Dong, Guangbin - The University of Chicago

个人简介

2023-present Weldon G. Brown Professor of Chemistry, University of Chicago, Illinois 2016-2022 Professor of Chemistry, University of Chicago, Illinois 2016 Professor of Chemistry, Pettit Centennial Chair (declined), University of Texas at Austin, 2016 2011 – 2016 Assistant Professor, University of Texas at Austin, Texas 2009 – 2011 Camille and Henry Dreyfus Postdoctoral Fellow, California Institute of Technology, Pasadena, California Advisor: Professor Robert H. Grubbs 2004 – 2009 Ph.D. in Chemistry, Stanford University, Stanford, California Advisor: Professor Barry M. Trost 1999 – 2003 B.S. in Chemistry, Peking University, Beijing, China Advisors: Professor Zhen Yang and Professor Jiahua Chen

研究领域

1) Developing novel catalytic C-H and C-C bond activation methods for efficient small-molecule agents synthesis: we aim to address the challenges of “enabling C–C activation as a useful/practical method for complex molecule synthesis” and “controlling site-selectivity of C–H functionalization using common functional groups”. 2) Developing new transition-metal catalysts based on supramolecular chemistry for chemoselective C-H bond activation of small molecules: we are particularly interested in methane activation and subsequent conversion to useful fine chemicals. 3) Establishing efficient synthetic routes to access natural products with high potent anticancer and immunosuppressive activity and their unnatural analogues and evaluating in vitro and in vivo efficacy of rationally designed natural product analogues and understanding the origins of the selectivity in the cell-killing and the immunosuppressive process. 4) Developing new methods for preparation of novel atomically precise graphene nanoribbon materials from a bottom-up approach.

近期论文

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Choi, Shinyoung; Yoon, Ki-Young* and Dong, Guangbin* “Modular Synthetic Platform for Interior-Functionalized Dendritic Macromolecules Enabled by the Palladium/Norbornene Catalysis” J. Am. Soc. Chem 2024. Chen, Miao; Knox, Christian D.; Madhusudhanan, Mithun C.; Tugwell, Thomas T.; Liu, Coco; Liu, Peng* and Dong, Guangbin* “Stereospecific alkenylidene homologationof organoboronates by SNV reaction” Nature 2024. Liu, Xin; Zhu, Qi and Dong, Guangbin* “Beyond Tertiary Amines: Introducing Secondary Amines by Palladium/Norbornene-Catalyzed Ortho Amination” Angew. Chem. Int. Ed. 2024 e202404042. Choi, Shinyoung and Dong, Guangbin* “Rapid and Modular Access to Multifunctionalized 1,2-Azaborines via Palladium/Norbornene Cooperative Catalysis” J. Am. Chem. Soc. 2024, 146, 9512-9518. Yu, Congjun; Zhang, Zining and Dong, Guangbin* “Split cross-coupling via Rh-catalysed activation of unstrained aryl-aryl bonds” Nat. Catal. 2024, 7, 432-440. Li, Gang; Wang, Hanfei; Loes, Michael; Saxena, Anshul; Yin, Jiangliang; Sarker, Mamun; Choi, Shinyoung; Aluru, Narayana*; Lyding, Joseph*; Sinitskii, Alexander* and Dong, Guangbin* “Hybrid Edge Results in Narrowed Band Gap: Bottom-up Liquid-phase Synthesis of Bent N=6/8 Armchair Graphene Nanoribbons” ACS Nano 2024, 18, 4297-4307. Chen, Miao; Tugwell, Thomas; Liu, Peng* and Dong, Guangbin* “Introducing Alkene Moieties via Iterative Carbenoid Insertions: Vinylene Homologation of Organoboronates” Nat. Synth. 