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个人简介

周斌,南京农业大学动物医学院预防兽医系主任,农业农村部动物细菌学重点实验室主任。2000 年华中农业大学畜牧兽医学院本科毕业,2003 年南京农业大学动物医学院硕士毕业后留校工作至今。 2010 年南京农业大学生命科学学院理学博士。2013.6-2014.6 美国康奈尔大学兽医学院访问学者。科研上主要从事非洲猪瘟、猪瘟和日本乙型脑炎等猪重要疫病防控技术研究,先后主持和参加国家重点研发计划、国家自然科学基金面上项目和重点项目等。迄今发表科研论文80 余篇,参编著作 5 部。近期以第一作者/通讯作者发表 SCI 论文 19 篇(含 PLOS Pathogens 1篇和 Journal of Virology 8 篇)。近期获得江苏省优秀硕士学位论文指导教师称号 3 次。 科研项目: 1. 国家自然科学基金面上项目,32172840,内吞体分选转运复合体调控猪瘟病毒感染宿 主细胞的分子机制研究,2020-01 至 2025-12,58 万元,在研,主持。 2. 国家自然科学基金面上项目,31872471,Rab 蛋白调控猪瘟病毒入胞后的转运以及参 与核衣壳释放的分子机制研究,2019-01 至 2022-12,60 万元,在研,主持。 3. 国家自然科学基金面上项目,31572554,不同种属 Mx 蛋白抑制猪瘟病毒增殖的分 子机制研究及其关键结构域分析,2016-01 至 2019-12,79.2 万元,已结题,主持。 4. 国家自然科学基金委员会,重点项目,31930109,PEDV 经母猪乳汁垂直传播给新生 仔猪的机制研究,2020-01-01 至 2024-12-31,294 万元,在研,参与。 5. 国家重点研发计划,2021YFD1801303,非洲猪瘟亚单位疫苗研发,2021-12 至 2024-11, 150 万,在研,参加。 6. 国家重点研发计划,2018YFD0500801,猪瘟净化技术研究与示范,2018-07 至2021-06, 34 万,已结题,参加。 7. 国家重点研发计划,2016YFD0500703、猪重要疫病蛋白芯片检测技术研究,2016-01 至 2019-12,60 万,已结题,参加。 8. 企业横向经费,非洲猪瘟 4 个结构蛋白的表达、单抗制备及其诊断方法的建立和应用, 2019-01 至 2022-12,120 万,在研,主持。 荣誉奖项: 1. 2016 年江苏省优秀学术学位硕士学位论文(指导老师) 2. 2020 年江苏省优秀学术学位硕士学位论文(指导老师) 3. 2021 年江苏省优秀专业学位硕士学位论文(指导老师) 发明专利: 1. 同时检测 CSFV、PPV、JEV、PRRSV 抗体的荧光标记蛋白芯片制备和检测方法,201911097381.9,本人排名 1 2. 抗乙型脑炎病毒的单克隆抗体及其应用,ZL201110272334.0,2013,本人排名 1 3. 一 种 能 一 致 乙 型 脑 炎 病 毒 复 制 与 感 染 的 shRNA 及 其 应 用 ( 分 案 ),ZL201010507298.7,2012,本人排名 5 4. 一种复合猪 α 干扰素基因及其重组载体,ZL201010125057.6,2011,本人排名 10 5. 三肽囊素特异性结合肽及筛选方法,ZL200810155724.8,2011,本人排名 6

