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个人简介

陆明敏,南京农业大学高层次引进人才。主要从事重要动物寄生虫的感染与致病机制研究、分子疫苗研发等工作。旨在通过探究寄生虫入侵宿主及致病的生物学过程,揭示寄生虫与宿主互作的分子机制及其免疫逃避机理,为重要动物寄生虫病的防治提供新的理论依据和防控策略。同时从事禽类基础免疫学研究,致力于为禽病防控提供有价值的免疫学工具。以第一作者/通讯作者在免疫学、寄生虫学、兽医学等领域 Top 期刊发表论文多篇,以共同作者身份发表论文近 30 篇。参与美国农业部 ARS/USDA CRISProject、USDA/NIFA Program、国家 973 计划、十三五国家重点研发计划等科研项目。Frontiers in Veterinary Science 编 委 , Animal Nutrition 、 Frontiers in Immunology 、Experimantal Parasitology 等期刊审稿人。中国畜牧兽医学会兽医寄生虫学分会、中国畜牧兽医学会兽医食品卫生学分会、美国免疫学学会、美国兽医医学协会、美国家禽病理学家协会会员。现主持南京农业大学高层次引进人才启动项目, 省优势学科人才引进启动项目。 工作教育经历 2021 年 11 月-至今,南京农业大学动物医学院,副教授 2018 年 09 月-2021 年 10 月,美国农业部农业研究局 (USDA-ARS),博士后 2013 年 09 月-2018 年 07 月,南京农业大学动物医学院,农学博士(硕博连读) 2008 年 09 月-2013 年 07 月,南京农业大学动物医学院,农学学士

