个人简介
范红结,1968 年 7 月 26 日生,安徽望江人,南京农业大学动物医学院党委书记。1990 年毕业于安徽农师院兽医专业,获学士学位;1996 年毕业于扬州大学传染病与预防兽医学专业,获硕士学位;2003年毕业于南京农业大学动物医学院,获预防兽医学博士学位。1996 年 7 月至今在南京农业大学动物医学院,从事兽医微生物学及免疫学的教学、科研工作,历任助教、讲师、副教授,2008 年 12 月晋升教授;2009 年 11 月至 2014 年 6 月任动物医学院院长,2013 年 12 月任动物医学院党委书记。2003-2004 年在新疆农业大学援教,2005、2006 年两次赴德国 Erlangen 大学微生物与免疫学研究所合作科研。先后主持国家和部省级研究课题 20 多项,主要涉及猪链球菌病、动物沙门氏菌病、猪流行性腹泻致病机理、快速检测及免疫预防等方面的研究。已发表学术论文 150 余篇,以通讯作者发表 SCI 收录论文 50 多篇,获国家科技进步二等奖和国家教学成果奖二等奖各一项,另获其他部省级奖励 6 项,已培养博士研究生 15 名,硕士研究生 80 多名。2015 年入选农业部农业科研杰出人才及创新团队。
在研科研项目:
1 、 病 原 菌 毒 力 调 控 机 制 研 究 . 国 家 重 点 研 发 计 划 课 题 ( 项 目 编 号 :
2017YFD0500203),2017,7-2020,12;530 万元,主持;
2、STKs/STPs 系统在猪链球菌 2 型突破血脑屏障中的作用机制. 国家自然科学
基金(项目编号:31672574),2017,1-2020,12;76 万元,主持;
3、农业科研杰出人才及创新团队,2016,1-2020,12;100 万元,主持;
4、江苏、安徽等地区动物源性沙门菌病防控技术研究与示范. 公益性行业(农
业)科研专项(项目编号:201403054),2014,1-2018,12;101 万元,主持;
5、猪抗猪链球菌抗病相关基因的克隆、鉴定. 转基因重大专项(项目编号:
2014ZX08009-046B),2014,1-2017,12;193 万元,主持。
6、江苏省农业科技资助创新项目子课题,猪流行性腹泻综合控制技术(项目编
号:CX(16)1028),2016,7-2018,12;50 万元,主持。
荣誉奖项:
1、“动物医学卓越人才培养的探索与实践”获 2013 年度江苏省教学成果奖一等奖(第一完成人);
2、“猪链球菌病研究及防控技术”获 2007 年度国家科技进步二等奖(第三完成人);
3、2015 年入选农业部农业科研杰出人才;
4、2013 年入选江苏特聘教授;
5、2008 年入选度教育部新世纪优秀人才。
发明专利:
1、专利号:ZL201210002347.0,专利名称:一种马链球菌兽疫亚种的酶联免疫
检测试剂盒及检测方法,授权日期:20150204;
2、专利号:ZL201210340309.6,专利名称:表达猪圆环病毒 2 型 Cap 蛋白的重
组猪痘病毒载体疫苗及其制备方法,授权日期:20140319;
3、专利号:ZL201110076562.0,专利名称:表达马链球菌兽疫亚种类 M 蛋白的
重组猪痘病毒载体疫苗,授权日期:20130814;
4、专利号:ZL200910143936.9,专利名称:一种马链球菌兽疫亚种 PCR 检测方
法及用于该方法的试剂盒,授权日期:20110727;
5、专利号:ZL200610075969.0,专利名称:一种链球菌重组亚单位疫苗及其制
备方法,授权日期:20080521;
近期论文
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(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
1、Peng Jie, Ma Zhe, Hongjie Fan*, et al. Virulent and Vaccine Strains of
Streptococcus equi ssp. zooepidemicus Have Different Influences on Phagocytosis
and Cytokine Secretion of Macrophages. Journal of Proteome Research, 2017,
16:77-86
2、Ma Fang, Guo Xiao, Hongjie Fan*, et al. Extracellular Nucleases of Streptococcus
equi subsp. zooepidemicus Degrade Neutrophil Extracellular Traps and Impair
Macrophage Activity of the Host. Applied and Environmental Microbiology,
2017,83(2): e02468
3、Lin Huixing, Ma Zhe, Hongjie Fan*, et al. Construction and immunogenicity of a
recombinant swinepox virus expressing a multi-epitope peptide for porcine
reproductive and respiratory syndrome virus. Scientific Reports, 2017, 7:43990
4. Yi Li, Wang Yang, Fan Hongjie*, et al. Identification and characterizationof a
