个人简介
徐立新,预防兽医学兽医寄生虫分子与免疫博士在读。从事家畜寄生虫病学及实验动物学的教学、科研等。
科研项目:
1. 国家自然科学基金国际(地区)合作与交流项目,31661143017,鸡球虫树突状
细胞刺激性抗原的确定及其应用,2016.11-2019.10,250 万元,在研,参加
2. 2016 年动物卫生行业标准项目,2016-127,牛毛滴虫病诊断技术(修订),
2016.1-2016.12,4 万元,结题,参加
3. 国家“973”计划子课题,2015CB150305,寄生虫免疫逃避重要分子的鉴定与
功能,2015-2019,前两年 267 万元(2015-2016 年),在研,参加
4. 国家自然科学基金面上项目,31372428,鸡艾美耳球虫侵入部位特异性关键
分子研究,2014.01-2017.12,70 万元,在研,参加
5. 国家自然科学青年基金项目,31201896,鸡球虫共同抗原的确认及免疫原性
分析,2013.01-2015.12,24 万元,已结题,参加
6. 国家自然科学基金面上项目,31172308,捻转血矛线虫重组 galectin 抑制山
羊外周血淋巴细胞细胞因子转录的通路研究,2012.01-2015.12,62 万元,结题,参加
荣誉奖项:
获得 2016 年度“勃林格殷格翰奖教金”
发明专利:
1. 李祥瑞,徐立新,严若峰,宋小凯,一种用于弓形虫感染的诊断抗原及其制
备方法和应用,2015.09.16,中国,ZL201310124956.8
2. 李祥瑞,严若峰,徐立新,宋小凯,高云路,一种鸡球虫多价重组蛋白亚单
位疫苗及其应用,2015.02.18,中国,ZL201310273603.4
3. 李祥瑞,宋小凯,严若峰, 徐立新,任喆,一种鸡艾美耳球虫免疫调节型多
价表位 DNA 疫苗,2014.09.03 ,中国,ZL201110307305.3
4. 李祥瑞,宋小凯,严若峰,徐立新,雷晨昱,宋鸿雁,预防鸡巨型艾美耳球
虫的免疫调节型 DNA 疫苗,2012.07.04,中国,ZL200810234982.5
5. 李祥瑞,徐立新,宋小凯,严若峰,宋鸿雁,预防鸡堆型艾美耳球虫的免疫
调节型 DNA 疫苗,2012.07.04,中国,ZL200810155079.X
近期论文
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(1)Song X, Zhang Z, Liu C, Xu L, Yan R, Li X. Evaluation of the persistence,
integration, histopathology and environmental release of DNA vaccine encoding
Eimeria tenella TA4 and chicken IL-2. Vet Parasitol. 2016, 229:22-30.
(2)Javaid Ali Gadahi, Bu Yongqian, Muhammad Ehsan, ZhenChao Zhang, Shuai
WANG, RuoFeng Yan, XiaoKai Song, LiXin Xu, XiangRui Li. Haemonchus
contortus excretory and secretory proteins (HcESPs) suppress functions of PBMCs in
vitro. Oncotarget,2016 , 7(24): 35670-35679.
(3)Gadahi JA, Wang S, Bo G, Ehsan M, Yan R, Song X, Xu L, Li X. Proteomic
Analysis of the Excretory and Secretory Proteins of Haemonchus contortus (HcESP)
Binding to Goat PBMCs In Vivo Revealed Stage-Specific Binding Profiles. PLoS
One. 2016, 11(7): e0159796.
(4)Li Y, Yuan C, Wang L, Lu M, Wang Y, Wen Y, Yan R, Xu L, Song X, Li X.
Transmembrane protein 147 (TMEM147): another partner protein of Haemonchus
contortus galectin on the goat peripheral blood mononuclear cells (PBMC). Parasit
Vectors. 2016, 9(1): 355.
(5)Zhang Z, Liu X, Yang X, Liu L, Wang S, Lu M, Ehsan M, Gadahi JA, Song X,
Xu L, Yan R, Li X. The Molecular Characterization and Immunity Identification of
Microneme 3 of Eimeria acervulina. J Eukaryot Microbiol. 2016, doi:
10.1111/jeu.12318.
(6)Zhang Z, Liu L, Huang J, Wang S, Lu M, Song X, Xu L, Yan R, Li X. The
molecular characterization and immune protection of microneme 2 of Eimeria
acervulina. Vet Parasitol. 2016, 215:96-105.
(7)Hoan TD, Zhang Z, Huang J, Yan R, Song X, Xu L, Li X. Identification and
immunogenicity of microneme protein 2 (EbMIC2) of Eimeria brunetti. Exp Parasitol.
2016, 162:7-17.
(8)Fang Wang, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan. Identification
of differentially expressed proteins between free-living and activated third-stage
larvae of Haemonchus contortus. Veterinary parasitology, 2016, 215(1): 72-77.
(9)Gadahi JA, Ehsan M, Wang S, Zhang Z, Wang Y, Yan R, Song X, Xu L, Li X.
Recombinant protein of Haemonchus contortus 14-3-3 isoform 2 (rHcftt-2) decreased
the production of IL-4 and suppressed the proliferation of goat PBMCs in vitro. Exp
Parasitol. 2016, 171:57-66.
(10) Javaid Ali Gadahi, Baojie Li, Muhammad Ehsan1, Shuai Wang, Zhenchao Zhang,
Yujian Wang, Muhammad Waqqas Hasan, Ruofeng Yan, Xiaokai Song, Lixin Xu and
Xiangrui Li. Recombinant Haemonchus contortus 24 kDa excretory/ secretory protein
(rHcES-24) modulate the immune functions of goat PBMCs in vitro. Oncotarget,
2016, 7(51): 83926-83937.
( 11 ) Xiaokai Song, Yunlu Gao, Lixin Xu, Ruofeng Yan, Xiangrui Li. Partial
protection against four species of chicken coccidia induced by multivalent subunit
vaccine, Vet Parasitol., 2015, 212(3-4):80-85.
(12)Xiaokai Song, Ze Ren, Ruofeng Yan, Lixin Xu, Xiangrui Li. Induction of
protective immunity against Eimeria tenella, Eimeria necatrix, Eimeria maxima and
Eimeria acervulina infections using multivalent epitope DNA vaccines, Vaccine, 2015,
33(24):2764-2770.
( 13 ) Xiaokai Song, Lixin Xu, Ruofeng Yan, Xinmei Huang, Xiangrui Li.
Construction of Eimeria tenella multi-epitope DNA vaccines and their protective
efficacies against experimental infection, Vet Immunol Immunopathol, 2015,
166(3-4):79-87.
(14)Xiaokai Song, Xinmei Huang, Ruofeng Yan, Lixin Xu, Xiangrui Li. Efficacy of
chimeric DNA vaccines encoding Eimeria tenella 5401 and chicken IFN-γ or IL-2
against coccidiosis in chickens, Exp Parasitol., 2015, 156:19-25.
(15)Xiaokai Song, Ruirui Zhang, Lixin Xu, Ruofeng Yan, Xiangrui Li. Chimeric
DNA vaccines encoding Eimeria acervulina macrophage migration inhibitory factor
(E.MIF) induce partial protection against experimental Eimeria infection, Acta
Parasitol., 2015, 60(3):500-508.