2024, 3, 337-346. Liu, Xin and Dong, Guangbin* “Asymmetric access to β-funebrene via a trans-selective annulation of allenylsilane-enes” Chem 2024, 10,1-2. Rago, Alexander J.;† Ye, Rong;† Liu, Xin* and Dong, Guangbin* “A four-component reaction to access 3,3- disubstituted indolines via the palladium–norbornene-catalyzed ortho amination/ipso conjunctive coupling” Chem. Sci. 2024, 15, 1318-1323. Xu, Yan* and Dong, Guangbin* “Deracemization through C–C bond manipulation” Sci. Bull. 2024, 69, 285-287 Zhang, Rui; Yu, Tingting and Dong, Guangbin* “Rhodium catalyzed tunable amide homologation through a hook-and-slide strategy” Science 2023, 382, 951-957. Lyu, Hairong; Tugwell, Thomas H.; Chen, Zhijie; Kukier, Garrett A.; Turlik, Aneta;Wu, Yifei; Houk, K. N.*; Liu, Peng* and Dong, Guangbin* “Modular synthesis of 1,2-azaborines via ring-opening BN-isostere benzannulation” Nat. Chem. 2024, 16, 269-276. Zhang, Zining; Zhu, Qi; Pyle, Daniel; Zhou, Xukai* and Dong, Guangbin* “Methyl Ketones as Alkyl Halide Surrogates: A Deacylative Halogenation Approach for Strategic Functional Group Conversions” J. Am. Chem. Soc. 2023, 145, 21096−21103. Liu, Xin; Zhou, Yun; Qi, Xiaotian; Li, Renhe*; Liu, Peng* and Dong, Guangbin* “Palladium/Norbornene-Catalyzed Direct Vicinal Di-Carbo-Functionalization of Indoles: Reaction Development and Mechanistic Study” Angew. Chem. Int. Ed. 2023. e202310697 Liu, Xin; Fu, Yue.; Chen, Zhijie; Liu, Peng* and Dong, Guangbin* “Ortho-C–H Methoxylation of Aryl Halides Enabled by a Polarity Reversed N–O Reagent” Nat. Chem. 2023, 15, 1391-1399. Yin, Jiangliang; Choi, Shinyoung; Pyle, Daniel; Guest, Jeffrey R. and Dong, Guangbin* “Backbone Engineering of Monodisperse Conjugated Polymers via Integrated Iterative Binomial Synthesis” J. Am, Chem. Soc. 2023, 145, 19120-19128. Xie, Qiqiang; Zhang, Rui and Dong, Guangbin* “Programmable Amine Synthesis via Iterative Boron Homologation” Angew. Chem. Int. Ed. 2023, e202307118. Huo, Jingfeng; Fu, Yue; Tang, Melody J.; Liu, Peng* and Dong, Guangbin* “Escape from Palladium: Nickel-Catalyzed Catellani Annulation” J. Am. Chem. Soc. 2023, 145, 11005-11011. Xie, Jiaxin and Dong, Guangbin* “Cyclopropylcarbinyl cation chemistry in synthetic method development and natural product synthesis: cyclopropane formation and skeletal rearrangement” Org. Chem. Front. 2023, 10, 2346–2358. Xue, Yibin; Parsad, Arjuna and Dong, Guangbin* “α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis” Org. Synth. 