Streptococcus equi ssp. Zooepidemicus immunogenic GroEL protein involved in
biofilmformation. Veterinary Research, 2016, 47:50
5. Liu Rui, Ma Zhe*, Fan Hongjie*, et al. A novel suicide shuttle plasmid for
Streptococcus suis serotype 2 and Streptococcus equi ssp zooepidemicus gene
mutation. Scientific Reports, 2016, 6: 27133
6. Ma Zhe, Peng Jie , Fan Hongjie*, et al. SILAC and LC-MS/MS identification of
Streptococcus equi ssp. zooepidemicus proteins that contribute to mouse brain
microvascular endothelial cell infection. Applied Microbiology and Biotechnology,
2016, 5: 1–12
7. Lin Huixing, Chen Lei, Fan Hongjie*, et al. Epidemic strain YC2014 of porcine
epidemic diarrhea virus could provide piglets against homologous challenge. Virology
Journal , 2016, 13(68): 1–7
8. Xu Bin, Yang Xinyi, Fan Hongjie*, et al. The arginine deiminase system facilitates
environmental adaptability ofStreptococcus equi ssp. zooepidemicus through pH
adjustment. Research in Microbiology, 2016, 1-10
9. Xu Bin,Pei Xiaomeng,Fan Hongjie*, et al. Capsule of Streptococcus equi subsp
zooepidemicus hampers the adherence and invasion of epithelial and endothelial cells
and is attenuated during internalization. Fems Microbiology Letters,2016, 363(16):
164.
10. Zhuge Xiangkai, Dai Jianjun*, Fan Hongjie*, et al. AutA and AutR, Two Novel
Global Transcriptional Regulators, Facilitate Avian Pathogenic Escherichia coli
Infection. Scientific Reports, 2016; 6: 25085
11. Fang Yizhen, Lin Huixing, Fan Hongjie*, et al. Construction and immunogenicity
of recombinant swinepox virus expressing outer membrane protein L of Salmonella,
Journal of Microbiology and Biotechnology , 2016, 26(1):1–13
12. Yuan Xiaomin, Lin Huixing, Fan Hongjie*, et al. Efficacy and immunogenicity of
recombinant swinepox virus expressing the A epitope of the TGEV S protein,Vaccine,
2015,33:3900–3906
13. Huan Changchao, Fan Hongjie*, Xiang Mao*, et al. Porcine epidemic diarrhea
virus uses cell-surface heparan sulfate as an attachment factor,Archives of Virology,
2015,160:1621–1628
14. Bo Ni, HongJie Fan*, Xiang Mao*, et al. The involvement of
FAK-PI3K-AKT-Rac1 pathway in porcine reproductive and respiratory syndrome
virus entry,Biochemical and Biophysical Research Communications,2015,458:
392e398
15. Hongping Hao, Hongjie Fan*, Xiang Mao*, et al. LiCl inhibits PRRSV infection
by enhancing Wnt/b-catenin pathway and suppressing inflammatory responses.
