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个人简介

教育背景和工作履历: 1999.09-2003.07 福建农林大学 动物科学 本科 2003.09-2006.07 福建农林大学 临床兽医学 硕士 2006.09-2009.06 南京农业大学 预防兽医学 博士 导师 陆承平教授,从事猪链球菌致病机制及疫苗研制 2009.06-2011.12 南京农业大学动物医学院 讲师 2010.01-2011.02 法国巴斯德研究所 博士后 Pascale Cossart 教授实验室,从事单增李斯特菌小 RNA 调控细菌毒力研究 2011.12-2017.12 南京农业大学动物医学院 副教授 2014.09-2015.09 法国国家科学研究中心 访问学者 Pascale Romby 博士实验室,从事金黄色葡萄球菌小 RNA 调控细菌毒力研究 2017.12-至今 南京农业大学动物医学院 教授 代表性专利(*表示通讯作者): 国家发明专利:专利名称“制备猪链球菌 GZ0565 株无痕缺失突变株的方法”(专利号 ZL201210467416.5);发明人:吴宗福、邵靓、琚存祥、王卫雪、唐敏、陆承平 科研项目(负责人): 1. 主持 国家自然科学基金面上项目 “sRNA rss31 促进猪链球菌抵抗巨噬细胞清 除和调控其所在 ICE 水平转移的分子机制” (2022.01 - 2025.12) (No. 32172859) 2. 子课题负责人 国家重点研发计划“畜禽重要病原菌生长代谢和毒力调控机 制研究”项目任务“猪链球菌基因组进化及毒力变异和调控的分子机制” (2021.05-2025.12)(2021YFD1800402) 3. 主持 科技部 2018 年度“中法杰出青年科研人员交流计划”,农业领域, (2018.01-2018.12)(国科外函[2018]17) 4. 主持 国家自然科学基金面上项目 “双功能小 RNA rss03 促进猪链球菌在猪血 中存活的分子机制” (2019.01-2022.12)(No. 31872469) 5. 子课题负责人 国家重点研发计划“畜禽重要疫病病原学与流行病学研究” 任务“猪链球菌病原学与流行病原研究”(2017.07-2020.12)(No. 2017YFD0500102) 6. 主持 国家自然科学基金面上项目 “猪链球菌小 RNA rss04 促进脑膜炎形成的 分子机制” (2016.01-2019.12)(No. 31572544) 7. 主持 国家青年科学基金“LysM 结构蛋白在猪链球菌 9 型脑膜炎分离株中的 分子致病机制” (2012.1-2014.12) (No.31101828) 8. 主持 教育部留学回国人员科研启动基金 “DNA 核酸酶在猪链球菌 9 型脑膜 炎分离株中的分子致病 机制” (2013.05-2015.05)(教外司留[2013]693) 9. 主持 江苏省自然科学基金“丝氨酸裂解酶等胞外酶在猪链球菌 9 型脑膜炎分 离株中的分子致病机理” (2011.7-2014.6)(No.BK2011644) 10. 主持 教育部 2011 年度高等学校博士学科点专项科研基金——新教师类“5’- 核苷酸酶在猪链球菌 9 型脑膜炎分离株中的分子致病机制”(2012.1- 2014.12)(No. 20110097120016) 11. 主持 南京农业大学基本科研业务费专项基金 “猪链球菌 Mac-1 结构蛋白抗吞 噬对致病力的影响”(2013.5-2016.5)(No.KYZ201314) 12. 主持 南京农业大学青年科学基金“核苷酸酶等胞外酶在猪链球菌 9 型脑膜炎 分离株中的分子致病机理” (2011.7-2013.6)(No.KJ2011012) 邀请报告 1. 2021.12.09,南京,南京农业大学与联合国粮农组织同一健康全球专家论坛, 报告题目“The etiology and diagnosis of swine streptococcosis” 2. 2019.06.04,加拿大蒙特利尔,第四届猪链球菌国际研讨会,报告题目“The competitive advantage of Streptococcus suis novel capsular polysaccharide locus (NCL) 4 strain WUSS351 and the identification of six new NCLs of S. suis” 3. 2018.11.26,法国斯特拉斯堡,法国国家科学研究中心 RNA 结构与反应研究 所,报告题目“Roles of small RNAs and novel surface proteins in Streptococcus suis virulence” 4. 2018.04.13,上海,第九届长三角预防兽医学博士论坛,报告题目“猪链球菌 新的毒力调控因子——小 RNA” 5. 2016.09.08,德国布伦瑞克,第三届猪链球菌国际研讨会,报告题目 “Streptococcus suis Small RNA rss04 Contributes to Meningitis in Mouse Infection Model” 6. 2011.11.12,江苏徐州,江苏省微生物学会,报告题目“应用免疫蛋白组学方 法鉴定猪链球菌 2 型与 9 型共同抗原” 7. 2009.03.29,法国巴黎 巴斯德研究所,报告题目“Identifying Immunogenic Proteins and Revealing Putative Virulence-associated Factors of Streptococcus suis Serotype 9” 荣誉及奖项: 1. 江苏省第六期“333 高层次人才培养工程”第三层次培养对象:2022.01- 2016.12 2. 2020 年四川省科学技术进步三等奖,四川猪链球菌病综合防控技术研究集 成与应用,10/23 3. 2019 年山东省农牧渔业丰收二等奖,猪链球菌病高通量快速诊断新技术研 究与示范推广,4/20 4. 南京农业大学动物医学院 2017 年度先进工作者 5. 南京农业大学动物医学院 2015 年“勃林格殷格翰”奖教金 6. 2013 年第五届欧洲微生物学会青年科学家会议资助奖(中国唯一获奖人) 7. 江苏省微生物学会 2011 年会暨青年学术报告会优秀论文 8. 南京农业大学动物医学院 2011 年获“生泰尔”奖教金