2023, 100, 99-112. Zhou, Xukai; Pyle, Daniel; Zhang, Zining and Dong, Guangbin* “Deacylative Thiolation by Redox-Neutral Aromatization-Driven C−C Fragmentation of Ketones” Angew. Chem., Int. Ed. 2023, 62, e202213691. Xie, Jiaxin; Zheng, Zhong; Liu, Xin; Zhang, Nan; Choi, Shinyoung; He, Chuan and Dong, Guangbin* Asymmetric Total Synthesis of (+)-Phainanoid A and Biological Evaluation of the Natural Product and Its Synthetic Analogues” J. Am. Chem. Soc. 2023, 145, 4828–4852. Zhou, Bo; Deng, Shuang.; Xu, Yin.; Qi, Xiaotian and Dong, Guangbin* Iridium-Catalyzed Intramolecular β-C–H Alkenylation of Ketones with Alkynes via a Hydride-Transfer Approach” J. Am. Chem. Soc. 2022, 144, 23230–23238. Hou, Si-Hua;† Yu, Xuan;† Zhang, Rui; Wagner, Cole and and Dong, Guangbin* “Rhodium-Catalyzed Diastereo- and Enantioselective Divergent Annulations between Cyclobutanones and 1,5-Enynes: Repaid Construction of Complex C(sp3)-Rich Scaffolds” J. Am. Chem. Soc. 2022, 144, 22159–22169. Yang, Sen; Fan, Huike; Xie, Licheng; Dong, Guangbin* and Chen, Ming* “Photoinduced Desaturation of Amides by Palladium Catalysis” Org. Lett.. 2022, 24, 6460–6465. Yin, Jiangliang; Jacobse, Peter H.; Pyle,Daniel; Wang, Ziyi; Crommie, Michael F.* and Dong, Guangbin* “Programmable Fabrication of Monodisperse Graphene Nanoribbons via Deterministic Iterative Synthesis” J. Am. Chem. Soc. 2022, 144, 16012–16019. Xue, Yibin and Dong, Guangbin* “Deconstructive Synthesis of Bridged and Fused Rings via Transition-Metal-Catalyzed “Cut-and-Sew” Reactions of Benzocyclobutenones and Cyclobutanones” Acc. Chem. Res. 2022, 55, 2341–2354. Zhou, Xukai; Yu, Tingting and Dong, Guangbin* “Site-Specific and Degree-Controlled Alkyl Deuteration via Cu-Catalyzed Redox-Neutral Deacylation” J. Am. Chem. Soc. 2022, 144, 9570–9575. Yu, Xuan;† Zhang, Zining† and Dong, Guangbin* “Catalytic Enantioselective Synthesis of γ-Lactams with β-Quaternary Centers via Merging of C–C Activation and Sulfonyl Radical Migration” J. Am. Chem. Soc. 2022, 144, 9222–9228. Xie, Qiqiang and Dong, Guangbin* “Programmable Ether Synthesis Enabled by Oxa-Matteson Reaction” J. Am. Chem. Soc. 2022, 144, 8498–8503. Huang, Jiangkun; Zhang, Rui; Wu, Xiuli; Dong, Guangbin* and Xia, Ying* “Intramolecular One-Carbon Homologation of Unstrained Ketones via C–C Activation-Enabled 1,1-Insertion of Alkenes” Org. Lett. 2022, 24, 2436–2440. Ochi, Shusuke; Zhang, Zining; Xia, Ying* and Dong, Guangbin* “Rhodium-Catalyzed (4+1) Cycloaddition between Benzocyclobutenones and Styrene-Type Alkenes” Angew. Chem., int. Ed. 2022, 61, e202202703. Wu, Zhao and Dong, Guangbin* “Rapid Access to Multisubstituted Acrylamides from Cyclic Ketones via Palladium/Norbornene Cooperative Catalysis” Angew. Chem., Int. Ed. 2022, 61, e202201239. Zhu, Jun;† Xue, Yibin;† Zhang, Rui; Ratchford, Benjamin L. and Dong, Guangbin* “Catalytic Activation of Unstrained C(Aryl)–C(Alkyl) Bonds in 2,2′-Methylenediphenols” J. Am. Chem. Soc. 2022, 144, 3242–3249. Zhou, Xukai; Xu, Yan* and Dong, Guangbin* “Olefination via Cu-Mediated Dehydroacylation of Unstrained Ketones” J. Am. Chem. Soc. 2021, 143, 20042–20048. Xie, Jiaxin; Liu, Xin; Zhang, Nan; Choi, Shinyoung and Dong, Guangbin* “Bidirectional Total Synthesis of Phainanoid A via Strategic Use of Ketones” J. Am. Chem. Soc. 2021, 143, 19311-19316. Wu, Zhao; Xu, Xiaolong; Wang, Jianchun and Dong, Guangbin* “Carbonyl 1,2-transposition through triflate-mediated α-amination” Science 2021, 374, 734-740. Ashfeld, Brandon L.; Judd, Andrew