研究领域

兽医寄生虫分子与免疫、兽医公共卫生

近期论文

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1. Lu M, Lee Y, Li C, Lillehoj HS. Immunological characterization of chicken tumor necrosis factorα (TNF-α) using new sets of monoclonal antibodies specific for poultry TNF-α. Developmental & Comparative Immunology. 2022;131: 104374. 2. Lu M, Tian X, Zhang Y, Wang W, Tian A-L, Aimulajiang K, Liu L, Li C, Yan R, Xu L, Song X, Li X. Protection studies of an excretory–secretory protein HcABHD against Haemonchus contortus infection. Veterinary research. 2021;52: 1-16. 3. Lu M, Panebra A, Kim WH, Lillehoj HS. Characterization of immunological properties of chicken chemokine CC motif ligand 5 using new monoclonal antibodies. Developmental & Comparative Immunology. 2021;119: 104023. 4. Lu M, Tian X, Wang W, Zhang Y, Aimulajiang K, Tian AL, Li C, Yan R, Xu L, Song X, Li X. The excretory–secretory antigen HcADRM1 to generate protective immunity against Haemonchus contortus. Parasitology. 2021;148:1497-508. 5. Lu M, Yuan B, Yan X, Sun Z, Lillehoj HS, Lee Y, Baldwin-Bott C, Li C. Clostridium perfringensinduced host-pathogen transcriptional changes in the small intestine of broiler chickens. Pathogens. 2021;10:1607. 6. Lu M, Tian X, Tian AL, Li C, Yan R, Xu L, Song X, Li X. A novel α/β hydrolase domain protein derived from Haemonchus Contortus acts at the parasite-host interface. Frontiers in immunology. 2020;11: 1388. 7. Lu M, Tian X, Yang Z, Wang W, Tian A-L, Li C, Yan R, Xu L, Song X, Li X. Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins. Veterinary research. 2020;51: 1-14. 8. Lu M, Tian X, Zhang Y, Aimulajiang K, Wang W, Ehsan M, Charles Li, Yan R, Xu L, Song X, Li X. Unveiling the immunomodulatory properties of Haemonchus contortus adhesion regulating molecule 1 interacting with goat T cells. Parasites & vectors. 2020; 13: 1-13. 9. Lu M, Kim WH, Lillehoj HS, Li C. Development and characterization of novel mouse monoclonal antibodies against chicken chemokine CC motif ligand 4. Veterinary Immunology and Immunopathology. 2020;227: 110091. 10. Lu M, Li RW, Zhao H, Yan X, Lillehoj HS, Sun Z, Oh ST, Wang Y, Li C. Effects of Eimeria maxima and Clostridium perfringens infections on cecal microbial composition and the possible correlation with body weight gain in broiler chickens. Research in Veterinary Science. 2020;132: 142-149. 11. Lu M, Tian X, Yang X, Yuan C, Ehsan M, Liu X, Yan R, Xu L, Song X, Li X. The N-and C-terminal carbohydrate recognition domains of Haemonchus contortus galectin bind to distinct receptors of goat PBMC and contribute differently to its immunomodulatory functions in host-parasite interactions. Parasites & vectors. 2017;10: 1-11. 共同作者论文 1. Lee Y, Lu M, Lillehoj HS. Coccidiosis: Recent Progress in Host Immunity and Alternatives to Antibiotic Strategies. Vaccines. 2022; 10:215. 2. Li C, Lu M. Putting antimicrobial resistance in the corner. Nature Food. 2020; 1: 103-. 3. Lee Y, Lu M, Lillehoj HS. Immunological studies on chicken interferon-kappa using an antigen-capture ELISA developed using new mouse monoclonal antibodies. Developmental & Comparative Immunology. 2021;124:104204. 4. Tian X, Lu M, Jia C, Bu Y, Aimulajiang K, Zhang Y, et al. Haemonchus contortus transthyretin domain-containing protein (HcTTR): a promising vaccine candidate against Haemonchus contortus infection. Veterinary Parasitology. 2020;279:109045. 5. Tian X, Lu M, Wang W, Jia C, Muhammad E, Yan R, Xu L, Song X, Li X. Hc TTR: a novel antagonist against goat interleukin 4 derived from the excretory and secretory products of Haemonchus contortus. Veterinary research. 2019;50:1-11. 6. Tian A-L, Lu M, Calderón-Mantilla G, Petsalaki E, Dottorini T, Tian X, Wang Y, Huang SY, Hou J, Li X, Elsheikha HM, Zhu XQ. A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells. Parasites & vectors. 2018;11:1-14. 7. Tian A-L, Lu M, Zhang F-K, Calderón-Mantilla G, Petsalaki E, Tian X, Wang W, Huang SY, Li X, Elsheikha HM, Zhu XQ. The pervasive effects of recombinant Fasciola gigantica Ras-related protein Rab10 on the functions of goat peripheral blood mononuclear cells. Parasites & vectors. 2018;11:1-14. 8. Wang Y, Lu M, Wang S, Ehsan M, Yan R, Song X, Xu L, Li X. Characterization of a secreted macrophage migration inhibitory factor homologue of the parasitic nematode Haemonchus contortus acting at the parasite-host cell interface. Oncotarget. 2017;8:40052. 9. Ehsan M, Gadahi JA, Lu M, Yan R, Xu L, Song X, Zhu XQ, Du A, Hu M, Li X. Recombinant elongation factor 1 alpha of Haemonchus contortus affects the functions of goat PBMCs. Parasite immunology. 2020;42:e12703. 10. Ehsan M, Gadahi JA, Liu T, Lu M, Wang Y, Hasan MW, Haseeb M, Yan R, Xu L, Song X, Zhu XQ, Li X. Identification of a novel methyltransferase-type 12 protein from Haemonchus contortus and its effects on functions of goat PBMCs. Parasites & vectors. 