研究领域

猪链球菌等动物细菌性病原致病机理、分子流行病学、耐药、防控

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. 《猪链球菌病》,陆承平、吴宗福 主编,北京:中国农业出版社,2015.11 3. Zhaoying Liu, Qiuhua Xu, Pujun Liang, Zeren Peng, Huochun Yao, Han Zheng*, Zongfu Wu*. The characteristics of population structure and antimicrobial resistance of Streptococcus suis serotype 8, a non-negligible pathotype. Transboundary and Emerging Diseases, 2022, doi: 10.1111/tbed.14592 4. Zijing Liang, Huizhen Wu, Chen Bian, Hao Chen, Yanling Shen, Xueping Gao, Jiale Ma, Huochun Yao, Liping Wang, Zongfu Wu*. The antimicrobial systems of Streptococcus suis promote niche competition in pig tonsils. Virulence, 2022, 13 (1): 781–793 5. Shuoyue Wang, Miaohang Ma, Zijing Liang, Xinchi Zhu, Huochun Yao, Liping Wang, Zongfu Wu*. Pathogenic investigations of Streptococcus pasteurianus, an underreported zoonotic pathogen, isolated from a diseased piglet with meningitis. Transboundary and Emerging Diseases, 2021, doi.org/10.1111/tbed.14413 6. Pujun Liang, Mingliu Wang, Marcelo Gottschalk, Ana I. Vela, April A. Estrada, Jianping Wang, Pengcheng Du, Ming Luo, Han Zheng*, Zongfu Wu*. Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs. Emerging Microbes & Infections, 2021, 10 (1): 1960-1974 7. Xiaoming Wang, Junjie Sun, Chen Bian, Jianping Wang, Zijing Liang, Yanling Shen, Huochun Yao, Jinhu Huang, Liping Wang*, Han Zheng*, Zongfu Wu*. The population structure, antimicrobial resistance, and pathogenicity of Streptococcus suis cps31. Veterinary Microbiology, 2021, 259: 109149 8. 陈琳, 王硕玥, 姚火春, 吴宗福*. 碳酸酐酶对猪链球菌生长及抗氧化应激的 影响[J]. 南京农业大学学报, 2021, 44(5): 903-910. 9. 杨诗鑫, 卞晨, 吴宗福*. 猪链球菌分子流行病学研究方法[J]. 微生物学报, 2021, 61(12): 3928–3936 10. Jinhu Huang, Xi Liu, Hao Chen, Li Chen, Xueping Gao, Zihao Pan, Jian Wang, Chengping Lu, Huochun Yao, Liping Wang*, Zongfu Wu*. Identification of six novel capsular polysaccharide loci (NCL) from Streptococcus suis multidrug resistant non-typeable strains and the pathogenic characteristic of strains carrying new NCLs. Transboundary and Emerging Diseases, 2019, 66: 995–1003. 11. Jiao Dai, Liying Lai, Huanyu Tang, Weixue Wang, Shuoyue Wang, Chengping Lu, Huochun Yao, Hongjie Fan, Zongfu Wu*. Streptococcus suis synthesizes deoxyadenosine and adenosine by 5’-nucleotidase to dampen host immune responses. Virulence, 2018, 9(1): 1509-1520. 12. Shouming Zhang, Xueping Gao, Genhui Xiao, Chengping Lu, Huochun Yao, Hongjie Fan, Zongfu Wu*. Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model. Journal of Visualized Experiments, 2018 (137), e57658. 13. Liying Lai, Jiao Dai, Huanyu Tang, Shouming Zhang, Chunyan Wu, Wancen Qiu, Chengping Lu, Huochun Yao, Hongjie Fan, Zongfu Wu*. Streptococcus suis serotype 9 strain GZ0565 contains a type VII secretion system putative substrate EsxA that contributes to bacterial virulence and a vanZ-like gene that confers resistance to teicoplanin and dalbavancin in Streptococcus agalactiae. Veterinary Microbiology, 2017, 205:26-33. 14. Genhui Xiao, Huanyu Tang, Shouming Zhang, Haiyan Ren, Jiao Dai, Liying Lai, Chengping Lu, Huochun Yao, Hongjie Fan, Zongfu Wu*. Streptococcus suis small RNA rss04 contributes to the induction of meningitis by regulating capsule synthesis and by inducing biofilm formation in a mouse infection model. Veterinary Microbiology, 2017, 199: 111-119. 