Antiviral Research, 2015, 117: 99–109
16、Ma Zhe, Yu Lei, Fan Hongjie*, et al. Identification of novel genes expressed
during host infection in Streptococcus equi ssp. Zooepidemicus ATCC35246,
Microbial Pathogenesis,2015,79:31-40
17、Yi Li,Wang Yang,Fan Hongjie*, et al. Biofilm Formation of Streptococcus equi
ssp. zooepidemicus and Comparative Proteomic Analysis of Biofilm and Planktonic
Cells,Current Microbiology,2014,69(3):227-233
18、Lin Huixing,Ma Zhe,Fan Hongjie*, et al. A novel vaccine against Porcine
circovirus type 2 (PCV2) and Streptococcus equi ssp. zooepidemicus (SEZ)
co-infection,Veterinary Microbiology,2014,171(1-2):198-205
19、Zhang Hui,Zheng Junxi,Fan Hongjie*, et al. The identification of six novel
proteins with fibronectin or collagen type I binding activity from Streptococcus suis
serotype 2,Journal of Microbiology,2014,52(11):963-969
20、Li Yue,Zhang Junxi,Fan Hongjie*, et al. Effect of Tran on virulence through
regulating metabolism and stress tolerance of Streptococcus suis serotype 2,
Microbiology Research,2014,169(9):666-674
21、Yi Li,Lu Chengping,Fan Hongjie*, et al. Contribution of fibronectin-binding
protein to pathogenesis of Streptococcus equi ssp zooepidemicus,Pathogens and
Disease,2013,67(3):174-183
22、Ma Zhe,Fan Hongjie*,Hu Songnian*, et al. Insight into the specific virulence
related genes and toxin-antitoxin virulent pathogenicity islands in swine
streptococcosis pathogen Streptococcus equi ssp zooepidemicus strain ATCC35246,
BMC Genomics,2013,14:1-12
23、Yi Li,Lu Chengping,Fan Hongjie*, et al. Identification of genes transcribed by
Streptococcus equi ssp zooepidemicus in infected porcine lung,Microbial
Pathogenesis,2013,59-60:7-12
24、Zhou Hong,Ma Zhe,Fan Hongjie*, et al. Identification and Characterization of
Putative Virulent Genes in Streptococcus equi ssp zooepidemicus,Journal of
Integrative Agriculture,2013,12(2):327-333
25、 Zheng Junxi,Li Yue,Fan Hongjie*, et al. Identification and Characterization of
a Novel Hemolysis-Related Gene in Streptococcus suis Serotype 2,PLoS One,2013,
8(9)
26、Yang Yongchun,Liu Yinglong,Fan Hongjie*, et al. Molecular Characterization
of Streptococcus agalactiae Isolated from Bovine Mastitis in Eastern China,PLOS
ONE,2013,8(7)
27、Zhang Hui,Ma Zhe,Fan Hongjie*, et al. Identification of a novel collagen type
I-binding protein from Streptococcus suis serotype 2,Veterinary Journal,2013,197
(2):406-414
28、Memon Javed,Kashif Jam,Fan Hongjie*, et al. Molecular Characterization and
Antimicrobial Sensitivity of Pathogens from Sub-Clinical and Clinical Mastitis in
Eastern China,Pakistan veterinary journal, 2013,33(2):170-174
29、Zhicheng Zhang,Wei Dai,Hongjie Fan*, et al. Analysis of synonymous codon
usage patterns in torque teno sus virus 1 (TTSuV1),Archives of Virology,2013,
158:145–154
30、Lichang Sun, Hongjie Fan*, Zuzhang Wei*, et al. Porcine reproductive and
respiratory syndrome virus ORF5a protein is essential for virus viability. Virus
Research, 2013,171:178– 185
学术兼职
兼任中国微生物学会理事、江苏省畜牧兽医学会副理事长、中国微生物学会兽医微生物专业委员会委员、中国免疫学会兽医免疫学专业委员会委员、中国畜牧兽医学会兽医公共卫生学分会常务理事、第七届农业部新兽药评审委员等职