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个人简介

郑龙三,韩国培材大学基因工程专业,1998 年获学士学位,2001 年获硕士学位,2005 年获博士学位。2005-2007 年,韩国忠南国立大学生物技术研究所从事研究工作;2007-2013年,美国加州大学戴维斯分校兽医学院博士后;2013 年作为“引进高层次人才”受聘于南京农业大学动物医学院。主要从事非洲猪瘟病毒、PEDV 等重大动物疫病防控理论、技术及产品研发,包括研究病毒与宿主互作机制;细胞工程;抗病毒药物研发。在 PNAS、J Virol、JID、MCB 和 JBC 等国际知名刊物共发表 SCI 论文 47 篇;获得中国、日本、美国、加拿大、澳大利亚和韩国等国专利 12 项。担任 Journal of Biological Chemistry、Oncogene、Journal of CellScience、Veterinary Research、Transboundary Emerging Diseases 等期刊论文评审人。 科研项目: 1. 国家重点研发揭榜挂帅项目课题(主持,项目编号 2021YFD1801204,2021-2024 年) 2. 企业合作横向课题(主持,2019-2023 年) 3. 国家重点研发计划(子课题主持,项目编号 2018YFC1603603,2018-2021 年) 4. 海外青年科学家研究基金项目(主持,项目编号 Y0201700559,2017-2020 年) 5. 中央高校基本业务费(主持,项目编号 Y021300526,2014-2016 年) 6. 南京农业大学引进人才启动经费 7. 江苏省优势学科人才引进启动经费 荣誉奖项: 江苏省五一劳动荣誉奖(2019 年) “生泰尔”奖教金(2014 年)