研究领域

动物分子病毒学与免疫学;动物疫病诊断与防控

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Liu Chun-chun; Liu Ya-yun; Zhou Jiang-fei; Chen Xi; Chen Huan; Hu Jia-huan; Chen Jing; Zhang Jin; Sun Rui-cong; Wei Jian-chao; Go Yun Young; Morita Eiji; Zhou Bin*; Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection, PLoS Pathogens, 2022, 18(2): e1010294 2. Liu Chun-Chun; Liu Ya-Yun; Cheng Yan; Zhang Yun-Na; Zhang Jin; Liang Xiao-Dong; Gao Ya; Chen Huan; Baloch Abdul-Sattar; Yang Qian; Go Yun-Young; Zhou Bin*; The ESCRT-I Subunit Tsg101 Plays Novel Dual Roles in Entry and Replication of Classical Swine Fever Virus, Journal of Virology,2021, 95(6): e01928-20 3. Cheng Yan; Lou Jin Xiu; Liu Chun Chun; Liu Ya Yun; Chen Xiong Nan; Liang Xiao Dong; Zhang Jin; Yang Qian; Go Yun Young; Zhou Bin*; Microfilaments and Microtubules Alternately Coordinate the Multi-step Endosomal Trafficking of Classical Swine Fever Virus, Journal of Virology, 2021, 95(10): e02436-20 4. Liu Ya-Yun; Liang Xiao-Dong; Liu Chun-Chun; Cheng Yan; Chen Huan; Baloch Abdul Sattar; Zhang Jin; Go Yun Young; Zhou Bin*; Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B, Journal of Virology, 2021, 95(17): e00781-21 5. Zhou Jing; Chen Jing; Zhang Xiao-Min; Gao Zhi-Can; Liu Chun-Chun; Zhang Yun-Na; Hou Jin-Xiu; Li Zhao-Yao; Kan Lin; Li Wen-Liang; Zhou Bin*; Porcine Mx1 protein inhibits classical swine fever virus replication by targeting nonstructural protein NS5B, Journal of Virology, 2018, 92(7):e02147-17 6. Shi Bao-Jun; Liu Chun-Chun; Zhou Jing; Wang Shi-Qi; Gao Zhi-Can; Zhang Xiao-Min; Zhou Bin*; Chen Pu-Yan; Entry of Classical Swine Fever Virus into PK-15 Cells via a pH-, Dynamin-, and Cholesterol- Dependent, Clathrin-Mediated Endocytic Pathway That Requires Rab5 and Rab7, Journal ofVirology, 2016, 90(20): 9194-9208 7. Liu Chun-Chun; Zhang Yun-Na; Li Zhao-Yao; Hou Jin-Xiu; Zhou Jing; Kan Lin; Zhou Bin*; Chen Pu-Yan; Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells, Journal of Virology, 2017, 91(19): e01113-17 8. Zhang Yun-Na; Liu Ya-Yun; Xiao Fu-Chuan; Liu Chun-Chun; Liang Xiao-Dong; Chen Jing; Zhou Jing; Baloch Abdul-Sattar; Kan Lin; Zhou Bin*; Qiu Hua-Ji*; Rab5, Rab7, and Rab11 Are Required for Caveola-Dependent Endocytosis of Classical Swine Fever Virus in Porcine Alveolar Macrophages, Journal of Virology, 2018, 92(15): e00797-18 9. Zhou Bin; Yang, Kui; Wills, E; Tang, Liang; Baines, JD; A mutation in the DNA polymerase accessory factor of herpes simplex virus 1 restores viral DNA replication in the presence of raltegravir, Journal of Virology, 2014, 88(19): 11121-11129 10. Gao Ya; Hu Jia-Huan; Liang Xiao-Dong; Chen Jing; Liu Chun-Chun; Liu Ya-Yun; Cheng Yan; Go Yun Young; Zhou Bin*; Curcumin inhibits classical swine fever virus replication by interfering with lipid metabolism, Veterinary Microbiology, 2021, 259: 109152 11. Chen Jing; Wu Yue; Wu Xu-Dan; Zhou Jing; Liang Xiao-Dong; Abdul Sattar-Baloch; Qiu Ya-Feng; Gao Song; Zhou Bin*; The R614E mutation of mouse Mx1 protein contributes to the novel antiviral activity against classical swine fever virus, Veterinary Microbiology, 2020, 