, Hong Zhou, Huixing Lin*, Hongjie Fan*;
Glaesserella parasuis induces inflammatory response in 3D4/21 cells through
activation of NLRP3 inflammasome signaling pathway via ROS, Veterinary
Microbiology, 2021,256:109057.
2. Huixing Lin, Bin Li, Mingxing Liu, Hong Zhou, Kongwang He, Hongjie Fan*;
Nonstructural protein 6 of porcine epidemic diarrhea virus induces autophagy to
promote viral replication via the PI3K/Akt/mTOR axis, Veterinary Microbiology,
2020,244:108684.
3. Lin Huixing, Zhou Hong, Gao Lu, Li Bin, He Kongwang, Fan Hongjie*.
Development and application of an indirect ELISA for the detection of antibodies
to porcine epidemic diarrhea virus based on a recombinant spike protein. BMC
Veterinary Research, 2018, 14:243.
4. Huixing Lin, Bin Li, Lei Chen, Zhe Ma, Kongwang He, Hongjie Fan*.
Differential Protein Analysis of IPEC-J2 Cells Infected with Porcine Epidemic
Diarrhea Virus Pandemic and Classical Strains Elucidates the Pathogenesis of
Infection. Journal of Proteome Research, 2017, 16: 2113-2120.
5. Huixing Lin, Zhe Ma, Lei Chen, Hongjie Fan*. Recombinant swinepox virus
expressing glycoprotein E2 of classical swine fever virus confers complete
protection in pigs upon viral challenge. Frontiers in Veterinary Science, 2017,
4:81.
6. Huixing Lin, Zhe Ma, Xin Hou, Lei Chen, Hongjie Fan*. Construction and
immunogenicity of a recombinant swinepox virus expressing a multi-epitope
peptide for porcine reproductive and respiratory syndrome virus. Scientific
Reports, 2017, 7:43990.
7. Huixing Lin, Lei Chen, Lu Gao, Xiaomin Yuan, Zhe Ma, Hongjie Fan*.
Epidemic strain YC2014 of porcine epidemic diarrhea virus could provide piglets
against homologous challenge. Virology Journal, 2016, 13(68): 1-7.
8. Huixing Lin, Zhe Ma, Xuqiu Yang, Hongjie Fan*, Chengping Lu. A novel
vaccine against Porcine circovirus type 2 (PCV2) and Streptococcus equi ssp.
zooepidemicus (SEZ) co-infection, Veterinary Microbiology, 2014,
171(1-2):198-205.
9. Huixing Lin, Zhe Ma, Hongjie Fan*, Chengping Lu. Construction and
immunogenicity of recombinant swinepox virus expressing capsid protein of
PCV2, Vaccine, 2012, 30:6307- 6313.
10. Huixing Lin, Dongyan Huang, Ye Wang, Chengping Lu, Hongjie Fan*. A novel
vaccine against Streptococcus equi ssp zooepidemicus infections: The
recombinant swinepox virus expressing M-like protein, Vaccine, 2011,
29(40):7027-7034.
参编英文著作:
1. 《Vaccine Technologies for Veterinary Viral Diseases》,2016,Springer 出版社。