研究领域

分子病毒学与免疫细胞生物学

近期论文

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1. Liumei Sun, Huan Chen, Xin Ming, Zongyi Bo, Hyun-Jin Shin, Yong-Sam Jung*, Yingjuan Qian*. Porcine epidemic diarrhea virus infection induces caspase-8 mediated G3BP1 cleavage and subverts stress granules to promote viral replication. J Virol, 2021 Feb 10;JVI.02344-20. 2. Bo Z, Miao Y, Xi R, Zhong Q, Bao C, Chen H, Sun L, Qian Y, Jung YS*, Dai J. PRV UL13 inhibits cGAS-STING mediated IFN- production via phosphorylating IRF3. Vet Res 2020 Sep 15;51(1):118. 3. Chen H, Qian Y, Chen X, Ruan Z, Ye Y, Chen H, Babiuk LA, Jung YS*, Dai J. HDAC6 Restricts Influenza A Virus by Deacetylation of the RNA Polymerase PA Subunit. J Virol 2019,93(4):e01896- 18. 4. Sun H, Yao W, Wang K, Qian Y, Chen H, Jung YS*. Inhibition of neddylation pathway represses influenza virus replication and pro-inflammatory responses. Virology 2018, 514:230-239. 5. Lian X, Ming X, Xu J, Cheng W, Zhang X, Chen H, Ding C, Jung YS*, Qian Y. First molecular detection and characterization of Marek's disease virus in red-crowned cranes (Grus japonensis): a case report. BMC Vet Res 2018,14(1):122. 6. Yan W, Scoumanne A, Jung YS, Xu E, Zhang J, Zhang Y, Ren C, Sun P and Chen X. Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation. Genes Dev. 2016, 30(5):522-34. 7. Jung YS, Qian Y, Yan W, and Chen X. Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63. J. Investi. Dermatol. 2013, 133(5):1178-87. 8. Cho SJ, Rossi A, Jung YS, Yan W, Liu G, Zhang J, Zhang M, Chen X. Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proc Natl Acad Sci USA. 2013, 110(23):9362-7. 9. Qian Y# , Jung YS# , and Chen X. DEC1 controls the response of p53-dependent cell survival versus cell death to a stress signal through macrophage inhibitory cytokine-1. Proc Natl Acad Sci USA 2012, 109, 11300-11305. 10. Jung YS, Qian Y, and Chen X. DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation. DNA Repair (Amst) 2012, 11(2), 177- 184. 11. Jung YS, Qian Y, and Chen X. Pirh2 RING-finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapy. FEBS Lett 2012, 586, 1397-1402. 12. Cho SJ, Jung YS, Zhang J, Chen X. The RNA-binding Protein RNPC1 Stabilizes the mRNA Encoding the RNA-binding Protein HuR and Cooperates with HuR to Suppress Cell Proliferation. J Biol Chem 2012, 287(18), 14535-14544. 13. Zhang Y, Yan W, Jung YS, Chen X. Mammary epithelial cell polarity is differentially regulated by p73 isoforms via epithelial-to-mesenchymal transition. J Biol Chem 2012, 287(21), 17746-13. 14. Jung YS, Qian Y, and Chen X. The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation. J Biol Chem 2011, 286, 35388-35395. 15. Jung YS, Hakem A, Hakem R, and Chen X. Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Mol Cell Biol 2011, 31, 3997-4006. 16. Jung YS, Liu G, and Chen X. Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation. Mol Cell Biol 2010, 30, 1041-1048. 17. Jung YS, Qian Y, and Chen X. Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 2010, 22, 1003-1012. 18. Jung YS, Kim HY, Lee MG, Pouyssegur J, and Kim E. Physical interaction and functional coupling between Daxx and sodium hydrogen exchanger isoform 1, an implication regarding Daxx role in ischemic stress-induced cell death. J Biol Chem 2008, 283, 1018-1025. 19. Jung YS, Kim HY, Lee YJ, and Kim E. Subcellular localization of Daxx determines its opposing functions in ischemic cell death. FEBS Lett 2007, 581, 843-852. 中文核心期刊论文: 1. 赵诗莹,陈新,陈欢,钱莺娟,郑龙三*,戴建君. 黄腐酚对流行性腹泻病毒的体外抑制作用.病毒学报 2020 DOI:10.13242/j.cnki.bingduxuebao.003769 2. 陈新,曹雨,薄宗义,陈欢,孙雯,张志芳,印春生,钱莺娟*,JUNG Yong-Sam*,戴建君. Tubacin 对蓝舌病 毒感染的抑制作用.中国兽医学报 2019,39(10):1902-1906. 3. 叶跃天,郇文彬,陈欢,钱莺娟,JUNG Yong-Sam*,戴建君. 黄连素抑制猪流行性腹泻病毒复制和组装. 中国兽医学报 2019,39(10):1829-1835. 4. 王飞飞,刘珂,郇贝丽,欧安妮,魏建超,李蓓蓓,邵东华,邱亚峰,钱莺娟,JUNG Yong-Sam*,马志永*. ATP5J 促进猪繁殖与呼吸综合征病毒复制研究.畜牧与兽医 2018,50(08):54-58 5. 阮智杨,陈新,孙雯, JUNG Yong-Sam*,钱莺娟*. 奶牛乳房炎病原菌的分离鉴定及药物敏感试验.畜 牧与兽医 2018,50(6):105-109. 6. 鲍晨沂,连雪,杨莎莎,张旭,JUNG Yong-Sam*,钱莺娟*. 马立克病病毒致瘤蛋白 Meq 转录调节鸡 p21 基因的表达. 畜牧与兽医 2018,50(5):84-88. 7. 李雪琪, 陈鸿军,连雪,鲍晨沂,孙海伟, JUNG Yong-Sam*,钱莺娟*.鸡源性 p53 单克隆抗体的制 备和鉴定.中国动物传染病学报 2018,26(3):72-77. 8. 王飞飞,刘珂,郇贝丽,魏建超,邵东华,李蓓蓓,邱亚峰,石元元,钱莺娟,马志永*,JUNG Yong-Sam*.猪源 干扰素刺激基因 PPBP 荧光定量 PCR 检测方法的建立及初步应用.中国动物传染病学报 2018.26(3):28-33. 9. 李雪琪,连雪,鲍晨沂,孙海伟,陈鸿军,JUNG Yong-Sam*,钱莺娟*. 细胞周期蛋白依赖性激酶抑制 蛋白 p21 单克隆抗体制备. 中国兽医科学 2017,17(06):701-706.

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