15. 唐欢宇,任海燕,吴宗福*,陆承平. DNA核酸酶与猪链球菌9型毒力的关系.微生物 学报. 2017, 57(4): 1-10. 16. Zongfu Wu, Jing Shao, Haiyan Ren, Huanyu Tang, Mingyao Zhou, Jiao Dai, Liying Lai, Huochun Yao, Hongjie Fan, Dai Chen, Jie Zong, Chengping Lu. A Streptococcus suis LysM domain surface protein contributes to bacterial virulence. Veterinary Microbiology, 2016, 187: 64-69. 17. Zongfu Wu, Chunyan Wu, Jing Shao, Zhenzhen Zhu, Weixue Wang, Wenwei Zhang, Min Tang, Na Pei, Hongjie Fan, Jiguang Li, Huochun Yao, Hongwei Gu, Xun Xu, Chengping Lu. The Streptococcus suis transcriptional landscape reveals adaptation mechanisms in pig blood and cerebrospinal fluid. RNA, 2014, 20(6):882-898. 18. Zongfu Wu, Weixue Wang, Min Tang, Jing Shao, Chen Dai, Wei Zhang, Hongjie Fan, Huochun Yao, Jie Zong, Dai Chen, Junning Wang, Chengping Lu. Comparative genomic analysis shows that Streptococcus suis meningitis isolate SC070731 contains a unique 105K genomic island. Gene, 2014, 535(2):156-164. 19. Zongfu Wu, Wei Zhang, Yang Wang, Yan Lu, Chengping Lu. Identification of Antigens Common to Streptococcus suis Serotypes 2 and 9 by Immunoproteomic Analysis. Journal of Integrative Agriculture, 2012, 11(9):1517-1527. 20. Zongfu Wu, Wei Zhang, Jing Shao, Yang Wang, Yan Lu, Chengping Lu. Immunoproteomic assay of secreted proteins of Streptococcus suis serotype 9 with convalescent sera from pigs. Folia microbiologica, 2011, 56(5): 423-430. 21. Zongfu Wu, Wei Zhang, Yan Lu, Chengping Lu. Transcriptome profiling of zebrafish due to Streptococcus suis infection. Microbial Pathogenesis, 2010, 48(5):178-187. 22. Zongfu Wu, Wei Zhang, Chengping Lu. Comparative proteome analysis of secreted proteins of Streptococcus suis serotype 9 isolates from diseased and healthy pigs. Microbial Pathogenesis, 2008, 45(3): 159-166. 23. Zongfu Wu, Wei Zhang, Chengping Lu. Immunoproteomic assay of surface proteins of Streptococcus suis serotype 9. FEMS Immunology and Medical Microbiology, 2008, 53(1): 52-59. 24. David Lalaouna, Jessica Baude, Zongfu Wu, Arnaud Tomasini, Johana Chicher, Stefano Marzi, François Vandenesch, Pascale Romby, Isabelle Caldelari, Karen Moreau. RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation. Nucleic Acids Research, 2019, 47 (18): 9871–9887. 25. Zihao Pan, Jin Liu, Yue Zhang, Shenshen Chen, Jiale Ma, Wenyang Dong, Zongfu Wu, Huochun Yao. A novel integrative conjugative element mediates transfer of multi-drug resistance between Streptococcus suis strains of different serotypes. Veterinary Microbiology, 2019, 229: 110-116. 26. Genhui Xiao, Zongfu Wu, Shouming Zhang, Huanyu Tang, Fengqiu Wang, Jiao Dai, Chengping Lu. Mac Protein is not an Essential Virulence Factor for the Virulent Reference Strain Streptococcus suis P1/7. Current Microbiology, 2017, 74 (1): 90-96. 27. Wenyang Dong, Yinchu Zhu, Ye Ma, Jiale Ma, Yue Zhang, Lvfeng Yuan, Zihao Pan, Zongfu Wu, Huochun Yao. Multilocus sequence typing and virulence genotyping of Streptococcus suis serotype 9 isolates revealed high genetic and virulence diversity. FEMS Microbiology Letters, 2017, 364 (22): fnx192. 