S.; Xie, Jiaxin and Dong, Guangbin “Chloro(1,5-Cyclooctadiene)Rhodium(I) Dimer” Encyclopedia of Reagents for Organic Synthesis; John Wiley & Sons, Ltd: Hoboken, NJ, 2021. Li, Renhe and Dong, Guangbin* “Redox-Neutral Vicinal Difunctionalization of Five-Membered Heteroarenes with Dual Electrophiles” Angew. Chem., Int. Ed. 2021, 60, 26184-26191. Xie, Qiqiang and Dong, Guangbin* “Aza-Matteson Reactions via Controlled Mono- and Double-Methylene Insertions into Nitrogen–Boron Bonds” J. Am. Chem. Soc. 2021, 143, 14422-14427. Zhou, Xukai.; Xu, Yan* and Dong, Guangbin* “Deacylation-aided C–H alkylative annulation through C–C cleavage of unstrained ketones” Nat. Catal. 2021, 4, 703-710. Zhu, Jun‡.; Zhang, Rui‡ and Dong, Guangbin* “Orthogonal cross-coupling through intermolecular metathesis of unstrained C(aryl)–C(aryl) single bonds” Nat. Chem. 2021, 13, 836-842. Zhou, Bo.; Qi, Xiaotian.;* Liu, Peng.* and Dong, Guangbin* “Development and Mechanistic Studies of the Iridium-catalyzed C−H Alkenylation of Enamides with Vinyl Acetates: A Versatile Approach for Ketone Functionalization” Angew. Chem., Int. Ed. 2021, 60, 20926-20934. Zhang, Rui; Xia, Ying and Dong, Guangbin* “Intermolecular [5+2] Annulation between 1-Indanones and Internal Alkynes by Rh-catalyzed C−C Activation” Angew. Chem., Int. Ed. 2021, 60, 20476-20482. Liu, Xin; Wang, Jianchun* and Dong, Guangbin* “Modular Entry to Functionalized Tetrahydrobenzo[b]azepines via the Palladium/Norbornene Cooperative Catalysis Enabled by a C7-Modified Norbornene” J. Am. Chem. Soc. 2021, 143, 9991–10004. Xue, Yibin and Dong, Guangbin* “Total Synthesis of Penicibilaenes via C–C Activation-Enabled Skeleton Deconstruction and Desaturation Relay-Mediated C–H Functionalization” J. Am. Chem. Soc. 2021, 143, 8272-8277. Wu, Zhao; Fatuzzo, Nina and Dong, Guangbin* “Palladium/Norbornene-Catalyzed Distal Alkenyl C–H Arylation and Alkylation of cis-Olefins” Tetrahedron 2021, 90, 132173. Tsogoeva, Svetlana B*; Dong, Guangbin* and Ackermann, Lutz* “Editorial: The Catalysis of Ring Synthesis” ChemCatChem 2021, 13, 1–4. Rago, Alexander J. and Dong, Guangbin* “Synthesis of C3,C4-Disubstituted Indoles via the Palladium/Norbornene-Catalyzed ortho-Amination/ipso-Heck Cyclization” Org. Lett. 2021, 23, 3755-3760. Hairong Lyu; Kevlishvili, Ilia; Yu, Xuan; Liu, Peng* and Dong, Guangbin* “Boron insertion into alkyl ether bonds via zinc/nickel tandem catalysis” Science 2021, 372, 175-182. Zhang, Rui and Dong, Guangbin* “Transfer hydroarylation of ketones using directing-group-free, unstrained alcohols” Chem 2021, 7, 841-842. “Deconstructive Asymmetric Total Synthesis of Morphine‐Family Alkaloid (‐)‐Thebainone A” Hou, Si-Hua; Prichina, Adriana Y. and Dong, Guangbin* Angew. Chem. Int. Ed. 2021, 60, 13057-13064. Rago, Alexander J. and Dong, Guangbin* “Synthesis of indoles, indolines, and carbazoles via palladium-catalyzed C–H activation” Green Synth. Catal. 2021, 2, 216-227. Chen, Ming and Dong, Guangbin* “Platinum‐catalyzed α,β‐Desaturation of Cyclic Ketones through Direct Metal‐enolate Formation” Angew. Chem. Int. Ed. 2021, 60, 7956-7961.