2020;13:1-15. 11. Bu Y, Cao M, Tian X, Lu M, Li J, Mao D, Yu L, Memon MA, Li C, Xu L, Song X, Yan R, Li X. HcFAR, a functional inhibitor of goat TGF-β1 identified from excretory and secretory products of Haemonchus contortus. Veterinary Parasitology. 2020:109236. 12. Tian A-L, Tian X, Chen D, Lu M, Calderón-Mantilla G, Yuan X-D, Li X, Elsheikha HM, Zhu XQ. Modulation of the Functions of Goat Peripheral Blood Mononuclear Cells by Fasciola gigantica Thioredoxin Peroxidase In Vitro. Pathogens. 2020;9:758. 13. Ehsan M, Gao W, Gadahi JA, Lu M, Liu X, Wang Y, Yan R, Xu L, Song X, Li X. Arginine kinase from Haemonchus contortus decreased the proliferation and increased the apoptosis of goat PBMCs in vitro. Parasites & vectors. 2017;10:311. 14. Aimulajiang K, Naqvi MA-u-H, Chu W, Lu M, Tian X, Bu Y, Memon MA, Li X, Xu L, Song X, Yan R. Adhesion-Regulating Molecule from Haemonchus Contortus: Potential Antigen for Diagnosis of Early Infection in Goats. Pathogens. 2020;9:34. 15. Wang Q, Wu L, Hasan MW, Lu M, Wang W, Yan R, Yan R, Xu L, Song X, Li X. Hepatocellular carcinoma-associated antigen 59 of Haemonchus contortus modulates the functions of PBMCs and the differentiation and maturation of monocytederived dendritic cells of goats in vitro. Parasites & vectors. 2019;12:1-14. 16. Wang W, Wang Y, Tian X, Lu M, Ehsan M, Yan R, Song X, Xu L, Li X. Y75B8A. 8 (HC8) protein of Haemonchus contortus: a functional inhibitor of host IL‐2. Parasite immunology. 2019;41:e12625. 17. Wen Y, Wang Y, Wang W, Lu M, Ehsan M, Tian X, Yan R, Song X, Xu L, Li X. Recombinant Miro domain-containing protein of Haemonchus contortus (rMiro-1) activates goat peripheral blood mononuclear cells in vitro. Veterinary Parasitology. 2017;243:100-4. 18. Liu X, Ma Q, Sun X, Lu M, Ehsan M, Hasan MW, Xu L, Yan R, Song X, Li X. Effects of recombinant Toxoplasma gondii citrate synthase I on the cellular functions of murine macrophages in vitro. Frontiers in Microbiology. 2017;8:1376. 19. Li Y, Yuan C, Wang L, Lu M, Wang Y, Wen Y, Yan R, Xu L, , Song X, Li X. Transmembrane protein 147 (TMEM147): another partner protein of Haemonchus contortus galectin on the goat peripheral blood mononuclear cells (PBMC). Parasites & vectors. 2016;9:1-12. 20. Liu X, Li C, Li X, Ehsan M, Lu M, Li K, Xu L, Yan R, Song X, Li X. Proteomics analysis reveals that the proto-oncogene eIF5A indirectly influences the growth, invasion and replication of Toxoplasma gondii tachyzoite. Parasites & vectors. 2021;14:1-14. 21. Liu X, Li X, Wang Q, Sun X, Lu M, Ehsan M, et al. Toxoplasma gondii Histone 4 Affects Some Functions of Murine Ana-1 Macrophages In Vitro. Journal of Eukaryotic Microbiology. 2018;65:860-9. 22. Ehsan M, Wang W, Gadahi JA, Hasan MW, Lu M, Wang Y, Liu X, Haseeb M, Yan R, Xu L, Song X, Li X. The serine/threonine-protein phosphatase 1 from Haemonchus contortus is actively involved in suppressive regulatory roles on immune functions of goat peripheral blood mononuclear cells. Frontiers in immunology. 2018;9:1627. 23. Zhang Z, Liu L, Huang J, Wang S, Lu M, Song X, Xu L, Yan R, Li X. The molecular characterization and immune protection of microneme 2 of Eimeria acervulina. Veterinary parasitology. 2016;215:96-105. 24. Zhang Z, Wang S, Huang J, Liu L, Lu M, Li M, Sui Y, Xu L, Yan R, Song X, Li X. Proteomic analysis of Eimeria acervulina sporozoite proteins interaction with duodenal epithelial cells by shotgun LC–MS/MS. Molecular and Biochemical Parasitology. 2015;202:29-33. 25. Zhang Z, Liu X, Yang X, Liu L, Wang S, Lu M, Ehsan M, Gadahi JA, Song X, Xu L, Yan R, Li X. The molecular characterization and immunity identification of microneme 3 of Eimeria acervulina. Journal of Eukaryotic Microbiology. 2016;63:709-21. 26. Lee K-W, Lillehoj HS, Kim W, Park I, Li C, Lu M, Hofacre C. Research Note: First report on the detection of necrotic enteritis (NE) B-like toxin in biological samples from NE-afflicted chickens using capture enzyme-linked immunosorbent assay. Poultry Science. 2021:101190. 27. Aimulajiang K, Cao M, Liao S, Naqvi MA-u-H, Tian X, Li Z, Lu M, Lakho SA, Li X, Xu L, Song X, Yan R. Development and Potential Application of Ras Domain Containing Protein from Haemonchus contortus for Diagnosis of Goat Infection. Animals. 2020;10:138. 28. Liu L, Yan X, Lillehoj H, Sun Z, Zhao H, Xianyu Z, Lee Y, Melville S, Gu C, Wang Y, Lu M, Li C. Comparison of the Pathogenicity of Five Clostridium perfringens Isolates Using an Eimeria maxima Coinfection Necrotic Enteritis Disease Model in Commercial Broiler Chickens. Avian Diseases. 2020;64:386-92.

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