243: 108621 12. Liang Xiao-Dong; Zhang Yun-Na; Liu Chun-Chun; Chen Jing; Chen Xiong-Nan; Baloch Abdul Sattar; Zhou Bin*; U18666A inhibits classical swine fever virus replication through interference with intracellular cholesterol trafficking, Veterinary Microbiology, 2019, 238: 108436 13. Wu Yue; Wu Xu-Dan; Hou Jin-Xiu; Chen Xiong-Nan; Huang Xiao-Bo; Zhou Bin*; Two novel protein chips for the detection of antibodies against porcine parvovirus, BMC Veterinary Research, 2020, 16(1): 57 14. Wu Yue; Wu Xu-Dan; Chen Jing; Hu Jing-Fei; Huang Xiao-Bo; Zhou Bin*; A novel protein chip for simultaneous detection of antibodies against four epidemic swine viruses in China, BMC Veterinary Research, 2020, 16(1): 162 15. Baloch Abdul-Sattar; Liu Chun-Chun; Liang Xiao-Dong; Liu Ya-Yun; Chen Jing; Cao Rui-Bing; Zhou Bin*; Avian Flavivirus Enters BHK-21 Cells by a Low pH-Dependent Endosomal Pathway, Viruses, 2019, 11: 1112 16. Zhou J, Wang SQ, Wei JC, Zhang XM, Gao ZC, Liu K, Ma ZY, Chen PY,Zhou B*,2017.Mx Is Not Responsible for the Antiviral Activity of Interferon-αagainst Japanese Encephalitis Virus.Viruses. 9(1). pii: E5. 17. Zhang X, Jing J, Li W, Liu K, Shi B, Xu Q, Ma Z, Zhou B*, Chen P,2015.Porcine Mx1 fused to HIV Tat protein transduction domain (PTD) inhibits classical swinefever virus infection in vitro and in vivo.BMC Vet Res. 15;11:264. 18. He DN, Zhang XM, Liu K, Pang R, Zhao J, Zhou B*, Chen PY,2014.In vitroinhibition of the replication of classical swine fever virus by porcine Mx1 protein.Antiviral Res,104:128-135. 19. Deng WL, Guan CY, Liu K, Zhang XM, Feng XL, Zhou B*, Su XD, Chen PY,2014.Fine mapping of a linear epitope on EDIII of Japanese encephalitis virususing a novel neutralizing monoclonal antibody.Virus Res,179:133-139. 20. Zhao J, Shi BJ, Huang XG, Peng MY, Zhang XM, He DN, Pang R, Zhou B*, Chen PY, 2013. A multiplex RT-PCR assay for rapid and differential diagnosis of four porcine diarrhea associated viruses in field samples from pig farms in East Chinafrom 2010 to 2012, Journal of Virological Methods,194,107-112. 21. Zhang XM, He DN, Zhou B*, Pang R, Liu K, Zhao J, Chen PY, 2013. In vitro inhibition of vesicular stomatitis virus replication by purified porcine Mx1 protein fused to HIV-1 Tat protein transduction domain (PTD). Antiviral Research99,149-157. 22. Pang R, He DN, Zhou B*, Liu K, Zhao J, Zhang XM, Chen PY, 2013. In vitro inhibition of Japanese encephalitis virus replication by capsid-targeted virus inactivation. Antiviral Research 97,369-375. 23. Feng XL#,Zhou B#,Cao RB, Liu QT, Liu K, Liu XD, Zhang YP, Huang L, Ji XB,Luo J, Zhang G, Chen PY*,2012. Immunomodulatory roles and functional analysis of pre-B lymphocyte DT40 cells with the bursal-derived BSP-II treatment. Peptides,36(2): 292-298. 24. Zhou B, Liu K, Jiang Y,Wei JC,Chen PY*, 2011.Multiple linear B-cell epitopes of classical sw ine fever virus glycoprotein E2 expressed in E.coli as multiple epitopevaccine induces a protect ive immune response. Virology Journal (8):378.

学术兼职

兼任中国畜牧兽医学会动物传染病学分会理事,《畜牧与兽医》杂志主编、《病毒学报》编委

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