28. Delphine Bronesky, Zongfu Wu, Stefano Marzi, Philippe Walter, Thomas Geissmann, Karen Moreau, François Vandenesch, Isabelle Caldelari, Pascale Romby. Staphylococcus aureus RNAIII and Its Regulon Link Quorum Sensing, Stress Responses, Metabolic Adaptation, and Regulation of Virulence Gene Expression. Annual Review of Microbiology, 2016, 70: 299-316. 29. Pierre Fechter, Delphine Parmentier, Zongfu Wu, Olivier Fuchsbauer, Pascale Romby, Stefano Marzi. Traditional Chemical Mapping of RNA Structure In Vitro and In Vivo. Methods in Molecular Biology, 2016, 1490: 83-103. 30. Xiangkai Zhuge, Fang Tang, Hongfei Zhu, Xiang Mao, Shaohui Wang, Zongfu Wu, Chengping Lu, Jianjun Dai, Hongjie Fan. AutA and AutR, Two Novel Global Transcriptional Regulators, Facilitate Avian Pathogenic Escherichia coli Infection. Scientific Reports, 2016, 6: 25085 31. Sandeep Kumar Misra, Francine Moussan Désirée Aké, Zongfu Wu, Eliane Milohanic, Thanh Nguyen Cao, Pascale Cossart, Josef Deutscher, Véronique Monnet, Cristel Archambaud, Céline Henry. Quantitative Proteome Analyses Identify PrfA-Responsive Proteins and Phosphoproteins in Listeria monocytogenes. Journal of Proteome Research, 2014, 13(12):6046-6057. 32. Jing Shao, Wei Zhang, Zongfu Wu, Chengping Lu. The Truncated Major Pilin Subunit Sbp2 of the srtBCD Pilus Cluster Still Contributes to Streptococcus suis Pathogenesis in the Absence of Pilus Shaft. Current microbiology, 2014, 69(5):703-707. 33. Christophe Bécavin, Christiane Bouchier, Pierre Lechat, Cristel Archambaud, Sophie Creno, Edith Gouin, Zongfu Wu, Andreas Kühbacher, Sylvain Brisse, M. Graciela Pucciarelli, Francisco García-del Portillo, Torsten Hain, Daniel A. Portnoy, Trinad Chakraborty, Marc Lecuit, Javier Pizarro-Cerdá, Ivan Moszer, Hélène Bierne, Pascale Cossart. Comparison of widely used Listeria monocytogenes strains EGD, 10403S, and EGD-e highlights genomic variations underlying differences in pathogenicity. mBio, 2014, 5(2):e00969-00914. 34. Yang Wang, Li Yi, Zongfu Wu, Jing Shao, Guangjin Liu, Hongjie Fan, Wei Zhang, Chengping Lu. Comparative proteomic analysis of Streptococcus suis biofilms and planktonic cells that identified biofilm infection-related immunogenic proteins. PLoS One, 2012, 7(4):e33371. 35. Haodan Zhu, Dongyan Huang, Wei Zhang, Zongfu Wu, Yan Lu, Hongying Jia, Ming Wang, Chengping Lu. The novel virulence-related gene stp of Streptococcussuisserotype 9 strain contributesto a significant reduction in mouse mortality. Microbial Pathogenesis, 2011, 51(6):442-53. 36. Yang Wang, Wei Zhang, Zongfu Wu, Chengping Lu.Reduced virulence is an important characteristic of biofilm infection of Streptococcus suis. FEMS microbiology letters, 2011, 316(1): 36-43. 37. Yang Wang, Wei Zhang, Zongfu Wu, Xianglei Zhu, Chengping Lu.Functional analysis of luxS in Streptococcus suis reveals a key role in biofilm formation and virulence. Veterinary microbiology, 2011, 152 (1-2): 151-160.

学术兼职

Microbes and Infection: Editor, 2022.04—至今,法国巴斯德研究所官方期刊

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